The invention discloses a Chinese medicine effective part composition with an antitumor effect and a preparation method thereof, in particular to a Chinese medicine effective part composition extracted from oldenlandia diffusa, astragalus mongholicus and centipede and a preparation method thereof, belonging to the field of traditional Chinese medicines. In the Chinese medicine composition, effective parts are extracted from the oldenlandia diffusa, the astragalus mongholicus and the centipede as main ingredients, then corresponding auxiliary materials are added so as to prepare pills, tablets, granules, hard capsules, mixtures, pill drops, soft capsules, effervescent tablets, injections or powder-injections used for inhabiting tumor growth, reducing a tumor body, adjusting immunologic function, improving immunity of a human body, prolonging the life of a patient with the tumor, effectively relieving adverse reactions such as leucopenia, dizziness, tireness, weakness, magersucht, poor appetite, nausea and vomiting and the like caused by operation, radiotherapy or chemotherapy of the patient with the tumor; and the Chinese medicine effective part composition has the advantages of definite effective ingredients, obvious drug effect, less dosage and diversified formulation, is convenient to use, conforms to the modern requirements on the traditional Chinese medicine and has betterdevelopment prospect.