43results about How to "Reduce the binding force" patented technology

The application belongs to the technical field of circuit board manufacturing, and particularly relates to an embedded circuit board and a preparation method thereof. The preparation method of the embedded circuit board comprises the following steps: obtaining an embedded module, manufacturing a first bonding layer on at least part of the surface of the embedded module; placing the embedded module in a containing groove formed by communication of the grooves, and pressing the laminated plate structure to embed the embedded module in the containing groove; pressing a second build-up layer to fan out signals of the embedded module to the first build-up layer; forming an insulating layer and a connecting layer on the second build-up layer to obtain the embedded circuit board. The first bonding layer on the surface of the embedded module has high bonding force and stress buffering effect with the embedded module, an SIC chip and resin, and can be used as an intermediate buffering layer to connect the embedded module and a PP layer, thereby effectively reducing the problem of delamination due to insufficient bonding force.

Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular disorders or CNS disorders wherein the rAAV comprise one or more substitutions of amino acids that interact with heparan sulfate proteoglycan. The invention provides methods for improved transduction of retinal cells and methods for treating ocular diseases with improved compositions of rAAV particles. Further provided herein are improved recombinant adeno-associated virus (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of disorders of the CNS. The invention provides methods for delivering the rAAV to the CNS, methods for treating disorders of the CNS with improved compositions of rAAV particles, and kits for delivering the rAAV to the CNS and / or treating a CNS disorder.

The application belongs to the technical field of ship exhaust purification, and particularly relates to a catalyst for decomposing N2O in the exhaust of a ship ammonia internal combustion engine and a preparation method thereof. 3+ By replacing Co ions in the Co3O4 spinel lattice into the lattice, the doping behavior can effectively reduce the number of hydroxyl groups on the surface of the catalyst, significantly weaken the adsorption and combination ability of water molecules, and thus improve the stability of the catalyst in a high-humidity exhaust environment. As an additive, CeO2 uses its oxygen storage capacity to promote the migration and desorption of oxygen species in the reaction, preventing the deactivation of active sites due to oxygen poisoning. The molecular sieve carrier not only provides a highly dispersed surface for the active component to prevent sintering, but also optimizes the adsorption and activation path of N2O and alleviates the poisoning effect of nitrogen-containing intermediate species or impurities in the exhaust on the Co active center during the reaction.

The invention discloses a cellulose fiber material and a preparation method thereof.The preparation method of the cellulose fiber material comprises the following steps that a metal salt solution and a lactic acid solution are added into dispersion liquid of cellulose fibers, and a mixed product is obtained; and carrying out pre-pressing treatment on the mixed product, and then carrying out hot-pressing treatment to obtain the cellulose fiber material. According to the cellulose fiber material and the preparation method thereof, the metal salt solution and the lactic acid solution are added into the dispersion liquid, and the ionic crosslinking and chemical crosslinking synergistic method is adopted, so that the interface bonding between cellulose fibers is improved, the bonding force between the cellulose fibers and water is weakened, and the dehydration efficiency of the cellulose fiber material is improved.

The invention discloses a sequential enzymatic-ionic synergistic soybean protein isolate modification method, which comprises the following steps: dispersing soybean protein isolate in water to prepare a protein solution, adding glutamine transaminase, carrying out heating reaction to inactivate enzyme to obtain an enzyme cross-linked protein solution, adding MgCl2 into the enzyme cross-linked protein solution, and carrying out heating reaction to induce protein aggregation to obtain a modified soybean protein isolate solution; and cooling to room temperature after the reaction is finished. The invention also discloses an application of the soybean protein product obtained by the sequential enzymatic-ionic synergistic soybean protein isolate modification method as a food additive. According to the method, the sensitization of the soybean protein can be remarkably reduced, meanwhile, the unique stomach resistance-intestinal efficient release dynamic characteristic is shown, and the small intestine peptide fragment release amount is promoted to be increased.

The invention relates to the technical field of batteries, in particular to a wide-temperature-range high-rate lithium battery ester-based electrolyte and application. The electrolyte comprises soluble lithium salt and a liquid component, the liquid component is a solvent; the solvent comprises at least three of propylene carbonate, fluoroethylene carbonate, isopropyl trifluoroacetate, ethyl trifluoroacetate, ethyl acetate, methyl acetate and methyl trifluoroacetate; the lithium salt lithium battery comprises at least two of common lithium salts. The electrolyte developed by the invention is used in the lithium battery and can stably work at 40-60 DEG C, the specific discharge capacity of the battery is still 62.83% of the specific discharge capacity of the battery at room temperature even at 30 DEG C and 4C multiplying power, and the electrolyte has excellent wide-temperature fast charge performance. In addition, the electrolyte effectively inhibits the growth of lithium dendrites and the side reaction of an electrode-electrolyte interface at low temperature, and promotes the formation of a solid interface film which is rich in inorganic matters and low in interface impedance. The invention has the advantages of reasonable component design and excellent product performance, and is convenient for industrial application.

The invention relates to the technical field of medical instruments, in particular to an ERCP novel bile duct stent and a preparation method thereof.The bile duct stent prepared through the preparation method has certain antibacterial ability by using an AMP-Chol12 peptide chain with the antibacterial ability, the bacterial membrane structure is destroyed through the electric charge effect, bacterial death is caused, and the bile duct stent has a certain antibacterial ability. Therefore, the bacterial infection risk is reduced. The physical antibacterial mechanism does not depend on chemical release, so that the antibacterial property is lasting, silver ions and antibiotics are not contained, bacterial drug resistance is not caused, meanwhile, good biocompatibility is achieved, the lubricating property can be improved, friction and damage are reduced, and bile sludge deposition is reduced.

This application discloses a static electricity neutralization method and apparatus based on PECVD, belonging to the field of semiconductor thin film deposition technology. It includes: applying a first radio frequency (RF) to a reaction chamber to ionize a continuously introduced reactive gas into the chamber, forming plasma which is then deposited onto the wafer surface; after stopping the introduction of the reactive gas and the application of the first RF, applying a second RF in the chamber, wherein the power of the second RF is lower than that of the first RF, and the voltage polarity of the second RF is opposite to that of the first RF; moving a heater base on which the wafer is placed downwards to increase the gap between the wafer and the heater base, thereby facilitating the neutralization of static electricity between the wafer and the heater base by the second RF; and after stopping the application of the second RF, introducing a purge gas into the chamber to clean the wafer surface. This application neutralizes static electricity through low-power plasma discharge, avoiding the problems of wafer breakage and adhesion caused by electrostatic forces between the wafer and the heater base.

The application provides a polymethyl methacrylate product and a preparation method thereof. The preparation method of the polymethyl methacrylate product comprises the following steps: S1. mixing a resin matrix, a toughening agent, an antioxidant and a light stabilizer to obtain a mixture; the resin matrix comprises a polymethyl methacrylate resin; the toughening agent comprises a core-shell structure toughening agent and a polyester-based toughening agent; the core-shell structure toughening agent comprises a core and a shell layer; the core comprises polybutyl acrylate, and the shell layer comprises polymethyl methacrylate; S2. melt blending, extruding and granulating the mixture, and drying, injection molding, cooling and annealing. In the application, the core-shell structure toughening agent and the polyester-based toughening agent can synergistically improve the toughening effect.

Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular disorders or CNS disorders wherein the rAAV comprise one or more substitutions of amino acids that interact with heparan sulfate proteoglycan. The invention provides methods for improved transduction of retinal cells and methods for treating ocular diseases with improved compositions of rAAV particles. Further provided herein are improved recombinant adeno-associated virus (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of disorders of the CNS. The invention provides methods for delivering the rAAV to the CNS, methods for treating disorders of the CNS with improved compositions of rAAV particles, and kits for delivering the rAAV to the CNS and / or treating a CNS disorder.

The invention discloses a cleaning method for a semiconductor photoetching mask substrate, and belongs to the technical field of semiconductor manufacturing. According to the method, dynamic cleaning logic of step cooperation and energy matching is adopted, and the steps of interface wetting and pre-cleaning, chemical soft interface construction, low-damage mechanical stripping and synchronous washing, targeted reaction clearing, microstructure deep cleaning, interface dehydration and modification and final energy-assisted drying are sequentially executed. The method is characterized in that through the dependency relationship of chemical interface softening and low-damage mechanical stripping in sequence, the rotation speed of a substrate in each step is strictly controlled to meet the specific dynamic relationship (V2 < V1 < V4 < V3 < V5 < V6), and precise cooperation of chemical action, physical stripping and energy field cleaning is achieved. The contradiction between efficiency and substrate damage in a traditional cleaning process is effectively solved, full-scale pollutants from micron-scale particles to nano-scale molecular contamination can be removed without dead corners, and a clean, stable and secondary pollution resistant surface state is actively reconstructed at a cleaning end point; and the cleanliness and the service life of the mask substrate and the yield of a downstream photoetching process are remarkably improved.

The application relates to a preparation method of an entropy-based oxide catalyst with high metallic property and application of the entropy-based oxide catalyst in hydrogen production by acidic electrolytic water, and belongs to the field of catalysis. A water-soluble salt containing at least Ru, Ir and A is uniformly mixed, hydrolyzed and reduced under water bath stirring condition by taking zinc oxide as a carrier and a sodium borohydride solution as a reducing agent, then the black powder of the medium-entropy alloy is formed through filtration, washing and drying, and finally the black powder is subjected to rapid incomplete oxidation under the condition of 300-500 DEG C and air atmosphere, and then is subjected to acid pickling, filtration, washing and drying to prepare the entropy-based oxide catalyst with high metallic property. The catalyst contains a large amount of Ir-Ir metal bonds and / or Ir-Ru metal bonds, and the proportion can reach 30%-40%. The mismatch between the metal atom fingerprint structure and the metal-oxygen atom coordination structure causes serious lattice distortion, induces unbalanced distribution of stress and strain, and promotes the kinetics of the acidic oxygen evolution reaction.

This invention relates to the field of adsorption separation technology, specifically to an adsorbent for selectively adsorbing organic esters from industrial wastewater and its preparation method. The adsorbent contains polar functional groups capable of adsorbing organic esters and does not contain hydroxyl or carboxyl groups; the adsorbent's adsorption capacity for organic esters is not less than 12% of its total weight, and the density of the adsorbent is 0.5-1.2 g·cm³. ‑3 The adsorbent of this invention contains abundant polar functional groups, exhibiting strong selectivity for organic esters. This effectively avoids competitive adsorption of other molecules in the solution at the active sites, thus improving the purity of the recovered product. Under high liquid hourly space velocity (HLH), the adsorbent of this invention can purify the concentration of organic esters in the solution to below 1000 ppm.

This invention discloses an anti-aging power metering box cabinet material, relating to the field of organic materials technology. The anti-aging power metering box cabinet material comprises the following raw materials by weight percentage: 25%-35% unsaturated polyester resin, 11%-15% low-shrinkage agent, 0.5%-2% initiator, 2.5-8% additives, 35%-50% organic composite filler, and 15%-25% modified chopped glass fiber. This application adds the prepared modified chopped glass fiber to the unsaturated polyester resin, along with the remaining additives required for preparing the electrical cabinet material, to obtain the cabinet material for use in power metering boxes. The power metering box cabinet material prepared in this application has advantages such as excellent mechanical properties, stable environmental aging resistance, low dielectric loss, and low dielectric constant.

The utility model discloses a kind of anti-blocking coal drop pipes, belong to coal drop pipe structure technical field, including coal drop pipe ontology, connecting frame, breathing mechanism and drive mechanism;Several connecting holes for fixing breathing mechanism are staggered and arranged on coal drop pipe ontology, connecting frame is fixed on connecting hole;Breathing mechanism includes pressing ring, adapter frame, sealing membrane, sealing cover and expansion rubber plate, the outside of adapter frame and connecting frame is connected, pressing ring is fixed between adapter frame and connecting frame, sealing membrane is compressed between the outer wall of pressing ring and coal drop pipe ontology, sealing cover is fixed to the outside of pressing ring, breathing cavity is formed between sealing cover and sealing membrane, sealing membrane is made of elastic material, expansion rubber plate is set inside coal drop pipe ontology and edge connection connecting hole;Breathing mechanism and connecting hole are connected;Drive mechanism connects breathing cavity.The utility model makes coal powder fall off by breathing cavity and expansion rubber plate cooperation, realizes coal drop by similar peristalsis mode, prolongs the life of coal drop pipe.

The present application relates to the technical field of lithium battery current collector, in particular to a novel extremely thin copper foil and a preparation method thereof, which adopts a mixed copper foil layer, realizes atomic level deposition through pulse electron beam sputtering, can quickly diffuse to form a dense film, and can control the molar ratio of amorphous copper and nanocrystalline copper of the mixed copper foil layer to be 6-6.5:3.5-4, and the thickness of the mixed copper foil layer is 1.8-2.5 μm. The amorphous copper has high strength due to no grain boundary defects, the nanocrystalline copper improves the strength through grain boundary strengthening effect and meanwhile retains certain ductility, realizes the balance of strength and plasticity, makes the elongation rate reach 8%-12% and the tensile strength reach 290-320 MPa, is superior to the traditional 6 μm copper foil, the thickness is reduced by 60%-70%, the copper consumption is significantly reduced, the copper material cost is reduced, the battery volume energy density can be increased by about 3%-5% per 1 μm reduction of the copper foil thickness. The thickness of 1.8-2.5 μm can make the energy density increase by 12%-18%, and meet the high endurance requirement.

This invention relates to the field of medical blood purification equipment technology, and discloses a lipid adsorption material regeneration device, including a main body, a rotary switching module, an adsorption column module, a dynamic pressure balancing system, a fluid pipeline system, and a main controller. The rotary switching module drives the adsorption column module to switch between three stations: treatment, regeneration, and balancing preparation. The adsorption column module is filled with pH-responsive hydrogel material to achieve adsorption and regeneration functions. The dynamic pressure balancing system forms a magnetic circuit through a magnetic piston and electromagnetic drive components in a bypass pipe, which senses and adjusts the pressure inside the column in real time. The fluid pipeline system controls the connection of input and output connectors via an electric push rod to achieve fluid switching. The main controller integrates data from multiple sensors, including pressure, pH, and optical sensors, to intelligently terminate the regeneration process. This invention achieves in-situ online regeneration of the adsorption material, continuous uninterrupted treatment, and precise closed-loop control, improving treatment efficiency and safety, and significantly reducing consumable costs.

The present application relates to a kind of antiperspirant deodorant composition and its application in male antiperspirant deodorant product.The composition includes the following components: Sophora root extract, Oldenlandia diffusa extract, salvia extract, Hibiscus sabdariffa flower extract and Radix Ophiopogonis extract, the weight ratio of the Sophora root extract, Oldenlandia diffusa extract, salvia extract, Hibiscus sabdariffa flower extract and Radix Ophiopogonis extract is (0.05-2) :(0.01-1) :(0.01-1) :(0.005-2) :(0.01-1).The composition of the present application can achieve the purpose of deodorization from the two aspects of inhibition and bacteriostasis by reasonable collocation of the above ingredients, and specifically regulate the influence of androgen on sweating, more suitable for adding in male antiperspirant deodorant product.

The present application provides methods of ameliorating rejection-related symptoms, reducing premature separation, and methods of producing compounds of interest having an altered epitope profile. Knockout pigs having disrupted genes and pig organs, tissues, and cells derived therefrom are provided.

This invention relates to a degumming composition, its preparation method, and the degumming method thereof. The degumming composition comprises the following components in weight percentages: 84%–93.5% degumming solvent, 3%–5% solvent oil, 0.5%–3% solid wax, 1%–3% organobentonite, and 2%–5% polar activator; wherein the degumming solvent includes one or more of dichloromethane, N-methylpyrrolidone, and ethylene glycol monobutyl ether. This invention combines the degumming solvent, solid wax, solvent oil, organobentonite, and polar activator in a specific ratio, achieving synergistic effects among the components to obtain a degumming composition with slow evaporation and short degumming time.

The utility model belongs to the technical field of FPC (flexible printed circuit) board multi-layer pressing, in particular to an FPC board multi-layer pressing device which comprises a machine table, two supporting plates are arranged above the machine table, sliding grooves are formed in the side faces, close to each other, of the two supporting plates, a double-shaft motor is fixedly mounted on the inner side wall of each sliding groove, and the double-shaft motor is connected with the machine table. The output end of each double-shaft motor is fixedly provided with two lead screws, the outer surface of each lead screw is in threaded connection with a nut, the outer surface of each nut is fixedly provided with a moving block, the inner wall of each moving block makes contact with the inner wall of the corresponding sliding groove, and the interior of each sliding groove is slidably connected with a stripper plate. Through the arrangement of the supporting plate, the sliding groove, the double-shaft motor, the lead screw, the nut, the moving block, the stripper plate, the mounting plate, the push rod, the material frame, the ejector rod, the small fan and the cooling air pipe, the small fan and the cooling air pipe are used for properly cooling a circuit board firstly, so that the circuit board is shrunk, and the binding force between the circuit board and the stripper plate is reduced.

Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular disorders or CNS disorders wherein the rAAV comprise one or more substitutions of amino acids that interact with heparan sulfate proteoglycan. The invention provides methods for improved transduction of retinal cells and methods for treating ocular diseases with improved compositions of rAAV particles. Further provided herein are improved recombinant adeno-associated virus (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of disorders of the CNS. The invention provides methods for delivering the rAAV to the CNS, methods for treating disorders of the CNS with improved compositions of rAAV particles, and kits for delivering the rAAV to the CNS and / or treating a CNS disorder.

The utility model discloses a kind of automobile silica gel pipe water pressure demolding devices, solve the problem of low efficiency, great labor intensity of traditional manual demolding. The device includes fixed frame, connector and detachable forming die, and there is support tube in forming die, support tube is connected water pump by water pipe, support tube is connected shunt pipe, and water tank is equipped on the surface of forming die. Its preferred structure has the support sleeve of forming die large diameter end inside and the threaded connection of connector movable end, water pump input end is connected external water tank through inlet pipe, connector sleeve sealing ring, support tube and forming die coaxial and shunt pipe equidistant arrangement, water tank is shunt groove with strip-shaped opening, and shunt pipe and die inner wall have sealing pad layer. Its beneficial effect is to use water pressure to demould easily, improve efficiency, reduce labor intensity, and connection is stable, sealing performance is good, ensure that device normal operation, meet large-scale production demand, reduce personnel injury risk, improve work efficiency and quality.

The application relates to the sewage treatment technical field, and particularly discloses a sludge discharging device for sewage treatment, which comprises a box body, a stirring tank is arranged at the upper end of the box body, a water outlet pipe is arranged on the side wall of the box body, a stirring assembly is arranged in the stirring tank, and a separation mechanism is arranged in the box body; sewage is added into the stirring tank; the stirring assembly in the application can strip the sludge wrapped on the surface of the stone, thereby reducing the separation difficulty of the subsequent sludge and the stone, improving the separation effect of the sludge and the stone, the stirred sewage enters into the box body, the separation mechanism can separate the sludge and the stone and respectively output to the outside of the box body, thereby realizing the separation of the sludge and the stone in the sewage, improving the resource recovery efficiency, reducing the disposal cost, and the water outlet pipe can discharge the upper layer water in the bottom of the box body after the separation.

The application provides a door lock mechanism and a dishwasher adopting the same. The door lock mechanism comprises an execution mechanism and a trigger mechanism cooperating with the execution mechanism. The execution mechanism comprises a small load mechanism, a large load mechanism, a locking body and a switching device. The trigger mechanism comprises a driving mechanism, a push rod and a latch. The driving mechanism is connected to the push rod and can drive the push rod to move. The front end of the push rod is provided with the latch which cooperates with the locking body. The small load mechanism and the large load mechanism act on the locking body to provide the locking force of the latch. The switching device changes the acting mode of the small load mechanism and the large load mechanism on the locking body to realize the size switching of the locking force of the latch. The small load mechanism and the large load mechanism act on the locking body through the switching device, the opening and closing doors and the locking state have different load forces, the operation feeling is optimized, the fingers and other parts of the operator are prevented from being clamped when the door is automatically closed, the operator is protected, and the safety hazard is eliminated.

An electric toilet seat with a water tank assembly, comprising a base, a casing, a water tank assembly and a circuit board arranged in an installation cavity formed by the base and the casing, the water tank assembly comprising a water tank with a water inlet and a water outlet and an electric heating tube extending into a water storage cavity of the water tank, characterized in that the water tank assembly further comprises an electrode device arranged in the water storage cavity of the water tank and a metal potential detection piece, the electrode device comprising an electrode rod and a metal potential reference piece, the circuit board being provided with a voltage output module connected with the electrode rod and a potential detection module connected with the potential detection piece, and the potential reference piece being electrically connected with a GND port of the circuit board through a wire. The electric toilet seat with the water tank assembly can reduce the generation of scale and improve the stability and safety of the electric toilet seat through the above design.

The invention provides an electronic-grade vitamin C trace iron ion directional capture and multistage membrane composite purification system and method, and relates to the technical field of semiconductor high-purity reagent preparation.The method comprises the steps that firstly, a heterogeneous composite membrane system based on a conductive polymer is constructed, and a positive polarization gradient is formed on a membrane interface through a potential trap model; the reduction effect of vitamin C on iron ions is inhibited by utilizing an electronic shielding effect, and the problem of capture failure caused by unstable valence state of impurities under a strong reduction matrix is solved; then, an acoustic flow field enhanced mass transfer mechanism is introduced, mass transfer boundary layer resistance under ppb-level concentration is broken through micro vortexes generated by high-frequency acoustic microflow, and active directional impacting and capturing of trace impurities are achieved; and finally, irreversible locking is carried out based on orbital hybridization in a nanometer confinement range, system self-adaptive adjustment is achieved in cooperation with a PID acoustoelectric coupling compensation algorithm, the limitation of traditional adsorption equilibrium is effectively broken through, and deep removal and semiconductor-grade purification of trace iron ions are achieved.

The present invention relates to a bispecific antibody. Having high binding affinity tumor cells expressing PD-L1 and / or CD47, the bispecific antibody of the present invention exhibits an excellent anti-tumoral effect with minimal side effects of hemagglutination.

Provided are an anti-VEGFA-anti-PD-1 bispecific antibody and a use thereof. Specifically, the anti-VEGFA-anti-PD-1 bispecific antibody comprises: a PD-1-targeted first protein functional region and a VEGFA-targeted second protein functional region. According to an EU numbering system, mutation occurs at two positions of positions 234 and 235 of a heavy chain constant region of the immunoglobulin contained in the bispecific antibody, and after the mutation, an affinity constant of the bispecific antibody with FcyRI, FcyRIIa, FcyRIIIa, and / or C1q is decreased compared to that before the mutation. The bispecific antibody can specifically bind to VEGFA and PD-1, specifically relieve immunosuppression of VEGFA and PD-1 on an organism, and inhibit tumor-induced angiogenesis, and thus has good application prospects.