403results about "Blood transfusion" patented technology

In some embodiments, a system can include a fluid delivery assembly and a motor drive assembly. The fluid delivery assembly is configured to be releasably mechanically and, optionally, electrically coupled to the motor drive assembly. When the fluid delivery assembly is releasably coupled to the motor drive assembly, the motor drive assembly can control delivery of fluid from the fluid delivery assembly (e.g., to a patient). For example, the motor drive assembly can be releasably coupled to the fluid delivery assembly to control delivery of fluid from the fluid delivery assembly to provide continuous (e.g., non-pulsatile) fluid flow from the fluid delivery assembly.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.

The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.

A portable centrifuge comprising a base, which includes a rotational mechanism contained within. A sequester wheel having a plurality of concentric rings, forming at least one channel and a central container. The at least one channel comprising a second volume and the central container comprising a first volume. A first cover is disposed over the sequester wheel to create a seal. A second cover is disposed over the first cover and is rotatable to engage with the rotational mechanism to initiate rotation at a predetermined RPM. The whole blood and / or other tissue is separated into its constituent components and deposited into the at least one channel and the central container. Specific volumes of the constituent components may be calculated to match or substantially match the first and second volumes for predetermined volume control and ease of access.

The present invention relates to a unique method for obtaining secretomes from platelets and the secretome uses in regenerative medicine, in the treatment of diseases, including cell therapy, and in vitro cell culture. This method is developed with the aim of obtaining platelet-derived bio-products enriched in platelet granular cargo, rich in growth factors, and depleted of other platelet-derived molecules and plasma for universal use. The method avoids the use of platelet inhibitors or temperature-shock during the process, assuring the integrity of the platelet biological source. Furthermore, the potential processing of the product would allow additional clinical applications and solve storage limitations. This method and the characterization thereof of secretomes at the molecular level in health and disease will contribute to the identification of biomarkers for disease diagnosis and prognosis.

A blood separation device includes a pump system, a separator, and a controller. The controller is programmed to execute a blood separation procedure including a red blood cell collection stage in which blood is conveyed into the separator, red blood cells are separated from the blood in the separator, and the separated red blood cells are conveyed from the separator into a collection container. The red blood cell collection stage is ended when a target volume of blood has been separated in the separator. The controller then determines a percentage of the red blood cells from the target volume of blood that have been collected in the collection container based on the volume of red blood cells and the hematocrit of the fluid in the collection container, a volumetric flow rate of pure red blood cells in the blood conveyed into the separator, and the procedure time.

A medical contact shock freezer (10, figure 1) for fast freezing a plurality of individual bags containing a medical liquid (e.g. blood plasma) comprises a first pair of freezing plates comprising a f

Provided herein are systems and methods for implementing a modular light device for use in an electronic processing device according to embodiments of the present disclosure. In one or more embodiments, the modular light device can be implemented as a separate component that can be inserted into or removed from the processing device. In one or more embodiments, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, and the light source array chamber can include one or more light source arrays and light sensors collectively configured as part of the light device to illuminate a biological sample with light.

The application discloses a blood bag bin for a centrifuge, belongs to the field of medical devices, and relates to a fixing pin, a body, a limiting hole, a positioning groove, a limiting column, and elastic members. The body is rotatably installed on the fixing pin. The body is provided with the limiting hole, the positioning groove, and the limiting column. The two ends of the elastic members are respectively in contact with the body and the fixing pin, so that the body can move in the vertical direction relative to the fixing pin. When the body moves upward relative to the fixing pin, the positioning pin is separated from the limiting hole, the body can rotate relative to the fixing pin, the positioning groove accommodates the plug rod of the bag, and the limiting column extends into the through hole of the bag, so that the joint of the plug rod and the bag body is positioned. When the body moves downward relative to the fixing pin, the positioning pin is located in the limiting hole, so that the body is circumferentially positioned relative to the upper cover. Through the above design, the plug rod of the bag is buckled in the positioning groove, the limiting column extends into the through hole of the bag, so that the joint of the plug rod and the bag body is positioned. When the centrifuge is centrifuged, the bag and the plug rod joint part can be prevented from being poured and intercrossed and wound, and multiple bags can be separated conveniently.

A system and method of isolating extracellular vesicles. The method includes loading one or more of blood or bone marrow into an input port of a concentration system and centrifuging one or more of the blood or bone marrow to separate one or more of red blood cells, platelet poor plasma, or platelet rich plasma / bone marrow concentrate fractions via a centrifuge device. The method further includes pumping one or more of bone marrow / platelet rich plasma fractions and platelet poor plasma fractions into a receptacle of the concentration system and adding a concentrated aqueous two-phase solution to one or more of the bone marrow concentrate / platelet rich plasma fractions and platelet poor plasma fractions. The method also includes drawing the concentrated aqueous two-phase solution and one or more of the bone marrow concentrate / platelet rich plasma fractions or platelet poor plasma fractions back into the centrifuge device to isolate one or more of extracellular vesicles and platelet rich plasma / bone marrow concentrate fractions.

The invention provides a bulb tube current feedback and synchronous irradiation control system in a blood irradiator, and belongs to the technical field of medical irradiation equipment. Comprising a current acquisition module used for processing target blood by a target blood irradiator and outputting a current signal, a signal conditioning module used for carrying out filtering, level conversion and electromagnetic noise suppression processing on the output current signal, and a current control module. An STM32 microcontroller adopts an incremental proportional control algorithm to dynamically adjust output gain of a high-voltage generator, a synchronous irradiation control module, generation of a synchronous control signal and operation of a management module, a target blood irradiator is controlled to enter a low-power-consumption mode in a non-irradiation stage, and the current of a bulb tube is collected in real time and is processed, so that the current of the high-voltage generator is obtained. High precision and stability of the current signal are ensured, a synchronous control signal is generated according to the current signal after signal conditioning and the irradiation process state, and coordination control of sample rotation and radiation output is realized.

The blood treatment system includes durable hardware components and disposable fluid flow circuits. The hardware components include a control unit configured to perform procedures for separating and collecting red blood cells from whole blood. An additive solution can first be provided in the red blood cell collection container of the fluid flow circuit, and the control unit operates the pump system of the hardware components to convey the additive solution from the red blood cell collection container to the additive solution container of the fluid flow circuit. After the red blood cells are separated from the blood and conveyed to the red blood cell collection container (along with at least a portion of the additive solution from the additive solution container), the red blood cells and the additive solution in the red blood cell collection container are conveyed to the whole blood container for collection and storage.

The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.

A blood component collection system (10) is equipped with a centrifugal separation device (14) and a biological component collection device (27). The biological component collection device (27) comprises a first pressed soft portion (60) pressed by a first load detecting unit (88), and a second pressed soft portion (61) pressed by a second load detecting unit (89) for correcting reference data.

This invention belongs to the field of medical device technology and discloses a blood bag with built-in tubing and its compression separation method for separating plasma with chylous stratification after high-speed centrifugation. The bag includes a bag body and a tubular assembly disposed on the end face opposite to the side of the bag body that bears the centrifugal force during centrifugation. The tubular assembly includes a separation tube extending into the bag body with its opening always located at the bottom of the bag body on the opposite side of the fixed end. The separation tube has a higher hardness than the bag body. The method involves removing and fixing the bag body after centrifugation, where the upper chyle layer and lower plasma layer are separated. Then, the plasma is pushed out from both sides of the larger area of ​​the bag body by manual squeezing or external squeezing. This invention has a simple structure and low cost, but can avoid the influence of centrifugation while recovering and reusing plasma with high chyle content that is difficult to utilize.

A platelet-rich plasma (PRP) activation system for activating PRP contained in a container includes a housing, a power supply, a piezoelectric transducer array, a support structure, and a coupling medium. The power supply is located in the housing. The piezoelectric transducer array is operably connected to the power supply and is located in the housing. The piezoelectric transducer array is configured to generate a focused shock wave using power from the power supply. The support structure is operably connected to the housing and is configured (i) to receive the container, and (ii) to position the container at least partially within the housing, such that at least a portion of the PRP is located at a focal volume formed by the focused shock wave. The coupling medium is located in the housing and is positioned between the piezoelectric transducer array and the container.

Device for separating blood, wherein a sample tube with three sections, namely a lower chamber, an observation tube and an upper chamber, is provided, and a method for separating blood with such a device, wherein blood is filled into the device, then centrifuged, so that red blood cells, platelet-rich plasma and leukocytes are separated from each other.

A body fluid component separation device according to one embodiment may include: a housing; a piston that divides the housing into a first space and a second space and fluidly connects the first space and the second space; and a manipulator operatively coupled to the piston and configured to maintain pressure balance between the first space and the second space, while adjusting the movement of the piston between a first position having a first volume in the first space and a second position having a second volume in the first space different from the first volume, and for fixing the piston at any position between the first position and the second position.

Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.

The present invention pertains to the field of medicine and relates to a bag used for the collection, storage and separation of blood derivatives. The present patent is designed to enable the collection and separation of blood components in a single bag, suitable for generating fractionated bags and blood sample aliquots. This practice eliminates the risk of contamination due to the transfer and / or exposure of the blood products. The invention relates to a bag (1) composed of two superimposed polymeric films (2) and (3) sealed along their perimeter, and provided at its two ends with connectors (4), (5), (6), and (7), and handles (8) and (9), respectively; the bag (1) comprises an hourglass-shaped narrowing (10), formed by two trapezoidal seams (11) and (12) arranged opposite each other; the narrowing (10) has a length of between 6 mm and 15 mm (preferably 10 cm), a width of between 2 cm and 6 cm (preferably 4 cm), and angles (α), (β), (γ), and (δ) of between 10° and 60° (preferably 20°), while two or more demarcation lines (13) and (14) are placed transversely on both faces, on the narrowed region (11).

The present disclosure relates to Oxygen Reduction Disposable kits (ORDKit), devices and methods for the improved preservation of whole blood and blood components. The improved devices and methods for the collection of blood and blood components provide for whole blood and blood components having reduced levels of oxygen. The devices and methods provide for the rapid preparation of deoxygenated blood and blood components for storage that improves the overall quality of the transfused blood and improves health outcomes in patients.

A method for collecting blood components, comprising: separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from whole blood available after separating the first amount of plasma; if the total collection amount after the separation of the total amount of platelets is less than a maximum value adjusted by real-time data related to collection, then separating a second amount of plasma from the whole blood available after the separation of the total amount of platelets, and then separating a total amount of erythrocytes from the whole blood available after the separation of the second amount of plasma; and if the total collection amount is at a maximum adjusted by the real-time data relating to the collection, separating a total amount of red blood cells from the whole blood available after separating the total amount of platelets.

The application discloses a cold deposit full-automatic post-processing instrument and a preparation method of cold deposit blood clotting factors. The cold deposit full-automatic post-processing instrument comprises a separation system, the separation system comprises a squeezing disc and a weighing disc, and the squeezing disc is provided with a squeezing cavity; a transportation tensioning system can transport the first blood bag to the squeezing cavity, transport the second blood bag to the weighing disc, cut the pipeline of the double-pipe and tighten the double-pipe; a heat sealing system can heat seal the first heat sealing point, the second heat sealing point, the third heat sealing point and the fourth heat sealing point on the tightened double-pipe; a material head removing system, the transportation tensioning system can transport the double blood bag after heat sealing to the material head removing system to remove the Y-shaped material head; and a collection system comprising a first collection box and a second collection box. The application can improve the heat sealing efficiency of the blood bag, improve the working environment and shorten the exposure time of the plasma at room temperature.

Embodiments of apparatus, systems, and methods are disclosed that provide a fractionation apparatus for fractionating or separating blood or bone marrow aspirate (BMA) into one or more component layers and efficiently collecting the layers of interest. The fractionation apparatus comprises a generally cylindrical side wall, an upper wall connected to the upper part of the side wall, a bottom wall connected to the lower part of the side wall, and an internal partition. The internal partition includes an inclined portion in contact with the side wall and a vertical portion in contact with the upper wall.

To provide a method for collecting plasma.SOLUTION: A method for collecting plasma comprises determining the weight, the height and the hematocrit of a donor, and calculating donor plasma volume and target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method comprises then withdrawing blood from the donor through a line connected to a blood component separation device, and introducing an anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device into a plasma collection container. The method may comprise then calculating volume of pure plasma collected within the plasma collection container, and continuing processing / collecting until the calculated volume of pure plasma equals the target plasma collection volume.SELECTED DRAWING: Figure 3

A method including coupling a disposable device to a reusable device, wherein the disposable device includes: a heating segment including a fluid conduit including an inlet and an outlet, a first dielectric window at an upstream location, and a second dielectric window at a downstream location, wherein the reusable device includes: a receptacle configured to receive the disposable device, a first electrode positioned to be aligned with the first dielectric window, and a second electrode positioned to be aligned with the second dielectric window; supplying blood to the inlet to pass the blood through the fluid conduit; and activating the reusable device to cause the reusable device to apply an RF current between the first electrode and second electrodes, whereby the RF current is conducted into the fluid conduit through the first and second dielectric windows, thereby being conducted through the blood in the fluid conduit to heat the blood.