79 results about "Blood separation" patented technology

Clot material may be removed from a patient and separated from blood so that the blood may be collected using an efficient dual-stroke technique. The methods described herein withdraw clot and blood from a patient during a first stoke of a pump at a first rate, filter the blood to remove clot, and drive the filtered blood into a collection chamber at a second rate that is different from the first rate. The first rate may be optimized to disrupt and remove clot, while the second rate may be optimized to move the blood without damaging, e.g., lysing, the blood.

A processing device includes a pump system, a valve system, a centrifuge, and a controller. A fluid flow circuit is mounted to the device to execute a procedure in which whole blood is processed into a red blood cell product, a plasma product, and a platelet concentrate product. The blood is first separated into red blood cells, buffy coat, and plasma using the centrifuge, with the red blood cells and plasma being removed from the centrifuge, while the buffy coat remains in the centrifuge. The fluid remaining in the centrifuge is circulated through the centrifuge to form a homogenous mixture. Once the mixture is formed, it is separated in the centrifuge into platelet concentrate and red blood cells. A platelet product is then collected by using whole blood or previously collected red blood cells to push the platelet concentrate from the centrifuge to a collection container.

The present application belongs to the technical field of blood separation, and particularly relates to a blood separator, which comprises an upper chamber, a middle chamber, a lower chamber, a connecting part, an injection hole, an injection needle with an air filter plug, a sealing cap and a sampling port. The injection needle with the air filter plug facilitates blood injection and prevents the blood from being polluted by the external environment. During the separation process, the liquid level in the chamber can be adjusted by extruding the upper chamber or the lower chamber, so that the target product reaches the highest possible purity, and the liquid level adjustment mode effectively solves the problem of liquid leakage. The upper chamber and the middle chamber, and the lower chamber and the middle chamber can be communicated or isolated by controlling the rotation angle of the rotating piston, which is convenient and fast.

The utility model relates to a blood separating and sampling device which comprises a test tube, the tube cap is detachably arranged on the test tube, a catheter is arranged on the tube cap, and the lower end of the catheter is located in the test tube; the sampling pipe is arranged in the guide pipe in a lifting manner, and a sampling channel is arranged in the sampling pipe; a flexible plug and a bottom end cover are respectively arranged at the upper end and the lower end of the sampling tube and are used for plugging the sampling channel; the flexible plug protrudes out of the upper end face of the pipe cap, and a sampling opening communicated with the sampling channel is formed in the lower end of the sampling pipe. When the sampling tube is in a closed state, the bottom end cover is propped against the conduit, so that liquid in the test tube is prevented from entering the conduit and the sampling channel; a needle tube is arranged at one end of the sampler, the sampling tube descends to enable the sampling opening to enter the liquid at the bottom of the test tube, and the needle tube pierces the flexible plug to suck the liquid in the test tube into the sampler. The utility model provides a blood separating and sampling device which can be used for carrying out sample collection on a specific layer of a centrifugally layered blood sample.

An EBDLR system includes a multi-layered bio purifier having a plurality of layers. Each layer includes a membrane, a first type of cells on a first side of the membrane in a first channel, and a second type of cells on a second side of the membrane in a second channel. The EBDLR includes a plasma separator to receive blood from a subject and separate a plasma component from the blood, a first reservoir to collect the plasma component, and a second pump to move the plasma component from the first reservoir to the multi-layered bio purifier. The multi-layered bio purifier distributes the plasma component into the first and second channels of each layer to purify the plasma component. The EBDLR includes a second reservoir to collect the purified plasma component and a third pump to infuse the purified plasma component from the second reservoir into the subject.

The invention discloses a temperature-controllable magnetic separation blood transfusion pipeline, and belongs to the technical field of blood separation pipelines. The blood transfusion pipeline comprises an inner-layer pipe and an outer-layer sleeve arranged on the periphery of the inner-layer pipe in a sleeving mode. A gap between the inner-layer tube and the outer-layer sleeve is arranged to be a first channel and is used for transporting a cooling medium, and the inner-layer tube is arranged to transport blood to be separated; one end of the inner-layer pipeline is provided with a non-return tip, one side of the non-return tip is provided with a non-return bead, and the non-return bead and the non-return tip are sequentially arranged in the blood transportation direction. The non-return ball and the non-return tip are matched with each other, so that only blood can pass through the non-return ball, and magnetized cells or non-magnetic particles with relatively large particle sizes are prevented from entering back-section blood circulation; the first channel directly cools the blood flowing through the inner-layer tube, the cooling efficiency is high, cooling is uniform, heat exposure of the blood is reduced to the maximum extent from the path, and the heat injury risk is reduced.

The present invention discloses a method for evaluating the chromatographic effect of a blood-separated plasma sample based on image detection. First, a high-resolution camera or a video camera is used to collect a blood separation image in real time, and a suitable light source is configured to eliminate errors caused by changes in the color or transparency of the blood. Furthermore, the collected image is preprocessed (such as grayscale processing) to convert the original blood stratification effect into a clear grayscale image. Furthermore, after the blood is centrifuged to form a red blood cell layer, a white blood cell-platelet layer, and a plasma layer, and then the top layer of the blood, i.e., the plasma layer, or an area containing a small portion of the white blood cell-platelet layer, is quickly located and extracted through coarse segmentation. Furthermore, through fine segmentation, the white blood cell-platelet layer is removed from the plasma layer to obtain an image with clear edges and containing only the plasma layer. Finally, an evaluation is performed based on the impurity content of the plasma layer in the image, and a purity analysis result is ultimately given.

The utility model discloses a blood separator based on puerpera bleeding detection. The blood separator comprises a shell, the upper part of the shell is provided with circular groove bodies which are symmetrically arranged; a rotary drum is rotationally connected into the tank body; a hollow shaft is fixedly connected to the bottom center of the drum; a separation cylinder is arranged in each rotating cylinder; limiting blocks which are symmetrically arranged are fixedly connected to the outer side of the separating cylinder; limiting grooves are formed in the positions, corresponding to the limiting blocks, of the side wall of the rotary drum. After a medical worker uses the separating cylinder to receive amniotic fluid and blood mixed liquid flowing out of a puerpera, the amniotic fluid and blood mixed liquid is placed in the rotating cylinder, the motor is used for driving the rotating cylinder to rotate, then the mixed liquid is centrifuged in the rotating cylinder under the cooperation of the rotating cylinder, the separating cylinder and the curved plate, and the sliding rod can be operated after standing for a little time; according to the scheme, blood is discharged into the container, then medical staff can know the condition of the puerpera by observing the blood in real time, and guarantee is provided for life safety of the puerpera.

The application discloses a self-driven disc type blood separation and detection device and method, which comprises a sample adding layer, a separation layer and a detection layer, and the layers are sequentially connected through screw fixation. The sample adding layer is provided with a sample adding port and a first screw hole; the separation layer comprises four repeated blood separation units and a second screw hole, and each separation unit comprises a sample inlet, a micro-fluidic channel, a filter groove, a sample outlet and a waste liquid collecting chamber; and the detection layer is provided with a screen-printed electrode interface and a third screw hole. Blood samples are dripped into the device from the sample adding port, and under the driving of the internal negative pressure of the device, the blood samples enter the micro-fluidic channel, and blood filtration is realized by using the gravity difference between blood cells and blood plasma. The filtered blood plasma flows into the detection layer and contacts with the screen-printed electrode detection unit, so that electrochemical detection is realized. The device does not need external power supply, thereby reducing sample operation, reducing the volume of the separation device, improving the blood separation efficiency, and facilitating instant detection and multi-channel detection of blood samples.

The utility model discloses an automatic platelet-rich plasma separator, and relates to the technical field of blood separation. According to the automatic platelet-rich plasma separator, by arranging a collecting cylinder, a piston, a connecting pipe, a mounting plate, an extraction pipe, an electric telescopic rod and a supporting frame, the function of automatically collecting enriched liquid is achieved, an air cylinder is started to drive the collecting cylinder to move through a moving plate, and the collecting cylinder drives the extraction pipe to enter a test tube through the mounting plate; the electric telescopic rod drives the piston to slide, so that enriched liquid can be conveniently extracted or discharged, the extraction process is more stable, plasma layering and mixing caused by vibration during manual extraction are avoided, and the quality of a finished product is improved.

The utility model discloses an air tightness detection device for a blood separation cup, and relates to the technical field of blood separation cup detection, the detection device comprises a machine body provided with a standard cavity and a detection cavity, two pump bodies, a first pressure gauge and a second pressure gauge, the first pressure gauge is used for detecting air pressure in the standard cavity, and the second pressure gauge is used for detecting air pressure in the detection cavity. The second pressure gauge is used for detecting the air pressure in the detection cavity; one pump body is connected with the standard cavity and is used for pressurizing the gas in the standard cavity, and the other pump body is connected between the standard cavity and the detection cavity and is used for transmitting the pressurized gas in the standard cavity into the detection cavity so as to detect the blood separation cup in the detection cavity through the second pressure gauge; wherein the volume size of the standard cavity is consistent with the volume size of the detection cavity. Through the arrangement, the technical problem that the detection mode of the blood separation cup in the prior art is unreliable can be solved.

The present invention provides a rapid detection microfluidic chip and detection method for prostate cancer markers, which belongs to the technical field of rapid screening of prostate cancer. The technical problems of the existing detection methods being cumbersome to operate and having a long detection cycle are solved. The technical solution is as follows: it includes a microarray structure for blood separation and a color development microchannel structure for detecting free prostate-specific antigen F-PSA and total prostate-specific antigen T-PSA respectively; the microarray composed of "V"-shaped grooves forms a blood separation structure, which separates red blood cells, white blood cells, and large platelet particles in the blood by physical separation; the functional fragments of F-PSA and T-PSA are fixed and captured in advance in the color development microchannel structure, and the semi-quantitative detection of F-PSA and T-PSA is achieved by measuring the color development length of the color development microchannel. The beneficial effects of the present invention are: the microfluidic chip of the present invention is simple to operate, the results are easy to read, and the analysis is fast.

The application discloses a real-time monitoring and intelligent control system and method for blood separation, comprising a blood separation module, a real-time detection module, a data processing and analysis module and a parameter dynamic adjustment module. The blood separation module is used for performing blood separation operation, the real-time detection module is used for real-time detection of process state parameters in the blood separation operation, the data processing and analysis module compares the state parameters with ideal separation parameters and generates adjustment instructions, and the parameter dynamic adjustment module receives the adjustment instructions and adjusts the operation parameters of the blood separation module. The application utilizes the blood separation module to separate blood to be separated, the real-time detection module detects state parameters, and the operation parameters of the blood separation module are automatically adjusted according to the state parameters, so that efficient and accurate separation of blood is realized, and the separation effect and efficiency are improved.

The invention provides a double-position centrifugal plasma purification system, and belongs to the technical field of plasma purification. Comprising a plasma collection system, a plasma adsorption system and a liquid feedback system, the plasma collection system and the liquid feedback system are both connected with a blood supplier to form a blood closed-loop conveying loop, and the plasma adsorption system is connected with the plasma collection system and the liquid feedback system; the plasma collecting system comprises two centrifugal machines and further comprises a back-flushing cleaning system, and the two centrifugal machines are alternately connected with the plasma collecting system and the back-flushing cleaning system through a first control valve and a second control valve. The centrifugal machine after each round of blood separation is flushed through the backflushing cleaning system, blood residues in a container of the centrifugal machine are avoided, free hemoglobin rising caused by long-time centrifugation of blood components is avoided, and the effect of improving the safety and reliability of the blood purification process is achieved.

The present invention relates to an intelligent blood separation workstation, comprising a workbench, a cover, a storage box, a blood collection tube fixing assembly, a pipette tip storage rack for storing pipette tips, a three-axis gripping mechanism, and a pipette assembly. The three-axis gripping mechanism comprises a three-dimensional mobile drive assembly; the pipette assembly comprises a mounting frame, a plurality of screw rods provided on the mounting frame, a gear mounting block threadedly connected to the screw rods, a mounting bar provided on the gear mounting block, and a pipette gun fixedly connected to the mounting bar; the gear mounting block is provided with a plurality of rotary gears, the rotary gear is provided with a gear transmission shaft connected to the rotary gear, and the mounting bar is provided with a first vertical rack meshing with the rotary gear. In the intelligent blood separation workstation of the present invention, the three-axis gripping mechanism and the pipette assembly are separated into two independent groups of components, so that the gripping and blood separation functions can be operated separately, thereby improving the efficiency of storage and blood separation, and increasing reliability.

The utility model discloses a connecting piece and a leukocyte-depleted filter composed of the same, and belongs to the technical field of blood separation. The connecting piece comprises a filter connecting pipe and a pipeline connecting pipe which are coaxially connected, the circumferential surface of the filter connecting pipe is an inclined surface, and a threaded area is arranged on the circumferential surface of the filter connecting pipe. The leukocyte-depleting filter comprises a filter body 201 and the connecting piece. Threaded areas are arranged on the inner walls of interfaces at the liquid inlet end and the liquid outlet end of the filter body, the inner walls of the interfaces are inclined planes, and the filter connecting pipe of the connecting piece is inserted into the interfaces and is in threaded connection with the interfaces. According to the application, the leukocyte-depleting filter made of the PP material is connected with the pipeline made of the PVC material through the connecting piece made of the polycarbonate material, and transition is performed through the connecting piece, so that the joint of the connecting piece and the leukocyte-depleting filter as well as the joint of the connecting piece and the pipeline are relatively stable in the damp-heat sterilization process, the phenomenon of separation is avoided, and the yield is increased.

Systems and methods are provided for improving efficiency and quality of plasma being removed from a blood separation chamber. The system includes a separation chamber in which plasma is separated from cellular blood components, a pump for moving the plasma and an outlet line for removing the separated plasma from the blood separation chamber. An optical sensor assembly is configured to monitor the blood separation chamber and measure an interface position between the separated component and the plasma, and to generate an output indicative of the measured interface position. A controller is programmed to utilize a lipid concentration input of the blood and to set an original lipemia offset, a lipemia threshold and lipemia final setpoint from a predetermined database, and to use a proportional-integral-derivative control loop to assess the actual interface position plus the lipemia threshold to adjust and achieve a final lipemia setpoint for use during separation procedures.

The invention relates to the technical field of biomedical equipment, and particularly provides a blood separation workstation. Specifically, the blood separation workstation comprises a storage device, a pipetting device, a centrifugation device, a visual quality control device, a first uncovering device, a second uncovering device, a first transfer device and a second transfer device, the storage device is used for storing blood samples and consumables, the first uncovering device is used for uncovering blood collection tubes, and the second uncovering device is used for uncovering blood collection tubes. The first transfer device can move out the blood collection tubes in the storage device; the pipetting device can transfer blood in the blood collection tube into the centrifugal tube, and the centrifugal device is used for centrifuging the blood; the visual quality control device is used for collecting and identifying layered images of blood, the pipetting device can respectively move out the layered blood, and the second cover opening device is used for opening and closing a cover of the centrifugal tube; and the second transfer device can transfer the centrifugal tube. According to the blood separation workstation, blood separation work can be automatically achieved, and the working efficiency and quality of blood separation are improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating blood stasis type pulmonary nodules and a preparation method thereof. The pharmaceutical composition for treating blood stasis type pulmonary nodules has the effects of regulating pivot and dispersing blood stasis, and is prepared from the following raw material medicines: scutellaria baicalensis, cassia twig, dried ginger, radices trichosanthis, angelica sinensis, liquorice, radix bupleuri, peach kernel, safflower, platycodon grandiflorum, ligusticum wallichii and fructus aurantii. Through the synergistic effect of'pivot regulation 'and'stasis removal', the limitation of qi and blood separation intervention in a traditional treatment method is solved, and the purpose of bidirectional regulation and control is achieved; furthermore, a scheme of treating both qi and blood is provided for integrated intervention aiming at the complex pathogenesis of modern diseases of emotion depression combined with blood stasis, finally, the aim of effectively treating or improving the blood stasis type pulmonary nodules is achieved, and a brand new technical scheme is provided for clinical treatment of the blood stasis type pulmonary nodules.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing / collecting until the calculated volume of pure plasma equals the target plasma collection volume.

The utility model relates to the technical field of umbilical cord blood separation, and particularly discloses an umbilical cord blood separation preparation bag which comprises a plurality of blood bags, a main pipeline, a three-way valve, a needle head and a Luer taper. Wherein each blood bag is used for storing umbilical cord blood in the blood collection bag; one end of the main pipeline is communicated with the plurality of blood bags; an outlet of the three-way valve communicates with the main pipeline; the needle is communicated with one inlet of the three-way valve; the Luer taper is communicated with the other inlet of the three-way valve; the Luer taper is used for being connected with an injector so that the injector can be communicated with the blood bag. By means of the arrangement, when the needle head is communicated with the blood collection bag, transfer of umbilical cord blood from the blood collection bag to the blood bag can be completed; when the Luer taper is communicated with the injector, the reagent in the injector can be smoothly injected into the blood bag, leakage is avoided, and the safety of reagent adding is improved. Wherein the reagent is a hematopoietic stem cell separating medium.

To provide an improved blood separation system, apparatus and method for monitoring pressure in a leukoreduction filter, identifying the cause of flow restriction in the filter, and adjusting fluid processing.SOLUTION: Systems, devices and methods for processing whole blood are disclosed. The system includes a reusable separation device, a disposable fluid flow circuit, and a controller configured to detect a flow restriction in the leukocyte depletion filter and identify a cause of the flow restriction.SELECTED DRAWING: Figure 1

This invention relates to the field of blood separation technology, and more particularly to an optically visualized layering system and method for blood separation. This method aims to solve the problems of low separation efficiency, insufficient visualization capabilities, and poor layering accuracy in existing centrifugation techniques. The system includes an optical microscopy imaging module, a preprocessing module, a layering recognition module, and a 3D visualization module. A three-stage training strategy (pre-training, fine-tuning, and dynamic enhancement) improves the robustness of the layering recognition module model, achieving a layering error rate of ≤3% and a total process time of <5 minutes. This significantly improves the accuracy, efficiency, and visualization effects of blood separation, making it suitable for clinical diagnosis and biomedical research.

The utility model relates to the technical field of fish and shrimp processing, in particular to a waste fish and shrimp smashing device which comprises a shell, a smashing device body and a separating part are arranged in the shell, and the smashing device body is matched with the separating part to smash fish and shrimps and conduct solid-liquid separation on fish and shrimp meat paste; wherein a cleaning assembly is further arranged in the shell, the cleaning assembly comprises a push plate, the push plate is used for cleaning meat paste, a brush plate is detachably connected to the bottom of the push plate, fish and shrimps are effectively smashed, the meat paste and blood can be separated in cooperation with a sieve plate, the meat paste obtained after blood is separated is beneficial to subsequent processing treatment, and in addition, the cleaning assembly is used for cleaning the meat paste. While meat paste is discharged through the push plate, the brush plate can be used for cleaning the sieve plate, the sieve plate is prevented from being blocked by the meat paste to affect use, the push plate and the sieve plate can be rapidly detached and replaced, the situation that the crushing efficiency of fishes and shrimps is affected by the tedious disassembly and assembly process is avoided, the structure is simple, and operation is easy and convenient.

1. Name of the product in this design: Sterile PRP Blood Separation Kit. 2. Purpose of this design: PRP blood separation kit. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention relates to a blood separation tube for a centrifugal separation apparatus, and more specifically to a blood separation tube having a cell activation section, wherein physical pressure is generated through collision with the centrifuged blood, thereby activating blood cells such as platelets, leukocytes, and lymphocytes in the blood. To this end, the invention is characterized by comprising: a tube body having a chamber for containing blood; and a cell activation section protruding from the inner surface or interior of the chamber to activate blood cells through physical collision with the centrifuged blood.

The invention discloses a cord blood separation and pathogen detection integrated system in the technical field of blood detection. The cord blood separation and pathogen detection integrated system comprises an information acquisition module, a data processing module, a separation module and a pathogen confirmation module, the information acquisition module is used for acquiring image information of umbilical cord blood cells; the data processing module analyzes the acquired image information through a trained deep learning model, judges whether the sample is HIV infection, HBV infection or non-infection, marks the sample which is judged to be HIV infection and HBV infection, and transmits the marked sample to the pathogen confirmation module; the separation module is used for centrifuging the umbilical cord blood sample and extracting stem cells; the pathogen confirmation module comprises a nucleic acid detection unit and an antigen-antibody detection unit, and the nucleic acid detection unit is used for automatically extracting cell nucleic acid and confirming whether the samples are infected or not according to the HIV infected and HBV infected samples marked by the data processing module; the antigen-antibody unit and a nucleic acid detection result are mutually verified through a chemical judge immunoassay method.

The application discloses a blood separation equipment with a calling function, and relates to the technical field of medical devices, comprising: an equipment main body, a power shaft, a rotating disc, a material placing rack and a sample bottle. The application also discloses a separation method of the blood separation equipment with the calling function, comprising the following steps: sample placing, sample separation and sample taking. The application is characterized in that the power shaft, the rotating disc, the material placing rack and the sample bottle are arranged, the rotating disc and the power shaft are detachably connected through a spline shaft and a spline groove, and the material placing rack and the sample bottle are turned over under the action of centrifugal force when the sample is centrifugally separated, so that the sample bottle tends to be parallel, the sample in the sample bottle is stratified, and after the sample bottle is restored to the vertical state, the stratified sample can be kept in the stratified state, thereby the stratification effect is saved, the sample bottle is conveniently taken and placed, and the stratification efficiency of the device is improved.