22results about How to "Eliminate side effects" patented technology

The invention discloses an application of an intestinal strain in preparation of a cholesterol-lowering product, and belongs to the technical field of microbial medicines. The intestinal bacterial strain is Oscillibacter ruminant, the viable bacteria concentration of the intestinal bacterial strain is controlled to be (4.8-5.2) * 10 < 9 > CFU / mL, the intestinal bacterial strain can be prepared into bacterial liquid, freeze-dried powder, capsules or tablets and other dosage forms, and pharmaceutically acceptable auxiliary materials such as lactose and microcrystalline cellulose can be added. According to the cholesterol-lowering product, the total cholesterol, triglyceride and low-density lipoprotein cholesterol level of an object can be remarkably reduced under the action of peste des petits ruminants, and meanwhile, the high-density lipoprotein cholesterol level is increased; in addition, abnormal blood glucose induced by high-fat diet can be improved, arterial lipid accumulation is reduced, and the plaque area proportion of atherosclerotic lesions is improved.

The invention particularly relates to a glycosylated dendrimer for co-delivery of small interfering RNA (Ribonucleic Acid) and small molecular drugs as well as a preparation method and application of the glycosylated dendrimer. The nano platform provided by the invention is characterized in that an anti-inflammatory drug resveratrol (Res) and electrostatic adsorption small interfering RNA (si-Cp2e1) are loaded in a glycosylated dendrimer G5-Gal. The preparation method and the application comprise the following steps: preparation of G5-Gal, preparation of Res (at) G5-Gal, and preparation of Res (at) G5-Gal / si-Cp2e1. The preparation method is simple, the required raw materials are easy to obtain, the synthesis process is simple and convenient, separation and purification are easy, and the synthesized nano-drug has a liver targeting capability, can realize dual treatment of small molecule drug-small interfering RNA, and has a potential application prospect in the aspect of treatment of alcohol-related liver diseases.

The application discloses a liposome drug carrier with mucosal adhesion, a preparation method and application thereof, and specifically, the drug carrier is DSPE-PEG-PBA, which can be used for loading cyclosporine A and crocin I, and the carrier of the application is used for loading cyclosporine A and crocin I. The liposome loaded with the two drugs has good stability and adhesion, can inhibit the side effect of cyclosporine A on the increase of ROS level, and has a wide application prospect in the treatment of inflammation and epithelial tissue damage.

The present application relates to the technical field of external use patch, disclose a kind of neck shoulder waist leg pain health care patch and its preparation method, the health care patch includes backing layer, ointment layer and anti-adhesion release layer;Ointment layer raw material includes: traditional Chinese medicine extract flow leaching paste, L- (+) -tartaric acid, PVP K30, PEG-400, ternary eutectic solvent, polyacrylate pressure sensitive adhesive matrix and ultrafine medicinal powder.Preparation, after flow leaching paste, tartaric acid etc. are mixed, gel precursor is formed by vacuum dewatering and dealcoholization, swelling is added again with eutectic solvent, and then mixed with pressure sensitive adhesive matrix and medicinal powder high shear, finally coating solidification.The present application constructs physical crosslinking gel network in colloid interior and promotes effective component acid-base salt formation, effectively avoids polar component crystallization precipitation, reduces the skin irritation caused by drug burst release, simultaneously improves the cohesion of ointment, realizes long-acting smooth drug release.

The invention relates to the technical field of biological medicine, in particular to selenium and application of a selenium composition, a nasal composition and application of the nasal composition. The invention provides application of selenium in inhibition of nasal cavity or airway epithelium inflammatory factor expression and a nasal composition containing the selenium. The selenium element is used for regulating and controlling a signal channel, so that the expression of key inflammatory factors in epithelial cells of the nasal cavity or the airway is effectively reduced, the level of reactive oxygen species (ROS) of the epithelial cells of the nasal cavity or the airway is reduced, and the dual effects of inflammation resistance and oxidation resistance are achieved. Therefore, the nasal composition containing the selenium element can effectively block the preinflammatory syndrome driven by upstream oxidative stress by regulating and controlling dual mechanisms of inflammation and oxidative stress reaction, and nasal cavity or airway diseases such as rhinitis and allergic rhinitis are relieved and treated from the source.

The application provides a camellia plant endophytic bacteria, a bacterial agent thereof and an anti-influenza virus A application; the camellia plant endophytic bacteria is Bacillus thuringiensis, which is preserved in the China General Microbiological Culture Collection Center with a preservation number of CGMCC No.32945. The fermentation product of the strain shows good antiviral activity in in vitro and in vivo experiments, can effectively inhibit the replication of influenza virus, and protect infected mice from lethal influenza virus; also shows the effect of regulating immune response, enhances the secretion of IFN-gamma by down-regulating the secretion of pro-inflammatory factors such as IL-6 and IL-10, thereby improving the immune resistance of the body.

The application discloses a kind of multi-band electromagnetic wave auxiliary methods for assisting in treating hypertension, and specifically includes the following steps: S1, healthy human biological information acquisition;S2, resonance reflection wave collection and storage;S3, treatment information extraction and processing;S4, treatment instrument debugging and parameter setting;S5, patient pretreatment and positioning;S6, personalized treatment implementation;S7, treatment process monitoring;S8, course evaluation and scheme optimization;The application relates to the technical field of electromagnetic wave therapy. The multi-band electromagnetic wave auxiliary method for assisting in treating hypertension, by using multi-band treatment wave cooperation treatment, breaks through the limitation of single waveband curative effect, and different frequency bands of treatment wave are respectively used for nerve regulation, vasodilation, endothelial function improvement and other multiple blood pressure regulation pathways, to realize systematic combined intervention, significantly improve the comprehensiveness and stability of treatment.

This invention discloses an antibiotic patch and its application. The antibiotic patch includes a transdermal microneedle module, an antibiotic reservoir layer, and an osmotic pressure driving module, with the reservoir layer and the driving module separated by an elastic membrane. The osmotic pressure driving module includes a water chamber, a propulsion layer, and an osmotic pressure active sheet. It generates a constant thrust through unidirectional permeation of the semi-permeable membrane, propelling the antibiotic through the hollow microneedles for transdermal infusion and achieving zero-level release. The independent antibiotic reservoir layer can hold large doses of antibiotics, and it is also equipped with a filling port and a venting port to ensure flexible and stable medication administration. The antibiotic patch is suitable for various scenarios, including home and outdoor use, and can reduce the risk of antibiotic resistance and side effects, providing a convenient and efficient new solution for the treatment of bacterial infections.

This invention discloses the application of an anionic open-ring cucurbituril derivative in improving the water solubility and antitumor activity of paclitaxel. The inclusion complex is formed by the assembly of anionic open-ring cucurbituril as the host molecule and paclitaxel as the guest molecule through non-covalent host-guest interactions, wherein the molar ratio of paclitaxel to anionic open-ring cucurbituril is 1-10:1. By forming a stable host-guest inclusion complex, the extremely poor water solubility and chiral stability of paclitaxel are significantly improved, effectively enhancing its antitumor efficacy and showing broad application prospects in targeted drug delivery and clinical oncology treatment.

This invention discloses a tumor electric field therapy device and system. The tumor electric field therapy device consists of a frame and electrode modules. The frame forms the skeleton structure of the therapy device, and the electrode modules are attached to the frame. Each electrode module has several electrode contacts, and each electrode contact can be either an active or passive contact. The active contacts can form a circuit with a radio frequency generation module. When the therapy device is implanted into the tumor resection site, all electrode contacts become active contacts, and each electrode contact forms a circuit with the radio frequency generation module, distinguishing between normal tissue and diseased tissue. After distinguishing between normal tissue and diseased tissue, the electrode contacts in the normal tissue area become passive contacts, and the electrode contacts in the diseased tissue area become active contacts, enabling targeted treatment of the diseased tissue and thus reducing the side effects of electric field therapy.

Provided is the compound represented by formula I, or tautomer thereof, or meso thereof, racemate thereof, and mixture of meso and racemate thereof, or enantiomer thereof, diastereomer, and mixture of enantiomer and diastereomer, or pharmaceutically acceptable salt thereof, or deuterate thereof. The compound of formula I can be used as a kinase inhibitor, as a drug for the treatment of ROS1, NTRK, ALK and other kinase-mediated diseases.

The invention discloses an mRNA (messenger ribonucleic acid) delivery system based on a nucleic acid nanostructure as well as a preparation method and application of the mRNA delivery system. The mRNA delivery system comprises an mRNA scaffold chain, an RNA staple chain, a lipid-nucleic acid coupling chain and an auxiliary lipid; the mRNA scaffold chain comprises a nucleic acid sequence for coding target protein mRNA; the mRNA scaffold chain and the RNA staple chain are self-assembled through complementary base pairing to form a nucleic acid nanostructure; the lipid-nucleic acid coupling chain comprises a lipid molecule and a nucleic acid chain coupled with the lipid molecule. According to the invention, mRNA molecules of coding functional protein are used as scaffold chains to be accurately integrated into the nucleic acid nanostructure, so that the purpose of protecting and delivering mRNA is achieved, and the effect of accurately regulating and controlling the expression of target protein is achieved.

The application discloses poplar phellinus polysaccharide SVP-50-1 and a preparation method and application thereof, and belongs to the field of biological medicines.The poplar phellinus polysaccharide SVP-50-1 is obtained by water extraction and 50% ethanol solution precipitation of poplar phellinus fruiting bodies.The poplar phellinus polysaccharide SVP-50-1 can regulate a tumor metabolic process, inhibit the activity of a tumor cell mitochondrial respiratory chain and an oxidative phosphorylation process, thereby inhibiting the energy source of tumor cells, and achieving an anti-tumor effect.The poplar phellinus polysaccharide SVP-50-1 can play a synergistic effect when combined with radiotherapy and chemotherapy drugs.The combined treatment strategy can significantly improve the curative effect of an existing tumor treatment, while reducing adverse reactions, and provides a new optimized scheme for clinical tumor treatment.

This invention belongs to the field of biomedical technology, specifically relating to the application of α-ketoglutarate in the preparation of drugs that enhance the sensitivity of aquatic pathogens to florfenicol. This invention is the first to discover that α-ketoglutarate can significantly enhance the bactericidal effect of florfenicol against aquatic pathogens. Combined injection of α-ketoglutarate and florfenicol can reduce the number of bacteria in the liver and spleen of aquatic organisms, including fish, infected with aquatic pathogens, thus reducing damage to the organs and tissues of fish and other aquatic organisms and improving their survival rate. Therefore, α-ketoglutarate can be used as a synergist for florfenicol. Its combined application in the preparation of compound antibacterial agents can improve the efficacy of aquatic antibacterial drugs, significantly reduce the dosage of antibacterial drugs, and consequently reduce side effects and drug residues. This has significant application value and importance in the production and development of drugs against aquatic pathogens.

This disclosure relates to antibody-drug conjugates, and more specifically to antibody-drug conjugates (ADCs) carrying Ras mutation inhibitors, compositions containing said ADC molecules, and their therapeutic applications.

The present application relates to the technical field of medical data processing system, and particularly relates to a data processing method and system for medical diagnosis and treatment driven by artificial intelligence. The present application comprises a multi-modal medical data acquisition module for acquiring and processing multi-source heterogeneous medical data of a patient to generate a standardized data set; a medical feature deep extraction module for performing multi-dimensional feature extraction on the data set to construct a dynamic evolution feature matrix; a multi-dimensional health state space construction module for constructing a multi-dimensional health state space of the patient according to the matrix to determine a key medical early warning index set; a real-time medical data fusion module for mapping real-time data to the space to generate real-time health risk factors; and a medical risk prediction and decision module for establishing a personalized model according to the real-time health risk factors to output a disease occurrence probability and generate an individualized treatment suggestion. The system solves the problems of difficult medical data processing, incomplete diagnosis analysis, and lack of individualization in treatment schemes, and improves the accuracy of diagnosis and the pertinence of treatment.

The present invention relates to poly(pentafluorophenyl ester)-based polymers for manufacturing electrochemical sensors, wherein the polymers have high reactivity with amine functional groups, cause less hydrolysis, maintain good solubility in organic solvents for general purposes, and have less steric hindrance and toxicity or side effects compared to polymers having similar structures, and thus are useful in insertion-type devices, especially continuous glucose monitoring systems whose part is inserted into the human body.

Disclosed are an antibody drug conjugate, a preparation method therefor and an application thereof, which are in particular, a conjugate of an anti-PD-L1 antibody and a TLR7 and / or TLR8 agonist, a pharmaceutical composition thereof, a preparation method therefor and an application thereof. In the present invention, a modified anti-PD-L1 antibody having mutated cysteine is obtained by means of gene editing, basically retains the structure of the original antibody, and may be used for the construction of antibody drug conjugates. By means of anti-tumor experiments, it has been discovered that the obtained antibody drug conjugate has good activity, such as strong anti-tumor activity, which may significantly improve the survival rate of tumor-bearing animals, and significantly reduce toxicity. Moreover, the antibody drug conjugate is less burdensome on the bodies of test animals, which greatly reduces the minimum effective dose of small molecular drugs when used alone, expands the therapeutic window thereof, is expected to be used in the development of therapeutic drugs for various diseases (such as tumors, viral diseases such as hepatitis B, etc.), and has good application prospects and value.

This invention provides a method for preparing and applying a multifunctional targeted nanomaterial for the treatment of various cancers. By modifying the surface of polycyclodextrin with a biotin receptor-targeting derivative and mixing it with a Golgi-targeting photosensitizer and a PD-L1 in situ inhibitor, the constructed novel multifunctional targeted nanomaterial can precisely target and recognize various tumor cells, increase the accumulation of photosensitizers at tumor sites, and further achieve accumulation in the Golgi apparatus, significantly disrupting its structure and function. Furthermore, this nano-drug delivery system can effectively downregulate PD-L1, further enhancing the photodynamic synergistic immunotherapy effect against tumors. The novel multifunctional targeted nano-drug delivery system prepared by this invention solves the problems of poor targeting and biosolubility of traditional photosensitizers, limited immune response capacity, and limited therapeutic effects, providing an innovative strategy for achieving targeted photodynamic synergistic immunotherapy for cancer.

The application particularly relates to an artificial skin with antibacterial and inflammation regulating functions and a preparation method thereof, and belongs to the technical field of artificial skin. The artificial skin is obtained by combining a dermis layer formed by doping silver sulfadiazine and loading simvastatin polylactic acid microspheres in collagen as a carrier material with a silicone epidermis layer. The silver sulfadiazine loaded in the collagen matrix can effectively avoid bacterial infection, the slow-release function of the polylactic acid microspheres can release simvastatin in the later stage of skin regeneration, promote the conversion of macrophages to M2 type, participate in the anti-inflammatory and repair processes, and accelerate skin regeneration. The silicone epidermis layer can prevent the loss of body fluid and bacterial invasion.

The invention belongs to the technical field of biological medicines, and particularly relates to a medicine for repairing an ovarian function and application thereof. The invention finds that NMDPEF (also known as S29434) can repair the ovarian function of a psychological stress individual, prevent premature activation of primordial follicles induced by psychological stress, improve the quality of oocytes and improve the fertilization ability and embryonic development potential of the oocytes. The NMDPEF protects a primordial follicle library of the psychological stress mouse and preserves fertility; mDPEF can improve the quality of the oocyte of the psychological stress mouse; the NMDPEF can improve the fertilization ability and blastocyst development rate of the oocyte of the psychological stress mouse. The medicine is easy to obtain, low in cost and suitable for large-scale production, and the treatment difficulty of patients is reduced; and the medicine has the advantages of obvious effect, quick response, shortened medication cycle, reduced toxic and side effects and improved patient compliance.