329 results about "Lipid lowering" patented technology

The present application relates to the technical field of oat bran deep processing, and particularly relates to an oat active polypeptide with GLP-1 secretion promotion, blood sugar reduction and lipid reduction activity, and a preparation method and application thereof.The present application is prepared by adding alkaline protease and ficin for double-enzyme step-by-step hydrolysis after homogenate, enzymolysis and alkali extraction and acid precipitation pretreatment, and then filtering, ultrafiltration desalination and drying, so that the oat active polypeptide with GLP-1 secretion promotion, blood sugar reduction and lipid reduction activity is obtained.The present application is simple to operate, low in equipment requirement, and suitable for industrial large-scale production.The prepared oat active polypeptide has GLP-1 secretion promotion, blood sugar reduction and lipid reduction activity, has a significant inhibitory effect on pancreatic lipase and alpha-glucosidase, has an obvious GLP-1 secretion promotion effect, and has a significant blood sugar reduction and lipid reduction effect.

The application discloses a Weizmannia coagulans with fat-reducing and weight-reducing functions, and belongs to the technical field of microorganisms. The Weizmannia coagulans screened by the application can inhibit the content and activity of fat synthesis enzyme on the basis of reducing blood fat and weight, can relieve liver damage caused by high-fat diet, has excellent acid tolerance, bile salt tolerance and high fat hydrolysis capacity, and is a multifunctional Weizmannia coagulans, and has a wide application prospect in the preparation of fat-reducing, weight-reducing and weight-losing products.

The present application relates to the technical field of traditional Chinese medicine, in particular to a kind of slimming traditional Chinese medicine composition and preparation method thereof.The present application uses the raw materials such as Buzha Leaf, hawthorn, lotus leaf, immature fruit of Chinese citron, magnolia officinalis, raphanus sativus, dried orange peel, pellitory, alisma orientalis and cassia obtusifolia, after decoction, lactic acid lactobacillus lactis CICC 6242 and royi mucous lactobacillus CICC 6121 are fermented with 0.4-0.8:1 ratio, then combined enzymolysis is carried out using ginger protease and snail protease, and then 15-25wt% ethanol is used for extraction, and the composition is endowed with excellent lipid-lowering and weight loss effect.

The invention discloses a plasmin lumbrukinase peptide dietary therapy formula suitable for rehabilitation of cardiovascular and cerebrovascular diseases, blood circulation promoting, blood stasis removing, thrombolysis, collateral dredging and microcirculation improving, and relates to the technical field of medicine and food homology dietary therapy. Soybean protein isolate and earthworm protein are used as core thrombolytic active raw materials, isomaltooligosacharide, xylitol, German Jilida collagen peptide, soybean peptide powder, Belgian imported inulin, red yeast rice and natto powder are compounded, microcrystalline cellulose and magnesium stearate are used as auxiliary materials, and probiotics / metabiotics strains such as rhamnolactobacilli JYLR-005 and the like can be selectively added. The raw materials have a synergistic effect through precise matching, plasmin and lumbrukinase peptide in earthworm protein can directly dissolve thrombus fibrin, natto powder and red yeast rice assist in lowering lipid and dissolving thrombus, multiple active peptides and prebiotics regulate intestinal microecology to improve microcirculation of the whole body, probiotics / metabiotics further strengthen the metabolic capacity of the body, no chemical medicine is added in the whole process, and the traditional Chinese medicine composition is free of toxic and side effects and free of toxic and side effects. The safety is high; the dietary therapy composition can achieve postoperative rehabilitation conditioning of cardiovascular and cerebrovascular diseases through daily consumption, effectively promote blood circulation to remove blood stasis, dissolve thrombus and dredge collaterals, improve microcirculation and relieve various discomfort caused by blood vessel clogging, raw materials are easy to obtain, compatibility is scientific, and the dietary therapy composition is suitable for large-scale production and popularization.

The invention is applied to the technical field of health-care products, and discloses a sea-buckthorn soft capsule, which comprises a capsule shell and a content, the capsule shell is composed of gelatin, water, glycerin and an auxiliary material, the auxiliary material is a preservative or a plasticizer, the content is composed of one of seabuckthorn seed oil or fruit oil, seabuckthorn powder and an auxiliary material, the auxiliary material is one of a suspending aid and an antioxidant or a mixture of the suspending aid and the antioxidant, the seabuckthorn powder is rich in flavone, and the auxiliary material is a mixture of the suspending aid and the antioxidant. The soft capsule has the effects of lowering lipid, softening blood vessels and preventing vascular diseases. According to the hippophae rhamnoides soft capsule, a product capsule shell is prepared from gelatin, water and glycerin according to a specific proportion, it can be guaranteed that the capsule shell has proper hardness and elasticity and is convenient to process and store, hippophae rhamnoides seed (fruit) oil and hippophae rhamnoides powder in the content are matched according to a reasonable proportion, the hippophae rhamnoides powder is rich in flavone, and the hippophae rhamnoides powder and the hippophae rhamnoides seed (fruit) oil act the effects of lowering lipid, softening blood vessels and preventing vascular diseases can be better exerted.

The invention discloses a lactobacillus rhamnosus HX-4F3 strain and application thereof, and belongs to the technical field of biology. The lactobacillus rhamnosus HX-4F3 disclosed by the invention is preserved in the China Center for Type Culture Collection, and the preservation number of the lactobacillus rhamnosus HX-4F3 is CCTCC (China Center for Type Culture Collection) NO: M 20251454. The invention discloses an application of a strain HX-4F3 in preparation of drugs or food for lowering lipid or / and blood sugar. The invention also discloses application of the compound in preparation of functional food or / and medicines for preventing or / and treating metabolic diseases. The invention also discloses a composition for lowering lipid or / and blood sugar, which comprises a live bacterium of the strain HX-4F3 or freeze-dried powder, a spore preparation, a metabolic supernatant or an inactivated bacterium of the strain HX-4F3, and a pharmaceutically or food acceptable carrier. According to the lactobacillus rhamnosus HX-4F3 provided by the invention, the glucose and lipid metabolism disorder can be remarkably improved through a multiple synergistic mechanism, and the glucose and lipid metabolism disorder can be remarkably improved through the lactobacillus rhamnosus HX-4F3.

The invention relates to a preparation method and application of a medicine-food homologous compound with weight-losing and lipid-lowering effects. According to the present invention, the weight of the obese mouse can be reduced by 23.23% at most, the serum total cholesterol is reduced, the leptin secretion is reduced, AST (aspartate transaminase) and ALT (alanine transaminase) have no significant difference compared to the model mouse, the volume of epididymal fat and inguinal fat cells is reduced, the number of cells in unit area is significantly increased, the fatty liver sample is relieved, the TMEM26 gene expression in the epididymal fat is significantly increased, and the weight of the obese mouse can be significantly reduced; the expression quantity of the UCP1 gene in brown fat is obviously increased. The traditional Chinese medicine composition adopts medicinal and edible substances as raw materials, is widely applicable to people, is more suitable for prevention and treatment of chronic diseases, is safe and effective, and causes little damage to liver and kidney after long-term use.

The invention relates to an shRNA (short hairpin Ribonucleic Acid) interference sequence of a targeted silence PCSK9 gene and a construction method and lipid-lowering application of a recombinant adeno-associated virus vector of the shRNA interference sequence. Hyperlipidaemia is a metabolic disease characterized by abnormal rising of cholesterol and triglyceride levels in blood, and the design of lipid-lowering drugs is the focus of attention to improvement of hyperlipidaemia. Proprotein convertase subtilisin / kexin type 9 (PCSK9) can be combined with a low-density lipoprotein receptor (LDL-R) and degrade the LDL-R, so that accumulation of LDL-C in blood is further promoted, and hyperlipidemia is caused. Aiming at the key target PCSK9, a specific shRNA interference sequence is designed, and a recombinant adeno-associated virus vector (rAAV) carrying the sequence is constructed by an enzyme digestion-connection method. In-vitro experiments prove that the vector can remarkably reduce the expression level of PCSK9 protein, so that the cyclic utilization of a low-density lipoprotein receptor (LDL-R) is promoted, and the concentration of low-density lipoprotein cholesterol (LDL-C) in plasma is reduced. The rAAV vector provided by the invention has the characteristics of low production cost, high transfection efficiency, lasting action time and the like, and provides a new thought for gene therapy of hyperlipidemia.

According to the subclinical non-obstructive coronary atherosclerosis metaphase plaque progress risk prediction method based on interpretable machine learning provided by the invention, multi-dimensional images and clinical features are integrated, and individualized risk prediction of subclinical non-obstructive coronary atherosclerosis is realized. Quantitative imaging biomarkers are managed for a long time, a key tool is provided for early screening of high-risk individuals, clinical doctors can be helped to judge whether comprehensive strategies such as enhanced lipid lowering, anti-inflammation and lifestyle intervention need to be adopted in time or not, plaque stabilization or fading is maximized, and the clinical effect is improved. And further, the future cardiovascular event risk is reduced. According to the method, a Shapley additive SAHP interpretation technology is introduced, the relative contribution of each prediction feature is quantified, and the interpretability of a machine learning model is improved. According to the method, a webpage tool for calculating the plaque progress probability on line is deployed, and the contribution degree of each feature to the plaque progress prediction result of a specific patient can be displayed more visually.

The application discloses application of O-acyl-alpha-hydroxy acid compounds in weight loss and lipid reduction, and belongs to the fields of biological medicine manufacturing, biological medicine use and functional food development. The O-acyl-alpha-hydroxy acid compounds can inhibit weight growth of high-fat diet-induced obese model mice and reduce body fat. Compared with GLP-1 receptor weight loss drugs which achieve the effect of reducing weight by inhibiting appetite, the O-acyl-alpha-hydroxy acid compounds are not dependent on appetite inhibition, and can reduce side effects such as gastrointestinal discomfort and muscle loss caused by inhibiting appetite. When combined or sequentially administered with GLP-1 drugs, the O-acyl-alpha-hydroxy acid compounds can maintain or enhance the weight loss effect while improving the side effects caused by GLP-1, and can prevent the risk of significant weight rebound after stopping GLP-1 by maintaining body weight. The application provides a safe and effective new strategy for weight loss and lipid reduction.

The invention provides a lipid-lowering traditional Chinese medicine composition and extract as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The lipid-lowering traditional Chinese medicine composition is prepared from the following raw materials: rhizoma cyperi and radix gentianae. The invention further provides an extract of the lipid-lowering traditional Chinese medicine composition. The extract is obtained by mixing rhizoma cyperi and radix gentianae and then co-extracting. The composition or the extract can be used for preparing medicines for preventing and / or treating hyperlipemia, and can be used for improving lipid metabolism disorder of liver cells and reducing the content of triglyceride and total cholesterol in the liver cells.

The invention provides a formula of low-sugar low-fat Fu tea ice cream containing partridge tea and a preparation process of the ice cream, and relates to the technical field of food processing. Comprising the following raw material components: 20-40 parts of a partridge tea extracting solution, 15-30 parts of a Fuzhuan tea extracting solution, 8-25 parts of a low-fat milk base material, 5-12 parts of a compound sweetening agent, 3-8 parts of dietary fibers and 2-5 parts of prebiotics. The preparation method has the advantages that the mallotus oblongifolius and the Fuzhuan tea extracting solution are in a specific proportion, the taste is improved through the synergistic effect of tea polyphenol, soft taste and rich flavor levels under the conditions of low sugar (less than or equal to 5%) and low fat (less than or equal to 5%) are achieved, low-temperature short-time sterilization and accurate congelation control are adopted in the process, heat-clearing and dampness-removing components of the mallotus oblongifolius and the bacteriostatic and lipid-lowering activity of golden flower of the Fuzhuan tea are effectively reserved, and the mallotus oblongifolius and the Fuzhuan tea are effectively preserved. The product has double health-care effects, solves the problems of high sugar and high fat, function deficiency and single flavor of the traditional tea-flavored ice cream, meets the requirement of healthy consumption, and has remarkable market value of country revitalizing and Hainan local tourism characteristic food.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a turbidity-dissolving and lipid-lowering composition and a preparation method thereof.The composition comprises 80-130 parts of polygonum cuspidatum, 50-90 parts of fried semen cassiae, 100-140 parts of hawthorn, 50-90 parts of rhizoma alismatis, 10-60 parts of rhizoma atractylodis macrocephalae fried with bran and 50-90 parts of rhizoma wenyujin concisum. The composition disclosed by the invention has the effects of eliminating phlegm, dissolving turbidity, promoting blood circulation to remove blood stasis, invigorating stomach and promoting diuresis, can be used for treating hyperlipidemia, hyperviscosity and arteriosclerotic cardia-cerebrovascular diseases, and has a very good application prospect.

The present application provides a composition with lipid-lowering and weight-reducing functions, which has clear components and controllable quality. The composition comprises Pu'er tea extract, wherein the Pu'er tea extract contains 10-90% theabrownine by weight, preferably also contains theophylline, the weight ratio of the theabrownine and theophylline is 10:1-60:1, and contains 0-15% tea polyphenols by weight. The theophylline can be selected from exogenous theophylline or theophylline contained in the Pu'er tea extract. The composition with lipid-lowering and weight-reducing functions of the present application also comprises Poria cocos extract; the weight ratio of the Pu'er tea extract to the Poria cocos extract is 1:3-3:1 based on the weight of theabrownine contained in the Pu'er tea extract. The composition of the present application has the advantages of clear effective components, simple preparation process, controllable quality, and stable lipid-lowering and weight-reducing effects.

The present application provides a kind of traditional Chinese medicine composition for weight loss, hypolipidemic and its preparation method and use.The traditional Chinese medicine composition is made of the following raw materials by weight parts: Bai Zhi 10-20 parts, Dang Shen 10-20 parts, Tu Fu Ling 15-25 parts, Dan Shen 15-25 parts, Rou Fu Zhi Shu 5-15 parts, Rou Fu Yi Ren 15-25 parts, Chen Pi 10-20 parts, Fa Ban Xia 10-20 parts, Shan Zha 5-15 parts, Huang Lian Pian 15-25 parts, Chao Jue Ming Zi 15-25 parts, Rou Fu Cang Zhu 5-15 parts, Gan Jiang 5-15 parts, Xiao Tong Cao 2-8 parts.The traditional Chinese medicine composition of the present application is based on the theory of TCM syndrome differentiation, and is reasonable in prescription compatibility, with significant effects of weight loss and lipid-lowering.

The invention relates to a high-absorptivity blood fat reducing composition containing a burdock root water extract as well as a preparation method and application thereof, and relates to the field of preparation of blood fat reducing compositions. The blood fat reducing composition is prepared from burdock root aqueous extract, hawthorn flavone, cassia seed glycoside and phosphatidylcholine according to the mass ratio of (6 to 10): (1 to 2): (0.8 to 1.5): (0.5 to 1). According to the composition, the burdock root aqueous extract is taken as a core, hawthorn flavone, cassia seed glycoside and phosphatidylcholine are matched, and the problems of low absorption rate and single curative effect of the existing traditional Chinese medicine lipid-lowering medicine are solved through the dual design that active ingredients synergistically lower lipid and absorption-promoting ingredients improve bioavailability.

The application discloses a norchizhiol triterpenoid compound, a preparation method and application thereof. The norchizhiol triterpenoid compound norchizhiol A can be quickly prepared from Ganoderma lucidum. The test proves that the norchizhiol A can inhibit the accumulation of triglyceride in the differentiation process of 3T3L1 preadipocytes. The norchizhiol A can also effectively reduce the weight increase and liver coefficient of high-fat-diet-induced obese mice, regulate the blood lipid level of the obese mice, and significantly intervene and improve the lipoprotein distribution of the body. The compound can be used for preparing anti-obesity and lipid-lowering medicines.

The invention provides application of loranthus parasiticus in preparation of a lipid-lowering medicine. The application has the advantages that the loranthus parasiticus extract can effectively improve HFD-induced obesity and glucose and lipid metabolism disorder; the loranthus parasiticus extract can relieve adipose tissue enlargement and liver fatty degeneration.

The present invention provides liquid oral dosage form of lipid lowering agent suitable for oral administration to human or animals.

This invention discloses a fermented traditional Chinese medicine for treating hyperlipidemia, its preparation method, and its application, relating to the field of traditional Chinese medicine. This fermented traditional Chinese medicine is prepared using Bacillus sp. JQ.Y-1, which was deposited on June 24, 2021, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M2021761. The fermented traditional Chinese medicine provided by this invention offers a new alternative drug for the treatment of hyperlipidemia of the dampness-obstruction type in the middle jiao (middle burner). It has a significant lipid-lowering effect, is safe and reliable, can regulate intestinal flora, protect the liver and kidneys, and has no side effects.

This invention discloses the application of α-hydroxyisocaproic acid in weight loss and lipid reduction, belonging to the fields of biopharmaceutical manufacturing, biomedical applications, and functional food development. This invention confirms the application of α-hydroxyisocaproic acid in weight loss; this compound can inhibit weight gain in high-fat diet-induced obese mouse models, reduce body fat, and decrease the area of ​​adipocytes in high-fat diet-induced obese mouse models. Compared to GLP-1 receptor weight-loss drugs that reduce weight by suppressing appetite, the compound α-hydroxyisocaproic acid intervenes in and prevents obesity by accelerating fat metabolism, thereby achieving weight reduction. This invention provides a safe and effective new strategy for weight loss and lipid reduction.

The invention relates to a composition for preventing cardiovascular and cerebrovascular diseases and a preparation method thereof, and belongs to the technical field of health food. The composition for preventing cardiovascular and cerebrovascular diseases is prepared from the following components in parts by weight: 20 to 100 parts of dihydroquercetin, 100 to 300 parts of red yeast rice, 50 to 150 parts of nattokinase, 50 to 200 parts of earthworm protein, 100 to 300 parts of hawthorn fruit extract, 100 to 300 parts of radix puerariae extract and 100 to 300 parts of sea-buckthorn extract. The composition prepared by the invention has the characteristics of lowering lipid, dissolving thrombus and protecting heart and blood vessels.

The application discloses Ixeris sonchifolia Hance polysaccharides, a preparation method and application thereof, belongs to the technical field of plant polysaccharides, and provides polysaccharides ISP-1a and ISP-2a, wherein the ISP-1a has a molecular weight of 2086 Da and is composed of seven monosaccharides of mannose, rhamnose, glucuronic acid, glucose, galactose, xylose and arabinose; the ISP-2a has a molecular weight of 1781 Da and is composed of five monosaccharides of mannose, rhamnose, galacturonic acid, xylose and arabinose. The whole grass of Ixeris sonchifolia Hance is subjected to hot water extraction after ethanol degreasing, neutral enzyme + Sevage method is used to remove protein, macroporous resin is used for decolorization, column chromatography elution is carried out, purification is carried out, and two kinds of uniform polysaccharides are obtained after freeze-drying. The polysaccharides ISP-1a and ISP-2a have good antioxidant and lipid-lowering effects, and can be applied to the preparation of food, health products or medicines with antioxidant and lipid-lowering functions.

The invention relates to phloroglucinol meroterpenoid compounds Hypercm A and B and a preparation method and application thereof, and belongs to the field of medical chemistry, the phloroglucinol meroterpenoid compounds Hypercm A and B are extracted and separated from Hypericum acalyx branches and leaves for the first time, and the structural formulas of the phloroglucinol meroterpenoid compounds Hypercm A and B are formula (I) and formula (II). The phloroglucinol meroterpenoids Hypericmoses A and B and pharmaceutically acceptable auxiliary materials have the advantages that the phloroglucinol meroterpenoids Hypericmoses A and B have obvious inhibition effects on HepG2 cells induced by oleic acid (OA) and have application potential in the field of lipid-lowering medicines, and the invention further relates to a pharmaceutical composition which comprises the phloroglucinol meroterpenoids Hypericmoses A and B and pharmaceutically acceptable auxiliary materials and has lipid-lowering effects.

The invention discloses a medicinal and edible weight-losing tea substitute formula as well as a preparation method and application thereof. According to the formula, spleen strengthening, dampness eliminating, digestion promoting and lipid lowering are taken as the core, Pu'er tea, Chinese yam, hawthorn, medicated leaven, white hyacinth bean, poria cocos, radix fici simplicissimae and barley malt are matched according to a specific proportion, and all the components synergistically play the roles of regulating the spleen and the stomach, eliminating damp evil and promoting fat metabolism. Wherein the Pu'er tea has the effects of inducing diuresis to reduce edema, the hawthorn has the effects of promoting digestion and relieving stasis, the poria cocos has the effects of clearing damp and promoting diuresis, and the Chinese yam and the white hyacinth bean have the effects of tonifying spleen and eliminating dampness. The preparation method comprises the following steps: cleaning the raw materials, drying at low temperature, crushing and sieving, mixing and sub-packaging, and preparing the portable tea bag. During application, 1-3 bags are brewed for drinking in different periods of time, and safe weight reduction can be realized in cooperation with healthy diet and sports. The formula is prepared from medicinal and edible components, has no side effect, is suitable for long-term conditioning of spleen deficiency and excessive dampness type obesity people, and has the advantages of scientificity, convenience and high efficiency.

The invention discloses a composition for comprehensive conditioning of an internal environment, which comprises the following components in parts by weight: 1000-1200 parts of alpha-linolenic acid, 100-300 parts of cordyceps militaris powder, 50-150 parts of oyster powder, 50-150 parts of ginseng powder, 50-150 parts of pueraria peptide, 50-150 parts of fresh lalang grass rhizome powder and 50-150 parts of polygonatum odoratum powder. Wherein the purity of the alpha-linolenic acid is not lower than 80%. According to the invention, high-purity alpha-linolenic acid and six specific medicinal and edible components are scientifically proportioned to construct a multi-level synergistic system, and all the components complement and synergism on a plurality of targets such as lipid lowering, circulation promoting, sugar stabilizing, acid discharging, repairing and the like, so that comprehensive conditioning on disorder of multiple indexes such as blood fat, blood sugar, uric acid, blood pressure and the like is realized; the limitation of a single component or a simple compound product is broken through, and the comprehensive synergistic conditioning of the internal environment is realized; all the components are selected from a medicinal and edible substance catalog, so that the traditional Chinese medicine composition is safe and mild, meets the physique requirements of Chinese people on warm nourishing and conditioning, gives consideration to conditioning and repairing, and is high in adaptability.

This invention relates to the field of functional food technology, and discloses a muscle-building, lipid-lowering, and weight-loss composition, its preparation method, and its application. The composition, by weight, comprises: 25-45 parts of complex protein peptides; 5-20 parts of fruit and vegetable powder; 2-8 parts of medicinal and edible extracts; 3-12 parts of complex prebiotics; 1-6 parts of complex vitamins and minerals; 0.5-3 parts of probiotics; 0.5-5 parts of calcium β-hydroxy-β-methylbutyrate; and the remainder being food-acceptable excipients. This invention achieves significant lipid-lowering and weight-loss while effectively increasing lean body mass and muscle mass, and the active ingredients exhibit good stability.

The invention provides a fermentation product of seedless clausena lansium as well as a preparation method and application of the fermentation product, and the fermentation product is prepared by performing ultrasonic-assisted fermentation on seedless clausena lansium through fermentation lactobacillus mucus Q7 with the preservation number of GDMCC NO: 65149. The preparation method comprises the following steps: pretreating a seedless clausena lansium raw material, inoculating the seedless clausena lansium raw material with an activated bacterial solution of the strain, and fermenting under the optimal process conditions that the fermentation time is 52 hours, the inoculation amount is 7%, the fermentation temperature is 37 DEG C, the ultrasonic power is 100 W and the ultrasonic time is 63 minutes. According to the method, the active ingredients of the product are remarkably improved, the total phenol content reaches 4.70 mg GAE / g, and the pancreatic lipase inhibition rate reaches 96.30%. The fermentation product is rich in phenols, flavones and organic acids, has excellent antioxidant activity and lipid-lowering activity, and can be used for developing functional food, health care products or medicines.

The application relates to the field of biological medicine, in particular to application of TDF in serum cholesterol regulation and a verification method. The application discloses that tenofovir disoproxil fumarate (TDF) can inhibit intestinal cholesterol absorption by specifically down-regulating the expression level of NPC1L1 protein in the intestinal tract, so as to reduce serum cholesterol. The regulation has tissue specificity, and TDF has no significant influence on the expression of key genes of liver cholesterol metabolism. The application also provides a method for verifying the regulation of TDF on serum cholesterol, which is evaluated by detecting blood lipid indexes and the gene and / or protein expression level of NPC1L1 in duodenal tissue. The application provides a treatment scheme with antiviral and cholesterol-lowering effects for patients with chronic hepatitis B combined with hypercholesterolemia, and provides a new idea for developing a lipid-lowering strategy targeting intestinal cholesterol absorption.

The invention discloses application of lactobacillus fermentum E1 in preparation of fat-reducing and weight-losing products, and belongs to the technical field of microorganisms. The lactobacillus fermentum E1 disclosed by the invention can remarkably promote fat metabolism in the zebra fish body in vivo, can remarkably reduce the content of triglyceride and total cholesterol in the hyperlipidemia zebra fish body, and has the potential of being applied to losing weight and regulating the blood fat level; theoretical reference and guidance basis are provided for developing probiotic preparations for treating or preventing obesity and hyperlipidemia by using the lactobacillus fermentum E1.