576results about How to "Produce efficiently" patented technology

An apparatus generates femtosecond pulses from laser amplifiers by nonlinear frequency conversion. The implementation of nonlinear frequency-conversion allows the design of highly nonlinear amplifiers at a signal wavelength (SW), while still preserving a high-quality pulse at an approximately frequency-doubled wavelength (FDW). Nonlinear frequency-conversion also allows for limited wavelength tuning of the FDW. As an example, the output from a nonlinear fiber amplifier is frequency-converted. By controlling the polarization state in the nonlinear fiber amplifier and by operating in the soliton-supporting dispersion regime of the host glass, an efficient nonlinear pulse compression for the SW is obtained. The generated pulse width is optimized by utilizing soliton compression in the presence of the Raman-self-frequency shift in the nonlinear fiber amplifier at the SW. High-power pulses are obtained by employing fiber amplifiers with large core-diameters. The efficiency of the nonlinear fiber amplifier is optimized by using a double clad fiber (i.e., a fiber with a double-step refractive index profile) and by pumping light directly into the inner core of this fiber. Periodically poled LiNbO3 (PPLN) is used for efficient conversion of the SW to a FDW. The quality of the pulses at the FDW can further be improved by nonlinear frequency conversion of the compressed and Raman-shifted signal pulses at the SW. The use of Raman-shifting further increases the tuning range at the FDW. For applications in confocal microscopy, a special linear fiber amplifier is used.

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Provided is a solid preparation which rapidly disintegrates in the presence of saliva or a small amount of water in the oral cavity, particularly, a rapidly disintegrating solid preparation useful as an orally-disintegrating solid preparation.Specifically provided is a rapidly disintegrating solid preparation containing coated granules wherein saccharide or sugar alcohol having an average particle size of not less than 75 μm and a high dissolution rate is coated with cellulose, and a rapidly disintegrating solid preparation containing a) an active ingredient, b) saccharide or sugar alcohol having an average particle size of not less than 400 μm, c) cellulose and d) a disintegrant.

The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.

A thermally enhanced semiconductor package and a fabrication method thereof are provided. A plurality of conductive bumps are formed on bond pads on an active surface of a chip. A heat sink is attached to an inactive surface of the chip and has a surface area larger than that of the chip. An encapsulation body encapsulates the heat sink, chip and conductive bumps, while exposing a bottom or surfaces, not for attaching the chip, of the heat sink and ends of the conductive bumps outside. A plurality of conductive traces are formed on the encapsulation body and electrically connected to the ends of the conductive bumps. A solder mask layer is applied over the conductive traces and formed with a plurality of openings for exposing predetermined portions of the conductive traces. A solder ball is implanted on each exposed portion of the conductive traces.

A method for fabricating a thermally enhanced semiconductor device. A support plate having at least one opening is mounted on a heat sink. At least one chip is mounted on the heat sink and received in the opening. An insulating layer is formed over the chip and the support plate and filled in the opening. A plurality of vias are formed in the insulating layer to expose electrode pads on the chip. A conductive layer is deposited on the insulating layer and the exposed electrode pads. A resist layer is formed on the conductive layer and patterned to expose a predetermine part on the conductive layer. Then, a patterned circuit layer is deposited on the exposed part of the conductive layer by electroplating. The patterned resist layer and the conductive layer underneath the patterned resist layer are removed. A plurality of conductive elements are formed on the circuit layer.

A method for the preparation of high strength air-dried organic aerogels. The method involves the sol-gel polymerization of organic gel precursors, such as resorcinol with formaldehyde (RF) in aqueous solvents with R / C ratios greater than about 1000 and R / F ratios less than about 1:2.1. Using a procedure analogous to the preparation of resorcinol-formaldehyde (RF) aerogeis, this approach generates wet gels that can be air dried at ambient temperatures and pressures. The method significantly reduces the time and / or energy required to produce a dried aerogel compared to conventional methods using either supercritical solvent extraction. The air dried gel exhibits typically less than 5% shrinkage.

According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.

Methods, apparatus, and applications for the on-site production of hydrogen peroxide are described. An embodiment of the apparatus comprises at least one anolyte chamber coupled to at least one anode, at least one catholyte chamber, wherein the at least one catholyte chamber is coupled to at least one cathode, at least one anode membrane and at least one cathode membrane, wherein the anode membrane is adjacent to the at least one anode, wherein the cathode membrane is adjacent to the at least one cathode, at least one central chamber disposed between the at least one anolyte chamber and the at least one catholyte chamber. Hydrogen peroxide is produced by reduction of an oxygen-containing gas at the cathode.

The present invention provides the following: a method for efficiently producing a reagent for detecting an antibody that specifically binds with an insoluble antigen protein present in a liquid sample; a reagent for antibody detection produced by the production method; and a use of the antibody. In a step for solubilizing an antigen protein, it is possible to efficiently solubilize and recover the antigen protein by using a cationizing agent; therefore, when compared to conventional methods, it is possible to efficiently produce a reagent for detecting an antibody that has bound to multiple antigen protein molecules in a carrier.

A switchable stereoscopic display system, wherein the switchable stereoscopic display system can display two-dimensional and three-dimensional images, includes: an organic light emitting diode (OLED) display device; Electronics that rapidly updates individual OLEDs; and a linearly polarizer for the OLED display device. Additionally, a circular polarizing layer changes light from linearly polarized light to circular polarized light. A polarization layer, on top of the circular polarization layer, switches a polarization direction of emitted light within the OLED display device. Other electronics switches the polarization direction within independent segments of the polarization layer. Refreshed OLEDs are synched with the independent segments of the polarization layer.

A technique for efficiently introducing a foreign gene into cells with the use of transposons. In particular, a technique for efficiently preparing a transgenic organism with the use of a transposon having its transposition activity strikingly enhanced through methylation of a sequence containing the transposon. The methylation is retained even after incorporation in a genome, and now can be utilized in actual gene incorporation in a genome. This technique can realize strikingly efficient gene transformation as compared with the a method of preparing a transgenic organism with the use of conventional transposons.

A structure having a parameter storing unit which stores a parameter to be used when a numeric control apparatus drives and controls the numeric control machine tool, a program interpretation unit which reads a part program to generate machining data for each block, an interpolation unit which interpolates a movement path instructed in an axis moving instruction referring to a parameter stored in the parameter storing unit and using an interpolation algorithm which is identical to a driving and controlling interpolation algorithm of the numeric control apparatus, an interpolation count counting unit which counts an interpolation count in the movement path, and an axis moving time calculating unit which multiplies an interpolation cycle when the numeric control apparatus drives and controls the numeric control machine tool and the counted interpolation count to calculate an axis moving time.

An organic material production system includes: a pretreatment device (12) that pulverizes a biomass material (11); a hydrothermal decomposition apparatus (14) that hydrothermally decomposes a pulverized biomass (13) by causing it to countercurrently contact with hot compressed water (15), elutes lignin components and hemicellulose components into the hot compressed water (15), and separates the lignin components and the hemicellulose components from a biomass solid residue; a first enzymatic hydrolysis device (19-1) that treats cellulose in a biomass solid residue (17), discharged from the hydrothermal decomposition apparatus, with an enzyme (18) to enzymatically hydrolyze it to a sugar solution containing hexose; a fermenter (21) that produces ethanol by fermentation using a sugar solution (20) obtained by the first enzymatic hydrolysis device (19-1); and a refiner 25 that refines an alcohol fermentation liquid (22), so as to separate it into ethanol (23) and a residue (24).

A method for performing super-resolution comprises steps of generating the high-resolution, low-frequency spatial and temporal bands of the input video sequence by interpolation, synthesizing the high-resolution, high-frequency spatial band by cross-frame spatial high-frequency extrapolation, and fusing these two bands to generate the spatio-temporally super-resolved video sequence A corresponding system for performing super-resolution comprises a stage where the high-resolution, low-frequency spatial and temporal bands of the input video sequence is generated by interpolation, a stage where the high-resolution, high-frequency spatial band is synthesized by cross-frame spatial high-frequency extrapolation, and a stage where these two bands are fused to generate the spatio-temporally super-resolved video sequence.

A unitary vehicular front end is provided comprising a left and right side, each having a handle section with a fork segment thereof, the left and right sides being bridged together via a connecting member having a central bar for receiving the frame of a vehicle, such as a motorcycle or other two or three-wheeled vehicle. A method of securing the unitary vehicular front end to the frame of a vehicle is also provided.

The method of the present invetion includes the steps of: (A) providing a first substrate, and a second substrate, wherein the first substrate includes a first light shielding layer provided within a non-display region, the first light shielding layer including a light-transmitting portion provided near an outer boundary of the first light shielding layer, the light-transmitting portion comprising a recess or an opening; (B) drawing a seal pattern with a sealant, the seal pattern being drawn outside the first light shielding layer so as to surround the display region, comprising the substeps of: (B1) beginning application of the sealant near the light-transmitting portion, (B2) applying the sealant along an outer periphery of the first light shielding layer, and (B3) forming a junction with the sealant having been applied near the light-transmitting portion; (C) applying a liquid crystal material within the display region surrounded by the sealant; (D) attaching the first substrate and the second substrate; and (E) performing light irradiation from the first substrate side to cure the sealant.

A modular oven, such as a batch process oven, having a standardized set of self supporting, interconnectable panels which, when assembled, from a self-supporting heat containment shell, free of added structural support members. Also described are the self-supporting modular oven panels themselves having common roof, sidewall and end wall shell configuration and a method of assembling the panels such as in the expansion or conversion of a first modular oven assembly to a second assembly more conducive to current production requirements.

The invention discloses a preparation method of a graphene / metal composite material. The preparation method comprises the steps that graphite oxide is obtained, and a graphene oxide dispersion system is prepared through the graphite oxide; a metal material is obtained and cleaned; an electro-deposition solution used for preparing the graphene / metal composite material is prepared through the graphene oxide dispersion system; and electro-deposition equipment parameters are set, the electro-deposition solution and the metal material are placed in the electro-deposition equipment, and the graphene / metal composite material is obtained after the equipment is powered on. By the adoption of the preparation method, the graphene / metal composite material which is high in heat dissipation performance and oxidization resistance and good in hydrophobicity can be obtained through a simple and convenient experimental facility easy to set up in an efficient and environmentally friendly mode.

A microcapsule is produced by dispersing a liquid organic dispersion in an aqueous medium to form a capsule particle in the aqueous medium, the liquid organic dispersion containing an acid group-containing resin, a colored particle and an organic solvent, and the capsule particle comprising a disperse system containing the liquid organic dispersion, and a wall encapsulating the disperse system, wherein the acid group of the resin has been at least partly neutralized with an alkanolamine. The wall comprises the resin, and the resin may be crosslinked or cured with a crosslinking agent. Moreover, the process may comprise crosslinking or curing the resin constituting the wall with the crosslinking agent, and further crosslinking or curing the residual crosslinking agent with a polyfunctional compound. Such a process can produce a microcapsule has a small and uniform particle size while encapsulating a disperse system dispersed a colored particle in an oil phase.

The invention provides a novel compound useful as a highly-sensitive photopolymerization initiator that has excellent stability, low sublimability, excellent developability, and high transmittance in the visible region and that efficiently absorbs, and is activated by, near-ultraviolet rays such as at 365 nm. Also provided are a photopolymerization initiator and a photosensitive composition using the above-described compound. Specifically, the invention provides an oxime ester compound represented by the following general formula (I), a photopolymerization initiator containing the same, and a photosensitive composition containing the photopolymerization initiator and a polymerizable compound having an ethylenically unsaturated bond:wherein, R1 and R2 each represent R11, COR11, CONR12R13, CN, etc.; R11, R12, and R13 each represent a C1-20 alkyl group, etc.; R3 and R4 each represent R11, OR11, COR11, CONR12R13, OCOR11, CN, a halogen atom, etc.; a and b each represent an integer of 0 to 4; X represents an oxygen atom, a sulfur atom, etc.; and R5 represents OH, COOH, or a group represented by general formula (II).

The present invention is related to a three-dimensional graphene oxide microstructure and making method of thereof. First, a photoreactive agent is added into a graphene oxide solution, wherein the photoreactive agent is a photoreactivator in a nonlinear optical method. Then, the photoreactivator in the graphene oxide solution is activated by a beam emitted from an excitation module to produce singlet oxygen with high activity. Finally, the graphene oxide is activated by the singlet oxygen for an unpaired electron of the graphene oxide covalently bonding with another graphene oxide to form a three-dimensional graphene oxide microstructure. Therefore, two-dimensional graphene oxides are efficiently cross-linked with each other to form a three-dimensional graphene oxide microstructure by a nonlinear optical technique of an ultrafast laser system so as to apply to the development of all electronic and optical components.

The invention is directed to a process for producing intermediates of a compound which exhibits an activated blood coagulation factor Xa inhibitory action and which is a useful preventive and a therapeutic agent for thrombotic diseases. The intermediate production process is represented by the following reaction scheme.

The invention discloses a series of high-efficiency producing strains of sauce-flavor characteristic aroma and its application in Chinese liquor brewing, belonging to the technical field of bioengineering. The bacterial strain provided by the present invention, which is classified as Bacillus licheniformis, is preserved in the General Microorganism Center of China Microbiological Culture Collection Management Committee, and the preservation numbers are CGMCC NO: 3961, CGMCC NO: 3962, and CGMCC NO: 3963. The strains are derived from high-temperature Daqu, a Chinese liquor, and can grow at a high temperature of 55°C. Fermented in liquid and solid media made of bran, barley, wheat, and sorghum, they can all produce an obvious characteristic aroma of sauce, and both It can be fermented and metabolized to produce C4, pyrazines, acids, phenols, and aromatic rings. The strains are used alone or in combination in the production process of sauce-flavored and sesame-flavored liquors. The quality of the produced liquors is improved, and the characteristic aroma is more prominent and longer-lasting. concentration increased.

A heat sink package structure and a method for fabricating the same are disclosed. The method includes mounting and electrically connecting a semiconductor chip to a chip carrier, forming an interface layer or a second heat dissipating element having the interface layer on the semiconductor chip and installing a first heat dissipating element having a heat dissipating portion and a supporting portion onto the chip carrier. The method further includes forming openings corresponding to the semiconductor chip in the heat dissipating portion, and forming an encapsulant for covering the semiconductor chip, the interface layer or the second heat dissipating element, and the first heat dissipating element. A height is reserved on top of the interface layer for the formation of the encapsulant for covering the interface layer. The method further includes cutting the encapsulant along edges of the interface layer, and removing the redundant encapsulant on the interface layer. Therefore, the drawbacks of the prior art of the burrs caused by a cutting tool for cutting the heat dissipating element and wearing of the cutting tool are overcome.

A strain which has an enhanced ability to produce 'epsilon'-poly-L-Lysine as compared with the conventional 'epsilon'-poly-L-Lysine-producing strains or improved variesties thereof, and is capable ofelevating 'epsilon'-poly-L-Lysine productivity; and a process for producing a remarkable amount of 'episilon'-poly-L-Lysine by using this strain which comprises mutagenizing a microorganism capable of producing 'epsilon'-poly-L-Lysine and belonging to the species Streptomyces albulus to thereby give a strain being tolerant to S-(2-aminoethyl)-L-cysteine at a high concentration of 10 mg / ml or above and caapble of producing 'epsilon'-poly-L-Lysine, aerobically incubating this strain in a medium, and collecting the 'epsilon'-poly-L-Lysine from the culture.

Organic acid ammonium solution is produced by the steps of obtaining a fermentation broth containing organic acid magnesium by using an organic acid-producing microorganism in the presence of a magnesium compound, producing organic acid ammonium and a magnesium compound by subjecting the organic acid magnesium contained in the fermentation broth to salt-exchange using an ammonia compound, and separating the produced magnesium compound to obtain organic acid ammonium solution.

Porous plate 13 is disposed between wind box 11 of dispersion board B and cylindrical vessel wall 12. Filling layer 14 of a structure packed with ceramic particles such as those of fused silica is disposed on the porous plate 13 so as to fill the inside of the cylindrical vessel wall. The filling layer 14 is composed of ceramic particles, so that the corrosion wear by chlorine gas can be inhibited and the durability thereof enhanced. Furthermore, a chlorine resistant member is disposed in a form so as to adhere to the internal surface of the cylindrical vessel wall 12, so that the corrosion wear by chlorine gas of the cylindrical vessel wall 12 can also be effectively inhibited. As a result, damage to the internal wall of the chlorination furnace can be minimized, and the state of allowing chlorine gas to be uniformly dispersed and supplied to fluidized bed 4 containing titanium ore and coke can be maintained for prolonged periods.

The present invention provides a (meth)acrylic acid-based copolymer useful to a detergent which is excellent in efficient removal capability of soil of clothes (in particular, hydrophobic soil such as collar dirt or greasy dirt), and prevention capability of soil redeposition, not to re-adhere the soil to laundries, even in carrying out washing with small amount of water. The present invention provides a (meth)acrylic acid-based copolymer comprising, as repeating units: a repeating unit (a) derived from a (meth)acrylic acid-based monomer (A) represented by the formula (1); and a repeating unit (b) derived from an alkyl(meth)acrylate-based monomer (B) represented by the formula (2) or a repeating unit (c) derived from a vinyl aromatic-based monomer (C); and 1 or, 2 or more kinds of repeating units (d) selected from the group consisting of a repeating unit (d-1) derived from an unsaturated monomer (D-1) represented by the formula (3), a repeating unit (d-2) derived from an unsaturated monomer (D-2) represented by the formula (4) a repeating unit (d-3) derived from a hydroxyalkyl(meth)acrylate-based monomer (D-3) represented by the formula (5), and a repeating unit (d-4) derived from a sulfonic acid group containing monomer (D-4) represented by the formula (6). Furthermore, the present invention provides a method for producing said (meth)acrylic acid-based copolymer.