66 results about "Post-chemotherapy" patented technology

The invention provides a composition for promoting hair regeneration after chemotherapy as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: modifying the surface of a gold nanocage with polydopamine, loading the modified gold nanocage on an exosome, complexing magnesium ions and zinc ions to prepare a modified exosome, preparing a nano drug-loaded liposome from curcumin, resveratrol and epigallocatechin gallate, mixing the nano drug-loaded liposome with the modified exosome to prepare a multi-layer liposome, and preparing the multi-layer liposome from the nano drug-loaded liposome. And mixing with a penetration enhancer, and adding into a temperature-sensitive hydrogel system to prepare the composition for promoting hair regeneration after chemotherapy. The composition for promoting hair regeneration after chemotherapy has a good transdermal absorption promoting effect, can slowly release drugs, promotes hair follicles to be converted from a resting stage to a growing stage under the synergistic effect of the drugs, regulates and controls multiple pathways (such as anti-apoptosis, angiogenesis promotion and anti-inflammation) at the same time, is matched with a complex pathological mechanism of hair regeneration after chemotherapy, and can promote hair regeneration after chemotherapy. Wide application prospects are realized.

The invention discloses a multi-mode chemotherapy response prediction system and method. A data set is based on pathological image data and gene data related to chemotherapy data; the first data processing module acquires a histopathological image data block through multi-parameter collaborative acquisition of chemotherapy patient pathological image slice segmentation and hole elimination; the second data processing module queries a gene data set according to gene expression standardization based on chemotherapy patient genes to obtain a first pathological gene feature vector; the third data processing module is used for processing the tissue pathological image data block based on an ImageNet pre-trained ResNet-50 model to obtain a first pathological image feature vector; the bilinear pooling module combines the first pathological gene feature vector and the first pathological image feature vector based on a cross-modal interaction method to obtain a fused pathological image gene feature vector; the attention clustering module performs package-level prediction on the fused pathological image features and gene features based on multi-instance learning to obtain patient chemotherapy response; the method can more accurately and reliably predict the potential response of the patient after chemotherapy.

The invention relates to the technical field of veterinary chemical drugs, and provides an application of a selenium-rich composition in a drug for preventing bone marrow suppression after chemotherapy of dogs, and the selenium-rich composition comprises nano-selenium-beta-glucan chelate and L-selenium-methyl selenocysteine, the mass ratio of the nano-selenium-beta-glucan chelate to the L-selenium-methyl selenocysteine is 1: (0.3-0.6), and the mass ratio of the nano-selenium-beta-glucan chelate to the L-selenium-methyl The molar ratio of the astragaloside IV to the cobamamide is (5 to 8): 1. Through the synergistic effect of the nano-selenium-beta-glucan chelate and the L-selenium-methyl selenocysteine and in combination with the loading technology of the silicon dioxide mesoporous carrier, the absorption rate of selenium is greatly improved.

The invention provides a solid-liquid phase-change microcapsule cooling cold cap for preventing alopecia in chemotherapy. The solid-liquid phase-change microcapsule cooling cold cap comprises a shell layer, a phase-change cooling layer and a heat-conducting attaching layer, the phase change cooling layer is sealed between the heat conduction bonding layer and the shell layer; the phase change cooling layer comprises a frame and phase change microcapsules; the frame is built between the shell layer and the heat-conducting laminating layer, and the phase change microcapsules are filled between the shell layer and the heat-conducting laminating layer; the phase change microcapsule is a microcapsule encapsulated by a low-temperature solid-liquid phase change material; the solid-liquid phase change material is used as a cooling material, the cooling effect is remarkable, the solid-liquid phase change material is not particularly hard after being frozen, still has a certain deformation space and can be attached to all parts of the head of a patient, medical silica gel is used as the scalp attaching layer, the scalp attaching layer is soft, breathable and good in heat conduction and scalp attaching effect, and the cooling effect is good. The cold cap and the head of the patient are attached more tightly, and the phenomenon that a gap exists between the cold cap and the scalp, and the head anti-falling effect is affected after chemotherapy is avoided.

The present invention provides a cold-stimulus-resistant nursing device after tumor chemotherapy, belonging to the field of nursing appliances. It includes a wrapping member; a heat-conducting pipe is arranged inside the wrapping member, and heat-generating devices are movably connected to both ends of the heat-conducting pipe. The heat-generating device includes an outer housing, and a blowing structure and a heat-adjusting structure are respectively arranged inside the outer housing. A leak-proof structure is connected between the heat-conducting pipe and the outer housing; the blowing structure includes a central shaft rod rotatably connected to the axis of the outer housing, a variable-frequency motor is fixedly connected inside the outer housing, and an output end of the variable-frequency motor is fixedly connected with a first bevel gear. This application can meet the use of people with different heights, generate heat quickly at the same time, form a circulating heating, the heat in each area is more uniform, and the heat can be automatically adjusted according to the wind speed, and the sealing effect of the structure at the connection between the outer housing and the heat-conducting pipe can be automatically adjusted according to the wind speed.

The invention discloses a traditional Chinese medicine composition for reinforcing qi, nourishing blood and strengthening body resistance after tumor chemoradiotherapy and a detection method thereof. The traditional Chinese medicine composition is prepared from astragalus membranaceus, codonopsis pilosula, angelica sinensis, poria cocos, cistanche, caulis spatholobi, radix paeoniae alba, glossy privet fruit, eclipta, hairyvein agrimony, medlar, Chinese yam, radix rehmanniae, radix ophiopogonis, deer-horn glue, tortoise-shell glue, pericarpium citri reticulatae and liquorice. The optimal traditional Chinese medicine composition and dosage are screened out through a large number of experimental screening and clinical medication experience, treatment is conducted on the basis of syndrome differentiation, compatibility is reasonable, the effects of reinforcing qi, nourishing blood and strengthening the body resistance are achieved together, immunity is improved, and the traditional Chinese medicine composition can be used for tumor chemoradiotherapy and postoperative conditioning and treatment of symptoms such as anemia, bone marrow suppression, thrombocytopenia and elderly weakness. Content determination is carried out through TLC identification and HPLC, and a scientific basis is provided for guaranteeing the clinical quality and effectiveness of reinforcing qi, nourishing blood and strengthening body resistance.

The present invention discloses the application of SREBF1 in the preparation of chemotherapeutic drugs for treating acute T-lymphoblastic leukemia, belonging to the technical field of biomedicine. The present invention clarifies the changes in the bone marrow microenvironment of T-ALL patients before and after chemotherapy and inhibits its protective effect on minimal residual disease, clarifies the role of SREBF1 in the abnormal lipidation of the bone marrow microenvironment after T-ALL chemotherapy, and inhibiting the function of SREBF1 can inhibit the generation of adipocytes induced by DEX, thereby reversing the protective effect of adipocytes on residual T-ALL cells. Therefore, inhibiting SREBF1 may be a feasible strategy to solve the recurrence dilemma of T-ALL, which is beneficial to the development of clinical therapeutic drugs for clearing minimal residual T-ALL, provides new treatment ideas and drugs for effectively clearing minimal residual disease of T-ALL and further improving the treatment of T-ALL, and has very important clinical significance.

The invention discloses a nutritional composition capable of regulating appetite and body weight of people after chemotherapy and improving taste perception capability and application thereof. The nutritional composition provided by the invention contains milk powder, soybean protein, concentrated whey protein, bovine colostrum powder, hydrolyzed yolk, a red bean extract, a Chinese date extract, lily freeze-dried powder, broccoli freeze-dried powder, a radish seed extract, a peach kernel extract, xanthan gum and Arabic gum. The food can obviously increase appetite of people after chemotherapy and restore weight, and is helpful for treating or improving symptoms such as inappetence, weight loss and weakness of chemotherapy patients. When being applied to paclitaxel (PTX)-induced taste disorder model animals, the paclitaxel protein can improve the taste perception capability, increase the cross sectional area of a taste bud, remarkably repair taste structural damage, reduce the level of proinflammatory factors in serum and relieve hepatotoxicity caused by a chemotherapeutic drug PTX; and moreover, the water solubility and the stability are better, adhesion and layering are avoided, and stable storage is facilitated.

The invention relates to the technical field of tumor chemotherapy, in particular to a nursing device used after tumor chemotherapy. According to the technical scheme, the nursing frame comprises a nursing frame body, a fixing frame and a supporting frame, the lower surface of the nursing frame body is connected with a sleeve frame, the upper surface of the nursing frame body is sleeved with the fixing frame, a fixing rod is fixed to the outer end face of one side of the fixing frame, and the outer end face of one side of the fixing rod is rotationally connected with a connecting bearing; a movable frame is rotationally connected to the outer end face of one side of the connecting bearing, a rotating plate is connected to the outer end face of one side of the movable frame, a mounting frame is connected to the lower surface of the supporting frame, a connecting frame sleeves the upper surface of the supporting frame, and a movable bearing is fixed to the outer end face of one side of the connecting frame; a rotating frame is rotationally connected to the outer end face of one side of the movable bearing, and massage layers are fixed to the inner walls of the nursing frame body, the sleeve frame, the supporting frame and the mounting frame. According to the invention, varicosity of a patient can be prevented, and liquid medicine exosmosis and phlebitis incidence rate can be reduced.

The invention discloses a traditional Chinese medicine prescription for treating myelosuppression after chemotherapy as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine prescription is prepared from ten traditional Chinese medicines including caulis spatholobi, flos caryophylli, astragalus membranaceus, rhizoma cimicifugae, sanguisorba officinalis, hairyvein agrimony, rhodiola rosea, codonopsis pilosula, cinnamon and angelica sinensis, and has the effect of obviously improving myelosuppression after chemotherapy. Meanwhile, the traditional Chinese medicine composition has good curative effects on four types of myelosuppression after chemotherapy, including leucopenia, neutropenia, thrombocytopenia and over-low hemoglobin. The prescription is good in stability, high in safety and remarkable in curative effect.

The invention discloses an anti-cold stimulation nursing appliance after tumor chemotherapy, and relates to the field of tumor chemotherapy nursing, the anti-cold stimulation nursing appliance comprises a fixing layer, a skin-friendly heat conduction layer is arranged at the bottom of the fixing layer, a shell is arranged at the top of the fixing layer, a heat insulation adjusting mechanism is arranged at the upper part of the interior of the shell, and a phase change energy storage unit is arranged at the lower part of the interior of the shell. A penetrating groove is formed in the side wall of the shell, the phase change energy storage unit is slidably connected with the shell through the penetrating groove, and the phase change energy storage unit is located below the heat insulation adjusting mechanism. A power system is completely abandoned, risks of electric leakage, electromagnetic radiation and short circuit are eradicated, the device is particularly suitable for chemotherapy patients with fragile body functions, the device can be safely used in any environment (even during oxygen uptake), stable constant-temperature care for 4-6 hours is provided continuously through the physical characteristics of the heat-conducting phase-change material, and the service life of the device is prolonged. The one-time working time is far longer than that of a traditional hot water bag and most electric heating products, and the nursing burden of frequent replacement is reduced.

The utility model relates to the technical field of anti-cold stimulation nursing protectors, in particular to an anti-cold stimulation nursing protector used after tumor chemotherapy, which solves the problems mentioned in the background technology and comprises a fixing tube, air bags are connected to the inner walls of the two ends of the fixing tube, a communicating hole is formed in a body of the fixing tube and communicated with the air bags, and the air bags are communicated with the communicating hole. The outer wall of the fixing pipe is fixedly connected with an air inlet pipe communicated with the communicating hole, an air inlet assembly is installed on the air inlet pipe, the outer wall of the fixing pipe is connected with a heat preservation pipe, a water cavity is formed in a body of the fixing pipe, the middle of the outer wall of the fixing pipe is fixedly connected with a water injection pipe, the water injection pipe is communicated with the water cavity, and the water injection pipe is in threaded connection with a packaging cap. The moving assembly is installed on the fixing pipe, air is injected into the air bag through the air inlet assembly to enable the air bag to expand, the fixing pipe is fixed to the arm, the moving ring is pulled through the traction rope, the friction plate rubs the skin of the arm, the problem of arm itching is solved, and the device is simple in structure and convenient to operate.

The present invention discloses a composition for improving rhinitis symptoms and nasal cleaning, as well as its preparation method and application. The composition comprises, by weight, 0.1 to 7 parts of yeast β-glucan and 0.1 to 6 parts of mussel mucin. The present invention prepares a composition for improving rhinitis symptoms and nasal cleaning by rationally combining ultra-low molecular weight yeast β-glucan, low molecular weight yeast β-glucan, medium molecular weight yeast β-glucan, high molecular weight yeast β-glucan, and mussel mucin. The composition can be effectively used for nasal cleaning of patients with nasal diseases such as acute rhinitis, chronic rhinitis, allergic rhinitis, nasal polyps, sinusitis, etc., and can also be used for nasal cleaning after nasal tumor surgery or chemotherapy.

The invention relates to a medicinal and edible compound extract for improving myelosuppression of a tumor patient after chemotherapy, and a preparation method and application of the medicinal and edible compound extract. The compound extract is extracted from a composition at least comprising the following raw material medicines in parts by weight: 0.9-10 parts of tricholoma matsutake, 0.9-10 parts of mulberry and 0.5-10 parts of rhizoma polygonati. The raw material medicine composition further comprises the following raw material medicines in parts by weight: 0.7-10 parts of longan, 0.5-10 parts of pericarpium citri reticulatae, 0.5-10 parts of scorched hawthorn fruit, 0.5-10 parts of fructus amomi, 1.1-10 parts of cordyceps sinensis rice flour and 2.5-15 parts of rice peptide. The selected raw material medicines are all medicinal and edible components, do not cause adverse effects on liver and kidney functions and gastrointestinal tracts of eaters, and are high in safety and high in patient acceptance degree. Effect verification results show that the mulberry compound extract has an improvement effect on the side effect of bone marrow suppression of tumor patients, especially in the early stage, no related adverse reaction is found, and a safe and effective treatment choice is provided for bone marrow suppression.

The present invention provides a kind of Chinese medicine preparation for preventing and treating myelosuppression after chemotherapy, relates to the field of Chinese medicine pharmacy, the Chinese medicine preparation is made of 1-15 parts of antler glue, 1-10 parts of astragalus, 1-10 parts of cinnamon twig, 1-10 parts of notoginseng, 1-10 parts of immature bitter orange, 1-10 parts of rhizoma anemarrhenae, 1-10 parts of phellodendron, and the Chinese medicine preparation of the present invention has the effects such as replenishing qi and blood, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. The Chinese medicine preparation of the present invention can reverse the myelosuppression caused by 5-FU chemotherapy by improving the peripheral blood count and bone marrow pathological damage of chemotherapy mice. In addition, the Chinese medicine preparation of the present invention can improve the 5-FU chemotherapy effect by increasing the 5-FU tumor inhibition rate, suppressing tumor weight, tumor volume and promoting tumor tissue necrosis. The Chinese medicine preparation of the present invention and the chemotherapy drug 5-FU are used in combination to have a certain synergistic and toxicity-reducing effect, and are expected to be developed as a medicine for preventing and treating myelosuppression after chemotherapy.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and application thereof. Aiming at the pathogenesis that the spleen and stomach are damaged by antituberculous drugs, so that the spleen is disabled in transportation, damp turbidity is stopped, stomach is disharmonized and reduced, and cold and heat are mixed, the invention provides a traditional Chinese medicine composition consisting of nine medicines such as fresh ginger, ginger processed pinellia, roasted rhizoma atractylodis macrocephalae, rhizoma atractylodis, dried tangerine or orange peel and poria cocos. The traditional Chinese medicine composition disclosed by the invention has the advantages of few medicines, quick response, high safety and good curative effect, can be used for remarkably improving gastrointestinal reaction of a tuberculosis patient after chemotherapy by being combined with conventional treatment, has a clear synergistic effect and has a remarkable application advantage.

The invention provides a pharmaceutical composition for protecting intestinal injury caused by chemotherapy and application, and belongs to the field of medicines. The invention also provides a pharmaceutical composition for protecting intestinal mucosa tight junction injury caused by chemotherapy. The pharmaceutical composition is prepared from the following raw material medicines in parts by weight: 1-3 parts of astragalus polysaccharide and 1-3 parts of ziyuglycoside I. According to the invention, the compatibility of astragalus polysaccharide and ziyuglycoside I not only can improve the immunity of the organism after chemotherapy, but also can protect intestinal mucosal injury caused by intestinal chemotherapy drugs, and solves the problem that no special-effect drug for intestinal injury after chemotherapy exists in the current market, and pharmacodynamic tests prove that when the compatibility of astragalus polysaccharide and ziyuglycoside I is used, the curative effect is obvious. The intestinal mucosa tight junction injury caused by chemotherapy is protected, and the synergistic effect is achieved. The composition disclosed by the invention has the effects of protecting intestinal injury caused by pet chemotherapy or diarrhea of young animals, maintaining the integrity of the form and the structure of intestinal tissues, enhancing the immunity of the young animals, reducing the economic loss and reducing the use of antibiotics.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for replenishing qi, enriching blood, tonifying spleen and nourishing kidney as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2 to 12 parts of radix angelicae sinensis, 5 to 20 parts of radix codonopsis, 5 to 20 parts of radix astragali seu hedysari, 2 to 12 parts of rhizoma atractylodis macrocephalae, 2 to 15 parts of poria cocos, 3 to 13 parts of colla corii asini, 3 to 13 parts of tortoise-shell glue, 2 to 12 parts of herba cistanche, 5 to 15 parts of radix rehmanniae praeparata, 3 to 15 parts of rhizoma polygonati, 3 to 13 parts of herba epimedii, 2 to 12 parts of fructus crataegi, 5 to 15 parts of arillus longan, 2 to 12 parts of fructus ligustri lucidi, 2 to 6 parts of fructus schisandrae chinensis and 1 to 5 parts of cortex cinnamomi. The traditional Chinese medicine composition has the main effects of replenishing qi, enriching blood, tonifying spleen and nourishing kidney, is used for rehabilitation after cancer surgery or chemotherapy and used for resisting cancer relapse, is particularly used for patients with spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy, and improves the problems of emaciation, insomnia, inappetence, mental fatigue and tiredness and the like of the patients with the patients with the spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy.

The invention discloses an anti-cancer selenium-enriched soft-shelled turtle soup medicated diet and a making method thereof, and belongs to the technical field of traditional Chinese medicine medicated diets and functional foods. The medicated diet is prepared by taking selenium-rich soft-shelled turtle as a main material and combining traditional Chinese medicinal materials such as lucid ganoderma, astragalus membranaceus, medlar, Chinese yam and poria cocos through scientific proportioning and a staged low-temperature stewing process. The medicated diet disclosed by the invention is rich in selenium element and polysaccharide and triterpenoid active ingredients, and has remarkable effects of resisting oxidation, enhancing immunity and inhibiting tumor cell growth. According to the preparation method, the nutritional ingredients and pharmacodynamic substances are reserved to the maximum extent through the technologies of raw material pretreatment, step-by-step feeding, precise temperature control and the like. The medicine is suitable for adjuvant therapy of cancer patients, physique recovery after radiotherapy and chemotherapy and anti-cancer health care of high-risk groups.

The invention is suitable for the technical field of biological medicine, and provides application of 20 (S)-protopanaxatriol in preparation of a medicine for inhibiting tumor metastasis of liver cancer chemotherapy. According to the embodiment of the invention, a molecular mechanism of chemotherapy-induced liver cancer immunosuppression and metastasis increase is analyzed and studied, a key effect of an SHP2-PI3K / AKT signal axis in TAM M2 polarization is disclosed, a novel natural small molecule 20 (S)-protopanaxatriol capable of inhibiting the activity of SHP2 is provided, TAM is blocked from being polarized to an M2 type by inhibiting phosphorylation of SHP2 and activation of a downstream PI3K / AKT signal channel, and the activity of SHP2 is inhibited. Therefore, the tumor immune microenvironment after chemotherapy is improved, the tumor metastasis risk after chemotherapy is reduced, and the overall treatment effect is improved on the premise that safety is guaranteed.

The application provides a pharmaceutical composition for protecting intestinal injury caused by chemotherapy and use, and belongs to the field of medicines. The application also provides a pharmaceutical composition for protecting tight junction injury of intestinal mucosa caused by chemotherapy, which is prepared from raw medicinal materials in the following proportions by weight: 1-3 parts of astragalus polysaccharide and 1-3 parts of sanguisorba officinalis saponin I. The astragalus polysaccharide combined with the sanguisorba officinalis saponin I can not only improve the immunity of the body after chemotherapy, but also protect the intestinal mucosa injury caused by intestinal chemotherapy drugs, and solves the problem that there is no specific drug for intestinal injury after chemotherapy on the market. The drug efficacy test proves that the astragalus polysaccharide combined with the sanguisorba officinalis saponin I has a synergistic effect on protecting the tight junction injury of intestinal mucosa caused by chemotherapy. The composition of the application can protect the intestinal injury of pets caused by chemotherapy or diarrhea of young animals, maintain the integrity of the intestinal tissue morphology and structure, enhance the immunity of young animals, reduce economic losses, and reduce the use of antibiotics.

The present disclosure relates to a medicinal composition and related methods using Lawsone (2-hydroxy-1,4-naphthoquinone) as a key active ingredient for treating pain associated with chemotherapy-induced palmar plantar erythrodysesthesia (Hand-Foot Syndrome). The medicinal composition may be administered topically as a gel, ointment, cream, lotion, suspension, spray, transdermal patch or liquid alone or in combination with other topical steroids, topical NSAIDS, antiarrhythmics, moisturizers, capsaicin, emollients, herbal remedies and essential or carrier oils. The medicinal composition eliminates the pain and burning sensation experienced with palmar-plantar erythrodysesthesia and allows patients to carry on with normal daily activities after a session of chemotherapy.

This invention relates to the field of special medical foods, and particularly to a special medical food formula for colorectal cancer patients, its preparation method, and its application. The raw materials, in parts by weight, include: 20-30 parts Codonopsis pilosula, 20-30 parts Rehmannia glutinosa (processed), 20-30 parts Astragalus membranaceus, 10-20 parts Coix lacryma-jobi (raw), 10-20 parts Atractylodes macrocephala, 10-20 parts Poria cocos, 10-20 parts Angelica sinensis, 10-20 parts Paeonia lactiflora, 10-20 parts Prunus persica, 3-6 jujubes, 3-15 parts Glycyrrhiza uralensis, 6-15 parts phycocyanin, and 6-15 parts citric acid. This formula can have anti-tumor effects, reduce the toxic side effects of chemotherapy, enhance the reticuloendothelial cell system, promote the enhancement of specific and non-specific immune functions in the body, thereby reducing tumor volume and inhibiting tumor proliferation and metastasis. The drug is encapsulated in Dunaliella salina exosomes and targeted modified to ensure accurate delivery to the lesion site, increasing bioavailability and reducing the drawbacks of a small therapeutic window and high toxicity.

The invention provides application of a traditional Chinese medicine composition in preparation of a medicine for relieving myelosuppression after chemotherapy, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises 18-30 parts of deer heart blood powder, 10-15 parts of ginseng, 4-10 parts of radix polygonati officinalis, 4-10 parts of semen ziziphi spinosae, 18-25 parts of semen coicis, 4-10 parts of fructus citri, 8-15 parts of poria cocos and 8-15 parts of radix puerariae, can relieve the bone marrow injury form after chemotherapy, promotes peripheral blood circulation and immune cell recovery, and shows the effect of relieving bone marrow suppression after chemotherapy. The traditional Chinese medicine composition is free of toxic and side effects, easy to absorb, high in safety after long-term use and free of obvious drug resistance, and has a good prospect in preparation of drugs for conditioning bone marrow functions after chemotherapy.

The invention provides application of selenocysteine or a derivative thereof in resisting chemotherapy injury. Experiments prove that selenocysteine or a derivative thereof can promote proliferation and growth of hematopoietic stem cells, enhance functions of the hematopoietic stem cells, inhibit apoptosis of the hematopoietic stem cells, resist chemotherapy injury, promote recovery of hematopoietic stem cells, leukocytes and platelets after chemotherapy and prolong the lifetime after chemotherapy.

The invention provides application of Yupingfeng granular polysaccharide, and particularly relates to application of the Yupingfeng granular polysaccharide in preparation of a medicine for preventing damage caused by cyclophosphamide. The Yupingfeng granule polysaccharide disclosed by the invention is used as an active ingredient of a medicine, can relieve chemotherapy injury caused by cyclophosphamide, such as weight loss, spleen injury and thymus injury, and can also play a role in relieving and even reversing the abnormal number of leukocytes.

The invention relates to an effect of ACSL6 in promoting colorectal cancer chemosensitization. According to clinical colorectal cancer patient specimens and queue follow-up F data, the expression level of ACSL6 in chemotherapy-tolerant colorectal cancer patient tissues is obviously reduced. The expression level of the ACSL6 shows obvious negative correlation with poor prognosis of a colorectal cancer patient after chemotherapy, so that the ACSL6 can be used for predicting the chemotherapy tolerance and sensitivity degree of the colorectal cancer, and early evaluation is provided for a scheme of preoperative treatment of the patient. The invention discloses a potential inhibitor for colorectal cancer chemotherapy resistance, which can be used for preparing a colorectal cancer chemotherapy sensitizing drug, and is beneficial to increasing the sensitivity of colorectal cancer cells to the chemotherapy drug so as to improve the treatment effect and prognosis of a colorectal cancer patient.

The application provides a kind of common solid tumor activity image evaluation method and medium in children abdomen, utilize 3D convolution neural network model, capture the change information of lesion on the image of plain scan and enhancement after intravenous period, carry out intelligentized silhouette generation lesion in the intensification area and intensification degree after chemotherapy, finally comprehensively all information is intelligently diagnosed, judge tumor activity, form abdominal solid tumor artificial intelligence auxiliary activity evaluation scheme after chemotherapy;The application utilizes the plain scan and enhanced CT image, realizes the automatic intensification degree quantitative evaluation of children hepatoblastoma, nephroblastoma and neuroblastoma by tumor automatic segmentation and registration subtraction image calculation, so as to extract lesion characteristics from multiple angles, fully excavate image information, which can significantly improve the accuracy and sensitivity of activity discrimination of children abdominal solid tumor after chemotherapy.

This invention discloses the application of Tiaoqi Jiedu Tongyou granules in the preparation of anti-esophageal cancer drugs targeting the IL1B / AHR / PSMD3 axis, belonging to the field of biomedical technology. Experiments have demonstrated that Tiaoqi Jiedu Tongyou granules can significantly downregulate the expression of IL1B, AHR, and PSMD3 proteins in cisplatin-induced esophageal cancer cells, inhibit cisplatin-induced treatment-related aging and aging-related secretory phenotypes, reduce the secretion of IL-6, IL-8, CXCL2, and TNF-α, and inhibit cell proliferation, migration, and invasion in a concentration-dependent manner. It can intervene in high-risk esophageal cancer patients identified by the IL1B / AHR / PSMD3 trigene prognostic model. This invention also discloses an anti-esophageal cancer drug containing the active ingredients of the granules and pharmaceutically acceptable excipients, which can intervene in high-risk esophageal cancer patients identified by the IL1B / AHR / PSMD3 trigene prognostic model. This invention provides a new drug intervention pathway for aging-related inflammation and recurrence after esophageal cancer chemotherapy, and has significant clinical application value.

The invention discloses a gastric cancer drug-resistant animal model with clinical chemotherapy drug resistance and a construction method of the gastric cancer drug-resistant animal model. The model is characterized in that the model carries Cldn18-CreERT2; apcfl / fl; trp 53fl / fl; the method comprises the following steps: hybridizing a gastric cancer spontaneous tumorigenesis transgenic mouse of KrasG12D (Cldn18-ATK) with a CadD1371A / D1371A gene knock-in mouse, so as to obtain a Cldn18-ATK CadD1371A / D1371A double gene edited mouse; experiments show that the tumor volume reduction degree of the model after 5-FU chemotherapy is obviously lower than that of a control group (Cad + / +), and the proliferative activity (Ki-67 level) and the lifetime prolonging effect are also obviously weakened, so that the model simulates the clinical chemotherapy drug resistance phenotype. The model provides an efficient tool for gastric cancer drug resistance mechanism research and chemotherapy drug screening, and has important application value.