10 results about "Subcutaneous fatty tissue" patented technology

A PTH1 ligand-binding nucleic acid complex that is delivered to a target organ to regulate expression or editing of a target gene, or a transcription or translation product thereof is provided. The PTH1 ligand-binding nucleic acid complex includes a nucleic acid having an antisense strand with an oligonucleotide having a nucleotide sequence 12 to 30 nucleotides in length, complementary to a target transcription product, is bound to a PTH1 ligand. Such nucleic acid complexes are useful for the treatment of diseases caused by such a gene. The ligand-binding nucleic acid complex can be delivered to an organ, tissue, or cell in which the PTH1 receptor is expressed, such as the kidney, bone, and subcutaneous fat tissue, or the vascular endothelial cells. Thus, such nucleic acid complexes are useful for treatment of diseases in such organs.

FIELD: plastic surgery.SUBSTANCE: under aseptic conditions and endotracheal anesthesia, hydropreparation of the subcutaneous fat tissue is performed with 0.04% ropivacaine solution 60.0 ml with adrenaline 1:100000, a skin incision in the area of the submammary groove of the mammary gland of 3.5–4.0 cm in length is made, the tissues are dissected layer by layer to the fascia of the pectoralis major muscle. A dissection is performed in the Chassignac space to the level of the lower pole of the areola or an incision is made in the skin in the area of the mammary gland along the lower semicircle of the areola, the tissues are perpendicularly dissected layer by layer to the fascia of the pectoralis major muscle. Next, dissection is performed in the Chassignac space to the level of the submammary groove, and the lateral edge of the right pectoralis major muscle is isolated. The retropectoral pocket for the implant is formed using blunt and sharp methods. The lower medial bundle of the pectoralis major muscle is mobilized to the level of 4 o'clock on a conventional clock dial for the right breast and to the level of 8 o'clock on a conventional clock dial for the left breast. Partial vertical myotomy of the free muscle flap is performed. The distal fragments of the pectoralis major muscle are fixed at three points to the posterior surface of the gland with an atraumatic Vikryl 2-0 thread at the level of the nipple-areolar complex. A silicone implant is placed into the formed pocket, and the implant is evenly distributed and centered within it.EFFECT: preventing uncontrolled cranialization of the pectoralis major muscle flaps during vertical myotomy in dual-plane augmentation mammoplasty.1 cl, 2 ex

The invention discloses multi-operation-head beauty equipment with a fat burning effect aiming at multiple fats, and particularly relates to the technical field of beauty equipment, the multi-operation-head beauty equipment comprises a beauty instrument device, an ultrasonic fat burning head, a negative pressure fat burning head, an infrared light fat burning head, a micro-current fat burning head and a telescopic assembly, the telescopic assembly is connected to the bottom of the beauty instrument device, and the telescopic assembly is connected to the bottom of the beauty instrument device. The length of the beauty instrument device is adjusted; the multiple operation heads are matched with multiple parts, precise and efficient fat burning is achieved, the ultrasonic fat burning heads are specially designed for thick fat layers of the waist and the abdomen, and fat cell structures are destroyed through the cavitation effect, the mechanical effect and the heat effect; the negative-pressure fat burning head is used for lifting subcutaneous fat tissues by moderate negative pressure aiming at delicate facial skin; the infrared light fat burning head meets the fat burning requirement of the arm, so that the infrared light completely and uniformly covers the arm; the micro-current fat burning head can assist each part, stimulate muscle contraction and promote lipolysis; by means of the precise design, the operation heads can play a role according to fat characteristics of different parts, and diversified beauty requirements of users are met.

The application relates to the technical field of subcutaneous fat transplantation, and particularly relates to application of regulatory T cells (Treg) in improving survival rate and survival quality of subcutaneous fat transplantation. The application first finds that the survival rate and survival quality of subcutaneous fat transplantation have a significant relationship with the proportion of regulatory T cells, and the survival rate of subcutaneous fat tissue mixed with regulatory T cells in a specific proportion is obviously improved, so that the application can be used as an innovative fat transplantation technology to improve the existing clinical solution, and has strong clinical transformation value.

Cosmetic system, comprehensive (a) a serum containing a peptide signaling complex which includes at least one peptide or peptide derivative which - stimulates the differentiation, lipogenesis or proliferation of adipocytes or - modulates matrix communication between dermis and subcutis, or - both effects combined, and (b) a lamellar cream with skin-identical lipid lamellae (phosphatidylcholine, ceramides, cholesterol, free fatty acids) for fixation and transduction of the peptides applied under (a); for cosmetic use to maintain and regenerate subcutaneous adipose tissue and dermal support structure.

The invention discloses an abdominal subcutaneous adipose tissue outer vesicle of a laying hen with fatty liver syndrome and application of the abdominal subcutaneous adipose tissue outer vesicle. The abdominal subcutaneous adipose tissue outer vesicle is separated from abdominal subcutaneous adipose tissue of the laying hen with fatty liver syndrome. The invention finds that the abdominal subcutaneous adipose tissue outer vesicle of the laying hen with the fatty liver syndrome has a liver tissue targeting effect for the first time, and finds that the abdominal subcutaneous adipose tissue outer vesicle of the laying hen with the fatty liver syndrome can transfer gga-let-7a-3p to the liver to regulate and control lipid metabolism disorder of the chicken liver for the first time.

The invention relates to an engineered exosome for local fat reduction and a preparation method thereof, and belongs to the field of biotechnology and medical beauty. Three fusion proteins, namely an Apelin-first scaffold protein, an NRG4-second scaffold protein and an FLRG-third scaffold protein, are simultaneously displayed on a membrane of the engineered exosome. The preparation method comprises the following steps: constructing a nucleic acid sequence for coding the three fusion proteins, cloning the nucleic acid sequence to an expression vector, introducing the expression vector into a mammal host cell, culturing, and separating and purifying from a cell supernatant to obtain the target exosome. The exosome can be further mixed with locally medicinal or cosmetically acceptable auxiliary materials to prepare local fat-reducing compositions such as gel, cream or essence. Three active proteins with complementary functions are synergistically delivered through a single exosome, glucose and lipid metabolism can be regulated and controlled in a multi-channel mode, muscles are maintained, the composition can act on subcutaneous adipose tissue after being smeared, and the fat reducing effect is achieved.

This invention provides a deep learning-based fat and muscle segmentation method and system based on Slicer, applied in the field of data processing technology. This application preprocesses preoperative CT image data of the target patient to generate skeletal muscle image features, subcutaneous adipose tissue image features, and visceral adipose tissue image features; preprocesses the training sample set, adjusting window width and level and normalizing it to generate target training image data; trains a pre-defined fat and muscle segmentation model based on a deep learning network using the target training image data to generate a target fat and muscle segmentation model; processes the skeletal muscle image features, subcutaneous adipose tissue image features, and visceral adipose tissue image features based on the target fat and muscle segmentation model to generate target image segmentation information; and processes the target image segmentation information and the target patient's gene detection information to generate preoperative warning information for the target patient.

The application discloses a special device for abdominal cavity opening suture, and belongs to the technical field of medical instruments. The device aims to solve the problems of traditional suture instruments, such as difficult closure of the inner incision, risk of mis-suture of adjacent organs, lack of real-time tension feedback and visual guidance function, and the like, in patients with thick subcutaneous fat tissue due to the limited depth of entry. The device comprises a guide sheath, a puncture execution mechanism and a tissue clamping assembly. The device realizes non-axial puncture through the deflection outlet and the arc transition section, the tissue clamping assembly clamps the inner incision edge, and the double-line loop suture structure enhances the gripping force, so that accurate operation can be guided and ensured and organ damage can be avoided. The suture device can effectively improve the accuracy, safety and standardization degree of abdominal wall suture of patients with thick fat layer, and reduce the risk of postoperative complications.

A kind of cascade lipolysis-oxidation nano reactor and preparation method thereof, medical device and application.Nano reactor has core-shell structure, its core is loaded triiodothyronine mesoporous polydopamine particle, shell is the mesoporous silica layer of surface fixed lipase.The structure retains the catalytic activity of lipase on the surface of particle while achieving T3 slow release;Lipase is stably anchored in the shell by amination and glutaraldehyde crosslinking, and the final surface Zeta potential is-17.5±0.5 mV.The present application further loads the nano reactor in the microneedle patch of gamma-polyglutamic acid matrix for local delivery of subcutaneous adipose tissue.It has been verified that the system can synergistically activate triglyceride hydrolysis and mitochondrial fatty acid oxidation, significantly reduce lipid droplet accumulation, improve mitochondrial membrane potential, up-regulate lipolysis and oxidation related gene expression, effectively restore the lipid turnover function of obese fat depot, and provide a solution for local intervention of obesity and related metabolic disorders.