82results about How to "Reduce the binding force" patented technology

The invention provides a hexagonal sheet-shaped melamine cyanurate and a preparation method and application thereof, and relates to the technical field of polymer material flame retardants. The melamine cyanurate in the form of particles with a regular hexagonal sheet structure solves the technical problem that when melamine cyanurate is used as a nano-scale material, the material is easy to agglomerate and difficult to disperse due to high surface free energy, too small size and poor fluidity, and achieves the technical effect of significantly reducing the surface free energy of nano-scale melamine cyanurate and weakening the binding force between its particles.

The application belongs to the technical field of circuit board manufacturing, and particularly relates to an embedded circuit board and a preparation method thereof. The preparation method of the embedded circuit board comprises the following steps: obtaining an embedded module, manufacturing a first bonding layer on at least part of the surface of the embedded module; placing the embedded module in a containing groove formed by communication of the grooves, and pressing the laminated plate structure to embed the embedded module in the containing groove; pressing a second build-up layer to fan out signals of the embedded module to the first build-up layer; forming an insulating layer and a connecting layer on the second build-up layer to obtain the embedded circuit board. The first bonding layer on the surface of the embedded module has high bonding force and stress buffering effect with the embedded module, an SIC chip and resin, and can be used as an intermediate buffering layer to connect the embedded module and a PP layer, thereby effectively reducing the problem of delamination due to insufficient bonding force.

The invention discloses an application of ultrasound and teuvincenone H diterpenoid treatment in reduction of tenebrio molitor protein allergy, the tenebrio molitor protein is treated by ultrasound and teuvincenone H diterpenoid, so that the binding capacity of the tenebrio molitor protein and immunoglobulin E (IgE) can be reduced, and the allergy of the tenebrio molitor protein is further reduced. The invention discloses other effects of teuvincenone H diterpene except for anti-tumor and anti-inflammatory effects for the first time, and the method has the advantages of simple process steps, short treatment time, low temperature, high efficiency, rapidness and environmental friendliness, is beneficial to wide application of related technologies in the field of food industry, and provides a brand new scheme for developing safe and high-quality insect protein food.

Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular disorders or CNS disorders wherein the rAAV comprise one or more substitutions of amino acids that interact with heparan sulfate proteoglycan. The invention provides methods for improved transduction of retinal cells and methods for treating ocular diseases with improved compositions of rAAV particles. Further provided herein are improved recombinant adeno-associated virus (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of disorders of the CNS. The invention provides methods for delivering the rAAV to the CNS, methods for treating disorders of the CNS with improved compositions of rAAV particles, and kits for delivering the rAAV to the CNS and / or treating a CNS disorder.

The invention discloses a multi-layer composite component and a preparation method thereof and a wind power blade, the multi-layer composite component comprises the following layers: a) a PE film at least containing ultra-high molecular weight polyethylene, b) a fiber layer and c) an elastic layer, the fiber layer is arranged between the PE film and the elastic layer, and the fiber layer is at least partially embedded in the PE film and / or the elastic layer; the PE film and the fibrous layer are joined in a first process to form a laminated composite, and the elastic layer is joined to the other side of the fibrous layer opposite the PE film in a second process to form the multilayer composite member. The multi-layer composite component has comprehensive performance such as high interlayer bonding strength and overall mechanical strength and excellent fatigue resistance, and the wind power blade manufactured through the multi-layer composite component is simple in manufacturing process, low in cost and capable of being safely applied to the severe environment for a long time.

The present invention relates to a high temperature wear resistant dry brake friction plate material and a preparation method thereof, belonging to the technical field of alloy friction materials. The material strengthens the iron-copper alloy matrix by precisely controlling the addition amount of Mo and Y2O3; adds a high entropy alloy strengthening phase (Al‑Cr‑Fe‑Ni‑Ti) to the iron-copper alloy to improve the wear resistance; adopts a composite lubricating phase (CaF2+BaF2+Ag), and adjusts its ratio so that CaF2‑BaF2 weakens the two-body wear effect and Ag weakens the three-body wear effect, thereby achieving the improvement of lubrication performance under high temperature and room temperature conditions; adds a high entropy alloy strengthening phase (Al‑Cr‑Fe‑Ni‑Ti) and a composite lubricating phase (CaF2+BaF2+Ag) at the same time, and adjusts its ratio so that (CaF2+BaF2+Ag) weakens the adhesive wear effect and (CaF2+BaF2+Ag) weakens the abrasive wear effect, thereby reducing the friction coefficient and wear rate.

The invention relates to a production process of borscht bags. Comprising the following steps: step 1, mixing yeast, iodine salt, white granulated sugar, potassium sorbate, water, egg pulp and a fermentation promoting agent, and stirring until the white granulated sugar is melted to obtain a mixture A; step 2, adding bread wheat flour into the mixture A, and continuously stirring at a second rotating speed to obtain a mixture B; step 3, adding butter into the mixture B, stirring at a first rotating speed, and then stirring at a second rotating speed to obtain a mixture C; step 4, adding vegetable oil into the mixture C, and stirring at a second rotating speed to obtain dough; and step 5, cutting, shaping, rolling, standing and baking the dough to obtain the borscht. The borscht which is good in flexibility, uniform in size and good in taste is formed by mixing the raw materials according to the specific combination, dosage and rotating speed. The process can be used for large-scale continuous industrial production, and compared with small-scale production, the production efficiency is improved, and meanwhile better comprehensive quality is obtained.

According to the instant ruditapes philippinarum food and the processing method thereof, ruditapes philippinarum is used as a raw material, and vacuum rolling, TG enzyme-ultrasonic coupling treatment, vacuum impregnation and far infrared drying and dehydration technologies are combined in the main steps of raw material pretreatment, pre-dehydration, seasoning, drying and the like. The allergen of the clam meat instant product is effectively reduced, the elasticity of the clam meat instant product is increased, the taste of the clam meat is ensured, and the clam meat instant product has certain reference significance for development of instant shellfish products.

The application belongs to the technical field of ship exhaust purification, and particularly relates to a catalyst for decomposing N2O in the exhaust of a ship ammonia internal combustion engine and a preparation method thereof. 3+ By replacing Co ions in the Co3O4 spinel lattice into the lattice, the doping behavior can effectively reduce the number of hydroxyl groups on the surface of the catalyst, significantly weaken the adsorption and combination ability of water molecules, and thus improve the stability of the catalyst in a high-humidity exhaust environment. As an additive, CeO2 uses its oxygen storage capacity to promote the migration and desorption of oxygen species in the reaction, preventing the deactivation of active sites due to oxygen poisoning. The molecular sieve carrier not only provides a highly dispersed surface for the active component to prevent sintering, but also optimizes the adsorption and activation path of N2O and alleviates the poisoning effect of nitrogen-containing intermediate species or impurities in the exhaust on the Co active center during the reaction.

The invention provides a composition, a kit and a method for detecting African swine fever virus, and relates to the technical field of gene detection. The primer group and the probe provided by the invention are used for detecting the African swine fever virus, the probe is a ZIPNA probe, the ZIPNA probe comprises a 5 '-terminal fluorophore, a 3'-terminal quenching group and a spermine group, and the ZIPNA probe can provide higher detection specificity because non-specific binding and background signals can be more effectively reduced. The positive ions coupled with the ZIPNA probe can neutralize negative charges of target nucleic acid and reduce electrostatic repulsion, and meanwhile, the ZIPNA probe coupled with a certain number of positive ion groups can reach a preset Tm value. The ZIPNA probe can effectively replace a small groove conjugate and locked nucleic acid, and can be used in various application fields based on nucleic acid detection. The ZIPNA probe has the advantages of being high in detection fluorescence increment, high in detection specificity, good in repeatability, high in sensitivity and the like, and practical application is facilitated.

The invention discloses a cellulose fiber material and a preparation method thereof.The preparation method of the cellulose fiber material comprises the following steps that a metal salt solution and a lactic acid solution are added into dispersion liquid of cellulose fibers, and a mixed product is obtained; and carrying out pre-pressing treatment on the mixed product, and then carrying out hot-pressing treatment to obtain the cellulose fiber material. According to the cellulose fiber material and the preparation method thereof, the metal salt solution and the lactic acid solution are added into the dispersion liquid, and the ionic crosslinking and chemical crosslinking synergistic method is adopted, so that the interface bonding between cellulose fibers is improved, the bonding force between the cellulose fibers and water is weakened, and the dehydration efficiency of the cellulose fiber material is improved.

The invention provides petroleum distribution sampling equipment for petroleum exploitation, belongs to the technical field of petroleum exploitation sampling, and solves the technical problems that an obtained sample is not representative, a detection result is not pure, detection is not facilitated, the accuracy of the detection result is fuzzy and the like due to the fact that only a single point position of each layer is drilled and sampled in the prior art. The petroleum distribution sampling equipment for petroleum exploitation comprises a positioning mechanism, a machine body is arranged on the positioning mechanism, a control panel is fixed to the top of the machine body, three sampling mechanisms are arranged in the machine body, each sampling mechanism comprises a first mounting plate and a second mounting plate which are fixed in the machine body, and a motor is fixed to the side corner of the top of each first mounting plate; a lead screw is fixed to the output end of the motor, the lead screw rotates between the first mounting plate and the second mounting plate, a double-hole sliding plate is connected to the lead screw in a threaded mode, and a sliding rod vertically penetrates through the double-hole sliding plate. The invention has the advantage of improving the accuracy of the sampling result by multi-angle sampling on the same horizontal plane.

The invention discloses a sequential enzymatic-ionic synergistic soybean protein isolate modification method, which comprises the following steps: dispersing soybean protein isolate in water to prepare a protein solution, adding glutamine transaminase, carrying out heating reaction to inactivate enzyme to obtain an enzyme cross-linked protein solution, adding MgCl2 into the enzyme cross-linked protein solution, and carrying out heating reaction to induce protein aggregation to obtain a modified soybean protein isolate solution; and cooling to room temperature after the reaction is finished. The invention also discloses an application of the soybean protein product obtained by the sequential enzymatic-ionic synergistic soybean protein isolate modification method as a food additive. According to the method, the sensitization of the soybean protein can be remarkably reduced, meanwhile, the unique stomach resistance-intestinal efficient release dynamic characteristic is shown, and the small intestine peptide fragment release amount is promoted to be increased.

The invention relates to the technical field of batteries, in particular to a wide-temperature-range high-rate lithium battery ester-based electrolyte and application. The electrolyte comprises soluble lithium salt and a liquid component, the liquid component is a solvent; the solvent comprises at least three of propylene carbonate, fluoroethylene carbonate, isopropyl trifluoroacetate, ethyl trifluoroacetate, ethyl acetate, methyl acetate and methyl trifluoroacetate; the lithium salt lithium battery comprises at least two of common lithium salts. The electrolyte developed by the invention is used in the lithium battery and can stably work at 40-60 DEG C, the specific discharge capacity of the battery is still 62.83% of the specific discharge capacity of the battery at room temperature even at 30 DEG C and 4C multiplying power, and the electrolyte has excellent wide-temperature fast charge performance. In addition, the electrolyte effectively inhibits the growth of lithium dendrites and the side reaction of an electrode-electrolyte interface at low temperature, and promotes the formation of a solid interface film which is rich in inorganic matters and low in interface impedance. The invention has the advantages of reasonable component design and excellent product performance, and is convenient for industrial application.

The invention discloses a novel living cell microtubulin probe and a construction method and application thereof.The probe is composed of EGFP and SPASTIN protein 1-325 amino acid, and the SPASTIN protein 1-325 amino acid is shown as SEQ ID NO.10. By means of a truncated body version, the SPASTIN protein loses the microtubule shearing function, interference to other physiological processes of cells is reduced, and the activity of the SPASTIN protein is improved. The combination with other non-specific structures can be reduced, the positioning accuracy of the probe is improved, the specific region or substructure of the microtube can be more accurately positioned, and the background interference is reduced; the problems of cell function interference, photobleaching, toxicity and the like of existing markers are solved, and a tool is provided for deep understanding of dynamic changes of the microtubules and roles of the microtubules in various biological processes of the microtubules.

A human interleukin 2-polyethylene glycol conjugate and use thereof. The human interleukin 2-polyethylene glycol conjugate comprises a recombinant human interleukin 2 containing at least one unnatural amino acid and PEG coupled to the at least one unnatural amino acid. The unnatural amino acid is a compound containing a carbonyl terminal group and having a structure as shown in formula (I) or an enantiomer thereof, and the PEG is coupled to the at least one unnatural amino acid by forming an oxime bond between the carbonyl terminal group and the PEG containing a hydroxylamine terminal group. The human interleukin 2-polyethylene glycol conjugate can be used individually or in combination with other anti-tumor drugs for the treatment of diseases such as solid tumors and hematologic tumors.

The invention provides an extraction method of egg phosvitin, the egg phosvitin is extracted by a magnetic separation technology by preparing a pH-sensitive composite magnetic nanogel, the pH-sensitive composite magnetic nanogel takes a magnetic porous gel as an inner core, after the surface of the magnetic porous gel is modified by polydopamine and athomin, the pH-sensitive composite magnetic nanogel is added into the magnetic porous gel, and the pH-sensitive composite magnetic nanogel is subjected to magnetic separation to obtain the egg phosvitin. And forming a sulfhydrylation shell layer, and connecting iron ions to the sulfhydrylation shell layer. According to the method, polydopamine combined on the surface of the magnetic porous gel can be rapidly combined with athomin with sulfydryl, and a sulfhydrylation shell layer is beneficial to combination of iron ions, so that egg phosvitin can be rapidly separated out under the action of an external magnetic field, finally, the external magnetic field is removed, and the egg phosvitin is placed in an alkaline environment; the egg phosvitin can be safely and efficiently separated out.

The invention relates to the technical field of medical instruments, in particular to an ERCP novel bile duct stent and a preparation method thereof.The bile duct stent prepared through the preparation method has certain antibacterial ability by using an AMP-Chol12 peptide chain with the antibacterial ability, the bacterial membrane structure is destroyed through the electric charge effect, bacterial death is caused, and the bile duct stent has a certain antibacterial ability. Therefore, the bacterial infection risk is reduced. The physical antibacterial mechanism does not depend on chemical release, so that the antibacterial property is lasting, silver ions and antibiotics are not contained, bacterial drug resistance is not caused, meanwhile, good biocompatibility is achieved, the lubricating property can be improved, friction and damage are reduced, and bile sludge deposition is reduced.

The present invention provides a design of a trispecific antibody, a preparation method and use thereof. The trispecific antibody of the present invention comprises (a) anti-Her2 monoclonal antibody Herceptin, (b) anti-CD16a (FcgRIIIa) single-chain antibody scFv, (c) SIRPa D1 protein, and (d) a flexible linker; the heavy chain C-terminus of the antibody Herceptin is connected to the anti-CD16a single-chain antibody through a linker, and the light chain C-terminus of the antibody Herceptin is connected to SIRPa D1 through a linker; the Fc segment of the antibody is modified to change its binding ability with the receptor and prolong the half-life of the protein; tumor cells expressing CD47 can be targeted by binding to SIRPa D1 and CD47 ligand; at the same time, a "don't eat me" signal can be blocked to activate macrophages to phagocytize tumor cells; anti-CD16a specifically binds to NK (Nature Killing) cells; therefore, macrophages and NK cells in the tumor microenvironment are recruited through SIRPa and anti-CD16a to kill tumor cells; the present invention ensures the specificity of anti-CD16a and does not cause side effects (neutropenia) caused by binding to CD16b on the surface of neutrophils.

This application discloses a static electricity neutralization method and apparatus based on PECVD, belonging to the field of semiconductor thin film deposition technology. It includes: applying a first radio frequency (RF) to a reaction chamber to ionize a continuously introduced reactive gas into the chamber, forming plasma which is then deposited onto the wafer surface; after stopping the introduction of the reactive gas and the application of the first RF, applying a second RF in the chamber, wherein the power of the second RF is lower than that of the first RF, and the voltage polarity of the second RF is opposite to that of the first RF; moving a heater base on which the wafer is placed downwards to increase the gap between the wafer and the heater base, thereby facilitating the neutralization of static electricity between the wafer and the heater base by the second RF; and after stopping the application of the second RF, introducing a purge gas into the chamber to clean the wafer surface. This application neutralizes static electricity through low-power plasma discharge, avoiding the problems of wafer breakage and adhesion caused by electrostatic forces between the wafer and the heater base.

The application provides a polymethyl methacrylate product and a preparation method thereof. The preparation method of the polymethyl methacrylate product comprises the following steps: S1. mixing a resin matrix, a toughening agent, an antioxidant and a light stabilizer to obtain a mixture; the resin matrix comprises a polymethyl methacrylate resin; the toughening agent comprises a core-shell structure toughening agent and a polyester-based toughening agent; the core-shell structure toughening agent comprises a core and a shell layer; the core comprises polybutyl acrylate, and the shell layer comprises polymethyl methacrylate; S2. melt blending, extruding and granulating the mixture, and drying, injection molding, cooling and annealing. In the application, the core-shell structure toughening agent and the polyester-based toughening agent can synergistically improve the toughening effect.

Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular disorders or CNS disorders wherein the rAAV comprise one or more substitutions of amino acids that interact with heparan sulfate proteoglycan. The invention provides methods for improved transduction of retinal cells and methods for treating ocular diseases with improved compositions of rAAV particles. Further provided herein are improved recombinant adeno-associated virus (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of disorders of the CNS. The invention provides methods for delivering the rAAV to the CNS, methods for treating disorders of the CNS with improved compositions of rAAV particles, and kits for delivering the rAAV to the CNS and / or treating a CNS disorder.

The invention discloses a preparation for activating insoluble phosphorus in soil and an application method thereof. The preparation comprises the following components in parts by weight: 50-60 parts of activated biochar, 20-30 parts of modified starch, 3-4 parts of sodium alginate and 3-5 parts of calcium chloride. The preparation is prepared by the following method: adding modified starch, sodium alginate and deionized water into a reaction kettle, adding deionized water, then adding activated biochar, mixing, dripping the mixed solution into a calcium chloride solution, filtering and precipitating, washing and freeze-drying, and obtaining the preparation. The preparation increases the stability of soil aggregates, improves the adsorption of insoluble phosphorus by soil aggregates, makes metal ions on insoluble phosphorus adsorbed by the preparation, activates insoluble phosphorus by competitive binding of metal ions, and synergizes with phosphate-solubilizing bacteria to activate insoluble phosphorus in soil aggregates.

The invention discloses a cleaning method for a semiconductor photoetching mask substrate, and belongs to the technical field of semiconductor manufacturing. According to the method, dynamic cleaning logic of step cooperation and energy matching is adopted, and the steps of interface wetting and pre-cleaning, chemical soft interface construction, low-damage mechanical stripping and synchronous washing, targeted reaction clearing, microstructure deep cleaning, interface dehydration and modification and final energy-assisted drying are sequentially executed. The method is characterized in that through the dependency relationship of chemical interface softening and low-damage mechanical stripping in sequence, the rotation speed of a substrate in each step is strictly controlled to meet the specific dynamic relationship (V2 < V1 < V4 < V3 < V5 < V6), and precise cooperation of chemical action, physical stripping and energy field cleaning is achieved. The contradiction between efficiency and substrate damage in a traditional cleaning process is effectively solved, full-scale pollutants from micron-scale particles to nano-scale molecular contamination can be removed without dead corners, and a clean, stable and secondary pollution resistant surface state is actively reconstructed at a cleaning end point; and the cleanliness and the service life of the mask substrate and the yield of a downstream photoetching process are remarkably improved.

The utility model relates to a stripper with a punching device, the stripper comprises an arc-shaped end part, a connecting rod and an operating handle, and the connecting rod is connected between the arc-shaped end part and the operating handle; a needle outlet is formed in the side surface of the arc-shaped end part; a limiting groove is formed in the side face of the operation handle and extends in the length direction of the operation handle. An operation raised head is arranged in the limiting groove; the operation raised head can slide in the limiting groove; one side of the lower end of the operation raised head is connected with the force transmission cable; a punching needle is arranged at the end part of the free end of the force transmission cable; communicated guide grooves are formed in the arc-shaped end part, the connecting rod and the operating handle; the force transmission cable can slide in the guide grooves; and the tail end of the guide groove is communicated with the needle outlet.

The application relates to a preparation method of an entropy-based oxide catalyst with high metallic property and application of the entropy-based oxide catalyst in hydrogen production by acidic electrolytic water, and belongs to the field of catalysis. A water-soluble salt containing at least Ru, Ir and A is uniformly mixed, hydrolyzed and reduced under water bath stirring condition by taking zinc oxide as a carrier and a sodium borohydride solution as a reducing agent, then the black powder of the medium-entropy alloy is formed through filtration, washing and drying, and finally the black powder is subjected to rapid incomplete oxidation under the condition of 300-500 DEG C and air atmosphere, and then is subjected to acid pickling, filtration, washing and drying to prepare the entropy-based oxide catalyst with high metallic property. The catalyst contains a large amount of Ir-Ir metal bonds and / or Ir-Ru metal bonds, and the proportion can reach 30%-40%. The mismatch between the metal atom fingerprint structure and the metal-oxygen atom coordination structure causes serious lattice distortion, induces unbalanced distribution of stress and strain, and promotes the kinetics of the acidic oxygen evolution reaction.

The present invention relates to a modified immunoglobulin constant region (Fc) mutant molecule having reduced binding to FcyR or C1q. The molecule can significantly reduce undesired ADCC and / or ADCP and / or CDC effector function in vivo. In addition, the present invention relates to a use of the Fc mutant molecule, a fusion protein comprising the mutant molecule and a use thereof.

The invention belongs to the technical field of adhesive preparation, and particularly relates to a preparation method of a starch adhesive for corrugated paper. The preparation method of the starch adhesive for the corrugated paper comprises the following steps: carrying out oxidation treatment on the starch to prepare a first reactant; adding water into the first reactant, uniformly mixing, then adding a sodium hydroxide solution, continuously reacting for 50-55 minutes, finally adding phosphorus oxychloride and dialdehyde starch, and reacting at 38-40 DEG C for 2.3-2.5 hours to prepare a second reactant; adding furfural, m-cresol and salicylic acid into the second reactant to carry out copolymerization reaction, finally adding poly (hydroxyethyl methacrylate) and vinyl acetate acrylate copolymer, and uniformly stirring to prepare the starch adhesive for corrugated paper. The starch adhesive for corrugated paper prepared by the method has excellent bonding strength and stability.

The application discloses a high-temperature-resistant and heat-conducting diamond-like film and a preparation method thereof, and relates to the field of film coating technology. The high-temperature-resistant and heat-conducting diamond-like film is a same-element hetero-interface structure plated on the surface of a substrate; the sp 3 -C bond content in the diamond-like film continuously changes along the thickness direction of the diamond-like film; the average sp 3 -C bond content accounts for more than 40% of the total carbon-carbon bond content in the diamond-like film. The application improves the interface thermal resistance effect of the whole film, improves the high-temperature-resistant performance of the diamond-like film, guarantees the balanced state of the film-substrate bonding force, internal stress, heat conduction and surface lubricity of the film, makes the film have excellent comprehensive performance, and further improves the applicable environment of the diamond-like material.