75results about How to "Reduce binding" patented technology

The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.

Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient's body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described.

The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.

Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.

The invention discloses a CoS graded nano-bubble composite S positive electrode material of a lithium sulfur battery, and belongs to the technical field of the lithium sulfur battery. The preparationmethod of the CoS graded nano-bubble composite S positive electrode material comprises the steps of firstly, synthesizing TiO2 composite hexadecylamine nanoparticle by hydrolysis of titanium isopropoxide; secondly, coating a surface of the TiO2 composite hexadecylamine nanoparticle with a layer of MOF-loying PVP so that the TiO2 composite nanoparticle can be absorbed during the growth process of ZIF67 and a surface is embedded and an interior are buried onto ZIF-67 to form a Chinese data structure; and finally, performing vulcanization to obtain a CoS graded nano-bubble material with a plurality of CoS hollow spheres sleeving a CoS hollow polyhedron by hydrothermal method of thioacetamide, and injecting S into the CoS graded nano bubbles by a melting method to obtain a final material. TheCoS graded nano-bubble composite S provided by the invention is used as a lithium sulfur battery positive electrode, relatively high charge-discharge performance and stable cycle property are shown, and the important application value in the field of the lithium sulfur battery is achieved.

The invention discloses a load exciting test analytical method for a rotor compressor of refrigeration equipment under the starting working condition. The load exciting test analytical method is characterized in that amplitude-response curves on all measuring points in the rotor compressor of the refrigeration equipment are acquired through vibration testing of the rotor compressor of the refrigeration equipment under the starting working condition, so that a displacement matrix is formed; a finite element analysis method is used for establishing a virtual prototype model of the rotor compressor, the amplitude responses of all the measuring points are analyzed by the virtual prototype model under the action of pulsed excitation loads, and the peak load time and magnitude are obtained by inverse computation through vibration testing results of all the measuring points under the starting working condition of the rotor compressor in accordance with loading and the characteristic that the peak time difference of amplitude responses caused by loading is constant. By the adoption of the method, the tubing reliability assessment accuracy under the starting working condition is effectively improved, and the tubing failure occurrence rate is lowered.

The present invention provides methods and compositions for controlling insects and virus transmission, including a genetic construct for inhibiting virus transmission by an arthropod, a transgenic plant, plant cell or plant tissue, a method of preventing transmission of an arthropod-dependent viral plant disease, a method of delivering an active toxic fragment of a Bacillus thuringinsis (Bt) toxin to an arthropod, and a biopesticidal composition for preventing transmission of an arthropod-dependent viral plant disease.

The invention discloses a decoloring method of natural colored animal fibers. The method comprises the following steps: 1, preprocessing; 2, carrying out first decoloring; 3, rinsing; 4, carrying out second decoloring; 5, carrying out third decoloring; and 6, carrying out air drying treatment. The method overcomes disadvantages of the prior art, and reduces damages of the decoloring process to the animal fibers.

The invention relates to a mouth care toothpaste containing prebiotics. The mouth care toothpaste is prepared from the prebiotics, calcium hydrophosphate, sorbitol, propylene glycol, cocamidopropyl betaine, sodium lauroyl sarcosine, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium pyrophosphate, essence, potassium sorbate and water in a certain weight ratio, wherein the prebiotics are a mixture of alkaline non-digestible functional oligosaccharide and non-alkaline non-digestible functional oligosaccharide. The mouth care toothpaste has the physicochemical properties of low calorie, stability, safety, nontoxicity and the like, the toothpaste can be utilized by bifidobacteria, lactobacilli and other beneficial bacteria in the mouth, reproduction of the beneficial bacteria is promoted, and the fermentation products of the beneficial bacteria, such as lactic acid, acetic acid and other organic acid, can inhibit growth of colibacillus, bacteroides, clostridia and other putrefying bacteria, the microbial community structure is optimized, the sub-health status of the mouth is improved, and the immunity of the organism is improved.

The invention relates to a method for improving functional characteristics of rice bran protein. The method comprises the following steps of (1) crushing fresh bran to obtain rice bran fine powder; (2) compounding cellulase and lipoxygenase mixed liquor, uniformly stirring enzyme mixed liquor with the rice bran fine powder, and performing a temperature-controlled humidity-controlled reaction; (3)performing extrusion stabilization on the rice bran after the reaction, performing drying, and performing defatting so as to obtain defatted rice bran; and (4) extracting the rice bran protein from the defatted rice bran by an alkali-solution and acid-isolation method, and performing freeze drying so as to obtain the rice bran protein having better functional characteristics. According to the ricebran protein prepared by the method, water retention property, oil retention property, emulsibility, emulsion stability, foamability and foaming stability of the rice bran protein can be comprehensively improved, and besides, the method is simple and easy to control.

The invention relates to an efficient physical hulling method for soybean seeds and belongs to the field of feed processing. The method comprises the following operation steps: selecting soybeans without mildew, and performing sun-drying, threshing, and sieving to remove soil, gravels and impurities to obtain clean soybean seeds; carrying out superheated steam treatment; carrying out two-stage ultrasonic treatment; placing the soybean seeds subjected to the ultrasonic treatment into a vacuum chamber of a roller; wherein a rotating speed of the roller is 30-40 r/min and a heating temperature is 80-90 DEG C; when a vacuum degree is 0.008 MPa and a normal pressure, carrying out circulation according to a time ratio of (20-30) s: (5-10) s and at a circulation period of 20-30 times; and stopping working, opening the vacuum chamber, and taking out the soybean seeds. Compared with the prior art, the efficient physical peeling method has advantages of having a good hulling effect and high hulling efficiency, and being energy-saving, environment-friendly, clean and sanitary. The efficient physical hulling method has important market and industrial values.

The invention relates to a silicon nitride whisker reinforced corundum porous ceramic filter and a preparation method thereof. According to the technical scheme, the preparation method comprises the following steps: mixing modified porous corundum ceramic fine powder, monatomic silicon powder and [alpha]-Al2O3 micro powder, adding sodium carboxymethyl cellulose, a water reducing agent, a defoaming agent, aluminum sol and deionized water, and stirring to obtain ceramic slurry (ceramic slurry for short) with thixotropy; immersing the pretreated polyurethane foam template into ceramic slurry, removing redundant slurry, curing, drying, and pre-sintering in a high-temperature furnace at 1200-1300 DEG C to obtain a silicon nitride whisker reinforced corundum porous ceramic filter pre-sintered body; and then dipping in ceramic slurry, carrying out vacuum pressure maintaining, centrifugal treatment, natural drying and heating drying, and sintering in a high-temperature furnace at 1350-1450 DEG C to obtain the silicon nitride whisker reinforced corundum porous ceramic filter. The prepared product is high in strength, good in thermal shock resistance, high in purification capacity and high in filtering effect, and is suitable for purification of aluminum and aluminum alloy melts and high-quality molten steel.

The invention belongs to the technical field of biosensors, and particularly relates to a construction method of a glucose biosensor assembled based on glutathione. The method comprises the following steps: by taking a glutathione modified gold electrode as a carrier, activating carboxylated graphene, loading the activated carboxylated graphene on the surface of the glutathione modified gold electrode to obtain a carboxylated graphene/glutathione modified gold electrode, soaking the carboxylated graphene/glutathione modified gold electrode in a cross-linking agent, and airing to obtain the glucose biosensor assembled based on glutathione. According to the invention, the glutathione-carboxylated graphene self-assembled glucose biosensor is successfully assembled. Glutathione and carboxylated graphene are used for immobilizing glucose oxidase, and the glucose biosensor with high sensitivity, good selectivity, good reproducibility and good stability is constructed.

The invention discloses a slope type refractive index distribution multi-core optical fiber with low inter-core crosstalk, and belongs to the technical field of space division multiplexing of opticalfiber communication. The slope type refractive index distribution multi-core optical fiber with low inter-core crosstalk comprises at least two fiber cores and a cladding, the fiber cores are arrangedin the cladding, the refractive index of the fiber cores is larger than that of the cladding, and the refractive indexes of the fiber core areas are symmetrically distributed on the two sides of theoptical fiber in a slope mode relative to the diameter of the optical fiber on the cross section of the optical fiber. The refractive index of the fiber core increases in the diameter direction of theconnection line from the center of the optical fiber to the center of each fiber core. According to the slope type refractive index distribution multi-core optical fiber with low inter-core crosstalk, coupling between fiber cores is reduced by changing distribution of refractive indexes of fiber core materials, inter-core crosstalk is reduced, and then the information transmission quality of themulti-core optical fiber is effectively improved.

The invention provides a sulfide solid electrolyte sheet and a preparation method thereof. The invention provides a sulfide solid electrolyte sheet which comprises a sulfide electrolyte material and aboron element doped in the sulfide electrolyte material, and the relative deviation (B0B100)/B0 between the mass concentration B0 of the boron element at any position on the surface of the electrolyte sheet and the mass concentration B100 of the boron element at a position 100 [mu] m away from the position does not exceed 20%. In the sulfide solid electrolyte sheet disclosed in the application, the boron element introduced into the sulfide solid electrolyte can effectively reduce the binding effect of anions on lithium ions, and improve the transmission capacity of the lithium ions; the boronelement is uniformly distributed in the sulfide solid electrolyte, the doping uniformity and the conductivity of the solid electrolyte are improved, and the surface roughness of the solid electrolytesheet is remarkably improved, so that the diffusion process of lithium ions in the sulfide solid electrolyte sheet and a lithium metal anode interface is facilitated, the interface impedance is reduced, and the cycle performance of the battery is improved.

The invention discloses a chemical heat storage and release material with high heat storage and release density and a preparation method thereof, the chemical heat storage and release material with high heat storage and release density comprises a heat storage and release precursor material, a modifier and a dispersant; wherein the heat storage and release precursor material is a magnesium-based compound of which the product after high-temperature calcination is only magnesium oxide; wherein the modifier is unitary, binary or ternary alkali metal nitrate with a fixed melting point. According to the invention, the reaction rate and the exothermic density of the exothermic material can be greatly improved; the heat storage reaction rate and the heat storage density are effectively improved,meanwhile, the agglomeration phenomenon of heat storage and release materials is reduced, the fluidity of solid powder in a reaction system and the diffusivity of reaction gas in the reaction system are enhanced, and the method has important significance in achieving medium-temperature industrial waste heat and solar heat storage and meeting the requirement of users for heat.

The invention relates to a fluorine-containing weak coordination anion modified copper-based catalyst for acetylene hydrochlorination reaction and a preparation method and application thereof, wherein a carrier of the catalyst is activated carbon, a main active component is copper ions, and fluorine-containing weak coordination anions are introduced on the basis. Fluorine, as an element with the maximum electronegativity, is very high in the electron withdrawing capacity, so that negative charges in molecules can be highly delocalized; therefore, fluorine-containing anions are stable, have weak coordination and are commonly used for activity research of electrophilic reagents. Fluorine-containing weak coordination anions are introduced into the copper-based catalyst, so that the Lewis acid acidity of metal ions is enhanced, an active center electronic structure is adjusted, on one hand, acetylene is conveniently activated by copper to generate a vinyl copper intermediate, and on the other hand, the adsorption and desorption capability of the catalyst on raw material gas and product gas is adjusted, and the activity and the stability of the copper-based catalyst are effectively improved.

The invention discloses a derivative of growth inhibitory hormone peptide and a preparation method thereof. The compound, the general structural formula of which is shown in the right, which can be used as the main component of anti-tumor drugs, is in favor for the combination of drug molecular and growth inhibitory hormone 2 or subtype receptor 5, thus producing a better tumor inhibitory effect and reducing combinations of drug molecular and other subtype receptors, therefore, the poison side-effects can be reduced and curative effect can be increased.

The invention relates to an ionic liquid compound, a preparation method thereof, an ionic liquid polymer, use of the ionic liquid polymer and polymer solid electrolyte containing the ionic liquid polymer and particularly provides an ionic liquid compound with the structure presented by a formula (1) (shown in the description), a preparation method of the ionic liquid compound, an ionic liquid polymer with the structure represented by a formula (20) (shown in the description) and a preparation method of the ionic liquid polymer. Anion centers of the ionic liquid compound and the ionic liquid polymer are perfluorsulfimide ions with relatively weak coordination capacity, so that the binding capacity of the anion centers to Li<+> is reduced, and the specific conductance and Li<+> transferencenumber of the polymer solid electrolyte containing the containing ionic liquid polymer are increased; and the ionic liquid polymer is compounded with lithium salt so as to form the polymer solid electrolyte containing an ionic liquid-polyion liquid compound, and the ionic liquid-polyion liquid compound has a micro-liquid phase structure, so that the specific conductance and Li<+> transference number of the electrolytecan be further increased.

The invention discloses high calorific value biomass pellet fuel and a preparation method thereof. The high calorific value biomass pellet fuel is prepared from the following raw material components:straw, wood chips, peanut shell, bagasse, arundo donax, bark, a biological treatment agent, paraffin, turpentine and dilute sulfuric acid. The preparation method concretely comprises the following steps: (1) mixing the straw, the wood chips, the peanut shell, the bagasse, the arundo donax and the bark, and then crushing to prepare an initial material; (2) soaking the initial material into dilute sulfuric acid, and then carrying out heating treatment; (3) adding the initial material, subjected to the heating treatment, into the biological treatment agent, oscillating for dispersing in a magnetic field environment, and then drying to obtain a dry material; (4) melting the paraffin and then adding the turpentine, mixing and then adding the dry material, and oscillating for dispersing again; (5) pouring the treated dry material into a pelletizer to obtain the high calorific value biomass pellet fuel. The biomass pellet fuel prepared by the method has the characteristics of being inflammable, high in calorific value, full in combustion, waterproof, light in weight, convenient to carry, and the like, thus being widely applied to outdoor or field heating and cooking.