3 results about "Therapy Preparation" patented technology

The invention relates to the technical field of biomedicine and cardiovascular disease treatment, and discloses application of an Aralar myocardial overexpression virus in preparation of a medicine for treating heart failure. The related product is a gene therapy preparation containing an effective amount of AAV9-cTnT-Aralar, and can be matched with pharmaceutically acceptable carriers, diluents and other auxiliary materials, and the preparation is an injection type. The preparation method comprises the following steps: firstly, constructing a cardiac troponin T-carrying promoter and an AAV9 carrier of an Aralar coding nucleic acid to form a recombinant adeno-associated virus, and then matching the virus with proper auxiliary materials to prepare the preparation. The product can be used for treating heart failure accompanied with mitochondrial dysfunction, can realize heart targeted delivery and myocardial cell specific overexpression of Aralr, relieves the heart failure course by improving the myocardial cell mitochondrial function and dynamic balance, and is good in preparation stability, convenient in administration and adaptive to clinical application requirements.

The present application belongs to the technical field of biological medicine, and relates to a gene therapy preparation for treating drug-resistant renal cell carcinoma as well as a preparation method and application thereof. It is found for the first time that UBL3 is a key gene for mediating cross-resistance of VEGFR inhibitors of renal cancer, and a lipid nanoparticle composite system integrating specific gene editing and active targeted delivery functions is constructed based on this. The preparation can effectively restore the sensitivity of drug-resistant tumors to first-line drugs such as sunitinib, and shows a significant anticancer effect in in-vivo and in-vitro models, and has important clinical transformation value.

The utility model relates to a moxibustion therapy bed special supervisor moxa bag, it includes the luggage of upper middle and lower structure and the accommodation in the at least one moxa bag of the middle box body of luggage and the accommodation in the at least one supervisor moxa auxiliary material of upper box body of luggage. The lower box body inside is provided with electric heating plate, the movable installation of multiple partition plates in the middle box body is in the vertical state, the bottom wall of middle box body is provided with the opening that communicates with the lower box body, and the opening is installed with the hollow screen that hangs in the upper of electric heating plate. Through the sliding partition plate, the positioning space that holds moxa bag is formed between two adjacent partition plates or between the partition plate and the side wall of middle box body, and moxa bag is located on the hollow screen. The side wall of middle box body is provided with the window for sliding partition plate. Each moxa bag includes wrapping paper and the ration moxa that is wrapped by wrapping paper. The utility model provides treatment material standardization configuration, shortens treatment preparation time, reduces the workload of medical staff, improves preparation work quality.