8results about How to "Injectable" patented technology

The invention belongs to the technical field of hydrogel, and provides photo-crosslinking hydrogel, a preparation method and application thereof, a radionuclide preparation and an application. The photo-crosslinking hydrogel with the adhesion comprises a crosslinking network structure formed by dopamine modified methacrylic acid gelatin and o-nitrobenzyl sulfide light trigger modified hyaluronic acid, has injectability, can be gelatinized after being triggered by light, is high in adhesion, and can be used for preparing the hydrogel while improving the mechanical property of the hydrogel. And the hydrogel can bear larger deformation and maintain better elasticity, so that physical-chemical synergistic enhanced adhesion is realized, and instant and firm adhesion with biological tissues can be realized. Furthermore, the photo-crosslinked hydrogel can be used as a carrier, for example, a radionuclide-loaded preparation, or a patch containing radionuclide is prepared, or the photo-crosslinked hydrogel can also be used as a hemostatic material.

The invention discloses supramolecular hydrogel capable of being used as a carrier as well as a synthesis method and application of the supramolecular hydrogel. The drug-loaded supramolecular hydrogel is prepared from the following raw materials: laponite, beta-cyclodextrin modified sodium hyaluronate, (ferrocenyl methyl) trimethyl ammonium bromide and the balance of deionized water. Wherein the hectorite is a substance for forming the network structure of the supramolecular hydrogel serving as the carrier. The supramolecular hydrogel can be used as a macrophage extracellular vesicle carrier for treating burn wounds, has injectable, proper viscosity, porous structure, antibacterial property and the like, is beneficial to wound closure, tissue regeneration, collagen synthesis, cell proliferation and angiogenesis, and is beneficial to tissue regeneration and remodeling.

The invention belongs to the technical field of medicine and hydrogel preparation, and particularly relates to stimuli-responsive injectable composite drug-loaded hydrogel as well as a preparation method and application of the stimuli-responsive injectable composite drug-loaded hydrogel. The structural formula of the stimuli-responsive injectable composite drug-loaded hydrogel is as shown in formula I in the specification. The preparation method is simple and easy to implement, the raw materials are simple, the cost is low, the prepared hydrogel has the soft property, meanwhile, the good tensile property and viscidity are achieved, the hydrogel can be continuously bonded with tissue along with pulling of the tissue, meanwhile, the rapid self-healing performance is achieved, and liquid leakage is prevented. The hydrogel wound dressing also has the characteristic of large drug loading capacity and can play a role according to different wound conditions, and the response type dressing based on the wound microenvironment can accurately release the drug at different times and places through different signals.

The invention relates to hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological hydrogel materials. The hydrogel comprises a prednisolone sodium phosphate hydrogel P-Gel skeleton and gold nanoparticles PCAu, wherein the gold nanoparticles PCAu are uniformly loaded on the P-Gel skeleton and are coated by procyanidine. According to the preparation method, a three-dimensional cross-linked network skeleton of PSP hydrogel P-Gel is self-assembled and constructed by utilizing ion coordination and hydrogen-bond interaction of prednisolone sodium phosphate PSP under the action of Ca < 2 + >, and the hydrogel PCAu-coated P-Gel is formed by uniformly loading gold nanoparticles PCAu which are green synthesized from procyanidine PC and have stable surfaces. The hydrogel can promote rapid repair of spinal cord injury and relieve far-end muscle atrophy and fibrosis; and meanwhile, the injectable self-healing hydrogel has the engineering advantages of injectability, self-healing and the like, and shows good clinical transformation potential.

The present application relates to the technical field of drug synthesis, and particularly relates to a nano-hydrogel precursor as well as a preparation method and application thereof. In the present application, the active ingredients GOx, Mn 2+ and HCQ loaded by the nano-hydrogel can strengthen cancer treatment by activating the STING pathway and regulating the autophagy pathway at the postoperative site. Among them, GOx and Mn 2+ act as a chemical kinetic therapy preparation, Mn 2+ acts as a STING agonist, and HCQ acts as an autophagy inhibitor; GOx and Mn 2+ can play the role of CDT, causing the release of cell membrane dsDNA and mitochondrial dsDNA, thereby further inducing the activation of the STING pathway, and HCQ can effectively inhibit the protective autophagy related to the activation of the STING pathway, further enhancing the anti-tumor immune response. The synergistic effect of the chemical kinetic therapy preparation, the STING agonist and the autophagy inhibitor can produce a specific immune response, significantly inhibit tumor recurrence, and thereby prolong the survival rate of the triple-negative breast cancer mice after surgery.

This invention discloses a CH@SHP099-NPs composite hydrogel, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the technical challenge of achieving long-term, safe, and precise metabolic intervention with SHP2, this invention constructs a hydrogel system composed of chondroitin sulfate and hyaluronic acid. This system can retain SHP099-loaded nanoparticles within the joint cavity, forming a long-acting intrasynovial drug library, thereby continuously inhibiting the SHP2-AMPK signaling axis. The CH@SHP099-NPs composite hydrogel prepared in this invention can effectively reprogram the metabolic state of macrophages, reduce glycolysis flux, restore synovial immune metabolic homeostasis, and significantly improve synovial inflammation, chondrocyte activity, and cartilage structural integrity in vivo. This invention proposes a mechanism-guided local delivery metabolic intervention strategy, which is expected to provide a new interventional approach for the treatment of osteoarthritis.

The application belongs to the field of biomedical materials, and particularly relates to a self-polarization degradable gradient electroactive hydrogel as well as a preparation method and application thereof. The application develops a novel degradable electroactive scaffold based on a high-electroactive natural macromolecule hydrogel, and through material component regulation and control and structure design, the piezoelectric performance of the scaffold is significantly improved, and the synergistic precise regulation and control of the scaffold on bone and cartilage regeneration are realized. Through the combination of electron transfer and ion transfer, the pathological electrical requirements of bone and cartilage regions are respectively adapted, and through the differential regulation and control of the electrical microenvironment and the material structure, the efficient bionics and bidirectional repair of the bone-cartilage interface are realized.

The application discloses a self-healing and injectable photocrosslinking double-network hydrogel and a preparation method thereof. The preparation method comprises the following steps: firstly, glycidyl methacrylate solution is used to perform methacryl modification on silk fibroin; then, sodium periodate solution is used to make dextran perform an oxidation reaction to generate oxidized dextran; and finally, a double-network hydrogel is formed through Schiff base crosslinking reaction between amino groups in the modified silk fibroin and aldehyde groups in the oxidized dextran. The double-network hydrogel prepared by the method has a more compact structure, and thus, the double-network hydrogel has a series of excellent performances, such as safety, injectability, good adhesion, good mechanical properties, self-healing property and drug release performance after drug loading.