43 results about "Blood separation" patented technology

A processing device includes a pump system, a valve system, a centrifuge, and a controller. A fluid flow circuit is mounted to the device to execute a procedure in which whole blood is processed into a red blood cell product, a plasma product, and a platelet concentrate product. The blood is first separated into red blood cells, buffy coat, and plasma using the centrifuge, with the red blood cells and plasma being removed from the centrifuge, while the buffy coat remains in the centrifuge. The fluid remaining in the centrifuge is circulated through the centrifuge to form a homogenous mixture. Once the mixture is formed, it is separated in the centrifuge into platelet concentrate and red blood cells. A platelet product is then collected by using whole blood or previously collected red blood cells to push the platelet concentrate from the centrifuge to a collection container.

The invention discloses a temperature-controllable magnetic separation blood transfusion pipeline, and belongs to the technical field of blood separation pipelines. The blood transfusion pipeline comprises an inner-layer pipe and an outer-layer sleeve arranged on the periphery of the inner-layer pipe in a sleeving mode. A gap between the inner-layer tube and the outer-layer sleeve is arranged to be a first channel and is used for transporting a cooling medium, and the inner-layer tube is arranged to transport blood to be separated; one end of the inner-layer pipeline is provided with a non-return tip, one side of the non-return tip is provided with a non-return bead, and the non-return bead and the non-return tip are sequentially arranged in the blood transportation direction. The non-return ball and the non-return tip are matched with each other, so that only blood can pass through the non-return ball, and magnetized cells or non-magnetic particles with relatively large particle sizes are prevented from entering back-section blood circulation; the first channel directly cools the blood flowing through the inner-layer tube, the cooling efficiency is high, cooling is uniform, heat exposure of the blood is reduced to the maximum extent from the path, and the heat injury risk is reduced.

The application discloses a self-driven disc type blood separation and detection device and method, which comprises a sample adding layer, a separation layer and a detection layer, and the layers are sequentially connected through screw fixation. The sample adding layer is provided with a sample adding port and a first screw hole; the separation layer comprises four repeated blood separation units and a second screw hole, and each separation unit comprises a sample inlet, a micro-fluidic channel, a filter groove, a sample outlet and a waste liquid collecting chamber; and the detection layer is provided with a screen-printed electrode interface and a third screw hole. Blood samples are dripped into the device from the sample adding port, and under the driving of the internal negative pressure of the device, the blood samples enter the micro-fluidic channel, and blood filtration is realized by using the gravity difference between blood cells and blood plasma. The filtered blood plasma flows into the detection layer and contacts with the screen-printed electrode detection unit, so that electrochemical detection is realized. The device does not need external power supply, thereby reducing sample operation, reducing the volume of the separation device, improving the blood separation efficiency, and facilitating instant detection and multi-channel detection of blood samples.

The application discloses a real-time monitoring and intelligent control system and method for blood separation, comprising a blood separation module, a real-time detection module, a data processing and analysis module and a parameter dynamic adjustment module. The blood separation module is used for performing blood separation operation, the real-time detection module is used for real-time detection of process state parameters in the blood separation operation, the data processing and analysis module compares the state parameters with ideal separation parameters and generates adjustment instructions, and the parameter dynamic adjustment module receives the adjustment instructions and adjusts the operation parameters of the blood separation module. The application utilizes the blood separation module to separate blood to be separated, the real-time detection module detects state parameters, and the operation parameters of the blood separation module are automatically adjusted according to the state parameters, so that efficient and accurate separation of blood is realized, and the separation effect and efficiency are improved.

The utility model discloses a connecting piece and a leukocyte-depleted filter composed of the same, and belongs to the technical field of blood separation. The connecting piece comprises a filter connecting pipe and a pipeline connecting pipe which are coaxially connected, the circumferential surface of the filter connecting pipe is an inclined surface, and a threaded area is arranged on the circumferential surface of the filter connecting pipe. The leukocyte-depleting filter comprises a filter body 201 and the connecting piece. Threaded areas are arranged on the inner walls of interfaces at the liquid inlet end and the liquid outlet end of the filter body, the inner walls of the interfaces are inclined planes, and the filter connecting pipe of the connecting piece is inserted into the interfaces and is in threaded connection with the interfaces. According to the application, the leukocyte-depleting filter made of the PP material is connected with the pipeline made of the PVC material through the connecting piece made of the polycarbonate material, and transition is performed through the connecting piece, so that the joint of the connecting piece and the leukocyte-depleting filter as well as the joint of the connecting piece and the pipeline are relatively stable in the damp-heat sterilization process, the phenomenon of separation is avoided, and the yield is increased.

Systems and methods are provided for improving efficiency and quality of plasma being removed from a blood separation chamber. The system includes a separation chamber in which plasma is separated from cellular blood components, a pump for moving the plasma and an outlet line for removing the separated plasma from the blood separation chamber. An optical sensor assembly is configured to monitor the blood separation chamber and measure an interface position between the separated component and the plasma, and to generate an output indicative of the measured interface position. A controller is programmed to utilize a lipid concentration input of the blood and to set an original lipemia offset, a lipemia threshold and lipemia final setpoint from a predetermined database, and to use a proportional-integral-derivative control loop to assess the actual interface position plus the lipemia threshold to adjust and achieve a final lipemia setpoint for use during separation procedures.

The invention relates to the technical field of biomedical equipment, and particularly provides a blood separation workstation. Specifically, the blood separation workstation comprises a storage device, a pipetting device, a centrifugation device, a visual quality control device, a first uncovering device, a second uncovering device, a first transfer device and a second transfer device, the storage device is used for storing blood samples and consumables, the first uncovering device is used for uncovering blood collection tubes, and the second uncovering device is used for uncovering blood collection tubes. The first transfer device can move out the blood collection tubes in the storage device; the pipetting device can transfer blood in the blood collection tube into the centrifugal tube, and the centrifugal device is used for centrifuging the blood; the visual quality control device is used for collecting and identifying layered images of blood, the pipetting device can respectively move out the layered blood, and the second cover opening device is used for opening and closing a cover of the centrifugal tube; and the second transfer device can transfer the centrifugal tube. According to the blood separation workstation, blood separation work can be automatically achieved, and the working efficiency and quality of blood separation are improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating blood stasis type pulmonary nodules and a preparation method thereof. The pharmaceutical composition for treating blood stasis type pulmonary nodules has the effects of regulating pivot and dispersing blood stasis, and is prepared from the following raw material medicines: scutellaria baicalensis, cassia twig, dried ginger, radices trichosanthis, angelica sinensis, liquorice, radix bupleuri, peach kernel, safflower, platycodon grandiflorum, ligusticum wallichii and fructus aurantii. Through the synergistic effect of'pivot regulation 'and'stasis removal', the limitation of qi and blood separation intervention in a traditional treatment method is solved, and the purpose of bidirectional regulation and control is achieved; furthermore, a scheme of treating both qi and blood is provided for integrated intervention aiming at the complex pathogenesis of modern diseases of emotion depression combined with blood stasis, finally, the aim of effectively treating or improving the blood stasis type pulmonary nodules is achieved, and a brand new technical scheme is provided for clinical treatment of the blood stasis type pulmonary nodules.

To provide an improved blood separation system, apparatus and method for monitoring pressure in a leukoreduction filter, identifying the cause of flow restriction in the filter, and adjusting fluid processing.SOLUTION: Systems, devices and methods for processing whole blood are disclosed. The system includes a reusable separation device, a disposable fluid flow circuit, and a controller configured to detect a flow restriction in the leukocyte depletion filter and identify a cause of the flow restriction.SELECTED DRAWING: Figure 1

This invention relates to the field of blood separation technology, and more particularly to an optically visualized layering system and method for blood separation. This method aims to solve the problems of low separation efficiency, insufficient visualization capabilities, and poor layering accuracy in existing centrifugation techniques. The system includes an optical microscopy imaging module, a preprocessing module, a layering recognition module, and a 3D visualization module. A three-stage training strategy (pre-training, fine-tuning, and dynamic enhancement) improves the robustness of the layering recognition module model, achieving a layering error rate of ≤3% and a total process time of <5 minutes. This significantly improves the accuracy, efficiency, and visualization effects of blood separation, making it suitable for clinical diagnosis and biomedical research.

1. Name of the product in this design: Sterile PRP Blood Separation Kit. 2. Purpose of this design: PRP blood separation kit. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention relates to a blood separation tube for a centrifugal separation apparatus, and more specifically to a blood separation tube having a cell activation section, wherein physical pressure is generated through collision with the centrifuged blood, thereby activating blood cells such as platelets, leukocytes, and lymphocytes in the blood. To this end, the invention is characterized by comprising: a tube body having a chamber for containing blood; and a cell activation section protruding from the inner surface or interior of the chamber to activate blood cells through physical collision with the centrifuged blood.

This disclosure relates to the adjustment of the measurement of cellular concentration in a fluid determined by a sensor. [Solution] The biofluid processing apparatus 10 includes a pump system and a valve system, a control unit, and an optical detection assembly. During the execution of the biofluid processing procedure, the control unit controls the operation of the pump system and the valve system to separate the cell-containing fluid from the blood of the blood supply source, and further controls the optical detection assembly to irradiate the cell-containing fluid with light. The control unit receives a signal from the optical detection assembly indicating the intensity of the light transmitted through the cell-containing fluid. The control unit receives or calculates an adjustment coefficient derived from historical data reflecting a cell collection procedure previously performed on the same blood supply source from which the cells were collected. The control unit determines the adjusted cell concentration of the cell-containing fluid based at least in part on the signal from the photodetector and the adjustment coefficient.

The present invention relates to a cartridge for the uptake and analysis of a fluid sample, comprising an inlet which allows to take up the sample; a filter zone comprising a filter membrane which allows for separating different components within the sample and for adding reagents to the sample; a landing zone which allows for delaying the movement of the sample and for blending the sample; a transport zone which allows for transporting the sample from the landing zone to a reaction chamber, comprising one or more fluidic channels; one or more reaction chambers, which are designed for mixing of reagents with the sample; one or more reaction chambers, which are designed to capture analytes from the sample and other reactants; a reaction chamber zone, which is designed for washing, examination and verification of assay reactions; and one or more stop zones where fluidic flow within the cartridge is stopped.

The utility model relates to an electromagnetic valve airtightness testing device applied to a blood separation process, which belongs to the field of electromagnetic valves and comprises a barometer, a sealing box body, a sealing plate, a sealing opening, a rubber threaded opening, an upper plate, an upper plate opening, a lower plate, a lower plate opening, an exhaust pipe, a vacuum negative pressure pump and a plug. A barometer is installed on the upper end face of the sealing box body, a pipeline of the barometer is connected into the sealing box body, the sealing plate is installed on the lower end face of the sealing box body, a sealing opening is formed in the middle of the sealing plate, a rubber threaded opening is fixedly installed on the sealing opening, an upper plate is installed on the upper end face of the sealing plate, and an upper plate opening is formed in the middle of the upper plate and concentric with the sealing opening. A lower plate is installed on the lower end face of the sealing plate, a lower plate opening is formed in the middle of the lower plate, the lower plate opening and the sealing opening are concentric, one end of an exhaust pipe is connected into the sealing box body, the other end of the exhaust pipe is connected with a vacuum negative pressure pump, and a plug is installed at the sealing opening.

The utility model belongs to the technical field of blood separation, and particularly relates to a blood separator convenient for injection and extraction, which comprises a separator main body and an upper cover in threaded connection with one end of the separator main body, the upper cover comprises an injection port, a liquid taking port and a vent hole; a buckle cover is arranged above the upper cover; the injection opening and the liquid taking opening can be protected through the buckle cover. According to the blood separator provided by the utility model, the injection of blood and the extraction of platelet-rich plasma are more convenient, and the pollution risk to the blood is reduced.

A biofluidic processing apparatus, a biofluidic processing system, and a method for implementing a controller to perform a biofluidic processing procedure for a blood source are disclosed. The biofluidic processing apparatus includes a pump system and a valve system, a controller, and an optical detection assembly. During the biofluidic processing procedure, the controller controls the operation of the pump system and the valve system to separate the cell-containing fluid from the blood of the blood source, and controls the optical detection assembly to emit light through the cell-containing fluid. The controller receives a signal from the optical detection assembly indicating the intensity of light passing through the cell-containing fluid. The controller receives or calculates a modulation factor derived from historical data reflecting previous cell collection procedures performed on the same blood source with the same type of cells collected. The controller determines the regulated cell concentration of the cell-containing fluid based at least in part on the signal from the photodetector and the modulation factor.

1. The name of the design product: blood separation container. 2. The use of the design product: for receiving blood to be able to separate the blood by a centrifugal separator. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The application relates to the technical field of pet medical blood separation, in particular to a pet PRP separation gel separation tube and a preparation method thereof. The separation tube is a rapid PRP separation vacuum separation tube containing separation gel, the main body is a siliconized glass tube with a diameter of 16*100 mm, the vacuum degree for dogs is-85kPa+ / -10%, the separation gel density is 1.055-1.080g / mL, the vacuum degree for cats is-55kPa+ / -10%, and the separation gel density is 1.040-1.065g / mL; the preparation method adopts 4% sodium citrate anticoagulation (the proportion of anticoagulant to whole blood is 1:9), centrifugation is carried out at 3500rpm for 15-20min, 1 / 2 of the upper platelet-poor plasma is discarded, and the white membrane layer is suspended by inverting the separation tube to obtain platelet-rich plasma; the application solves the problems of insufficient platelet enrichment and incomplete cell removal of general separation tubes, only one centrifugation is needed, the overall platelet recovery rate is higher than 80%, the prepared PRP is high in purity, stable in quality, easy to operate, and suitable for pet clinical popularization and application.

The invention relates to the technical field of biomedical equipment, and particularly provides a blood separation workstation. Specifically, the blood separation workstation comprises a blood separation system and an intelligent control system, the blood separation system is used for executing blood separation operation, and the intelligent control system can collect voice instructions of a user and control the blood separation system to execute corresponding blood separation operation according to the voice instructions of the user. According to the blood separation work station, the intelligent control system is arranged, and the intelligent control system can collect the voice instruction of the user and control the blood separation system to execute the corresponding blood separation operation according to the voice instruction of the user, so that the user can directly control the blood separation work station to perform blood separation work through voice; manual control is not needed any more, the working efficiency and convenience are greatly improved, and the user experience is improved.

The utility model discloses a kind of platelet-rich plasma preparation devices, it is related to medical instrument technical field;To solve the problem that blood separation mode is easy to pour red blood cell, inconvenient operation, and platelet recovery rate and efficiency are lower, the following technical scheme is proposed: it includes storage cavity, separation cavity and handle, the lower end of separation cavity is arranged in storage cavity, the lower end of storage cavity rotatably sets handle, the upper end surface of separation cavity is clamped with upper cover, and the lower connecting end of storage cavity is equipped with lower cover;Storage cavity is nested in reversal portion, and the cavity of storage cavity is communicated with separation cavity through reversal portion, and the lower chamber of storage cavity is equipped with piston, and the lower end surface of piston is abutted with the thread rod end surface of handle.The utility model realizes the complete independent separation storage of platelet-rich layer, plasma layer and red blood cell layer after whole blood centrifugal separation.Improve work efficiency and recovery rate, also ensure the safety and reliability of blood treatment, with extensive application prospect and popularization value.

The invention relates to the technical field of blood separation, in particular to an optical visual layering system and method for blood separation. The method aims at solving the problems that an existing centrifugal technology is low in separation efficiency, insufficient in visualization capability and poor in layering precision. The system comprises an optical microscopic imaging module, a preprocessing module, a layered identification module and a three-dimensional visualization module. The model robustness of the hierarchical recognition module is improved through a three-stage training strategy (pre-training, fine tuning and dynamic enhancement), the hierarchical error rate is less than or equal to 3%, and the whole process consumes the time result; the precision, the efficiency and the visualization effect of blood separation are remarkably improved, and the method is suitable for clinical diagnosis and biomedical research.

The utility model discloses an integrated liquid path unit box applied to a blood component separation process, and belongs to the technical field of blood separation, the integrated liquid path unit box comprises a unit box body, the two ends of the unit box body are open, a partition plate is arranged in the middle of the unit box body, the partition plate divides the unit box body into two cavities, a plurality of passage grooves are formed in the plane of the partition plate in one cavity, and the passage grooves are communicated with the passage grooves. The access groove is a circulation path for blood; a unit box upper cover is mounted at an opening in one end of the unit box body provided with a plurality of passage grooves, and the unit box upper cover is used for sealing the tops of the passage grooves; and a bottom soft film is arranged at the opening at the other end of the unit box body and is used for packaging the opening at the other end of the unit box body. The utility model aims to simplify a control flow, reduce resource waste and reduce operation difficulty.

The invention relates to a plasma separation device suitable for immunoassay, and relates to the field of medical instruments. Comprising a separation structure, separation consumables and a cell plasma collection structure, the separation consumable is mounted on the separation structure and is used for providing blood to be separated for plasma separation; the separation structure is used for separating to-be-separated blood into blood cells and plasma; and the cell plasma collecting structure is used for respectively collecting the separated blood cells and plasma. The passive separation of plasma is realized by using the gravity of whole blood and the negative magnetic separation effect, and the separation is rapid.

A separation assembly for an apheresis system includes a first solution bag, a second solution bag, a container, and a separation set. The first solution bag contains a first solution. The second solution bag contains a second solution. The container is configured to contain a third solution. The separation set includes a first tube and a second tube. The first tube has a first fitting configured to be coupled to the first solution bag. The first tube has a first length. The second tube has a second fitting configured to be coupled to the second solution bag. The second tube has a second length different from the first length. The separation set further includes a third tube configured to be coupled to the container.

Embodiments relate to a separation device, a method of blood separation and use. The separation device comprises a tube, a valve and a separation gel. The tube has a third tube section in the middle, dividing the tube into a first tube section and a second tube section. The first tube section has an opening and the second tube section is a closed cavity. The valve comprises a valve cover facing the first tube section and an elastic body connected thereto. The valve cover has an outer diameter between the inner diameter of the first tube section and the third tube section to be positioned at the third tube section during centrifugation. The valve cover has a gap portion to form a gap flow channel when cooperating with the third tube section to allow blood and separation gel to pass through during centrifugation and complete the layering. The elastic body springs back after centrifugation to lock the valve at the third tube section to mechanically separate the plasma from the blood cells. The separation gel has a density between the plasma and the blood cells and is positioned at the interface between the plasma and the blood cells after centrifugation. Thus, the separation of the plasma from the blood cells in the separation device and the separation thereof can be achieved after one centrifugation.

The utility model relates to an auxiliary device for extracting platelet-rich plasma, which belongs to the technical field of blood separation and is characterized in that a top cap is mounted at the top of a vertical column of the auxiliary device for extracting platelet-rich plasma, a base is mounted at the bottom of the vertical column, and a first reciprocating linear push-pull screw and a second reciprocating linear push-pull screw are inserted into the top surface of the top cap; a left supporting piece and a right supporting piece are arranged on the two sides of the stand column, a first injector and a second injector which are used for containing blood subjected to centrifugal treatment are installed on the side faces of the left supporting piece and the right supporting piece, the injectors are squeezed through a first reciprocating linear push-pull screw and a second reciprocating linear push-pull screw, and layered blood is pushed out and collected. The collection container can select a sticking bag and a binding bag for collection, the first injector and the second injector are kept vertically installed through supporting of the left supporting piece and the right supporting piece, the sticking bag, the binding bag or the collection container is replaced after blood is collected by one layer, the next layer continues to be collected, and the sealing cap is detached or installed in real time according to operation requirements in the process.

A method of treating a subject with acute liver failure is disclosed. The method involves including an EBDLR system into the subject's blood circuit and passing blood through the EBDLR system, where the blood is continuously taken from the subject. Further, the method includes separating the blood into a plasma component and remainder using a plasma separator of the EBDLR system and then passing the plasma component into a bio purifier having a plurality of layers. Each layer may include hepatocytes on a first side of a membrane in a first channel, and endothelial cells on a second side of the membrane in a second channel. Furthermore, the method includes splitting the plasma component into the first channel and the second channel of the plurality of layers to purify the plasma component, restoring the blood by combining the purified plasma component and the remainder, and continuously returning the restored blood into the subject.