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Application of spleen aminopeptide in preparation of drug for treating leukopenia

A technology of leukopenia and chemotherapy drugs, applied in the application field of medicine, can solve the problem that the treatment dose of leukopenia has not been studied in depth

Pending Publication Date: 2020-07-07
北京第一生物化学药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no in-depth study on whether spleen aminopeptide can effectively improve leukopenia and its appropriate therapeutic dose

Method used

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  • Application of spleen aminopeptide in preparation of drug for treating leukopenia
  • Application of spleen aminopeptide in preparation of drug for treating leukopenia
  • Application of spleen aminopeptide in preparation of drug for treating leukopenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The establishment and treatment of embodiment 1 leukopenia mouse model

[0037] 1. Materials: 6-8 weeks old female ICR mice, provided by the Department of Animals, Peking University Health Science Center.

[0038] 2. Establishment and treatment of leukopenia mouse model:

[0039] Thirty 6-8 week-old female ICR mice (provided by the Animal Department of Peking University Health Science Center) were randomly divided into 6 groups, 5 mice in each group.

[0040] The first group is the blank control group (CK), which is fed with 1ml of normal saline every day; the other five groups are the experimental groups, which are injected with equal doses of chemotherapy drug epirubicin hydrochloride solution (10mg / kg body weight) on the 0th, 5th, and 10th days respectively. ). Among them, the second group is the chemotherapy group (EPI), and the third to sixth groups are the treatment groups. Peptide (7.5mg / kg / day for intragastric administration, HD-SAOS), Ganoderma lucidum oral ...

Embodiment 2

[0041] Embodiment 2 The effect of spleen aminopeptide oral solution on leukopenia mouse index

[0042] 1. Effects of spleen aminopeptide oral solution, Ganoderma lucidum oral solution, and GCSF injection on the body weight of white chemotherapy mice

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Abstract

The invention discloses application of spleen aminopeptide in preparation of a drug for treating leucopenia. The leucopenia is caused by chemotherapy drugs such as epirubicin hydrochloride; and the spleen aminopeptide is a spleen aminopeptide solution or spleen aminopeptide freeze-dried powder, can significantly improve myelosuppression condition of mice, and has the effect of treating the leucopenia caused by the chemotherapy drugs. By constructing an ICR mouse chemotherapy model, the spleen aminopeptide is verified to be capable of remarkably improving the myelosuppression condition of the mice, effectively relieving the leucopenia symptom of the mice after chemotherapy, and remarkably improving the survival condition of the mice, so that a new way and method are provided for treating the leucopenia.

Description

technical field [0001] The invention belongs to the field of biochemical pharmacy, and relates to a new application of spleen aminopeptide, in particular to an application of spleen aminopeptide in preparing medicine for treating leukopenia. Background technique [0002] Malignant tumors are diseases that seriously threaten human life and health, and are one of the main causes of death. Chemotherapy is currently one of the important methods for treating malignant tumors, such as epirubicin hydrochloride, cyclophosphamide, and paclitaxel. Although these drugs have rescued There are many cancer patients, but the side effects such as low immune function, leukopenia, and hair loss seriously affect the survival status of patients. According to statistics, 80% of chemotherapy patients will suffer from myelosuppression, resulting in a decrease in the number of red blood cells, white blood cells, and platelets in the body, which in turn causes symptoms such as anemia and decreased i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61P7/00
CPCA61K38/012A61P7/00
Inventor 郑新越王瑾
Owner 北京第一生物化学药业有限公司
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