31results about How to "Reduce function" patented technology

The invention belongs to the technical field of medicines, and provides application of fritillaria alkaloid in preparation of a medicine for treating cardiomyopathy induced by chemotherapeutic drugs. The fritillaria alkaloid is fritillaria pallidiflora alkaloid; the chemotherapeutic drug is an anthracycline chemotherapeutic drug; the anthracycline chemotherapeutic drug is adriamycin. The fritillaria pallidiflora alkaloid can prevent and / or treat doxorubicin-induced cardiomyopathy by resisting myocardial fibrosis and relieving myocardial damage. The fritillaria pallidiflora alkaloid is a natural fritillaria pallidiflora alkaloid, through a multi-target action mechanism, cardiac function decline and cardiomyopathy damage caused by adriamycin are effectively relieved, and a novel candidate drug with potential and a treatment strategy are provided for preventing or treating chemotherapy drug induced cardiomyopathy.

The application provides a multi-chip stacked package structure and a preparation method thereof. The multi-chip stacked package structure comprises a first chip distributed on a substrate, a side surface of the first chip being covered by a first plastic package structure; a second chip stacked on the first chip, a side surface and a bottom surface of the second chip being covered by a second plastic package structure; and a heat dissipation structure comprising micro-flow channels located on both sides of the first chip and the second chip, the micro-flow channels penetrating a top surface of the second plastic package structure and extending to a bottom surface of the first plastic package structure, and side surfaces of the micro-flow channels being covered by the first plastic package structure and the second plastic package structure. The multi-chip stacked package structure can quickly conduct the heat generated by the chips to the outside of the overall package structure, avoid the accumulation of heat in the plastic package structure, and ensure the reliability and service life of the device.

The application relates to the technical field of integrated circuits and provides a high-speed serial interface physical IP verification platform, method, device and medium. The application provides a unified design and verification platform supporting coexistence and fusion of multiple protocol types and a multi-protocol physical layer intellectual property core design and verification, is based on a modular, parameterized, multi-protocol and harmonious coexistence design idea and a top-level architecture circuit design method, can effectively reduce the circuit design and verification manpower cost of various different protocol types in project development, significantly shortens the function and performance verification period of the physical layer intellectual property core, significantly improves the full-stack and full-field research and development efficiency of the architecture design, circuit development and full-amount function / performance verification for different protocol types, improves the design and verification platform reuse degree between different protocols, and provides an excellent paradigm of unified design and verification with high platform level.

The application provides a composition for improving memory and reducing blood lipid, a preparation method and application thereof, and belongs to the technical field of food, health care products and medicines. In order to solve the problems in the prior art, such as too simple components of health care products with the functions of reducing blood lipid or improving memory, difficulty in achieving the effect, too complex formula, large dosage, lack of function and safety evaluation, and difficulty in evaluating the effect, the application provides a composition which is mainly composed of walnut oil, soybean phospholipid, ginkgo leaf extract and natural vitamin E as raw materials, and suitable excipients, wherein the excipients are soybean oil, beeswax, gelatin, glycerol, purified water, titanium dioxide and cocoa shell pigment. The scientific and reasonable production process is adopted to process the suitable product, so that the function and effect of reducing blood lipid and improving memory are achieved.

This utility model discloses a detection device belonging to the field of X-ray detection technology, specifically an offline X-ray multi-angle detection device, comprising: a lead room, an imaging system, and a detection platform; the imaging system and the detection platform are installed in the lead room, and the imaging system is installed on the detection platform; the lead room is welded from a steel-lead steel structure to provide X-ray protection; the imaging system includes a radiation source fixing module and an imager motion module; the detection platform has structural motion in three directions: X-axis, Y-axis, and Z-axis, including an X-axis drive module, a Y-axis drive module, and a Z-axis drive module; this utility model provides a relatively economical, efficient, and widely applicable online X-ray multi-angle material detection device. It not only meets customers' needs for convenient and efficient 2.5D detection but also greatly reduces customers' procurement costs and eliminates the problem of functional redundancy, meeting the general needs of low-end customers in the industry.

The invention discloses a large-torque ultrathin permanent magnet brake and belongs to the technical field of permanent magnet brake production, the large-torque ultrathin permanent magnet brake comprises an outer groove disc, an inner groove disc, an electromagnetic coil, a retainer and a permanent magnet, the outer groove disc comprises an outer cylinder and an outer disc, the inner wall of the outer disc and the outer wall of one end of the outer cylinder are connected and integrally formed, and the inner groove disc comprises an inner cylinder and an inner disc; the inner wall of the inner disc and the outer wall of one end of the inner cylinder are connected and integrally formed, the part, close to the center position, of the surface of one side of the inner disc is the cavity wall surface of one side of the coil inner cavity, and the permanent magnet and the annular retainer are located between the part, close to the edge position, of the surface of one side of the inner disc and the outer disc. The purposes of remarkably increasing the braking torque and reducing the coil function and temperature rise on the premise that the axial size of the brake is not increased are achieved, finally the purposes of large torque, small power, small temperature rise and ultra-thin (namely extremely-small axial size) functions are achieved, and the application requirements of humanoid robots and other products with extremely-small axial size requirements are met.

The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

The utility model provides a glass curtain wall cleaning structure and a glass curtain wall, which belong to the technical field of glass curtain walls and comprise hollow toughened glass, an inner cavity cleaning mechanism and a reversing locking mechanism. Wherein the two pieces of hollow tempered glass are arranged in parallel at intervals, the edges of the two pieces of hollow tempered glass are used for being fixedly connected into a wall body of a glass curtain wall, and a middle cavity is defined between the two pieces of hollow tempered glass. The inner cavity cleaning mechanism is movably arranged in the middle cavity in the longitudinal direction, and brush heads making contact with the inner walls of the two pieces of hollow tempered glass are arranged on the two sides of the inner cavity cleaning mechanism. The reversing locking mechanism is arranged on the inner cavity cleaning mechanism and is configured to drive the brush head to automatically reverse when the inner cavity cleaning mechanism reaches the top or the bottom of the middle cavity. A series of adverse effects of reduction of local sealing performance of an existing glass curtain wall structure on the curtain wall appearance, the lighting function and the energy-saving effect can be reduced.

The utility model relates to a thermal -insulated quilt roll -out equipment technical field, concretely is a kind of thermal -insulated quilt limiting device, including base rod and the connecting rod connected with the base rod, two support tubes are fixedly arranged on base rod, rotatably connected with movable arm between two support tubes, the connecting rod on the side away from the support tube is fixed with adjusting assembly, and the adjusting assembly upper end is equipped with switch assembly. The utility model adopts the non-contact switch assembly of hall sensor and magnetic piece, replaces traditional mechanical contact structure, avoids the abrasion problem caused by mechanical friction, prolongs service life;Non-contact detection is not interfered with by greenhouse outside water vapor, dust simultaneously, greatly reduces malfunction or malfunction probability, ensures that roll-up curtain system stable trigger stop, reduces equipment damage, thermal -insulated quilt drop risk.

This application relates to an electromagnetic induction coil frame, including an inner frame, insulating columns, an insulating support plate, and an insulating plate. The inner frame is a cuboid, connected by multiple columnar structures bolted together. Multiple insulating columns are evenly distributed on the sides of the inner frame, with the insulating columns on both sides corresponding to each other. The insulating support plate includes upper and lower support plates, which are bolted to the front of the inner frame. The combined shape matches the front of the inner frame, with semi-circular openings of equal radius on the long side. The shape of the insulating plate matches the lower support plate. Multiple insulating plates are fixed between corresponding insulating columns in groups of at least two. This electromagnetic induction coil frame avoids closed-loop heating through a channel steel connection design. The insulating columns provide support to prevent heating from magnetic lines of force, resulting in a stable structure. The detachable design facilitates transportation, installation, inspection, and maintenance. The materials are lightweight and cost-effective. The outer protective cover of the insulating plate provides dust and electric shock protection. Overall insulation reduces potential hazards and meets equipment support requirements.

The invention relates to a file management method, device and system and a storage medium. The method comprises the steps that when an operation request of a client for a target file is received, metadata management operation matched with the operation request is executed in an embedded database of a file management system through a metadata manager of the file management system, and metadata of the target file is obtained; the metadata comprises a data reference identifier; analyzing the data reference identifier to obtain a data storage position; the data storage position is used for indicating a storage position of the target file in a target data storage rear end, and the target data storage rear end is one of a plurality of data storage rear ends butted with a storage abstraction layer of the file management system; and executing a file management operation matched with the operation request on the target file based on the data storage position in the target data storage rear end through a storage abstraction layer of the file management system. According to the scheme provided by the invention, the problems of function redundancy and hierarchical redundancy in the related technology can be solved.

This invention discloses a unified intermediate representation data model and construction method for hardware design, belonging to the field of electronic design automation. The model includes: a unified representation base class; structural relationship graph representation and temporal behavior representation, describing the structural composition and runtime behavior of the design, respectively; formal semantic consistency constraints to ensure semantic consistency between structure and behavior; and a semantic association architecture to establish bidirectional semantic mapping between various scenario representations such as HDL code, schematics, and waveforms and the unified representation base class. The construction method based on this model includes an incremental synchronization process, achieving automatic synchronization after any representation modification through change capture, cross-representation mapping indexing, and change propagation rules. This invention also provides an AI-assisted design method based on this model, improving AI interaction efficiency and the automation level of design verification through multi-dimensional context construction, syntax stripping, incremental interaction protocols, and automatic closed-loop verification.

The invention belongs to the technical field of biology, and particularly relates to application of nuciferine in preparation of a medicine for relieving pyroptosis of trophoblasts in preeclampsia. Nuciferine inhibits activation of NLRP3 inflammasomes and reduces caspase-1 cleavage and GSDMD mediated pyroptosis, so that placenta inflammation and dysfunction are relieved, and preeclampsia symptoms are improved. The nuciferine remarkably improves the symptoms of fetal growth limitation and placenta weight reduction of preeclampsia mice, and reduces placenta oxidative stress and inflammation level. In a cell model, nuciferine effectively reverses the pyroptosis phenotype of trophoblast cells, and the protein expression of NLRP3, cleaved-caspase-1, GSDMD-NT and IL-1beta is remarkably reduced. The application potential of nuciferine as a promising natural medicine in preeclampsia treatment is clarified, and the understanding of the relationship between inflammation and pyroptosis in preeclampsia pathogenesis is deepened.

According to the automatic batching and mixing device for radioactive waste solidification treatment, a screen is installed on the front face of a working main cabinet, and the position numbers and the grabbing times of all materials can be input in advance. The working main cabinet is connected with the upper cover through a first hinge and a second hinge, a switch is installed on the right side of the working main cabinet, a conveying structure is fixed to the lower portion in the working main cabinet and can enable the feeding structure and the material disc structure to move left and right, and a first support and a second support are fixed to the upper portion and the right side in the working main cabinet respectively. The telescopic structure is connected with the first support and the second support in a fastened mode, the lower end of the telescopic structure is connected with the grabbing structure in a fastened mode, so that the grabbing structure moves up and down, and materials such as radioactive nuclear waste, solidified base materials and additives are grabbed through the grabbing structure. According to the device, on the premise that workers do not make contact with the radioactive waste, materials such as the radioactive nuclear waste are quantitatively grabbed and mixed and solidified, so that the nuclear radiation function is reduced, and the harm of radiation to the workers is reduced.

The application belongs to the technical field of biological medicine, and relates to a BCLAF1 protein Ser564 site phosphorylation antigen peptide, a specific antibody and a preparation method and application thereof. The application identifies BCLAF1 protein Ser564 as a key phosphorylation site through SIK2 kinase screening, and designs and synthesizes a phosphorylation antigen peptide based on the site. After immunizing animals, a polyclonal antibody specifically recognizing BCLAF1 Ser564 site phosphorylation modification is successfully prepared. The antibody has high sensitivity and strong specificity, is suitable for various detection platforms such as immunohistochemistry and immunoblotting, and can be used for evaluating tumor immunotherapy efficacy. The application provides a key tool for analyzing BCLAF1 phosphorylation regulation mechanism, and lays a theoretical foundation for developing an immune combined therapy strategy targeting a SIK2-BCLAF1-CCL5 axis.

The utility model relates to an anti-disassembly key and an electric appliance, and belongs to the field of electric appliances. An anti-dismounting button comprises a housing assembly which is provided with an installation space, a movable groove and an installation hole; the limiting assembly is arranged on the shell assembly and located in the installation space, and the limiting assembly is spliced with the shell assembly; the pushing assembly is arranged on the shell assembly and located at the movable groove; and the driven assembly is arranged on the shell assembly and located in the mounting space, the pushing assembly and the driven assembly are arranged on the two sides of the mounting hole respectively and spliced, and the pushing assembly can drive the driven assembly to abut against the limiting assembly. According to the anti-disassembly key, the limiting assembly and the shell assembly are spliced through the ultrasonic welding technology, the pushing assembly and the driven assembly are spliced through the ultrasonic welding technology, and easy disassembly caused by loose connection is effectively prevented.

The application provides a handle assembly and an N-pole circuit breaker, relates to the technical field of circuit breakers, and is used for improving the assembly efficiency of a multi-pole circuit breaker and shortening the production and processing period of the multi-pole circuit breaker. A handle sleeve and N handles arranged in sequence along a first direction, wherein N is an integer greater than or equal to 2. The first direction is parallel to the rotation axis of the handle. At least one handle is provided with one of a groove and a buckle on at least one side along the first direction. The handle sleeve has an open accommodating space, and one end of the N handles is located in the accommodating space. The inner wall of the handle sleeve is used for driving contact with the N handles. The handle sleeve is correspondingly provided with the other one of the groove and the buckle, and the groove and the buckle in the opposite positions of the handle and the handle sleeve are matched.

This invention provides a method for preparing Astragalus colloidal phase, comprising the following steps: Preparing Astragalus decoction: Astragalus slices are extracted by reflux with water, filtered, and concentrated to obtain a standard Astragalus decoction; Phase separation: The standard Astragalus decoction is subjected to differential centrifugation and dialysis to obtain multiple physical phases, including a precipitate phase, a suspension phase, and a colloidal phase; Screening of active phases: The efficacy of each phase is evaluated using a renal edema model, and the phase with significant diuretic and anti-edema activity is selected as the Astragalus colloidal phase. The prepared Astragalus colloidal phase is a brownish-yellow transparent system with a particle size of 88.928 ± 0.683 nm and a PDI of 0.3516 ± 0.0162; the microstructure consists of spherical aggregates with a particle size distribution range of 30-200 nm; the yield is 23%. The colloidal phase of Astragalus membranaceus of this invention has nephroprotective and diuretic effects, and can be used in the preparation of drugs for treating renal edema. It provides a new and highly effective drug option for the treatment of related clinical diseases and the development of a new generation of innovative traditional Chinese medicine drugs for treating renal edema.

This utility model relates to the field of electronic product technology, specifically to a fast reset circuit for an MCU that has crashed. The fast reset circuit includes a timer chip U1, with pin 1 connected to an external button and pin 6 connected to the MCU's reset pin NRST. The external button is used to input a trigger signal to pin 1 of the timer chip U1. When the external button is continuously pressed for a preset time, pin 6 of the timer chip U1 outputs a low-level signal, pulling the MCU's reset pin NRST low, thus achieving a hardware reset. This pure hardware reset, achieved through an external button and timer chip, eliminates the need to disassemble the device casing, avoiding the structural damage of traditional reset methods. The long-press trigger mechanism and automatic timer reset function effectively prevent accidental operation, ensuring that the reset is triggered only under strict conditions.

The application discloses a device for shaping and hemostasis of an ovary wound surface in surgery, which comprises a mesh bag, a threading loop and a contraction and pressure wire, a plurality of threading loops are uniformly arranged on the contraction opening of the mesh bag, the contraction and pressure wire is wound around the bottom of the mesh bag, and then is respectively led to the two sides along the outer edge of the mesh bag, and is multi-pointly penetrated through the mesh bag wire double helix upwards, after the contraction and pressure wire reaches the edge of the contraction opening of the mesh bag, a section of the contraction and pressure wire is left after each winding half a turn along the threading loop on the contraction opening. The device can minimize the damage and function influence of the residual ovary tissue, and can obtain the shaping and hemostasis effect of the residual ovary tissue wound surface, and has the advantages of simple operation, safety and effectiveness and good hemostasis effect.

The utility model discloses a fermentation tank for collagen preparation, which comprises a mounting rack and a fermentation tank, the fermentation tank is rotatably connected with the mounting rack through a mounting shaft, the mounting shaft is sleeved with a gear, a rack is arranged in the mounting rack and is slidably connected with the mounting rack through a slider, a crank is rotatably mounted in the mounting rack, and the crank is connected with the mounting rack through a slider. A connecting rod is rotatably mounted on the sliding block, a mounting cover is fixedly mounted above the fermentation tank, the crank rotates and is matched with the connecting rod to convert the rotating motion of the crank into the reciprocating rectilinear motion of the rack driven by the sliding block on the mounting frame, and the rack is driven by the sliding block to move on the mounting frame in the reciprocating rectilinear motion process. The mounting shaft drives the fermentation tank to slowly swing left and right on the mounting frame by matching with the gear meshed with the mounting shaft, so that the fermented collagen raw materials in the fermentation tank are uniformly mixed, and the situation that the fermentation integrity of the raw materials in the fermentation tank is damaged by shearing force generated by traditional stirring, and consequently, the product denaturation or function loss is caused is reduced.

The invention relates to the technical field of improved breeding of animal husbandry, and particularly discloses an improved NK cell culture medium and a preparation method thereof. The improved NK cell culture medium comprises a basic culture medium, a supplement and a composite sustained-release body. All the components are mixed according to a specific proportion, and the requirements of NK cell proliferation and function maintenance are met. Wherein the inner layer of the composite sustained-release body takes trehalose and human recombinant serum albumin as protective agents to wrap the interleukin, and the outer layer of the composite sustained-release body is an acrylate prepolymer photocuring polymer containing a photoinitiator, so that the continuous and stable release of the interleukin is realized. Through component optimization and slow release system design, the NK cell culture efficiency and activity are effectively improved, and the method is suitable for NK cell multiplication culture.

The invention belongs to the technical field of biological medicines, and relates to a BCLAF1 protein Ser564 site phosphorylated antigen peptide, a specific antibody, and a preparation method and an application of the BCLAF1 protein Ser564 site phosphorylated antigen peptide. According to the invention, a BCLAF1 protein Ser564 is screened and identified as a key phosphorylation site through SIK2 kinase, a phosphorylation antigen peptide is designed and synthesized based on the site, and after an animal is immunized, a polyclonal antibody capable of specifically recognizing phosphorylation modification of the BCLAF1 Ser564 site is successfully prepared. The antibody has high sensitivity and strong specificity, is suitable for various detection platforms of immunohistochemistry, immunoblotting and the like, and can be used for evaluating the curative effect of tumor immunotherapy. According to the invention, a key tool is provided for analyzing a BCLAF1 phosphorylation regulation mechanism, and a theoretical basis is laid for developing an immune combination therapy strategy of a targeted SIK2-BCLAF1-CCL5 axis.

The invention relates to the field of medical instruments, and discloses a respirator mask for ICU (intensive care unit), which comprises a mask body and an air inlet pipe, second exhaust holes are formed in the outer side surface of the mask body, the air inlet pipe is mounted on the front surface of the mask body in a penetrating manner, one end of the air inlet pipe fixedly communicates with a communicating pipe, and a collecting cylinder is fixedly connected to the front end of the inner wall of the mask body. And a plurality of groups of exhaust holes I are formed between the collecting barrel and the air inlet pipe. According to the device, positive pressure oxygen from a breathing machine is used for pushing the fan blades and driving the air guide cylinder to overcome resistance of the second sealing ring and the first sealing ring to rotate, the air outlet moves to the position staggered with the through opening, at the moment, the air outlet is blocked, oxygen entering the air guide cylinder is gathered in the air outlet, and the air pressure is gradually increased; when oxygen is extruded, the air outlet coincides with the through opening again, the extruded oxygen enters the inner cavity of the mask body along the air outlet and the through opening, the oxygen is intermittently provided for a patient, and oxygen waste can be effectively prevented.

The invention discloses a unified operation control method and device for multiple entrances of an automatic system. The device comprises a function mapping module, an event interception and analysis module, an operation control task construction module, a unified operation control core module and an operation control execution module. A global function index is established between a system interface layer and a business logic layer, and scattered trigger channels are associated with corresponding function modules, so that centralized management of multi-entry operation is realized; the method comprises the following steps: monitoring an activation event of each trigger channel in real time, converting a channel identifier into a target module code, generating a running task package, and executing consistency management and task arbitration on a target module to ensure exclusiveness of module instance loading, foreground activation or suspension operation; by writing the newest state of the module into the system state table, the operational feasibility of subsequent channels can be constrained. Unified entry management of the multifunctional modules in the industrial automation system can be realized, operation continuity and system stability are improved, and function coordination requirements in different operation modes are met at the same time.

The invention discloses a hydrogeological drainage system which comprises a base and the following modules arranged on the a water inlet module comprising a water inlet pump, and a water inlet pipe and a water outlet pipe connected with the water inlet pump; the pretreatment module comprises a first connecting pipe, a transfer pipe, a first separating mechanism and a filtering mechanism, the first connecting pipe is connected between the water outlet pipe and the transfer pipe, and the first separating mechanism comprises a first boss and a first collecting barrel which are arranged on the first connecting pipe; the filtering mechanism comprises a filtering part arranged on the transfer pipe, a temporary storage cylinder connected with the transfer pipe and a lifting assembly capable of opening and closing the temporary storage cylinder and cleaning the filtering part; the post-treatment module comprises two slow flow chambers separated by a filter plate, the first slow flow chamber is connected with the transfer pipe, and the second slow flow chamber is provided with a second boss and an inclined plate and is connected with a drainage pipe; the backflow module comprises a backflow pool and a blow-off pipe with a blow-off pump, and the backflow module is connected with the pre-treatment module and the post-treatment module through a plurality of backflow pipes. According to the system, multi-stage impurity separation and self-cleaning are achieved, and drainage is continuous and stable.

The utility model discloses an electronic grade glycidyl ether type epoxy diluent's rectifying device relates to diluent processing technical field, including rectifying tank and dismounting subassembly, the side of rectifying tank middle part is installed with the feed pipe, for the convenient replacement of the dismounting subassembly of filling material is set up in the inside of rectifying tank, and the dismounting subassembly includes fixed block, fixed screw rod, movable block, dismounting plate, inner fixed strip and filling material box, the inside of fixed block is connected with movable block through fixed screw rod, and the side of movable block is connected with dismounting plate. This electronic grade glycidyl ether type epoxy diluent's rectifying device provides the base point for movable block and dismounting plate through fixed block to make the subsequent separation of dismounting plate, and the separation of rectifying tank moves outside fixed screw rod, so that filling material box exposes directly and is convenient for personnel to replace filling material box, thereby guaranteeing the rectification quality of electronic grade glycidyl ether type epoxy diluent, avoid the function decline caused by long -time use of filling material box.

The invention belongs to the field of tumors, and relates to application of an inorganic arsenic compound or a metabolite of the inorganic arsenic compound in preparation of NRF2 continuous high-expression drugs, after HaCaT and MIHA cells are exposed by DMMTAV with different concentrations, the total protein expression level of cell KEAP1 is reduced, and the total protein expression level of NRF2 is increased; furthermore, after the purified KEAP1 protein is treated by 10.0 [mu] M DMMTAV, free sulfydryl groups in the KEAP1 protein are obviously reduced. The result shows that the arsenic metabolite DMMTAV is combined with the key cysteine residue of the KEAP1 protein, so that the conformation is changed, the function is lost, and the stability is reduced, thereby releasing the NRF2 and activating the antioxidant pathway. In conclusion, the inorganic arsenic compound and metabolites can be combined with KEAP1 protein sulfydryl to mediate continuous high expression of NRF2.

The application provides a traceability diagram-driven multi-agent automated software development method, belonging to the technical field of software engineering, and receiving an original use case as input. The original use case can include fields such as use case name, description, participant, entry condition, event flow, exit condition and quality requirement. The framework first processes the original use case by a requirement refinement agent to obtain a refined use case with clear semantics and unified fields. Then, a design agent generates a class diagram and a sequence diagram according to the refined use case. Next, a development agent generates warehouse-level code according to the design model. Subsequently, a test agent generates and executes test cases. The entire process is checked for consistency between requirements, design and code by a verification agent, and problems found are fed back to the corresponding agent for iterative correction. The application is suitable for complex development scenarios and helps to improve the integrity, reliability and subsequent maintainability of the generation from requirements to code.