122 results about "Blood separation" patented technology

The invention relates to the technical field of blood potassium detection, in particular to a blood potassium detection paper-based sensor and a preparation method and application thereof.The sensor is obtained by integrating a substrate, a sensing electrode and a whole blood microfluid channel, and the sensing electrode is located between the substrate and the whole blood microfluid channel; the whole blood microfluid channel comprises a serum diffusion area, a whole blood separation area positioned above the serum diffusion area and a blood potassium detection area positioned below the serum diffusion area; a blood separation membrane is also arranged in the whole blood separation area; the substrate is qualitative filter paper, and the sensing electrode comprises an all-solid-state PBA working electrode and an Ag / AgCl reference electrode; compared with the prior art, calibration is not needed when potassium ions in whole blood are detected, the whole blood sample can be directly used, centrifugal separation is not needed, the detection speed is increased, the hemolysis problem of the whole blood sample in blood potassium detection can be avoided, and the detection sensitivity, accuracy and stability are further improved.

The invention relates to the technical field of blood separation, in particular to a platelet concentration-based gravity separation system, which comprises a tension disturbance extraction module, a viscosity response positioning module, a sedimentation retarding judgment module, a platelet export judgment module and a concentration layer interface output module. According to the method, real-time extraction of tension change frequency and mutation amplitude is introduced, and a normalization processing mode of disturbance polymerization indexes is combined, so that a mechanical unstable area under tiny disturbance in the blood standing sedimentation process is effectively described, and the sensitive recognition capability on potential layered behavior changes is enhanced. Through continuous tracking of a viscosity behavior curve in a disturbance time period, an accurate time anchor point is provided for judgment of a subsequent liquid column motion state. On the basis of microscopic changes of the liquid column height and the rate, through combined judgment of the acceleration change trend and the attenuation amplitude, the settlement state is distinguished no longer depending on a macroscopic parameter threshold value, but is dynamically regulated and controlled through the change trend and a fluctuation sequence.

Clot material may be removed from a patient and separated from blood so that the blood may be collected using an efficient dual-stroke technique. The methods described herein withdraw clot and blood from a patient during a first stoke of a pump at a first rate, filter the blood to remove clot, and drive the filtered blood into a collection chamber at a second rate that is different from the first rate. The first rate may be optimized to disrupt and remove clot, while the second rate may be optimized to move the blood without damaging, e.g., lysing, the blood.

The invention provides a composition for beautifying, which comprises a blood platelet concentrated solution prepared by differentiation of human pluripotent induced stem cells (iPSC), and an additive for preparing a blood platelet suspension or gel, and is characterized in that the composition for beautifying comprises the following components: a blood platelet concentrated solution prepared by differentiation of human pluripotent stem cells (iPSC), and an additive for preparing the blood platelet suspension or gel. The invention aims to provide a functional platelet-rich composition which can be prepared in a large scale, is stable in batch and can be produced in a standardized manner in the aspect of promoting wound healing. According to the composition, the platelet concentrate and platelet-rich plasma (PRP) separated from blood in the composition are completely different in component, the component is stable, and the slow-release growth factor is beneficial to tissue repair.

A processing device includes a pump system, a valve system, a centrifuge, and a controller. A fluid flow circuit is mounted to the device to execute a procedure in which whole blood is processed into a red blood cell product, a plasma product, and a platelet concentrate product. The blood is first separated into red blood cells, buffy coat, and plasma using the centrifuge, with the red blood cells and plasma being removed from the centrifuge, while the buffy coat remains in the centrifuge. The fluid remaining in the centrifuge is circulated through the centrifuge to form a homogenous mixture. Once the mixture is formed, it is separated in the centrifuge into platelet concentrate and red blood cells. A platelet product is then collected by using whole blood or previously collected red blood cells to push the platelet concentrate from the centrifuge to a collection container.

1. Name of the product of this design: Graphical user interface for operation control of blood separator for electronic equipment (XJ‑III). 2. Purpose of this design product: used in an electronic device. 3. The key design point of this design product lies in the content displayed in the graphical user interface. 4. The picture or photo that best illustrates the key points of the design: main view. 5. The electronic equipment is of conventional design and other views are omitted. 6. Purpose of the graphical user interface: The product interface is used to operate and control the blood separator. Through human-computer interaction, users can realize equipment self-test, plasma separation, red blood cell separation, PRP separation, consumables installation, information entry, parameter setting, plasma collection, etc. 7. Human-computer interaction mode of the graphical user interface: click "Device Self-Test" in the main view, the interface jumps to interface change state diagram 1; click "Confirm" in interface change state diagram 1, the interface jumps to interface change state diagram 2; click "Plasma Separation" in interface change state diagram 2, the interface jumps to interface change state diagram 3; click "Pre-charge" in interface change state diagram 3, the interface jumps to interface change state diagram 4; click "Next" in interface change state diagram 4, the interface jumps to interface change state diagram 5; click "Confirm" in interface change state diagram 5, the interface jumps to interface change state diagram 6; click "Stop" in interface change state diagram 6, the interface jumps to interface change state diagram 7. In addition, the cross in the interface represents replaceable text and / or numbers and / or letters and / or symbols.

The present application belongs to the technical field of blood separation, and particularly relates to a blood separator, which comprises an upper chamber, a middle chamber, a lower chamber, a connecting part, an injection hole, an injection needle with an air filter plug, a sealing cap and a sampling port. The injection needle with the air filter plug facilitates blood injection and prevents the blood from being polluted by the external environment. During the separation process, the liquid level in the chamber can be adjusted by extruding the upper chamber or the lower chamber, so that the target product reaches the highest possible purity, and the liquid level adjustment mode effectively solves the problem of liquid leakage. The upper chamber and the middle chamber, and the lower chamber and the middle chamber can be communicated or isolated by controlling the rotation angle of the rotating piston, which is convenient and fast.

The utility model relates to a blood separating and sampling device which comprises a test tube, the tube cap is detachably arranged on the test tube, a catheter is arranged on the tube cap, and the lower end of the catheter is located in the test tube; the sampling pipe is arranged in the guide pipe in a lifting manner, and a sampling channel is arranged in the sampling pipe; a flexible plug and a bottom end cover are respectively arranged at the upper end and the lower end of the sampling tube and are used for plugging the sampling channel; the flexible plug protrudes out of the upper end face of the pipe cap, and a sampling opening communicated with the sampling channel is formed in the lower end of the sampling pipe. When the sampling tube is in a closed state, the bottom end cover is propped against the conduit, so that liquid in the test tube is prevented from entering the conduit and the sampling channel; a needle tube is arranged at one end of the sampler, the sampling tube descends to enable the sampling opening to enter the liquid at the bottom of the test tube, and the needle tube pierces the flexible plug to suck the liquid in the test tube into the sampler. The utility model provides a blood separating and sampling device which can be used for carrying out sample collection on a specific layer of a centrifugally layered blood sample.

1. Name of the Design Product: Medical Centrifuge. 2. Use of the Design Product: For blood separation in the medical field. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph Most Indicating the Design Key Points: Perspective View 1.

1. The name of this design product: centrifuge. 2. Purpose of the product with this design: This product with this design is a special equipment used for cell separation, microorganism separation and blood separation. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

Systems and methods for separating whole blood into blood components includes a blood component separator and a processing circuit. The processing circuit receives whole blood characteristic data and at least one of inventory data and priority data. The processing circuit identifies a blood separator process based on the whole blood characteristic data and the at least one of inventory data and priority data. The blood component separator receives a first container comprising whole blood and automatically operates or is manually operated according to the identified blood separator process to separate at least one blood component from the whole blood for collection into a second or multiple, blood component containers.

An EBDLR system includes a multi-layered bio purifier having a plurality of layers. Each layer includes a membrane, a first type of cells on a first side of the membrane in a first channel, and a second type of cells on a second side of the membrane in a second channel. The EBDLR includes a plasma separator to receive blood from a subject and separate a plasma component from the blood, a first reservoir to collect the plasma component, and a second pump to move the plasma component from the first reservoir to the multi-layered bio purifier. The multi-layered bio purifier distributes the plasma component into the first and second channels of each layer to purify the plasma component. The EBDLR includes a second reservoir to collect the purified plasma component and a third pump to infuse the purified plasma component from the second reservoir into the subject.

The invention discloses a temperature-controllable magnetic separation blood transfusion pipeline, and belongs to the technical field of blood separation pipelines. The blood transfusion pipeline comprises an inner-layer pipe and an outer-layer sleeve arranged on the periphery of the inner-layer pipe in a sleeving mode. A gap between the inner-layer tube and the outer-layer sleeve is arranged to be a first channel and is used for transporting a cooling medium, and the inner-layer tube is arranged to transport blood to be separated; one end of the inner-layer pipeline is provided with a non-return tip, one side of the non-return tip is provided with a non-return bead, and the non-return bead and the non-return tip are sequentially arranged in the blood transportation direction. The non-return ball and the non-return tip are matched with each other, so that only blood can pass through the non-return ball, and magnetized cells or non-magnetic particles with relatively large particle sizes are prevented from entering back-section blood circulation; the first channel directly cools the blood flowing through the inner-layer tube, the cooling efficiency is high, cooling is uniform, heat exposure of the blood is reduced to the maximum extent from the path, and the heat injury risk is reduced.

The utility model discloses a tumor blood filter capable of quickly separating blood, which comprises a shell and an upper cover, the shell is detachably connected with the upper cover, the middle of the upper cover is communicated with a blood inlet pipe, the middle of the bottom end of the shell is communicated with a blood outlet pipe, and a filter component is arranged in the shell. The filtering assembly comprises a filtering cylinder, a flow dividing block, first supports, second supports and a filtering membrane, the filtering cylinder is connected with the inner wall of the shell, the flow dividing block is located in the middle of the inner side of the shell, the bottom end of the flow dividing block is vertically connected with the multiple first supports, and the other ends of the first supports are vertically connected with the second supports; the other end of the second support is connected with the bottom end of the inner wall of the filter cylinder, the filter membranes are arranged between the first supports and the second supports, through the design of the first supports and the second supports, the area of the filter membranes can be greatly increased in a limited space, the filter efficiency is improved, and through the design of the vibratable shunt block, the filter efficiency is improved. The condition of blood aggregation is avoided, and the blood circulation efficiency is improved.

The invention provides a composition for treating alopecia, which comprises a blood platelet concentrated solution prepared by differentiation of human pluripotent induced stem cells (iPSC), and an additive for preparing a blood platelet suspension or gel. The invention aims to provide a functional platelet-rich composition which can be prepared in a large scale, is stable in batch and can be produced in a standardized manner in the aspect of treating alopecia. According to the composition, the platelet concentrate and platelet-rich plasma (PRP) separated from blood in the composition are completely different in component, the component is stable, and the slow-release growth factor is beneficial to tissue repair.

Disclosed herein are kits, articles, and methods for blood separation, comprising: a support structure comprising an inlet, an outlet, and a channel between the inlet and the outlet; a separation device; and an absorbent layer; wherein the absorbent layer and support structure are configured such that the absorbent layer can be positioned in the support structure and be in fluidic connection with the inlet and the outlet of the support structure; wherein the separation device is removable from the support structure; wherein the outlet is a vessel and / or is configured to be in fluidic connection with a vessel.

The present invention discloses a method for evaluating the chromatographic effect of a blood-separated plasma sample based on image detection. First, a high-resolution camera or a video camera is used to collect a blood separation image in real time, and a suitable light source is configured to eliminate errors caused by changes in the color or transparency of the blood. Furthermore, the collected image is preprocessed (such as grayscale processing) to convert the original blood stratification effect into a clear grayscale image. Furthermore, after the blood is centrifuged to form a red blood cell layer, a white blood cell-platelet layer, and a plasma layer, and then the top layer of the blood, i.e., the plasma layer, or an area containing a small portion of the white blood cell-platelet layer, is quickly located and extracted through coarse segmentation. Furthermore, through fine segmentation, the white blood cell-platelet layer is removed from the plasma layer to obtain an image with clear edges and containing only the plasma layer. Finally, an evaluation is performed based on the impurity content of the plasma layer in the image, and a purity analysis result is ultimately given.

The utility model discloses a blood separator based on puerpera bleeding detection. The blood separator comprises a shell, the upper part of the shell is provided with circular groove bodies which are symmetrically arranged; a rotary drum is rotationally connected into the tank body; a hollow shaft is fixedly connected to the bottom center of the drum; a separation cylinder is arranged in each rotating cylinder; limiting blocks which are symmetrically arranged are fixedly connected to the outer side of the separating cylinder; limiting grooves are formed in the positions, corresponding to the limiting blocks, of the side wall of the rotary drum. After a medical worker uses the separating cylinder to receive amniotic fluid and blood mixed liquid flowing out of a puerpera, the amniotic fluid and blood mixed liquid is placed in the rotating cylinder, the motor is used for driving the rotating cylinder to rotate, then the mixed liquid is centrifuged in the rotating cylinder under the cooperation of the rotating cylinder, the separating cylinder and the curved plate, and the sliding rod can be operated after standing for a little time; according to the scheme, blood is discharged into the container, then medical staff can know the condition of the puerpera by observing the blood in real time, and guarantee is provided for life safety of the puerpera.

The application discloses a self-driven disc type blood separation and detection device and method, which comprises a sample adding layer, a separation layer and a detection layer, and the layers are sequentially connected through screw fixation. The sample adding layer is provided with a sample adding port and a first screw hole; the separation layer comprises four repeated blood separation units and a second screw hole, and each separation unit comprises a sample inlet, a micro-fluidic channel, a filter groove, a sample outlet and a waste liquid collecting chamber; and the detection layer is provided with a screen-printed electrode interface and a third screw hole. Blood samples are dripped into the device from the sample adding port, and under the driving of the internal negative pressure of the device, the blood samples enter the micro-fluidic channel, and blood filtration is realized by using the gravity difference between blood cells and blood plasma. The filtered blood plasma flows into the detection layer and contacts with the screen-printed electrode detection unit, so that electrochemical detection is realized. The device does not need external power supply, thereby reducing sample operation, reducing the volume of the separation device, improving the blood separation efficiency, and facilitating instant detection and multi-channel detection of blood samples.

The utility model discloses an automatic platelet-rich plasma separator, and relates to the technical field of blood separation. According to the automatic platelet-rich plasma separator, by arranging a collecting cylinder, a piston, a connecting pipe, a mounting plate, an extraction pipe, an electric telescopic rod and a supporting frame, the function of automatically collecting enriched liquid is achieved, an air cylinder is started to drive the collecting cylinder to move through a moving plate, and the collecting cylinder drives the extraction pipe to enter a test tube through the mounting plate; the electric telescopic rod drives the piston to slide, so that enriched liquid can be conveniently extracted or discharged, the extraction process is more stable, plasma layering and mixing caused by vibration during manual extraction are avoided, and the quality of a finished product is improved.

The utility model discloses an air tightness detection device for a blood separation cup, and relates to the technical field of blood separation cup detection, the detection device comprises a machine body provided with a standard cavity and a detection cavity, two pump bodies, a first pressure gauge and a second pressure gauge, the first pressure gauge is used for detecting air pressure in the standard cavity, and the second pressure gauge is used for detecting air pressure in the detection cavity. The second pressure gauge is used for detecting the air pressure in the detection cavity; one pump body is connected with the standard cavity and is used for pressurizing the gas in the standard cavity, and the other pump body is connected between the standard cavity and the detection cavity and is used for transmitting the pressurized gas in the standard cavity into the detection cavity so as to detect the blood separation cup in the detection cavity through the second pressure gauge; wherein the volume size of the standard cavity is consistent with the volume size of the detection cavity. Through the arrangement, the technical problem that the detection mode of the blood separation cup in the prior art is unreliable can be solved.

The present invention provides a rapid detection microfluidic chip and detection method for prostate cancer markers, which belongs to the technical field of rapid screening of prostate cancer. The technical problems of the existing detection methods being cumbersome to operate and having a long detection cycle are solved. The technical solution is as follows: it includes a microarray structure for blood separation and a color development microchannel structure for detecting free prostate-specific antigen F-PSA and total prostate-specific antigen T-PSA respectively; the microarray composed of "V"-shaped grooves forms a blood separation structure, which separates red blood cells, white blood cells, and large platelet particles in the blood by physical separation; the functional fragments of F-PSA and T-PSA are fixed and captured in advance in the color development microchannel structure, and the semi-quantitative detection of F-PSA and T-PSA is achieved by measuring the color development length of the color development microchannel. The beneficial effects of the present invention are: the microfluidic chip of the present invention is simple to operate, the results are easy to read, and the analysis is fast.

The invention discloses a turbidity evaluation processing method and system for a blood separation plasma sample and a storage medium, and the method comprises the steps: firstly, processing a first image containing target cells to obtain a second image, and intercepting a third image only containing the target cells from the second image; therefore, errors caused by subsequent identification of the attribute information of the target cell due to factors such as the surrounding environment of the target cell are reduced; inputting the third image into an image recognition model trained through operations such as a convolutional layer, a pooling layer and an activation function, detecting, recognizing and outputting five-level associated feature information of the target cell, performing associated recognition on the five-level associated feature information and a preset contrast feature information table, and outputting attribute information of the target cell; by guaranteeing the recognition precision of the sample image, the turbidity of the plasma sample is evaluated and monitored.

The application discloses a real-time monitoring and intelligent control system and method for blood separation, comprising a blood separation module, a real-time detection module, a data processing and analysis module and a parameter dynamic adjustment module. The blood separation module is used for performing blood separation operation, the real-time detection module is used for real-time detection of process state parameters in the blood separation operation, the data processing and analysis module compares the state parameters with ideal separation parameters and generates adjustment instructions, and the parameter dynamic adjustment module receives the adjustment instructions and adjusts the operation parameters of the blood separation module. The application utilizes the blood separation module to separate blood to be separated, the real-time detection module detects state parameters, and the operation parameters of the blood separation module are automatically adjusted according to the state parameters, so that efficient and accurate separation of blood is realized, and the separation effect and efficiency are improved.

The invention provides a double-position centrifugal plasma purification system, and belongs to the technical field of plasma purification. Comprising a plasma collection system, a plasma adsorption system and a liquid feedback system, the plasma collection system and the liquid feedback system are both connected with a blood supplier to form a blood closed-loop conveying loop, and the plasma adsorption system is connected with the plasma collection system and the liquid feedback system; the plasma collecting system comprises two centrifugal machines and further comprises a back-flushing cleaning system, and the two centrifugal machines are alternately connected with the plasma collecting system and the back-flushing cleaning system through a first control valve and a second control valve. The centrifugal machine after each round of blood separation is flushed through the backflushing cleaning system, blood residues in a container of the centrifugal machine are avoided, free hemoglobin rising caused by long-time centrifugation of blood components is avoided, and the effect of improving the safety and reliability of the blood purification process is achieved.

The present invention relates to an intelligent blood separation workstation, comprising a workbench, a cover, a storage box, a blood collection tube fixing assembly, a pipette tip storage rack for storing pipette tips, a three-axis gripping mechanism, and a pipette assembly. The three-axis gripping mechanism comprises a three-dimensional mobile drive assembly; the pipette assembly comprises a mounting frame, a plurality of screw rods provided on the mounting frame, a gear mounting block threadedly connected to the screw rods, a mounting bar provided on the gear mounting block, and a pipette gun fixedly connected to the mounting bar; the gear mounting block is provided with a plurality of rotary gears, the rotary gear is provided with a gear transmission shaft connected to the rotary gear, and the mounting bar is provided with a first vertical rack meshing with the rotary gear. In the intelligent blood separation workstation of the present invention, the three-axis gripping mechanism and the pipette assembly are separated into two independent groups of components, so that the gripping and blood separation functions can be operated separately, thereby improving the efficiency of storage and blood separation, and increasing reliability.

The utility model discloses a connecting piece and a leukocyte-depleted filter composed of the same, and belongs to the technical field of blood separation. The connecting piece comprises a filter connecting pipe and a pipeline connecting pipe which are coaxially connected, the circumferential surface of the filter connecting pipe is an inclined surface, and a threaded area is arranged on the circumferential surface of the filter connecting pipe. The leukocyte-depleting filter comprises a filter body 201 and the connecting piece. Threaded areas are arranged on the inner walls of interfaces at the liquid inlet end and the liquid outlet end of the filter body, the inner walls of the interfaces are inclined planes, and the filter connecting pipe of the connecting piece is inserted into the interfaces and is in threaded connection with the interfaces. According to the application, the leukocyte-depleting filter made of the PP material is connected with the pipeline made of the PVC material through the connecting piece made of the polycarbonate material, and transition is performed through the connecting piece, so that the joint of the connecting piece and the leukocyte-depleting filter as well as the joint of the connecting piece and the pipeline are relatively stable in the damp-heat sterilization process, the phenomenon of separation is avoided, and the yield is increased.

The utility model relates to a bonding device applied to a gas cut-off device in the blood separation process, and belongs to the field of gas cut-off devices. Comprising a device support, a fixing cross rod, a gas circuit connector, an upper cover linear air cylinder, an upper cover rotating air cylinder, an upper cover grabbing part, a lower cover linear air cylinder, a lower cover rotating air cylinder, a lower cover grabbing part, an upper cover adhesive material barrel, a lower cover adhesive material barrel, a gas cut-off device upper cover and a gas cut-off device lower cover. The upper cover rotating air cylinder and the lower cover rotating air cylinder are installed on the fixed transverse rod, the upper cover linear air cylinder and the lower cover linear air cylinder are installed on the rotating air cylinder, the upper cover grabbing part and the lower cover grabbing part are installed on the push rod, and the upper cover adhesive material barrel and the lower cover adhesive material barrel are located below the upper cover grabbing part and the lower cover grabbing part. Butt joint of the upper shell and the lower shell is controlled through the adhesive charging barrel and the air cylinder, and the problems of glue overflowing caused by too much and too deep adhesives and leakage caused by infirm bonding caused by too little and too shallow adhesives and manpower consumption are solved.

The present application provides a blood separation method for a sampling needle and a blood cell analyzer, the method comprising: collecting a blood sample through a sampling needle, the blood sample being distributed into multiple sections in sequence in the sampling needle; discarding the first section of the blood sample near the needle head in the sampling needle; allocating a first preset ratio of the blood sample near the first section of the blood sample in the sampling needle to a reticulocyte counting section; allocating a second preset ratio of the blood sample located in the middle section of the sampling needle to a white blood cell counting section and a hemoglobin / red blood cell counting section; and allocating a third preset ratio of the blood sample near the end of the sampling needle to a white blood cell classification counting section. The blood separation method for a sampling needle and the blood cell analyzer of the present application can allocate multiple blood sections in the sampling needle to appropriate counting sections, thereby improving the measurement performance of the blood cell analyzer.

The present invention combines membrane separation technology with biosensor technology to develop a blood separation sensor membrane that can simultaneously achieve blood separation and physiological indicator detection. A membrane tube with an Fe3O4 sensing layer is immersed in a sulfuric acid mixture containing aniline and ammonium persulfate for low-temperature oxidative polymerization, followed by washing and vacuum drying. A lactate oxidase solution and a glutamate oxidase solution are sequentially deposited on the inner surface and pores of the blood separation sensor membrane via vacuum filtration to obtain a blood separation sensor membrane. The separation membrane layer accurately intercepts blood cells while allowing serum to pass through without loss. The octahedral Fe3O4 sensing nanocrystals with high catalytic activity in the inner pores specifically respond to liver function indicators, generating current signals. This enables real-time screening and dynamic monitoring of the biological components of liver function indicators. The preparation process of this separation sensor membrane is simple and controllable, making it easy to implement large-scale and commercial production, thus resolving the current technical bottleneck in real-time dynamic monitoring of liver function in clinical practice.