108 results about "Sunitinib" patented technology

A Sunitinib alkali synthetic methodsynthesis method makes improvement on the synthetic route of Sunitinib alkali so as to avoid the problems in the traditional route and shorten the synthetic route by one step. From the initial synthesis idea, the following two steps are improved in the design: (1), the key intermediate 5-formyl -2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester and 5-fluoroindole-2-ketone are directly condensed in ethanol with piperidine serving as catalyst so as to obtain 5-((5-fluoro-2-oxo-indole-3-alkenyl) methyl)-2,4- dimethyl-1H-pyrrole-3-carboxylate; (2), under the effect of a specific catalyst, the 5-((5-fluoro-2-oxo-indole-3-alkenyl) methyl)-2,4- dimethyl-1H-pyrrole-3-carboxylate is further ammonolyzed with 2-(diethylamino) ethylenediamine in ethylene glycol dimethyl ether so as to directly obtain the Sunitinib alkali; the two products are confirmed through NMR spectrum. The two-step reaction has relatively high yield and shortens the reaction process so as to greatly reduce production costs.