4results about How to "Injectable" patented technology

The invention relates to hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological hydrogel materials. The hydrogel comprises a prednisolone sodium phosphate hydrogel P-Gel skeleton and gold nanoparticles PCAu, wherein the gold nanoparticles PCAu are uniformly loaded on the P-Gel skeleton and are coated by procyanidine. According to the preparation method, a three-dimensional cross-linked network skeleton of PSP hydrogel P-Gel is self-assembled and constructed by utilizing ion coordination and hydrogen-bond interaction of prednisolone sodium phosphate PSP under the action of Ca < 2 + >, and the hydrogel PCAu-coated P-Gel is formed by uniformly loading gold nanoparticles PCAu which are green synthesized from procyanidine PC and have stable surfaces. The hydrogel can promote rapid repair of spinal cord injury and relieve far-end muscle atrophy and fibrosis; and meanwhile, the injectable self-healing hydrogel has the engineering advantages of injectability, self-healing and the like, and shows good clinical transformation potential.

The present application relates to the technical field of drug synthesis, and particularly relates to a nano-hydrogel precursor as well as a preparation method and application thereof. In the present application, the active ingredients GOx, Mn 2+ and HCQ loaded by the nano-hydrogel can strengthen cancer treatment by activating the STING pathway and regulating the autophagy pathway at the postoperative site. Among them, GOx and Mn 2+ act as a chemical kinetic therapy preparation, Mn 2+ acts as a STING agonist, and HCQ acts as an autophagy inhibitor; GOx and Mn 2+ can play the role of CDT, causing the release of cell membrane dsDNA and mitochondrial dsDNA, thereby further inducing the activation of the STING pathway, and HCQ can effectively inhibit the protective autophagy related to the activation of the STING pathway, further enhancing the anti-tumor immune response. The synergistic effect of the chemical kinetic therapy preparation, the STING agonist and the autophagy inhibitor can produce a specific immune response, significantly inhibit tumor recurrence, and thereby prolong the survival rate of the triple-negative breast cancer mice after surgery.

This invention discloses a CH@SHP099-NPs composite hydrogel, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the technical challenge of achieving long-term, safe, and precise metabolic intervention with SHP2, this invention constructs a hydrogel system composed of chondroitin sulfate and hyaluronic acid. This system can retain SHP099-loaded nanoparticles within the joint cavity, forming a long-acting intrasynovial drug library, thereby continuously inhibiting the SHP2-AMPK signaling axis. The CH@SHP099-NPs composite hydrogel prepared in this invention can effectively reprogram the metabolic state of macrophages, reduce glycolysis flux, restore synovial immune metabolic homeostasis, and significantly improve synovial inflammation, chondrocyte activity, and cartilage structural integrity in vivo. This invention proposes a mechanism-guided local delivery metabolic intervention strategy, which is expected to provide a new interventional approach for the treatment of osteoarthritis.

The application discloses a self-healing and injectable photocrosslinking double-network hydrogel and a preparation method thereof. The preparation method comprises the following steps: firstly, glycidyl methacrylate solution is used to perform methacryl modification on silk fibroin; then, sodium periodate solution is used to make dextran perform an oxidation reaction to generate oxidized dextran; and finally, a double-network hydrogel is formed through Schiff base crosslinking reaction between amino groups in the modified silk fibroin and aldehyde groups in the oxidized dextran. The double-network hydrogel prepared by the method has a more compact structure, and thus, the double-network hydrogel has a series of excellent performances, such as safety, injectability, good adhesion, good mechanical properties, self-healing property and drug release performance after drug loading.