148results about How to "Injectable" patented technology

The invention discloses a post-unfreezing water burst prevention method of a non-full-depth freezing vertical shaft. The method comprises grouting form determination, water prevention opportunity determination, grouting position determination, grouting hole arrangement, grouting material preparation, grouting pressure setting, and grouting pipe manufacturing and installation, wherein single-liquid grouting serves as the main grouting, and double-liquid grouting serves as auxiliary grouting; the single-liquid grouting comprises, by mass ratio, water and portland cement with a ratio of 0.6:1 to 1.25:1; the double-liquid grouting comprises, by mass ratio, portland cement, sodium silicate and triethanolamine with a ratio of 1:1: (0.1%-0.25%); the high-pressure and the low-pressure are used simultaneously, during grouting, the working pressure is 1.2 to 1.5 times the hydrostatic pressure of the grouting position, and the final grouting pressure is 2-2.5 times the hydrostatic pressure of the grouting position; and deep holes and shallow holes are combined, a freezing surface soil section utilizes wall clearance grouting, a freezing bedrock section utilizes the wall clearance grouting and backwall grouting, a shallow hole grouting pipe is Phi 38 mm*600 mm, and a deep hole grouting pipe is Phi 38 mm*3100 mm. The post-unfreezing water burst prevention method of the non-full-depth freezing vertical shaft is convenient to construct and operate, strong in groutability and watertightness, good in compaction, high in strength and applicable to post-unfreezing vertical shafts.

The invention discloses a bottom water plugging agent system and process for a horizontal well. The bottom water plugging agent system for the conventional horizontal well is characterized by comprising an inorganic precipitation type system and a polysilicon system or polymer gel system.The bottom water plugging agent system for the thermal-recovery horizontal well is characterized by comprising an inorganic precipitation type system and a N2 foam system or temperature-sensitive gel system. The bottom water plugging agent process for the horizontal well comprise the following steps: (1) injecting an annular chemical plugging device by using a mechanical packer plugging device on the basis of clarifying a water outlet point so as to ensure the selectivity of the injection; (2) selecting the bottom water plugging agent system according to the temperature, the heterogeneity and other parameters of the oil reservoir at the horizontal well; and (3) injecting the bottom water plugging agent system. The bottom water plugging agent system is selected reasonably and combined properly. The technology of the bottom water plugging agent process can be applied to the horizontal well with high or ultrahigh water content to achieve the purpose of deeply plugging more than 90% of bottom water at high strength, so that the water content of the horizontal well is reduced effectively, and the productivity of the oil well is improved.

The invention relates to the field of hydrogel preparation, in particular to injectable polymer hydrogel based on an acylhydrazone bond, a preparation method thereof and a polymer hydrogel injection.The injectable polymer hydrogel based on the acylhydrazone bond comprises the raw materials of a first component obtained by modifying a hydrazide-based polysaccharide polymer, and a second componentobtained by modifying aldehyde-based polyvinyl alcohol, terminal-hydroxyl-based polyethylene glycol, and/or polyethylene oxide-polypropylene oxide-polyethylene oxide. The adding mass ratio of the first component and the second component meets that the range of hydrazide-based substitution degree/aldehyde-based substitution degree is 20-80%, and the balance water solvent is added. Very high fluidity is achieved within a few minutes after prepolymers of the first component and the second component are well mixed, and the prepolymers can be immediately injected to a specific mould or position tobe formed; if the prepolymers of the first component and the second component are mixed and subjected to gelatination, the injectable property is still achieved; the first component and the second component both have very excellent structure compatibility; and the certain fluidity is shown after the first component and the second component are mixed.

The invention provides a premixed calcium silicate based root canal filling material with suspension stability as well as a preparation method and an application thereof. At least one calcium silicate compound is used as a main phase, and at least a second phase for improving solidification performance, at least one nonaqueous phase solvent which can be mixed with water, at least one suspension stabilizing agent and at least one radiopaque material are added in order to prepare the root canal filling material with excellent injectable performance. An inorganic dispersant with suspension stabilizing effect is added into the premixed type calcium silicate based root canal filling material system, based on reservation of excellent biological compatibility, biological activity, marginal sealability, and the like of the calcium silicate material, layering, deposition or flocculation of the premixed system are effectively prevented, long-term dispersion stability of the premixed paste is improved, and the material can be used as a filling material for dental pulp capping, root canal therapy, and other dental restoration fields.

The invention discloses pH-responsive bi-crosslinked mussel bionic adhesive intelligent drug-loading hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The preparation method of the pH-responsive adhesive intelligent drug-loading hydrogel comprises the following steps: oxidizing a polymer containing ortho-hydroxyl into a polymer containing an aldehyde group; carrying out a Schiff base reaction with molecules containing amino groups and catechol structures to prepare a functional polymer of which the side chain contains catechol structure micromolecules; a solution of the functional polymer and the antibacterial nano material is mixed with a solution of a polymer containing amino groups and a proper amount of an oxidizing agent, so that the double-crosslinking adhesive drug-loaded hydrogel can be rapidly prepared. By adding hydrophilic drugs or drug-loaded nano particles and the like, application of the drug-loaded nano particles in biomedicine is endowed. The drug-loaded hydrogel is simple in preparation process, has good adhesion performance, can quickly release drugs through pH response, can be naturally dissociated after pH response, does not cause damage to tissues, and has the advantage of good biocompatibility.

The invention discloses a red mud based rapid-setting grouting material applicable to grouting reinforcement treatment of a sandy soil stratum. The red mud based rapid-setting grouting material is prepared from components in parts by weight as follows: 60-80 parts of red mud, 20-30 parts of an exciting agent and 5-10 parts of an admixture, wherein the exciting agent is prepared from a sodium hydroxide water solution, sodium silicate and sulphoaluminate cement clinker; the admixture is prepared from a carboxylic acid water reducer, talc powder, hydroxypropyl methyl cellulose and desulfurized gypsum powder. The red mud as a mineral material is supplemented by the exciting agent, the additive and other ingredients for preparation of the grouting material, and the grouting material can be applied to the field of grouting reinforcement of the sandy soil stratum. The gelatinization material is prepared by use of characteristics of high alkalinity and fine particle size of the red mud, and the gelatinization activity of the red mud is improved by use of sulphoaluminate cement clinker and the alkaline exciting agent. The working performance of the red mud based grouting material is adjusted by the additive, so that the red mud based grouting material with excellent engineering performance is prepared.

The invention discloses a bio-based self-repair gel based on a boric acid ester bond. The preparation method of the bio-based self-repair gel includes the steps of: (1) taking 3-aminobenzeneboronic acid as the functional group, and modifying a biomacromolecule containing carboxyl to obtain a benzeneboronic acid based biomacromolecule; (2) modifying guar gum with a quaternary ammonium salt to obtain cationic guar gum; and (3) mixing the benzeneboronic acid based biomacromolecule prepared by step (1) with the cationic guar gum prepared by step (2), and utilizing the reversible ester bond formedbetween benzeneboronic acid and guar gum and the electrostatic interaction of positive and negative charges to prepare the bio-based self-repair gel with a double cross-linked network structure. The bio-based self-repair gel provided by the invention has excellent biocompatibility, biodegradability and self-repairability, and has broad application prospects in biomedicine, functional devices, sensing and other fields.

The present invention relates to a dynamic imine bond polysaccharide polymer-based injectable hydrogel and a preparation method and an application thereof. The dynamic imine bond polysaccharide polymer-based injectable hydrogel comprises the following raw material components in weight percentages: 5-18% of a component A: oxidized sodium alginate, 0.1-20% of a component B: a mixture of one or two of water-soluble chitosan and 3,3'-dithiobis(propanohydrazide), and the balanced solvent. The materials are prepared into an even solution according to the ratio. Compared with the prior art, "Schiff base", amide bonds and other dynamic imine bonds are used to realize cross-linking and can form a gel under mild conditions of human body temperature and acid and alkali, and no biotoxic initiators areneeded. The hydrogel is fast in gel-forming speed and injectable after forming. The hydrogel is mild in the preparation conditions, and excellent in compression properties, biocompatibility and injectability, and has broad application prospects in the field of cartilage repair.

The invention relates to a grouting material for an impervious curtain of a refuse landfill and a preparation method of the grouting material. The grouting material comprises the following components in percentage by mass: 40 to 50 percent of MSWI (Municipal Solid Waste Incineration) fly ash, 0.5 to 1 percent of organic sulfur, 3 to 6 percent of cement, 45 to 55 percent of water, and 1.5 to 2 percent of calcium hydroxide. The method for preparing the grouting material comprises the following steps of: (1) weighing raw materials; (2) mixing the MSWI fly ash, the water and the organic sulfur, and uniformly stirring for 5 to 10 minutes; and (3) interfusing the cement and the calcium hydroxide, and uniformly stirring for 3 to 5 minutes. According to the grouting material, the problems of material selection difficulty, high cost, poor fluidity, low stability and poor impermeability of a conventional grouting material can be solved. The preparation method has the advantages of short processroute, simple operation, time saving and the like.

The invention belongs to the field of polymer composite hydrogel, and relates to an injectable and rapidly-gelatinized composite hydrogel and a preparation method thereof, wherein the composite hydrogel is formed by crosslinking a water-soluble polymer with an amino group and a water-soluble polymer with an aldehyde group; the composite hydrogel has the pH response characteristics and injectability; the composite hydrogel forms a three-dimensional network structure through the interaction between the amino group and the aldehyde group, various drugs or growth factors and other bioactive molecules can be loaded in the three-dimensional network structure. In addition, the composite hydrogel has injectability, and because the carbon-nitrogen double bond Schiff base linking structure formed bythe amino group and the aldehyde group has pH response characteristics, the composite hydrogel can be used as a polymer hydrogel wound dressing having certain application prospects in the fields of drug releasing, skin wound repair and the like.

The invention discloses an injectable articular cartilage tissue repair material and is characterized in that starting materials of the composite material contain the following components of: by weight, 100 parts of I-type collagen and 10-50 parts of hyaluronic acid, wherein oxidisability of hyaluronic acid is 20-60%. A monocyte layer in bone marrow fluid in vivo is embedded in the repair material. The thickness of the composite material is 1-5mm. Hyaluronic acid is oxidized into oxidized hyaluronic acid by the use of sodium periodate. The collagen solution, 5*PBS and a buffer are mixed at the volume ratio of 7:2:1 and the pH is adjusted to neutral. After dissolving oxidized hyaluronic acid by the use of ultrapure water, the dissolved oxidized hyaluronic acid is added into the neutral collagen solution and the mixed solution is uniformly stirred and stands in a refrigerator of 4 DEG C. The separated and extracted monocyte layer in the bone marrow fluid by a density gradient centrifugation method is uniformly mixed with the above collagen-oxidized hyaluronic acid solution. The mixed liquor is putted into a constant temperature incubator of 37 DEG C for standing or injection to the organism articular cartilage defects so as to form the composite material.

The invention provides a preparation method of an injectable high-strength chitin-based hydrogel product. The preparation method comprises the following steps: preparing binary or polybasic alkynyl modified hydrophilic polymer A, preparing an amino-containing chitin derivative B, mixing an aqueous solutions of A and B to form an injectable hydrogel precursor solution, and forming high-strenght hydrogel in situ under the physiological condition. The injectable hydrogel is prepared in situ under the physiological condition by utilizing spontaneous amine-alkyne click reaction and performing chemical crosslinking by forming enamine bond, any micromolecular catalysts, initiators or crosslinking agents are not needed, heating, ultraviolet or radiation is not needed, no toxicity and no irritationare realized, and any aftertreatment is not needed. In-situ physical crosslinking rapid formation is conducted by using a temperature-sensitive chitin derivative, and in-situ crosslinking is furtherconducted to prepare the injectable high-strength hydrogel. The hydrogel has high biocompatibility, pH sensitivity and biodegradability, and can be widely applied to the field of biological medicine.

The invention relates to preparation and applications for double-response bi-crosslinked injectable hydrogel used for fine-controlled release of insulin. A chitosan derivative having excellent biocompatibility, biodegradability and antibacterial property is employed as a basic high molecule, and two dynamic bonds comprising imine bond and phenylboronate are employed for preparing pH/glucose bi-sensitive injectable hydrogel, and meanwhile bio-active molecules, such as glucose oxidase and the like, are introduced into the gel substrate through a disulfide bond and the like dynamic bonds to form a double glucose response system. Through the two glucose response factors, phenylboronate and the glucose oxidase, the concentration change of glucose in external environment can be sensed at the same time, thereby causing reversible reaction of the imine bond and phenylboronate in the system, so that the bi-crosslinked network structure of the hydrogel is changed greatly to release the medicines. High sensitivity and quick response to concentration change of glucose are achieved through double sensing units (the glucose oxidase and the phenylboronic acid group) and double accepting units (the imine and phenylboronate).

The invention provides a segmented copolymer which comprises an A block having a structure shown in formula (I), a B block having a structure shown in formula (II), a C block having a structure shown in formula (III), a D block having a structure shown in formula (IV) and an E block having a structure shown in formula (V). The invention also provides a preparation method of the segmented copolymer, comprising the following steps of: under anaerobic condition, carrying out a polymerization reaction on N-isopropyl acrylamide, methacrylic acid, methacrylic acid ethylene glycol monomethyle ether and 2-methlene-1,3-dioxo-cycloheptane in an organic solvent under the action of an initiator, so as to obtain a midbody; and carrying out condensation reaction on the midbody and the compound having a structure shown in formula (VI) in an organic solvent under the action of a coupling agent, so as to obtain a segmented copolymer. The invention also provides a hydrogel of the segmented copolymer. The segmented copolymer has temperature sensitivity and electric activity, and the hydrogel of the segmented copolymer has the characteristics of temperature sensitivity, electric activity, water solubility, injectability, degradation and the like.

The invention relates to low-heat type compound bone cement and a preparation method thereof. Raw materials of the bone cement include a solid-phase component and a liquid-phase component; the solid-phase component comprises an acrylic polymer and a phase-change microcapsule material (PCM). The preparation method of the bone cement comprises the following steps: uniformly stirring and mixing the solid-phase component and the liquid-phase component at a certain ratio, injecting a mixture into a mould, and performing curing to obtain the low-heat type compound bone cement. The compound bone cement is nontoxic and has injectable property, curing rate and mechanical property suitable for clinic; the highest temperature in a curing process is greatly reduced, so that a thermal necrosis effect can be reduced and the use safety of the acrylic polymer bone cement in a human body is improved.

The invention provides a deep hole grouting technology and method at an advanced abutment pressure region for a comprehensive mining work surface of a coal mine. According to the method disclosed by the invention, early strength deep hole grouting materials are matched with a high-pressure mass-flow grouting pump, and an advanced hole forming technology, a pipe inserting technology, a hole sealing technology and a grouting technology for the advanced abutment pressure region are adopted, so that the problem that high-yield high-efficiency coal mining work surfaces with large mining height, top coal caving and the like can are often subjected to rib spalling can be solved; the method does not influence the production of the work surface, the mechanical properties of coal bodies are essentially improved, the completeness of the coal bodies is re-molded, and the method has a favorable popularization property.

The invention relates to the technical field related to tunnel driving equipment, in particular to a grouting structure in the tunnel driving process and a grouting method matched with the grouting structure. The grouting structure in the tunnel driving process and the grouting method aim at solving the problem that in the prior art, filling a gap in the back portion of a segment cannot be achieved through synchronous grouting. The grouting structure in the tunnel driving process sequentially comprises a rock stratum and a segment stratum inwards from the inner wall of a tunnel, and accordingly a side-top arch, in unit of blocks, is formed. A support frame is arranged between the segment stratum and the rock stratum, and accordingly a hollow interlayer is formed. A base lining platform is arranged on the bottom of the side-top arch, and reserved grouting holes communicating with the hollow interlayer are formed in the positions, corresponding to the side-top arch blocks, of the top of the segment stratum. The reserved grouting holes are moveably connected with grouting pipes, and the other ends of the grouting pipes are connected with a grouting machine. The grouting structure in the tunnel driving process and the grouting method have the beneficial effects that the grouting cost is not increased, the grouting process is smooth, the utilization rate of the grout is high, the structure of equipment is simple, repairing and later maintenance are convenient, the assembling and disassembling time is short, grouting pressure can be monitored at any time, the grouting quality can be guaranteed, and a framework layer is formed on the contact surface between the grout and water glass so that flowing of the grout to a cutterhead can be reduced.

The invention provides hydrogel capable of releasing nitric oxide and a preparation method of the hydrogel. The preparation method comprises the following steps: (1) carrying out a stirring reaction on a mixed aqueous solution of 2-methylimidazole and zinc acetate at 20-30 DEG C, carrying out centrifuging, and collecting precipitates to obtain first nanoparticles; (2) dispersing the first nanoparticles and N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine in an ethanol aqueous solution, carrying out stirring, adding dopamine hydrochloride and sodium hydroxide, carrying out stirring at 20-30 DEG C, carrying out reacting, and collecting precipitates to obtain second nanoparticles; and (3) uniformly dispersing the second nanoparticles, methacrylated gelatin and dextran oxide in a PBS solution, adding a photoinitiator, and initiating cross-linking under light with a wavelength of 365-760 nm to obtain the hydrogel capable of releasing nitric oxide. The hydrogel capable of releasing nitric oxide prepared by the method has good biocompatibility, and can significantly promote healing of full-thickness injury wounds, promote collagen deposition and inhibit bacterial growth.

The invention discloses an active polysaccharide composite bone repair material which is good in biocompatibility, good in plasticity, certain in mechanical strength and moderate in degradation velocity in bodies and can meet clinical requirements. The active polysaccharide composite bone repair material comprises a bottle A and a bottle B, wherein the bottle A comprises powder of tetracalcium phosphate, calcium hydrophosphate, chitosan, monosodium phosphate and hydroxypropyl methylcellulose; the bottle B comprises mannitol, an MES solution and a rhBMP-2 biological active factor freeze-dried aquatic product. The active polysaccharide composite bone repair material can induce formation of new bone in a human body, can form active tissue, has the advantages of good compatibility, plasticity and the like, is free of toxic reaction and can be tightly connected with sclerotin after being cured.

The invention discloses an injectable myocardial tissue engineering product used for treating myocardial infarction, in particular, the product applies OPF hydrogel as a scaffold and carries one or more different angiogenic growth factors such as bFGF, PDGF-BB, VEGF and the like, and the repair effect of the product on myocardial infarction regions is observed after the product is injected and transplanted into the certain regions of an animal myocardial infarction model. The product built by the scaffold can promote generation of myocardial capillary and arteriola, enhance generation of myofibroblast, promote regeneration of the myocardial tissues, increase the ventricular wall thickness of the infarction regions, reshape the original ventricle and improve the cardiac function. The invention is simple in operating process and mild in implementation conditions, provides a new product for the myocardial tissue engineering and is of great significance in the development of clinically treating heart diseases by tissue-engineered myocardium.

The invention provides silver nanoparticle composite hydrogel as well as a preparation method thereof. The pH of an aqueous solution of a chiral tryptophan derivative is adjusted to be alkaline, then,the aqueous solution is mixed with an aqueous solution of a silver salt, and the silver nanoparticle composite hydrogel is obtained after standing. The invention further provides application of the silver nanoparticle composite hydrogel. Ultrasonic treatment or additional reducing agents and stabilizing agents are not required during formation of the silver nanoparticle composite hydrogel. The preparation method of the composite hydrogel is simple and low in preparation cost. The composite hydrogel has injectability, good biocompatibility and excellent antibacterial properties.

The invention relates to an injectable composite hydrogel loaded with a vascular disrupting agent and near-infrared optothermal response nanometer particles and applications in resisting tumor. The composite hydrogel comprises a hydrogel substrate material, as well as the vascular disrupting agent and the near-infrared optothermal response nanometer particles loaded in the hydrogel substrate material. The prepared nanometer composite hydrogel has the sol-gel converting behavior realizing syringeability and thermal hysteresis. Under the illumination of near-infrared light, the hybridized hydrogel has the excellent optothermal property, and meanwhile, the curative effects of the vascular disrupting agent are improved by enhancing the permeability of the tumor vessels. The hybridized hydrogeladopting the combined treatment of the vascular disrupting agent and the optothermal function has good safety and curative effects in resisting tumor.

The invention discloses a method for preparing camptothecin prodrug supramolecular hydrogel for drug combination. The method comprises adding alpha-CD and a water-soluble anticancer drug into an aqueous solution of a camptothecin prodrug to obtain a mixed solution, carrying out ultrasonic dispersion, and then carrying out standing so that the mixed solution undergoes self-assembly crosslinking through camptothecin prodrug hydrophobic polymerization and alpha-CD-PEG chain-based subject-object action to form supramolecular hydrogel. Through different loading methods of two drugs and reducing substances inside and outside tumor cells, two drugs with different hydrophobicity and anti-cancer mechanisms can be loaded, can be released at different time points in different zones in multiple stagesto be used in anti-tumor combined drug, and can realize coordinated treatment with drugs and inhibit tumors. The supramolecular hydrogel can be degraded, has good biocompatibility, is injectable, canbe implanted into a lesion site by injection, prevents the pain and tediousness of the surgical implantation and is favorable for damaged site irregular filling.

The invention belongs to the technical field of engineering materials and discloses an assembling type building sleeve grouting material. The assembling type building sleeve grouting material is prepared from the following raw materials in parts by weight: 30-40 parts of cement, 3-8 parts of ultrafine steel slag powder, 2-6 parts of phosphorus gypsum, 3-5 parts of ceramic microbead, 30-50 parts ofquartz sand, 20-30 parts of broken nickle slag sand, 0.05-0.5 part of retarding and water-reducing agent, 0.05-0.1 part of reinforcing agent, 0.5-2 parts of shrinkage-reducing expanding component, 0.001-0.005 part of defoaming agent and 0.005-0.01 part of xanthan gum. The assembling type building sleeve grouting material disclosed by the invention has better fluidity and strong groutability, canpermeate into fine cracks or gaps, causes no water exudation and separation and can meet the requirements of the assembling type building.