95 results about "Lipolysis" patented technology

The invention relates to a washing and / or cleaning agent, comprising at least one peptide and at least one enzyme which has hydrolytic activity on an ester bond, preferably selected from lipase and esterase, in particular esterase with lipolytic activity, particularly preferably lipase, wherein the peptide is suitable for adhesion to a fat- and / or oil-containing surface or to a surface coated with fat and / or oil or to a surface provided with at least one fat- and / or oil-containing soil, wherein the surface consists of hard surfaces, more preferably surfaces containing or consisting of ceramic (e.g. porcelain, earthenware), metal, steel, stainless steel, plastic, glass, natural and artificial stone, painted and enamelled surfaces, wood, laminate, linoleum and mixtures thereof, particularly preferably tableware (preferably made of ceramic such as porcelain or earthenware and plastic), metal (e.g.cutlery or pots) or glass and mixtures thereof, particularly preferably tableware (preferably made of ceramic such as porcelain or earthenware and plastic), metal (e.g. cutlery or pots) or glass, and / or textiles, more preferably textiles containing or consisting of cotton, polyester, polyamide, polypropylene and mixtures thereof, particularly preferably cotton, polyester and mixtures thereof. Furthermore, the invention relates to methods for cleaning hard surfaces and / or textiles, and to the use of such peptides and agents for improving the cleaning performance on at least one greasy and / or oily soil.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

Provided is a Bifidobacterium bifidum strain, Bifidobacterium bifidum ibiome001, which can significantly reduce body weight gain and white adipose tissue weight gain of high fat diet-induced obese and diabetic mice, and enhances expression of lipolytic genes ATGL and HSL. Moreover, Bifidobacterium bifidum ibiome001 can significantly lower fasting blood glucose levels, area under curves (AUCs) of the oral glucose tolerance (OGTT) curve, plasma glycated hemoglobin levels and insulin levels of diabetic mice. It is suggested that Bifidobacterium bifidum ibiome001 is a promising potential probiotic strain for the treatment of metabolic syndrome such as obesity, diabetes and the like, which is more effective than other Bifidobacterium strains / compositions.

The present invention belongs to the field of pharmaceutical synthesis, and specifically relates to salviphorol derivatives and their application in drugs for treating cancer cachexia. Salviphorol compounds include compounds represented by formula (X) and / or formula (Y), or pharmaceutically acceptable salts or optical isomers of the compounds represented by formula (X) and / or formula (Y). The present invention also provides a pharmaceutical composition for treating cachexia diseases, and its application in the preparation of drugs for treating cancer cachexia, including muscle atrophy caused by tumor tissues, fat reduction caused by tumor tissues, reduced appetite caused by tumor tissues, inflammatory responses caused by tumor tissues, and cancer cachexia caused by digestive tract-related cancers, liver cancer, lung cancer, and colon cancer. The present invention also provides its application in the preparation of drugs or inhibitors for treating or inhibiting muscle atrophy, drugs or inhibitors for inhibiting or alleviating adipocyte lipolysis, and drugs or inhibitors for inhibiting or alleviating weight loss or reduction.

Provided in the present disclosure are materials, devices, systems, and methods for performing cryo-surgery in a mammalian subject. More particularly, presented are a slurry, devices, systems, and methods for subcutaneously injecting the slurry into a patient in need of bodyfat reduction intervention. The slurry, devices, systems, and methods permit highly efficacious subcutaneous ice phase-change lipolysis while not requiring that the patient be placed under general anesthesia, nor requiring significant new surgical training among practitioners.

The invention relates to the technical field of health-care products, and particularly discloses a roselle-containing composition and a preparation method thereof, and the roselle-containing composition comprises the following components: a roselle extract, a cocoa extract, coating protein, a fermentation compound and auxiliary materials; the added roselle extract is subjected to multi-step pretreatment, the extraction rate and stability of active ingredients are improved, and the polarity of the roselle extract can be adjusted by adopting a composite solvent for extraction, so that the bioavailability is improved; the added cocoa extract can reduce oxidation of anthocyanin, and the cocoa extract and the roselle extract are synergistically used for reducing blood fat by inhibiting lipase activity and adjusting cholesterol; the fermentation compound can generate urolithin A, pueraria peptide and perillyl alcohol to further assist in reducing blood fat, and the coating protein improves the stability and absorption efficiency of the roselle extract; the auxiliary materials can improve the bioavailability of the active components of the raw materials, and the prepared composition has the effects of inhibiting appetite, promoting lipolysis, inhibiting fat absorption and reducing blood fat through synergistic effects of all the components.

The present invention relates to an injection composition for lipolysis, which is safe and effective, and more specifically, to an injection composition for lipolysis, which comprises: one or more compounds selected from the group consisting of hyaluronidase and pentoxifylline, and one or more compounds selected from the group consisting of hyaluronidase, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline and pentoxifylline. 5 to 10% (v / v) of carnitine (Carnitine); and lidocaine (Lidocaine); and normal saline. As a composition having both safety and efficacy, the injection composition for lipolysis of the present invention has an excellent lipolysis effect, does not cause a yo-yo phenomenon over time, and thus has a characteristic of not causing side effects such as skin depression.

The present invention relates to a peptide complex having activities of preventing or treating fatty liver disease. The peptide complex of the present invention inhibits, in hepatocytes, the expression of fat synthesis-related genes and proteins and promotes the expression of fatty acid oxidation-related genes and proteins, and thus can inhibit, in hepatocytes, fat accumulation and promote lipolysis. In addition, the peptide complex of the present invention can inhibit the expression of inflammation-related genes in hepatocytes, and inhibits the expression of hepatotoxicity-related proteins, thereby having hepatoprotective activity. Furthermore, the peptide complex of the present invention can inhibit the degree of fat accumulation and liver fibrosis in liver tissue. Therefore, the peptide complex of the present invention is expected to be effectively used for preventing, alleviating or treating fatty liver disease.

The present disclosure relates to a fat removal surgery instrument. The present disclosure additionally arranges / provides a fiber support on a lipolytic fat suction passage of a waveguide tube, the fiber support being made of an insulating material and supporting an optical fiber in a restrained state while being fixed to the waveguide tube, such that the optical fiber is prevented from being deformed and coming into contact with the waveguide tube, and thus, even if various factors (e.g., weight, contact with human tissue, etc.) are applied to the optical fiber during a fat removal surgery, the optical fiber is guided to effectively avoid direct contact with the waveguide tube and thereby be damaged, while a series of deformations (e.g., a curved shape, etc.) are suppressed / controlled based on the strong restraint of the fiber support.

The invention relates to the technical field of biological medicine preparations, in particular to application of targeted nanoparticles in treatment of osteoporosis. The targeted nano-particles CL-NPs (at) NEs are developed, CL can stimulate lipolysis of bone marrow adipocytes, osteogenic differentiation is promoted, and therefore the bone marrow microenvironment is improved; meanwhile, autologous neutrophil is used as a carrier to transport CL-NPs, bone marrow fat cells beta3AR are accurately targeted, and the osteoporosis microenvironment can be further improved. Experiments prove that CL-NPs (at) NEs stimulate a bone marrow fat cell beta3 adrenoceptor in a targeted manner, can effectively improve OP, has safety and has the potential to become a novel medicine for osteoporosis.

The present invention belongs to the field of biotechnology and relates to a method for preparing shark nanobodies targeting pancreatic lipase and its application. The amino acid sequence of the shark nanobody VNAR-A4 is shown in SEQ ID No. 10. The shark nanobody VNAR-A4 prepared by the present invention has a molecular weight of about 15 kDa, which is smaller than traditional monoclonal antibodies, has an elongated CDR3 structure, and can better bind to the hidden epitopes of antigens; the shark nanobody VNAR-A4 has good stability, can maintain its activity under extreme pH conditions, and has good affinity and specificity for PL; the shark nanobody VNAR-A4 is expressed using an Escherichia coli prokaryotic expression system, is more easily genetically engineered, and can be obtained in large quantities. The shark nanobody VNAR-A4 has the potential to inhibit the activity of pancreatic lipase and provides a new lipolysis inhibitor for the treatment of obesity.

Provided herein are systems and methods for treating a patient's skin or other target tissue using RF energy. In various aspects, the methods and systems described herein can provide RF-based treatments in which the RF energy can be selectively controlled to promote heating uniformity during one or more of body sculpting treatments (lipolysis), skin tightening treatments (laxity improvement), and cellulite treatments, all as non-limiting examples. In various aspects, the system can include: a flexible applicator comprising a plurality of layers, the plurality of layers comprising a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the conductive layer is sandwiched between the first dielectric layer and the second dielectric layer, the plurality of layers defining a plurality of incisions; an interior region and N regions extending from the interior region, wherein the plurality of incisions divide the applicator into N regions.

The present invention relates to the use of a novel Arf1 inhibitor; a method for treating refractory, recurrent or metastatic cancer using these compounds; a method for selectively killing cancer stem cells and cancer cells by using the compounds and a specific dosing regimen; a method for targeting tumor stem cells to induce an anti-tumor immune response by inhibiting the Arf1 pathway, particularly the COPI / Arf1-lipolysis-β-oxidation pathway; a method for treating diseases associated with Arf1 pathway activity in mammals using the novel compounds; processes for preparing such compounds and their intermediates, and pharmaceutical compositions of related compounds.

The invention discloses a multi-source vegetable outer vesicle composition as well as a preparation method and application thereof. The multi-source vegetable outer vesicle composition is prepared from outer vesicles extracted from spinach leaves, ginger tubers, broccoli buds, bitter gourd fruits and celery stems. The spinach leaves, the ginger tubers, the broccoli flower buds, the bitter gourd fruits and the celery stems are mixed according to the fresh weight ratio of (3-5): (1-2): (2-3): (1-1.5): (2-4), and low-temperature homogenization, centrifugation and ultrafiltration purification are performed to obtain the spinach-ginger-containing beverage. The particle size of the multisource vegetable outer vesicle composition is 100-200 nm, and the multisource vegetable outer vesicle composition comprises transmembrane protein TET8 and membrane anchoring protein ANNEXIN, and further comprises active ingredients of miR159a, miR166a, quercetin and kaempferol. The outer vesicle can target a PPAR gamma / FAS pathway and regulate and control lipolysis and metabolism reprogramming of fat cells; meanwhile, an Nrf2 pathway is activated, free radicals are removed, oxidative stress injury is inhibited, and metabolic diseases such as obesity, type II diabetes mellitus and non-alcoholic fatty liver disease can be effectively improved.

The present invention relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has the effects of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis and reducing triglyceride levels.

Systems and methods utilizing RF energy to treat a patient's skin or other target tissues are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which RF energy can be selectively controlled to facilitate heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, all by way of non-limiting examples. In various aspects, the systems may include a flexible applicator comprising a plurality of layers, the plurality of layers comprises a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the first dielectric layer and the second dielectric layer sandwich the conductive layer, the plurality of layers define a plurality of kerfs, an inner region and N regions extending from the inner region, wherein the plurality of kerfs divide the applicator into N regions.

The invention relates to the field of daily chemicals, and discloses a composite massage preparation as well as a preparation method and application thereof. The preparation is prepared by compounding recombinant human-derived III-type collagen, a high-activity pollen protein extract and traditional Chinese medicine herbal essence according to a specific proportion, the traditional Chinese medicine herbal essence is prepared by extracting and purifying 12 medicinal materials, and the contents of alkaloid, flavonoid and polysaccharide are respectively greater than or equal to 12%, 18% and 15%. The preparation technology comprises the following steps: preparing recombinant collagen through genetic engineering, extracting pollen protein through supercritical CO2, and carrying out low-temperature dynamic cycle extraction and molecular distillation purification on traditional Chinese medicine components. The preparation has a remarkable synergistic effect by promoting lipolysis, repairing skin injury and regulating the body state, and in-vitro, animal and human body tests prove that the preparation has excellent effects in the aspects of reducing fat accumulation, improving skin elasticity and assisting metabolism regulation. The composition can be prepared into various dosage forms, is used for shaping the body, beautifying the skin and conditioning sub-health, and is comprehensive in effect, high in safety and wide in market prospect.

To provide polypeptide-containing pharmaceutical compositions.SOLUTION: The invention relates to a pharmaceutical composition comprising a polypeptide, more specifically, a pharmaceutical composition for preventing or treating obesity, diabetes or non-alcoholic fatty liver disease. Th pharmaceutical composition is safe without any side effects such as nausea or vomiting with effects of reducing food intake, enhancing insulin secretion, suppressing gastric emptying, promoting lipolysis, and lowering a level of triglycerides. The invention relates to a polypeptide-containing pharmaceutical composition, medical use of the polypeptide-containing pharmaceutical composition, for example, use in treatment or prevention of obesity, diabetes or non-alcoholic fatty liver disease.SELECTED DRAWING: None

A yolk phospholipid composition having a lysophosphatidyl ethanolamine content of 1% by mass or less and an amino acid content of 50 mg / 100 g or more and 500 mg / 100 g or less.

The disclosed compositions, systems and methods relate to a dietary supplement for human consumption and comprises 1-methylxanthine and optionally other compounds that modulate the effects of 1-methylxanthine. Uses for the 1-methylxanthine-containing supplements contain improvement of at least one of endurance performance, mood, vigor, lipolysis, energy expenditure, exercise performance, and / or decreased appetite.

The invention provides a composition and a method for preserving marinated chicken wings, which are characterized in that a composite antioxidant consisting of rosemary extract, clove, vitamin C and citric acid and a composite preservative consisting of phytic acid, tea polyphenol and beta-carotene are respectively subjected to antioxidant treatment in a marinating and boiling stage of the chicken wings and before vacuum packaging; the synergistic oxidation effect among different natural antioxidants is utilized, so that the oxidative discoloration of the chicken wings during marinating and the lipolysis caused by irradiation are effectively inhibited. The two antioxidant treatments not only delay the decomposition rate of fat and protein in the chicken wings and prolong the shelf life of the product, but also protect the color of chicken and improve the quality of the chicken wings.

The present invention relates to a pharmaceutical composition including a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea, and has effects of reducing food intake, enhancing insulin secretion, suppressing gastric emptying, promoting lipolysis, and lowering a level of triglycerides.

This invention relates to peptide complexes with anti-diabetic activity and their uses. The peptide complexes of this invention promote cellular glucose uptake, inhibit insulin resistance signaling, promote insulin sensitivity signaling, and inhibit apoptosis of pancreatic β-cells, which are insulin-producing cells, thereby exhibiting a blood glucose-lowering effect. Furthermore, this invention also relates to peptides with anti-diabetic and anti-obesity activities and their uses. The peptides of this invention have activities that inhibit insulin resistance signaling, promote insulin sensitivity signaling, and promote lipolysis in adipocytes.

A peptide of the present invention has muscle formation-promoting activity in myoblasts. The peptide of the present invention has the activities of inhibiting fat accumulation and promoting lipolysis in hepatocytes and adipocytes. The peptide of the present invention inhibits the expression of insulin resistance factors and increases the expression of insulin sensitivity factors in hepatocytes and adipocytes. Therefore, the peptide of the present invention can be used as an active substance for the treatment, prevention or amelioration of muscle diseases, obesity, fatty liver, and diabetes.

Systems and methods utilizing RF energy to treat a patient's skin or other target tissues are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which RF energy can be selectively controlled to facilitate heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, all by way of non-limiting examples. In various aspects, the systems may include a flexible applicator comprising a plurality of layers, the plurality of layers comprises a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the first dielectric layer and the second dielectric layer sandwich the conductive layer, the plurality of layers define a plurality of kerfs, an inner region and N regions extending from the inner region, wherein the plurality of kerfs divide the applicator into N regions.

The invention discloses a whole blood sample treatment liquid, a kit and a whole blood direct expansion method, and the whole blood sample treatment liquid comprises a buffer solution, a lysis solution, a nucleic acid protection solution, an impurity removal solution, a precipitation solution and an adsorption substance. According to the method, the whole blood sample treating fluid and the whole blood sample are uniformly mixed and centrifuged, the vast majority of inhibitors can be effectively removed only through simple centrifugation, and the whole process is simple, convenient, rapid and accurate to operate. The nucleic acid extraction-free whole blood direct expansion method disclosed by the invention has good tolerance to clinically common complex blood samples such as hemolysis, lipolysis and jaundice, effectively avoids the problem of leak detection caused by complex blood, and is simpler and more convenient to operate, more efficient and lower in cost compared with a blood purification method. The precipitation liquid and the adsorption substance can remove impurities, the inhibition effect of inhibitors in blood on PCR amplification is obviously reduced, and the problem of leak detection caused by too many inhibitors can be effectively reduced.

The invention relates to a detergent and / or cleaning agent, comprising at least one peptide, at least one enzyme having a hydrolytic activity on an ester bond, preferably selected from lipase and esterase, in particular esterase having a lipolytic activity, particularly preferably lipase, and optionally at least one salt, wherein the peptide is suitable for adhesion to a grease- and / or oil-containing surface or to a surface coated with grease and / or oil or to a surface provided with at least one grease- and / or oil-containing stain, and the surface is selected from hard surfaces, more preferably surfaces containing or consisting of ceramic (e.g. porcelain, stoneware), metal, steel, stainless steel, plastic, glass, natural and artificial stone, painted and enameled surfaces, wood, laminate, linoleum and mixtures thereof, particularly preferably flatware (preferably made of ceramic such as porcelain or stoneware and plastic), metal (e.g. cutlery or pots) or glass and mixtures thereof, particularly preferably flatware (preferably made of ceramic such as porcelain or stoneware and plastic), metal (e.g. cutlery or pots) or glass, and / or textiles, more preferably textiles containing or consisting of cotton, polyester, polyamide, polypropylene and mixtures thereof, particularly preferably cotton, polyester and mixtures thereof. The invention further relates to methods for cleaning hard surfaces and / or textiles, to the use of such peptides, and to agents for improving the cleaning performance against at least one grease- and / or oil-containing stain.

The invention relates to a body fat scale electrotherapy optimization control method and system based on an artificial intelligence technology, and belongs to the field of electric digital data processing. According to the method, a high-precision body fat scale and an electro-therapeutic apparatus are integrated, deep learning and analysis are performed on body fat data, electro-therapeutic requirements and historical feedback of a user by using an artificial intelligence algorithm, and personalized customization and dynamic adjustment of different electro-therapeutic parameter combinations of different users are realized. The system comprises a data acquisition module, an artificial intelligence processing module and a control execution module, and can automatically optimize an electrotherapy parameter combination including electrotherapy intensity, frequency and duration according to real-time body fat conditions and electrotherapy reactions of different users to achieve high-amplitude fat reduction and health effects. According to the body fat scale, the intelligent level of the electrotherapy function of the body fat scale is effectively improved, and safer, more effective and more personalized health services are provided for users.

The risk of disease and / or vascular state in a subject is determined by using data gathered from a computer tomography (CT) scan along a length of two or more blood vessels to determine a value for the radiodensity and / or one or more radiomic features of the perivascular tissue surrounding each blood vessel or segment thereof. The radiodensity and / or one or more radiomic features of the perivascular tissue surrounding each blood vessel or segment thereof is used to determine the presence of disease and / or vascular state in each blood vessel or segment. A value is output based on the number of vessels or segments with disease and / or vascular state, indicating the subject’s presence or risk of disease and / or vascular state. The disease or vascular state may be one of inflammation, oedema, fibrosis, vascularity, lipolysis and adipogenesis. Also disclosed is a computer implemented method inputting a metric indicative of the number of vessels or segments with disease and / or vascular state into a trained machine learning or statistical model, and a method of training said machine learning or statistical models.

The invention discloses an injectable gel-state composition with local fat reduction and drug sustained release effects as well as preparation and application of the injectable gel-state composition. The injectable gel-state composition consists of the following components in percentage by mass: 5-50% of phospholipid, 0.4-10% of cholic acid derivatives and / or salts thereof, 0-5% of divalent metal salt, 0-10% of amino acid and / or salts thereof, 0-10% of cholesterol and the balance of water, the stable hydrogel is formed by constructing a three-dimensional network structure by using phospholipid, cholic acid derivatives and / or salts thereof and water. The injectable gel-state composition is prepared by mixing a simple lipid and a water phase, and is simple to operate and environment-friendly. The injectable gel-state composition can be used as a gel-state carrier for delivering active substances (various fat-soluble and water-soluble drugs) or used for preparing injectable gel-state composition preparations loaded with the active substances, and can also be used as or used for preparing drugs with local fat reduction effects for local fat reduction for medical and / or cosmetic purposes. The application range is wide.