123 results about "Lipolysis" patented technology

Methods and systems for inducing apoptosis of adipose cells are disclosed herein. In some embodiments, the method comprises identifying a target area comprising the adipose cells and injecting a therapeutic agent at the target area. Injecting the therapeutic agent can inhibit a protein kinase B (Akt) pathway of the adipose cell, induce a proinflammatory response of adipose cells at the target area, and / or initiate lipolysis / cell death of the adipose cells at the target area. In doing so, a volume of the adipose cells at the target area can be reduced.

Methods and systems for inducing apoptosis of adipose cells are disclosed herein. In some embodiments, the method comprises identifying a target area comprising the adipose cells and injecting a therapeutic agent at the target area. Injecting the therapeutic agent can inhibit a protein kinase B (Akt) pathway of the adipose cell, induce a proinflammatory response of adipose cells at the target area, and / or initiate lipolysis / cell death of the adipose cells at the target area. In doing so, a volume of the adipose cells at the target area can be reduced.

The invention relates to a washing and / or cleaning agent, comprising at least one peptide and at least one enzyme which has hydrolytic activity on an ester bond, preferably selected from lipase and esterase, in particular esterase with lipolytic activity, particularly preferably lipase, wherein the peptide is suitable for adhesion to a fat- and / or oil-containing surface or to a surface coated with fat and / or oil or to a surface provided with at least one fat- and / or oil-containing soil, wherein the surface consists of hard surfaces, more preferably surfaces containing or consisting of ceramic (e.g. porcelain, earthenware), metal, steel, stainless steel, plastic, glass, natural and artificial stone, painted and enamelled surfaces, wood, laminate, linoleum and mixtures thereof, particularly preferably tableware (preferably made of ceramic such as porcelain or earthenware and plastic), metal (e.g.cutlery or pots) or glass and mixtures thereof, particularly preferably tableware (preferably made of ceramic such as porcelain or earthenware and plastic), metal (e.g. cutlery or pots) or glass, and / or textiles, more preferably textiles containing or consisting of cotton, polyester, polyamide, polypropylene and mixtures thereof, particularly preferably cotton, polyester and mixtures thereof. Furthermore, the invention relates to methods for cleaning hard surfaces and / or textiles, and to the use of such peptides and agents for improving the cleaning performance on at least one greasy and / or oily soil.

The invention discloses an application of a white kidney bean extract or a composition thereof in promoting lipolysis, provides a new application of the white kidney bean extract or the composition thereof, and particularly relates to an application of the white kidney bean extract or the composition thereof in preparing a product for promoting lipolysis. Meanwhile, according to the composition for promoting lipolysis provided by the invention, the white kidney bean extract and the bifidobacterium animalis subsp. Lactis MN-Gup are matched with each other, so that the composition has a synergistic effect on the function of promoting lipolysis.

The invention relates to the technical field of biological medicine, and discloses an intestinal insulinotropic analogue with multiple biological activities, a synthesis method, a pharmaceutical composition and application, the synthesized intestinal insulinotropic analogue has triple agonist activity of a GLP-1 receptor, a glucagon receptor and a CCK-1 receptor, not only has the treatment effect of GLP-1 on diabetes, but also has the treatment effect of GLP-1 on CCK-1, and also has the effect of GLP-1 on CCK-1 on CCK-1. The traditional Chinese medicine composition also has the regulating effect of glucagon on lipolysis and energy metabolism and the beneficial effect of CCK on appetite inhibition, so that a synergistic effect is generated on sugar, fat and energy metabolism; the application has great potential in preparation of drugs for treating metabolic syndromes, such as diabetes, obesity, non-alcoholic fatty liver diseases, dyslipidemia and other diseases.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

The invention discloses a pigeonpea extract and an active compound thereof, and application of the pigeonpea extract and the active compound in preparation of medicines or health care products for lowering lipid, reducing blood sugar and losing weight, the pigeonpea extract and the active compound thereof have a remarkable lipid lowering effect, and can remarkably reduce adipogenesis and lipolysis of 3T3-L1 cells; the pigeon pea extract and the active compound can remarkably reduce the expression quantity of SREBP-1c, PPAR gamma and C / EBP alpha, and signal molecules are important targets of some diabetes and weight-reducing medicines besides regulating synthesis and metabolism of fat, so that the pigeon pea extract and the active compound thereof can be possibly deduced to have application potential in the aspects of sugar control and weight reduction; the pigeonpea extract and the active compounds thereof are derived from natural plants, and the active compounds CAB and CAC are natural small molecule compounds, are low in toxicity and few in side effects, and have good development and application prospects.

The present invention features methods for reducing alcohol intake, intake of drugs of abuse, food intake, or to increase fat breakdown or lipolysis by administering a sphingosine-1-phosphate receptor modulator.

Provided is a Bifidobacterium bifidum strain, Bifidobacterium bifidum ibiome001, which can significantly reduce body weight gain and white adipose tissue weight gain of high fat diet-induced obese and diabetic mice, and enhances expression of lipolytic genes ATGL and HSL. Moreover, Bifidobacterium bifidum ibiome001 can significantly lower fasting blood glucose levels, area under curves (AUCs) of the oral glucose tolerance (OGTT) curve, plasma glycated hemoglobin levels and insulin levels of diabetic mice. It is suggested that Bifidobacterium bifidum ibiome001 is a promising potential probiotic strain for the treatment of metabolic syndrome such as obesity, diabetes and the like, which is more effective than other Bifidobacterium strains / compositions.

The present invention belongs to the field of pharmaceutical synthesis, and specifically relates to salviphorol derivatives and their application in drugs for treating cancer cachexia. Salviphorol compounds include compounds represented by formula (X) and / or formula (Y), or pharmaceutically acceptable salts or optical isomers of the compounds represented by formula (X) and / or formula (Y). The present invention also provides a pharmaceutical composition for treating cachexia diseases, and its application in the preparation of drugs for treating cancer cachexia, including muscle atrophy caused by tumor tissues, fat reduction caused by tumor tissues, reduced appetite caused by tumor tissues, inflammatory responses caused by tumor tissues, and cancer cachexia caused by digestive tract-related cancers, liver cancer, lung cancer, and colon cancer. The present invention also provides its application in the preparation of drugs or inhibitors for treating or inhibiting muscle atrophy, drugs or inhibitors for inhibiting or alleviating adipocyte lipolysis, and drugs or inhibitors for inhibiting or alleviating weight loss or reduction.

Provided in the present disclosure are materials, devices, systems, and methods for performing cryo-surgery in a mammalian subject. More particularly, presented are a slurry, devices, systems, and methods for subcutaneously injecting the slurry into a patient in need of bodyfat reduction intervention. The slurry, devices, systems, and methods permit highly efficacious subcutaneous ice phase-change lipolysis while not requiring that the patient be placed under general anesthesia, nor requiring significant new surgical training among practitioners.

The invention relates to the technical field of health-care products, and particularly discloses a roselle-containing composition and a preparation method thereof, and the roselle-containing composition comprises the following components: a roselle extract, a cocoa extract, coating protein, a fermentation compound and auxiliary materials; the added roselle extract is subjected to multi-step pretreatment, the extraction rate and stability of active ingredients are improved, and the polarity of the roselle extract can be adjusted by adopting a composite solvent for extraction, so that the bioavailability is improved; the added cocoa extract can reduce oxidation of anthocyanin, and the cocoa extract and the roselle extract are synergistically used for reducing blood fat by inhibiting lipase activity and adjusting cholesterol; the fermentation compound can generate urolithin A, pueraria peptide and perillyl alcohol to further assist in reducing blood fat, and the coating protein improves the stability and absorption efficiency of the roselle extract; the auxiliary materials can improve the bioavailability of the active components of the raw materials, and the prepared composition has the effects of inhibiting appetite, promoting lipolysis, inhibiting fat absorption and reducing blood fat through synergistic effects of all the components.

The present invention relates to an injection composition for lipolysis, which is safe and effective, and more specifically, to an injection composition for lipolysis, which comprises: one or more compounds selected from the group consisting of hyaluronidase and pentoxifylline, and one or more compounds selected from the group consisting of hyaluronidase, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline and pentoxifylline. 5 to 10% (v / v) of carnitine (Carnitine); and lidocaine (Lidocaine); and normal saline. As a composition having both safety and efficacy, the injection composition for lipolysis of the present invention has an excellent lipolysis effect, does not cause a yo-yo phenomenon over time, and thus has a characteristic of not causing side effects such as skin depression.

The utility model relates to a knife edge protective sleeve for ultrasonic fat dissolution. The device comprises a sleeve and an incision protection disc, wherein the near end of the sleeve is connected with the incision protection disc; a guide hole communicated with the sleeve is formed in the incision protection disc; the sleeve is characterized in that two clamping structures for preventing the sleeve from falling off are annularly arranged on the periphery of the sleeve; the clamping structure comprises a buckle, an elastic sheet, a connecting rod and a pressing plate; the outer side wall of the sleeve is provided with a groove extending from the incision protection disc to the far end, and the groove does not extend to the far end of the sleeve. The elastic piece is arranged in the groove, the far end of the elastic piece is connected to the far end of the groove, and the buckle is located on the outer side of the far end of the elastic piece; the inner end of the connecting rod is connected with the near end of the elastic piece, and the outer end of the connecting rod extends out of the incision protection disc and is connected with the pressing plate. The skin can be protected in the ultrasonic lipolysis operation, and the knife edge protection sleeve can be taken out through deformation when the skin is not damaged.

An amino dithioperacid thioester compound, a preparation method therefor, and use thereof. The structural formula of compound is as shown in formula I: wherein m=1-11, X is a nitrogen-containing aliphatic heterocyclic ring, and a nitrogen atom in the aliphatic heterocyclic ring is connected to a carbon atom of a thiocarbonyl group. The compounds disclosed by the invention are found to be capable of relieving muscular atrophy and lipolysis caused by cancer cachexia through in-vivo and in-vitro experiments. The compounds are also capable of obviously relieving weight and food intake reduction caused by cancer cachexia in animal experiments, so that the carbamo(dithioperoxo)thioates compounds have the effect on resisting cancer cachexia, can be applied to the treatment of cancer cachexia and related diseases, and become one kind of ideal cancer cachexia treatment medicament.

The present invention relates to a peptide complex having activities of preventing or treating fatty liver disease. The peptide complex of the present invention inhibits, in hepatocytes, the expression of fat synthesis-related genes and proteins and promotes the expression of fatty acid oxidation-related genes and proteins, and thus can inhibit, in hepatocytes, fat accumulation and promote lipolysis. In addition, the peptide complex of the present invention can inhibit the expression of inflammation-related genes in hepatocytes, and inhibits the expression of hepatotoxicity-related proteins, thereby having hepatoprotective activity. Furthermore, the peptide complex of the present invention can inhibit the degree of fat accumulation and liver fibrosis in liver tissue. Therefore, the peptide complex of the present invention is expected to be effectively used for preventing, alleviating or treating fatty liver disease.

The present disclosure relates to a fat removal surgery instrument. The present disclosure additionally arranges / provides a fiber support on a lipolytic fat suction passage of a waveguide tube, the fiber support being made of an insulating material and supporting an optical fiber in a restrained state while being fixed to the waveguide tube, such that the optical fiber is prevented from being deformed and coming into contact with the waveguide tube, and thus, even if various factors (e.g., weight, contact with human tissue, etc.) are applied to the optical fiber during a fat removal surgery, the optical fiber is guided to effectively avoid direct contact with the waveguide tube and thereby be damaged, while a series of deformations (e.g., a curved shape, etc.) are suppressed / controlled based on the strong restraint of the fiber support.

The invention relates to the technical field of biological medicine preparations, in particular to application of targeted nanoparticles in treatment of osteoporosis. The targeted nano-particles CL-NPs (at) NEs are developed, CL can stimulate lipolysis of bone marrow adipocytes, osteogenic differentiation is promoted, and therefore the bone marrow microenvironment is improved; meanwhile, autologous neutrophil is used as a carrier to transport CL-NPs, bone marrow fat cells beta3AR are accurately targeted, and the osteoporosis microenvironment can be further improved. Experiments prove that CL-NPs (at) NEs stimulate a bone marrow fat cell beta3 adrenoceptor in a targeted manner, can effectively improve OP, has safety and has the potential to become a novel medicine for osteoporosis.

The present invention belongs to the field of biotechnology and relates to a method for preparing shark nanobodies targeting pancreatic lipase and its application. The amino acid sequence of the shark nanobody VNAR-A4 is shown in SEQ ID No. 10. The shark nanobody VNAR-A4 prepared by the present invention has a molecular weight of about 15 kDa, which is smaller than traditional monoclonal antibodies, has an elongated CDR3 structure, and can better bind to the hidden epitopes of antigens; the shark nanobody VNAR-A4 has good stability, can maintain its activity under extreme pH conditions, and has good affinity and specificity for PL; the shark nanobody VNAR-A4 is expressed using an Escherichia coli prokaryotic expression system, is more easily genetically engineered, and can be obtained in large quantities. The shark nanobody VNAR-A4 has the potential to inhibit the activity of pancreatic lipase and provides a new lipolysis inhibitor for the treatment of obesity.

Provided herein are systems and methods for treating a patient's skin or other target tissue using RF energy. In various aspects, the methods and systems described herein can provide RF-based treatments in which the RF energy can be selectively controlled to promote heating uniformity during one or more of body sculpting treatments (lipolysis), skin tightening treatments (laxity improvement), and cellulite treatments, all as non-limiting examples. In various aspects, the system can include: a flexible applicator comprising a plurality of layers, the plurality of layers comprising a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the conductive layer is sandwiched between the first dielectric layer and the second dielectric layer, the plurality of layers defining a plurality of incisions; an interior region and N regions extending from the interior region, wherein the plurality of incisions divide the applicator into N regions.

The present invention relates to the use of a novel Arf1 inhibitor; a method for treating refractory, recurrent or metastatic cancer using these compounds; a method for selectively killing cancer stem cells and cancer cells by using the compounds and a specific dosing regimen; a method for targeting tumor stem cells to induce an anti-tumor immune response by inhibiting the Arf1 pathway, particularly the COPI / Arf1-lipolysis-β-oxidation pathway; a method for treating diseases associated with Arf1 pathway activity in mammals using the novel compounds; processes for preparing such compounds and their intermediates, and pharmaceutical compositions of related compounds.

The invention discloses a multi-source vegetable outer vesicle composition as well as a preparation method and application thereof. The multi-source vegetable outer vesicle composition is prepared from outer vesicles extracted from spinach leaves, ginger tubers, broccoli buds, bitter gourd fruits and celery stems. The spinach leaves, the ginger tubers, the broccoli flower buds, the bitter gourd fruits and the celery stems are mixed according to the fresh weight ratio of (3-5): (1-2): (2-3): (1-1.5): (2-4), and low-temperature homogenization, centrifugation and ultrafiltration purification are performed to obtain the spinach-ginger-containing beverage. The particle size of the multisource vegetable outer vesicle composition is 100-200 nm, and the multisource vegetable outer vesicle composition comprises transmembrane protein TET8 and membrane anchoring protein ANNEXIN, and further comprises active ingredients of miR159a, miR166a, quercetin and kaempferol. The outer vesicle can target a PPAR gamma / FAS pathway and regulate and control lipolysis and metabolism reprogramming of fat cells; meanwhile, an Nrf2 pathway is activated, free radicals are removed, oxidative stress injury is inhibited, and metabolic diseases such as obesity, type II diabetes mellitus and non-alcoholic fatty liver disease can be effectively improved.

The present invention relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has the effects of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis and reducing triglyceride levels.

1. The name of the product of this design: Handle of cryolipolysis device. 2. Purpose of this design product: used for weight loss and fat reduction in the medical beauty industry. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

Systems and methods utilizing RF energy to treat a patient's skin or other target tissues are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which RF energy can be selectively controlled to facilitate heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, all by way of non-limiting examples. In various aspects, the systems may include a flexible applicator comprising a plurality of layers, the plurality of layers comprises a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the first dielectric layer and the second dielectric layer sandwich the conductive layer, the plurality of layers define a plurality of kerfs, an inner region and N regions extending from the inner region, wherein the plurality of kerfs divide the applicator into N regions.

The invention relates to the field of daily chemicals, and discloses a composite massage preparation as well as a preparation method and application thereof. The preparation is prepared by compounding recombinant human-derived III-type collagen, a high-activity pollen protein extract and traditional Chinese medicine herbal essence according to a specific proportion, the traditional Chinese medicine herbal essence is prepared by extracting and purifying 12 medicinal materials, and the contents of alkaloid, flavonoid and polysaccharide are respectively greater than or equal to 12%, 18% and 15%. The preparation technology comprises the following steps: preparing recombinant collagen through genetic engineering, extracting pollen protein through supercritical CO2, and carrying out low-temperature dynamic cycle extraction and molecular distillation purification on traditional Chinese medicine components. The preparation has a remarkable synergistic effect by promoting lipolysis, repairing skin injury and regulating the body state, and in-vitro, animal and human body tests prove that the preparation has excellent effects in the aspects of reducing fat accumulation, improving skin elasticity and assisting metabolism regulation. The composition can be prepared into various dosage forms, is used for shaping the body, beautifying the skin and conditioning sub-health, and is comprehensive in effect, high in safety and wide in market prospect.

To provide polypeptide-containing pharmaceutical compositions.SOLUTION: The invention relates to a pharmaceutical composition comprising a polypeptide, more specifically, a pharmaceutical composition for preventing or treating obesity, diabetes or non-alcoholic fatty liver disease. Th pharmaceutical composition is safe without any side effects such as nausea or vomiting with effects of reducing food intake, enhancing insulin secretion, suppressing gastric emptying, promoting lipolysis, and lowering a level of triglycerides. The invention relates to a polypeptide-containing pharmaceutical composition, medical use of the polypeptide-containing pharmaceutical composition, for example, use in treatment or prevention of obesity, diabetes or non-alcoholic fatty liver disease.SELECTED DRAWING: None

A yolk phospholipid composition having a lysophosphatidyl ethanolamine content of 1% by mass or less and an amino acid content of 50 mg / 100 g or more and 500 mg / 100 g or less.

The disclosed compositions, systems and methods relate to a dietary supplement for human consumption and comprises 1-methylxanthine and optionally other compounds that modulate the effects of 1-methylxanthine. Uses for the 1-methylxanthine-containing supplements contain improvement of at least one of endurance performance, mood, vigor, lipolysis, energy expenditure, exercise performance, and / or decreased appetite.

The invention provides a composition and a method for preserving marinated chicken wings, which are characterized in that a composite antioxidant consisting of rosemary extract, clove, vitamin C and citric acid and a composite preservative consisting of phytic acid, tea polyphenol and beta-carotene are respectively subjected to antioxidant treatment in a marinating and boiling stage of the chicken wings and before vacuum packaging; the synergistic oxidation effect among different natural antioxidants is utilized, so that the oxidative discoloration of the chicken wings during marinating and the lipolysis caused by irradiation are effectively inhibited. The two antioxidant treatments not only delay the decomposition rate of fat and protein in the chicken wings and prolong the shelf life of the product, but also protect the color of chicken and improve the quality of the chicken wings.