58 results about "Lipolysis" patented technology

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

Provided is a Bifidobacterium bifidum strain, Bifidobacterium bifidum ibiome001, which can significantly reduce body weight gain and white adipose tissue weight gain of high fat diet-induced obese and diabetic mice, and enhances expression of lipolytic genes ATGL and HSL. Moreover, Bifidobacterium bifidum ibiome001 can significantly lower fasting blood glucose levels, area under curves (AUCs) of the oral glucose tolerance (OGTT) curve, plasma glycated hemoglobin levels and insulin levels of diabetic mice. It is suggested that Bifidobacterium bifidum ibiome001 is a promising potential probiotic strain for the treatment of metabolic syndrome such as obesity, diabetes and the like, which is more effective than other Bifidobacterium strains / compositions.

Provided in the present disclosure are materials, devices, systems, and methods for performing cryo-surgery in a mammalian subject. More particularly, presented are a slurry, devices, systems, and methods for subcutaneously injecting the slurry into a patient in need of bodyfat reduction intervention. The slurry, devices, systems, and methods permit highly efficacious subcutaneous ice phase-change lipolysis while not requiring that the patient be placed under general anesthesia, nor requiring significant new surgical training among practitioners.

The invention relates to the technical field of health-care products, and particularly discloses a roselle-containing composition and a preparation method thereof, and the roselle-containing composition comprises the following components: a roselle extract, a cocoa extract, coating protein, a fermentation compound and auxiliary materials; the added roselle extract is subjected to multi-step pretreatment, the extraction rate and stability of active ingredients are improved, and the polarity of the roselle extract can be adjusted by adopting a composite solvent for extraction, so that the bioavailability is improved; the added cocoa extract can reduce oxidation of anthocyanin, and the cocoa extract and the roselle extract are synergistically used for reducing blood fat by inhibiting lipase activity and adjusting cholesterol; the fermentation compound can generate urolithin A, pueraria peptide and perillyl alcohol to further assist in reducing blood fat, and the coating protein improves the stability and absorption efficiency of the roselle extract; the auxiliary materials can improve the bioavailability of the active components of the raw materials, and the prepared composition has the effects of inhibiting appetite, promoting lipolysis, inhibiting fat absorption and reducing blood fat through synergistic effects of all the components.

The present invention relates to an injection composition for lipolysis, which is safe and effective, and more specifically, to an injection composition for lipolysis, which comprises: one or more compounds selected from the group consisting of hyaluronidase and pentoxifylline, and one or more compounds selected from the group consisting of hyaluronidase, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline and pentoxifylline. 5 to 10% (v / v) of carnitine (Carnitine); and lidocaine (Lidocaine); and normal saline. As a composition having both safety and efficacy, the injection composition for lipolysis of the present invention has an excellent lipolysis effect, does not cause a yo-yo phenomenon over time, and thus has a characteristic of not causing side effects such as skin depression.

The present invention relates to a peptide complex having activities of preventing or treating fatty liver disease. The peptide complex of the present invention inhibits, in hepatocytes, the expression of fat synthesis-related genes and proteins and promotes the expression of fatty acid oxidation-related genes and proteins, and thus can inhibit, in hepatocytes, fat accumulation and promote lipolysis. In addition, the peptide complex of the present invention can inhibit the expression of inflammation-related genes in hepatocytes, and inhibits the expression of hepatotoxicity-related proteins, thereby having hepatoprotective activity. Furthermore, the peptide complex of the present invention can inhibit the degree of fat accumulation and liver fibrosis in liver tissue. Therefore, the peptide complex of the present invention is expected to be effectively used for preventing, alleviating or treating fatty liver disease.

The present disclosure relates to a fat removal surgery instrument. The present disclosure additionally arranges / provides a fiber support on a lipolytic fat suction passage of a waveguide tube, the fiber support being made of an insulating material and supporting an optical fiber in a restrained state while being fixed to the waveguide tube, such that the optical fiber is prevented from being deformed and coming into contact with the waveguide tube, and thus, even if various factors (e.g., weight, contact with human tissue, etc.) are applied to the optical fiber during a fat removal surgery, the optical fiber is guided to effectively avoid direct contact with the waveguide tube and thereby be damaged, while a series of deformations (e.g., a curved shape, etc.) are suppressed / controlled based on the strong restraint of the fiber support.

The invention relates to the technical field of biological medicine preparations, in particular to application of targeted nanoparticles in treatment of osteoporosis. The targeted nano-particles CL-NPs (at) NEs are developed, CL can stimulate lipolysis of bone marrow adipocytes, osteogenic differentiation is promoted, and therefore the bone marrow microenvironment is improved; meanwhile, autologous neutrophil is used as a carrier to transport CL-NPs, bone marrow fat cells beta3AR are accurately targeted, and the osteoporosis microenvironment can be further improved. Experiments prove that CL-NPs (at) NEs stimulate a bone marrow fat cell beta3 adrenoceptor in a targeted manner, can effectively improve OP, has safety and has the potential to become a novel medicine for osteoporosis.

The invention discloses a multi-source vegetable outer vesicle composition as well as a preparation method and application thereof. The multi-source vegetable outer vesicle composition is prepared from outer vesicles extracted from spinach leaves, ginger tubers, broccoli buds, bitter gourd fruits and celery stems. The spinach leaves, the ginger tubers, the broccoli flower buds, the bitter gourd fruits and the celery stems are mixed according to the fresh weight ratio of (3-5): (1-2): (2-3): (1-1.5): (2-4), and low-temperature homogenization, centrifugation and ultrafiltration purification are performed to obtain the spinach-ginger-containing beverage. The particle size of the multisource vegetable outer vesicle composition is 100-200 nm, and the multisource vegetable outer vesicle composition comprises transmembrane protein TET8 and membrane anchoring protein ANNEXIN, and further comprises active ingredients of miR159a, miR166a, quercetin and kaempferol. The outer vesicle can target a PPAR gamma / FAS pathway and regulate and control lipolysis and metabolism reprogramming of fat cells; meanwhile, an Nrf2 pathway is activated, free radicals are removed, oxidative stress injury is inhibited, and metabolic diseases such as obesity, type II diabetes mellitus and non-alcoholic fatty liver disease can be effectively improved.

The present invention relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has the effects of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis and reducing triglyceride levels.

Systems and methods utilizing RF energy to treat a patient's skin or other target tissues are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which RF energy can be selectively controlled to facilitate heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, all by way of non-limiting examples. In various aspects, the systems may include a flexible applicator comprising a plurality of layers, the plurality of layers comprises a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the first dielectric layer and the second dielectric layer sandwich the conductive layer, the plurality of layers define a plurality of kerfs, an inner region and N regions extending from the inner region, wherein the plurality of kerfs divide the applicator into N regions.

The invention relates to the field of daily chemicals, and discloses a composite massage preparation as well as a preparation method and application thereof. The preparation is prepared by compounding recombinant human-derived III-type collagen, a high-activity pollen protein extract and traditional Chinese medicine herbal essence according to a specific proportion, the traditional Chinese medicine herbal essence is prepared by extracting and purifying 12 medicinal materials, and the contents of alkaloid, flavonoid and polysaccharide are respectively greater than or equal to 12%, 18% and 15%. The preparation technology comprises the following steps: preparing recombinant collagen through genetic engineering, extracting pollen protein through supercritical CO2, and carrying out low-temperature dynamic cycle extraction and molecular distillation purification on traditional Chinese medicine components. The preparation has a remarkable synergistic effect by promoting lipolysis, repairing skin injury and regulating the body state, and in-vitro, animal and human body tests prove that the preparation has excellent effects in the aspects of reducing fat accumulation, improving skin elasticity and assisting metabolism regulation. The composition can be prepared into various dosage forms, is used for shaping the body, beautifying the skin and conditioning sub-health, and is comprehensive in effect, high in safety and wide in market prospect.

To provide polypeptide-containing pharmaceutical compositions.SOLUTION: The invention relates to a pharmaceutical composition comprising a polypeptide, more specifically, a pharmaceutical composition for preventing or treating obesity, diabetes or non-alcoholic fatty liver disease. Th pharmaceutical composition is safe without any side effects such as nausea or vomiting with effects of reducing food intake, enhancing insulin secretion, suppressing gastric emptying, promoting lipolysis, and lowering a level of triglycerides. The invention relates to a polypeptide-containing pharmaceutical composition, medical use of the polypeptide-containing pharmaceutical composition, for example, use in treatment or prevention of obesity, diabetes or non-alcoholic fatty liver disease.SELECTED DRAWING: None

A yolk phospholipid composition having a lysophosphatidyl ethanolamine content of 1% by mass or less and an amino acid content of 50 mg / 100 g or more and 500 mg / 100 g or less.

The disclosed compositions, systems and methods relate to a dietary supplement for human consumption and comprises 1-methylxanthine and optionally other compounds that modulate the effects of 1-methylxanthine. Uses for the 1-methylxanthine-containing supplements contain improvement of at least one of endurance performance, mood, vigor, lipolysis, energy expenditure, exercise performance, and / or decreased appetite.

The invention provides a composition and a method for preserving marinated chicken wings, which are characterized in that a composite antioxidant consisting of rosemary extract, clove, vitamin C and citric acid and a composite preservative consisting of phytic acid, tea polyphenol and beta-carotene are respectively subjected to antioxidant treatment in a marinating and boiling stage of the chicken wings and before vacuum packaging; the synergistic oxidation effect among different natural antioxidants is utilized, so that the oxidative discoloration of the chicken wings during marinating and the lipolysis caused by irradiation are effectively inhibited. The two antioxidant treatments not only delay the decomposition rate of fat and protein in the chicken wings and prolong the shelf life of the product, but also protect the color of chicken and improve the quality of the chicken wings.

This invention relates to peptide complexes with anti-diabetic activity and their uses. The peptide complexes of this invention promote cellular glucose uptake, inhibit insulin resistance signaling, promote insulin sensitivity signaling, and inhibit apoptosis of pancreatic β-cells, which are insulin-producing cells, thereby exhibiting a blood glucose-lowering effect. Furthermore, this invention also relates to peptides with anti-diabetic and anti-obesity activities and their uses. The peptides of this invention have activities that inhibit insulin resistance signaling, promote insulin sensitivity signaling, and promote lipolysis in adipocytes.

Systems and methods utilizing RF energy to treat a patient's skin or other target tissues are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which RF energy can be selectively controlled to facilitate heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, all by way of non-limiting examples. In various aspects, the systems may include a flexible applicator comprising a plurality of layers, the plurality of layers comprises a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the first dielectric layer and the second dielectric layer sandwich the conductive layer, the plurality of layers define a plurality of kerfs, an inner region and N regions extending from the inner region, wherein the plurality of kerfs divide the applicator into N regions.

The invention relates to a body fat scale electrotherapy optimization control method and system based on an artificial intelligence technology, and belongs to the field of electric digital data processing. According to the method, a high-precision body fat scale and an electro-therapeutic apparatus are integrated, deep learning and analysis are performed on body fat data, electro-therapeutic requirements and historical feedback of a user by using an artificial intelligence algorithm, and personalized customization and dynamic adjustment of different electro-therapeutic parameter combinations of different users are realized. The system comprises a data acquisition module, an artificial intelligence processing module and a control execution module, and can automatically optimize an electrotherapy parameter combination including electrotherapy intensity, frequency and duration according to real-time body fat conditions and electrotherapy reactions of different users to achieve high-amplitude fat reduction and health effects. According to the body fat scale, the intelligent level of the electrotherapy function of the body fat scale is effectively improved, and safer, more effective and more personalized health services are provided for users.

The risk of disease and / or vascular state in a subject is determined by using data gathered from a computer tomography (CT) scan along a length of two or more blood vessels to determine a value for the radiodensity and / or one or more radiomic features of the perivascular tissue surrounding each blood vessel or segment thereof. The radiodensity and / or one or more radiomic features of the perivascular tissue surrounding each blood vessel or segment thereof is used to determine the presence of disease and / or vascular state in each blood vessel or segment. A value is output based on the number of vessels or segments with disease and / or vascular state, indicating the subject’s presence or risk of disease and / or vascular state. The disease or vascular state may be one of inflammation, oedema, fibrosis, vascularity, lipolysis and adipogenesis. Also disclosed is a computer implemented method inputting a metric indicative of the number of vessels or segments with disease and / or vascular state into a trained machine learning or statistical model, and a method of training said machine learning or statistical models.

The invention discloses an injectable gel-state composition with local fat reduction and drug sustained release effects as well as preparation and application of the injectable gel-state composition. The injectable gel-state composition consists of the following components in percentage by mass: 5-50% of phospholipid, 0.4-10% of cholic acid derivatives and / or salts thereof, 0-5% of divalent metal salt, 0-10% of amino acid and / or salts thereof, 0-10% of cholesterol and the balance of water, the stable hydrogel is formed by constructing a three-dimensional network structure by using phospholipid, cholic acid derivatives and / or salts thereof and water. The injectable gel-state composition is prepared by mixing a simple lipid and a water phase, and is simple to operate and environment-friendly. The injectable gel-state composition can be used as a gel-state carrier for delivering active substances (various fat-soluble and water-soluble drugs) or used for preparing injectable gel-state composition preparations loaded with the active substances, and can also be used as or used for preparing drugs with local fat reduction effects for local fat reduction for medical and / or cosmetic purposes. The application range is wide.

The application discloses a modified starch-based petroleum drilling aid and a preparation method thereof, and comprises the following steps: S1, oxidizing dialdehyde starch into polycarboxyl starch by using sodium chlorite; S2, performing esterification treatment on the polycarboxyl starch, and then performing amidation reaction on the polycarboxyl starch and sodium p-aminobenzenesulfonate; S3, performing reduction treatment on the amide bond by using a reducing agent; and S4, performing lipolysis on the starch after the reduction treatment to obtain the modified starch. The modified starch prepared by the application can greatly improve the temperature resistance and salt resistance by grafting a large number of rigid benzene rings and hydration groups, and has excellent effects of increasing viscosity, improving cutting and reducing filtration loss.

The invention relates to a weight-losing composition and application thereof. The weight-losing composition is prepared from the following components in parts by weight: 10 to 20 parts of flaxseed oil powder, 10 to 20 parts of coconut water raw powder, 5 to 10 parts of galactooligosaccharide, 1 to 5 parts of white kidney bean-potato composite extract, 1 to 5 parts of psyllium husk powder and 0.1 to 1 part of epigallocatechin gallate. According to the weight-losing composition disclosed by the invention, through multi-dimensional synergy of energy metabolism enhancement, lipolysis blocking, intestinal micro-ecological regulation and blood sugar and appetite regulation and control, the efficacy of a single component is amplified, and the synergy effects of improving metabolism and reducing fat and weight are finally realized.

The present application relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has an effect of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis, and lowering triglyceride levels.

The invention discloses multi-operation-head beauty equipment with a fat burning effect aiming at multiple fats, and particularly relates to the technical field of beauty equipment, the multi-operation-head beauty equipment comprises a beauty instrument device, an ultrasonic fat burning head, a negative pressure fat burning head, an infrared light fat burning head, a micro-current fat burning head and a telescopic assembly, the telescopic assembly is connected to the bottom of the beauty instrument device, and the telescopic assembly is connected to the bottom of the beauty instrument device. The length of the beauty instrument device is adjusted; the multiple operation heads are matched with multiple parts, precise and efficient fat burning is achieved, the ultrasonic fat burning heads are specially designed for thick fat layers of the waist and the abdomen, and fat cell structures are destroyed through the cavitation effect, the mechanical effect and the heat effect; the negative-pressure fat burning head is used for lifting subcutaneous fat tissues by moderate negative pressure aiming at delicate facial skin; the infrared light fat burning head meets the fat burning requirement of the arm, so that the infrared light completely and uniformly covers the arm; the micro-current fat burning head can assist each part, stimulate muscle contraction and promote lipolysis; by means of the precise design, the operation heads can play a role according to fat characteristics of different parts, and diversified beauty requirements of users are met.

Systems and methods for minimally-invasive lipolysis in a target area by injecting the area with a solution of photo-absorbing nanoparticles such as substantially spherical gold nanoshells that may comprise a non-conducting core, and irradiating the injected area with a beam of near infrared (NIR) light adapted to excite the nanoparticles to melt or ablate fat within the target area.

The invention discloses a strain of yarrowia lipolytica for producing protease, which is preserved in the China General Microbiological Culture Collection Center (CGMCC), is classified and named as yarrowia lipolytica, has the preservation number of CGMCC NO.35648, and is preserved on August 18, 2025. According to the application of the yarrowia lipolytica in preparation of the polypeptide with DPP-IV inhibitory activity, when the yarrowia lipolytica is specifically applied, eels are fermented by utilizing the yarrowia lipolytica. According to the present invention, the dominant bacteria in the fish head of astrocandra glabra are subjected to enrichment culture, and the screening is performed to obtain the strain YM-5 having strong extracellular protease production ability, and the identification results show that the strain is the yarrowia lipolytica, and the strain has characteristics of acid and alkali resistance, nitrite resistance, low temperature resistance and the like. A polypeptide with DPP-IV (dipeptidyl peptidase-IV) inhibitory activity can be obtained by utilizing the strain to ferment the astrocandra glabra. The research of the invention not only improves the additional value of the eel head, but also has important meanings for the research of bioactive peptides and the treatment of type 2 diabetes mellitus.

The invention relates to a detergent and / or cleaning agent, comprising at least one peptide and at least one enzyme having a hydrolytic activity on an ester bond, preferably selected from lipase and esterase, in particular esterase having a lipolytic activity, particularly preferably lipase, wherein the peptide is suitable for adhering to a grease- and / or oil-containing surface or to a surface coated with grease and / or oil or to a surface provided with at least one grease- and / or oil-containing stain, and the surface consists of hard surfaces, more preferably surfaces containing or consisting of ceramic (e.g. porcelain, stoneware), metal, steel, stainless steel, plastic, glass, natural and artificial stone, painted and enameled surfaces, wood, laminate, linoleum and mixtures thereof, particularly preferably flatware (preferably made of ceramic such as porcelain or stoneware and plastic), metal (e.g. cutlery or pots) or glass and mixtures thereof, particularly preferably flatware (preferably made of ceramic such as porcelain or stoneware and plastic), metal (e.g. cutlery or pots) or glass, and / or textiles, more preferably textiles containing or consisting of cotton, polyester, polyamide, polypropylene and mixtures thereof, particularly preferably cotton, polyester and mixtures thereof. The invention further relates to methods for cleaning hard surfaces and / or textiles, to the use of such peptides, and to agents for improving the cleaning performance against at least one grease- and / or oil-containing stain.

Provided is a novel preparation having an excellent lipolysis-promoting effect, an excellent visceral fat and body fat reducing effect, an excellent body weight reducing effect, and an excellent BMI improving effect. Another purpose of the present invention is to provide a novel preparation having an excellent insulin resistance improving effect, an excellent cholesterol value reducing effect, and the like. The present invention is an internal composition containing hirsutin B, which is used for at least one of lipolysis, fat burning, fat consumption assistance, BMI improvement, BMI reduction assistance, abdominal fat reduction, visceral fat reduction, body fat reduction, waist reduction, insulin resistance improvement, and LDL cholesterol value reduction. The internal composition of the present invention is preferably used for adults having a BMI of 23 kg / m < 2 > or more and less than 30 kg / m < 2 > and for adults having a visceral fat area of 100 cm < 2 > or more.

The application provides a kind of based on organoid mediated drug delivery system and its application, utilize by prolactin and oxytocin stimulate mammary gland organoid has lactation function and contains a large number of lipid droplets lactation mammary gland organoid, drug-loaded organoids obtained by co-incubation of lactation mammary gland organoid and antitumor prodrug can realize efficient loading of antitumor prodrug, lactation mammary gland organoid lactation or lipid droplet lipolysis will load drug controllable release.The drug-loaded organoids provided by the application can effectively inhibit postoperative recurrence of tumor, and can promote regeneration and repair of postoperative breast tissue;The drug delivery and tissue regeneration mediated thereby can be extended to various organoids, thereby achieving treatment of various tumors and postoperative tissue repair, and having wide application prospects in tumor treatment and tissue regeneration.