145 results about "Lipolysis" patented technology

A light applicator configured for contacting a portion of a subject's body surface and applying light irradiation thereto for lipolysis of target tissue underlying the subject's body surface is provided. The light applicator includes: a substrate; a plurality of light emitting diodes (LEDs) arranged on the substrate. A beam divergence of each of the plurality of LEDs is in the range of 50 to 70 steradian. The plurality of LEDs is arranged such that their emitted light beams overlap during transmission to a target tissue underlying the subject's body surface.

The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of intracellular cAMP. In other preferred embodiments, the GPCR is expressed endogenously by adipocytes. In further preferred embodiments, the GPCR inhibits intracellular lipolysis. In other further preferred embodiments, the GPCR is a nicotinic acid receptor. The present invention also relates to methods of using a modulator of said GPCR. Preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, stroke, insulin resistance, and type 2 diabetes.

The present invention is directed to a lipolysis stimulator and a slimming agent which stimulate or facilitate lipolysis of accumulated adipose tissue, to thereby exert the body slimming effect. The lipolysis stimulator or the slimming agent of the present invention contains as an active ingredient any form of a plant or an extract thereof, the plant being selected from among common juniper, togenashi, rosehip, areca, polygala root, plantago herb, calumba, zuikorodoku, garden nasturtium, kidachiumanosuzukusa, bayberry, cogon grass, kohon, shoyokanzo, Japanese white birch, tanjin, kikubafuro, white mustard, common sunflower, ground ivy, Chinese wolfberry, Japanese pagota tree, sennenken, common fig, kankatto, Chinese hibiscus, usubaakaza, fenugreek, English walnut, sozuku, koniwa-zakura, gardenia, shima-kan-giku, akamino-akane, futaba-mugura, karoou, schizonepeta spike, purslane, karabyakushi, and prostrate knotweed.

The invention relates to the technical field of dairy product processing, in particular to a processing method for natural cheese suitable for the taste of Chinese people. In the method, fresh milk is pasteurized after being filtered, purified and standardized, and is then cooled to the curding temperature, compound starter is first added for preacidification, the acidity is then regulated, calcium chloride and compound rennin are then added, curds are formed by heat preservation and then cut into curd blocks, whey is discharged after the curd blocks are stirred and heated and the temperature is preserved, and the curd blocks are taken out, added with salt and Chinese ham powder, molded, vacuumized and fermented to ripen under the constant temperature. The curding speed is high, the period of fermentation is short, the production cost is low, proteolysis and lipolysis are moderate, the bitterness is light, and since the tastes of the cheese, the acidophilus milk and the Chinese ham are mixed together, the taste of the produced natural cheese is more suitable for the taste of Chinese people.

The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.

Synergistic anti-adipogenic and pro-lipolytic compositions for the prevention and amelioration of adipogenesis and lipolysis mediated diseases, comprising at least two extracts selected from enriched demethylated curcuminoids obtained from Curcuma longa, Moringa oleifera and Murraya koenigii. The anti-adipogenic and pro-lipolytic compositions optionally contain one or more anti-obesic agents. These compositions are useful for preventing anti-inflammatory and free radical mediated diseases.

The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis, and intestinal water and electrolyte secretion.

The present invention relates to a modified enzyme with lipolytic activity, a lipolytic enzyme capable of removing a substantial amount of fatty matter during a one cycle wash, a DNA sequence encoding said enzymes, a vector comprising said DNA sequence, a host cell harbouring said DNA sequence or said vector, and a process for producing said enzymes with lipolytic activity.

The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.

The invention provides a slimming composition. The effective components of the composition comprise a cereus extract, a green tea extract and a guarana extract. The composition is compounded from the cereus extract, green tea extract and guarana extract, wherein the cereus extract can regulate the activity of lipase, promote excessive fat to be quickly decomposed, and effectively prevent the fat from being absorbed by the intestinal tract, thereby achieving the slimming effect; the green tea extract has the functions of lowering and consuming the enzyme activity, reducing the food intake and energy absorption and increasing the lipolysis and metabolism; the guarana extract can increase the rate of metabolism, enhance the energy consumption and stimulate the lipolysis; and the three extracts, which are proportionally compounded, can obviously enhance the slimming effect and have a synergic action.

The invention provides methods, therapeutics and kits for treating and preventing diseases or conditions associated with excessive lipolysis, in particular TNF-α induced lipolysis, and / or excessive free fatty acid levels. Exemplary conditions include insulin-resistance, diabetes, in particular NIDDM, obesity, glucose intolerance, hyperinsulinemia, polycystic ovary syndrome, and coronary artery disease. In a preferred embodiment, the method includes administering to a subject in need a pharmaceutically effective amount of an inhibitor of the JNK signal transduction pathway and / or an inhibitor of the MAPK / ERK signal transduction pathway.

High Intensity Repetitious Training (HIRT) is an exercise regimen consisting of approximately three minutes of intense exercise that puts an exerciser at the end of the anaerobic energy transfer system and prevents the exerciser from entering the aerobic energy transfer system. The HIRT Program exercise regimen subjects the muscles to high frequency intense muscle contractions for approximately three minutes to the point that the lactic system reaches a maximum followed by a period of rest for at least one to two minutes to restore creatinine and remove some of the lactate acid out of the blood stream. The HIRT exercise regimen enhances the benefits of lactate accumulation, post-exercise insulin and growth hormone release with lipolysis or fat reduction.

The invention discloses essence containing plankton and an application of the essence in cosmetics. The essence contains plankton extract, hop extract, capsicum frutescens fruit extract, ruscus aculeatus root extract and solidago virgaurea extract. The mass ratio of plankton extract to hop extract to capsicum frutescens fruit extract to ruscus aculeatus root extract to solidago virgaurea extract is (3-9) g:(2-6) g: (1-5) g: (1-3) g: (1-3) g. The essence and the cosmetics containing the essence comprehensively act on various fat cells, lipolysis is promoted, accumulation of fat is avoided, local microcirculation disturbance is eliminated, edema is eliminated, leg fatigue and heaviness are relieved, and remarkable moisturizing, slimming and local slimming effects are achieved.

The invention discloses a preparation method of astaxanthin and resveratrol-containing self-microemulsion particles. The preparation method comprises the following steps: at a temperature of 40-60 DEG C, carrying out mixed dissolving on a surfactant, caprylic / capric triglyceride and a co-emulsifier, so that a blank self-microemulsion is obtained; adding resveratrol and astaxanthin into the blank self-microemulsion, and uniformly stirring, so that an astaxanthin and resveratrol-containing self-microemulsion is obtained; adding hydroxypropyl methylcellulose into the astaxanthin and resveratrol-containing self-microemulsion, and uniformly stirring, so that a mixed suspended astaxanthin and resveratrol-containing self-microemulsion is obtained; and finally, adding microcrystalline cellulose, so that the astaxanthin and resveratrol-containing self-microemulsion is changed into solid granular powder, namely, astaxanthin and resveratrol-containing self-microemulsion particles. Through the way, the preparation method disclosed by the invention is simple, and no special high-energy-consumption production equipment is required in the process of preparation; obtained products effectively increase the solubility of astaxanthin and resveratrol in water, and improve the influence of stomach scattering and intestinal lipolysis; and the effective bioavailability is high.

The invention relates to a low nucleic acid yeast product and a preparation method thereof. The low nucleic acid yeast product comprises 45 percent to 55 percent of protein, 0.05 percent to 1.0 percent of nucleic acid, 100ppm to 5,000ppm of calcium, 30ppm to 1,000ppm of iron, and 30ppm to 1,000ppm of zinc. The invention further relates to the preparation method of the low nucleic acid yeast product. The preparation method comprises the following steps: yeast is mixed with water into a solution with a mass percentage concentration of 5 percent to 10 percent; the pH (hydrogen ion concentration)of the solution is regulated to a value between 6.0 and 10.0; the heat of the yeast solution is preserved for 1 to 6 hours at a temperature of 60 DEG C to 100 DEG C; the pH of the yeast solution is further regulated to a value between 5.0 and 7.0; the yeast solution is separated, washed and dried; and then the low nucleic acid yeast product is acquired. The method disclosed by the invention has the advantages that the nucleic acid content in the yeast is reduced simply, conveniently and effectively, namely the danger of gout caused by eating the yeast or relevant products produced by using the yeast as a raw material is reduced, and the nutritive value in the original yeast is preserved. The invention further relates to a weight-reducing product comprising the low nucleic acid yeast. The weight-reducing product has the advantages of low calorie, high nutrition, safety and effectiveness, and can promote lipolysis.

This present invention discloses a method for preparing a lipolysis-stimulating soy protein hydrolysate, proceeding a hydrolysis reaction, which is a predetermined concentration of soy protein mediated by Flavourzyme in a predetermined hydrolysis conditions, wherein Flavourzyme versus the soy protein is 1:100, and the optimal hydrolysis conditions including reaction pH value 7˜7.5, reaction temperature 40˜50° C. and hydrolysis time 100˜150 minutes. This invention further discloses nine recombinations of isolated peptide sequences from the soy protein hydrolysate including Val-His-Val-Val, Leu-Leu-Leu, Leu-Leu-Ile, Leu-Ile-Leu, Leu-Ile-Ile, Ile-Leu-Leu, Ile-Leu-Ile, Ile-Ile-Leu and Ile-Ile-Ile.

The invention relates to healthcare food, in particular to healthcare vinegar containing resveratrol and capable of resisting oxidation, protecting heart and cerebral vessels and increasing immunity and a production method of the healthcare vinegar. The healthcare vinegar comprises a main material and auxiliary materials, wherein the weight ratio of the main material to the auxiliary materials is 1:5-10, the main material is sticky rice, millet or wheat, and the auxiliary materials comprise at least one of polygonum cuspidatum, grape skin, grape seed, peanut skin, peanut seedling and peanut root and rice husk, salt, sugar, yeast and solid fermentative substrate of vinegar. The healthcare vinegar and the production method thereof have the advantages that the resveratrol can be fully dissolved in the vinegar, the stomach dispersing and intestinal tract lipolysis of the resveratrol are increased effectively, and the resveratrol can be easily absorbed by human bodies as compared with resveratrol healthcare food; the healthcare vinegar is simple in production process, easy in raw material obtaining, low in cost, high in nutritional value, good in healthcare effect, capable of delaying aging and enhancing immunity and suitable for everyone.

The invention discloses a slimming nano-liposome and a preparation method thereof, and belongs to the technical field of special cosmetics. The slimming nano-liposome is prepared from the following components in parts by weight: 0.10 to 30.00 parts of a slimming functional component, 1.00 to 10.00 parts of phospholipid, 0.10 to 5.00 parts of sterol, 1.00 to 10.00 parts of an emulsifier, 2.00 to 30.00 parts of polyhydric alcohol and the balance of water, totaling 100 parts. By directly or indirectly promoting lipolysis, inhibiting adipocyte differentiation, inhibiting intake of free fatty acidin adipocytes and synthesis of triglyceride, skin microcirculation is promoted. Therefore, the number and the volume of fat cells are reduced, and the slimming functional component for inhibiting andeliminating fat accumulation is loaded in the nano-liposome with the particle size of 10-500nm. The slimming nano-liposome has the characteristics of good stability, high safety (without hormone), targeted slow release, synergistic interaction, good transdermal absorption, long residence time, high bioavailability and the like, and thus, has a relatively ideal slimming effect.

The invention discloses maca ferment and a preparation method thereof. The method specifically includes the steps of firstly, stirring and mixing maca mixed fermentation raw materials to obtain a mixture; secondly, adding an enzyme activity keeping agent to the mixture; thirdly, adding bacterial liquid, and conducting sealing and fermenting; fourthly, conducting filtering. The maca mixed fermentation raw materials include, by weight, 5-15 parts of maca, 10-30 parts of apple, 10-20 parts of carrot, 5-15 parts of broccoli, 20-40 parts of shiitake and 10-20 parts of cucumber. The maca ferment contains multi-enzyme ferment, proteolysis ferment, lipolysis ferment and amylolysis ferment, contains macaenes, macamides, various natural vitamins, mineral substances, amino acid, trace elements and the like, can be used for enhancing vigor, adjusting reproduction and metabolism, promoting fertility, improving the sexual function, treating climacteric syndromes, climacteric syndromes and depression, increasing bone mineral density, treating anemia and resisting oxidation, and is a natural internal secretion adjustor. In addition, the ferment has effects on resisting cancer and leukemia and the like.

Cosmetic methods for obtaining a slimming effect are disclosed. The methods include providing a composition containing a carob (Ceratonia siliqua L.) seed extract as a slimming agent and a physiologically acceptable medium, and topically applying the composition on at least a portion of the body or face. The topical application of the composition includes the application of an effective amount of the composition that increases the expression of aquaglyceroporins, promotes lipolysis, and / or reduces localized excess body fat.

Disclosed is a transdermal composition, which uses high-purity phosphatidylcholine that is most susceptible to oxidation and the like, and which exhibits high stability and high migration into the skin. Specifically, a transdermal composition having good stability and migration into the skin is able to be obtained by preparing a transdermal composition (a colloidal dispersion liquid of phosphatidylcholine) that contains high-purity phosphatidylcholine, carnitine, a polyhydric alcohol and water. Since the transdermal composition does not contain an oleaginous base (an oil component), the transdermal composition has skin compatibility and is thus useful as a therapeutic agent or a cosmetic preparation. In addition, phosphatidylcholine and carnitine have an effect of achieving good migration into the skin and are capable of promoting systemic or local lipid metabolism in subcutaneous adipose tissues. Consequently, the transdermal composition is able to provide a transdermal preparation that is capable of promoting lipolysis in subcutaneous adipose tissues.

The invention provides a traditional Chinese medicine composition used for burning fat and losing weight as well as a patch and a weight losing package thereof. The traditional Chinese medicine composition comprises the following ingredients in parts by weight: 28-32 parts of lotus leaves, 15-20 parts of polygonum multiflorum, 18-24 parts of safflowers, 16-25 parts of peach kernels, 18-23 parts of rhizoma alismatis, 27-31 parts of Chinese angelica, 15-20 parts of immature bitter orange and 18-24 parts of medicated leaven; the patch is prepared from the traditional Chinese medicine composition and auxiliary materials in a ratio of parts by weight of 1:(2-5); and the weight losing package comprises the patch and food, and the food is prepared from the following ingredients in parts by weight: 25-35 parts of gorgon fruits, 28-32 parts of konjak, 18-22 parts of lotus leaves, 25-30 parts of hawthorn and 15-25 parts of poria cocos. The traditional Chinese medicine composition provided by the invention has the advantages that in vivo lipolysis is effectively promoted, not only is in vivo metabolic cycle improved, but also lipolysis efficiency is improved, and fat accumulation is prevented, so that a function of losing weight is achieved.

A system and method are provided for minimally-invasive lipolysis in a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength is adapted to excite the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.

A light applicator configured for contacting a portion of a subject's body surface and applying light irradiation thereto for lipolysis of target tissue underlying the subject's body surface is provided. The light applicator includes: a substrate; a plurality of light emitting diodes (LEDs) arranged on the substrate. A beam divergence of each of the plurality of LEDs is in the range of 50 to 70 steridian. The plurality of LEDs is arranged such that their emitted light beams overlap during transmission to a target tissue underlying the subject's body surface.

The invention provides biological active peptide for promoting growth of a piglet. The biological active peptide comprises an amino acid sequence shown in SEQ IDNo.1, the absorption and utilization rate of nutrient substances in feed for the piglet can be obviously increased through the biological active peptide, growth and development of the piglet can be promoted, the morbidity can be reduced, and the survival rate of the piglet can be increased. Furthermore, the preparation method of the biological active peptide for promoting growth of the piglet and application of the biological active peptide to promoting growth of the piglet and reducing the death rate of the piglet are provided. The biological active peptide for promoting growth and development of the piglet is generated under the synergistic effect of multiple kinds of enzyme production probiotics and is applied to the piglet, constructive metabolism and lipolysis of the organism are promoted, protein synthesis is promoted, and the aims of promoting growth of the piglet and increasing the growth speed of the piglet are achieved. The function of promoting growth and development of the piglet is achieved by adjusting the hormone level of an endocrine system, the problem of hormone residues is solved, and the aim of healthy and environment-friendly breeding is achieved.

The invention relates to an application of bile acid to preparation of a metabolic disease drug. DCA (deoxycholic acid), GDCA (glycodeoxycholic acid) and TDCA (taurodeoxycholic acid) can increase basic metabolism rate by increasing the steatolysis and oxidation functions of white adipose tissues, in-vivo glycolipid metabolism is improved, intestinal flora are adjusted, high fat induced mouse obesity is relieved, and the application has great significance for clinically translational target spot search.

The invention discloses a lipolysis-accelerating slimming composition and a preparation method thereof. The lipolysis-accelerating slimming composition comprises concentrated whey protein, fruit juicepowder, crystalline fructose, skimmed milk powder, isolated soybean protein, resistant dextrin, inulin, pea protein, galactooligosaccharide, oat fiber, wheat fiber, conjugated linoleic acid, xylooligosaccharide, konjaku flour, cod collagen peptide, psyllium husk and medium chain triglyceride. The invention also provides a preparation method of the composition. The lipolysis-accelerating slimmingcomposition has the advantages that prepared from pure natural materials, the composition has no side effect after exposure, boiling and processing and avoids of discomforting a human body after beingtaken; the composition can effectively extract active ingredients from the raw materials after double-effect extraction by distilled water and alcohol, increase the utilization rate of the materials,effectively reduce the fat content of the human body and effectively promote lipolysis, and is high in satiety degree and nutrition, thereby achieving weight loss.

The described invention relates to methods for treating, preventing, or diagnosing the pathology of progressive cognitive disorders resulting from accumulation of an amyloid peptide, in particular, Alzheimer's disease, Down's syndrome and cerebral amyloid angiopathy, in mammalian subjects using a composition comprising therapeutically effective amount of a leptin, leptin mimic, leptin derivative, leptin agonist, or AMP-dependent protein kinase activator, alone, or in combination with, one or more lipolytic / antilipogenic compounds. It further relates to methods for improving cognitive function using a composition comprising a therapeutically effective amount of leptin, a leptin mimic, a leptin derivative, an AMP-dependent protein kinase activator, a leptin agonist, a leptin blocker, a mimic of a leptin blocker, a leptin antagonist, an AMP-dependent protein kinase inhibitor; or a pharmaceutically acceptable salt thereof.