36 results about "Post-chemotherapy" patented technology

The invention relates to the technical field of tumor chemotherapy, in particular to a nursing device used after tumor chemotherapy. According to the technical scheme, the nursing frame comprises a nursing frame body, a fixing frame and a supporting frame, the lower surface of the nursing frame body is connected with a sleeve frame, the upper surface of the nursing frame body is sleeved with the fixing frame, a fixing rod is fixed to the outer end face of one side of the fixing frame, and the outer end face of one side of the fixing rod is rotationally connected with a connecting bearing; a movable frame is rotationally connected to the outer end face of one side of the connecting bearing, a rotating plate is connected to the outer end face of one side of the movable frame, a mounting frame is connected to the lower surface of the supporting frame, a connecting frame sleeves the upper surface of the supporting frame, and a movable bearing is fixed to the outer end face of one side of the connecting frame; a rotating frame is rotationally connected to the outer end face of one side of the movable bearing, and massage layers are fixed to the inner walls of the nursing frame body, the sleeve frame, the supporting frame and the mounting frame. According to the invention, varicosity of a patient can be prevented, and liquid medicine exosmosis and phlebitis incidence rate can be reduced.

The invention discloses an anti-cold stimulation nursing appliance after tumor chemotherapy, and relates to the field of tumor chemotherapy nursing, the anti-cold stimulation nursing appliance comprises a fixing layer, a skin-friendly heat conduction layer is arranged at the bottom of the fixing layer, a shell is arranged at the top of the fixing layer, a heat insulation adjusting mechanism is arranged at the upper part of the interior of the shell, and a phase change energy storage unit is arranged at the lower part of the interior of the shell. A penetrating groove is formed in the side wall of the shell, the phase change energy storage unit is slidably connected with the shell through the penetrating groove, and the phase change energy storage unit is located below the heat insulation adjusting mechanism. A power system is completely abandoned, risks of electric leakage, electromagnetic radiation and short circuit are eradicated, the device is particularly suitable for chemotherapy patients with fragile body functions, the device can be safely used in any environment (even during oxygen uptake), stable constant-temperature care for 4-6 hours is provided continuously through the physical characteristics of the heat-conducting phase-change material, and the service life of the device is prolonged. The one-time working time is far longer than that of a traditional hot water bag and most electric heating products, and the nursing burden of frequent replacement is reduced.

The invention relates to a medicinal and edible compound extract for improving myelosuppression of a tumor patient after chemotherapy, and a preparation method and application of the medicinal and edible compound extract. The compound extract is extracted from a composition at least comprising the following raw material medicines in parts by weight: 0.9-10 parts of tricholoma matsutake, 0.9-10 parts of mulberry and 0.5-10 parts of rhizoma polygonati. The raw material medicine composition further comprises the following raw material medicines in parts by weight: 0.7-10 parts of longan, 0.5-10 parts of pericarpium citri reticulatae, 0.5-10 parts of scorched hawthorn fruit, 0.5-10 parts of fructus amomi, 1.1-10 parts of cordyceps sinensis rice flour and 2.5-15 parts of rice peptide. The selected raw material medicines are all medicinal and edible components, do not cause adverse effects on liver and kidney functions and gastrointestinal tracts of eaters, and are high in safety and high in patient acceptance degree. Effect verification results show that the mulberry compound extract has an improvement effect on the side effect of bone marrow suppression of tumor patients, especially in the early stage, no related adverse reaction is found, and a safe and effective treatment choice is provided for bone marrow suppression.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and application thereof. Aiming at the pathogenesis that the spleen and stomach are damaged by antituberculous drugs, so that the spleen is disabled in transportation, damp turbidity is stopped, stomach is disharmonized and reduced, and cold and heat are mixed, the invention provides a traditional Chinese medicine composition consisting of nine medicines such as fresh ginger, ginger processed pinellia, roasted rhizoma atractylodis macrocephalae, rhizoma atractylodis, dried tangerine or orange peel and poria cocos. The traditional Chinese medicine composition disclosed by the invention has the advantages of few medicines, quick response, high safety and good curative effect, can be used for remarkably improving gastrointestinal reaction of a tuberculosis patient after chemotherapy by being combined with conventional treatment, has a clear synergistic effect and has a remarkable application advantage.

The invention provides a pharmaceutical composition for protecting intestinal injury caused by chemotherapy and application, and belongs to the field of medicines. The invention also provides a pharmaceutical composition for protecting intestinal mucosa tight junction injury caused by chemotherapy. The pharmaceutical composition is prepared from the following raw material medicines in parts by weight: 1-3 parts of astragalus polysaccharide and 1-3 parts of ziyuglycoside I. According to the invention, the compatibility of astragalus polysaccharide and ziyuglycoside I not only can improve the immunity of the organism after chemotherapy, but also can protect intestinal mucosal injury caused by intestinal chemotherapy drugs, and solves the problem that no special-effect drug for intestinal injury after chemotherapy exists in the current market, and pharmacodynamic tests prove that when the compatibility of astragalus polysaccharide and ziyuglycoside I is used, the curative effect is obvious. The intestinal mucosa tight junction injury caused by chemotherapy is protected, and the synergistic effect is achieved. The composition disclosed by the invention has the effects of protecting intestinal injury caused by pet chemotherapy or diarrhea of young animals, maintaining the integrity of the form and the structure of intestinal tissues, enhancing the immunity of the young animals, reducing the economic loss and reducing the use of antibiotics.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for replenishing qi, enriching blood, tonifying spleen and nourishing kidney as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2 to 12 parts of radix angelicae sinensis, 5 to 20 parts of radix codonopsis, 5 to 20 parts of radix astragali seu hedysari, 2 to 12 parts of rhizoma atractylodis macrocephalae, 2 to 15 parts of poria cocos, 3 to 13 parts of colla corii asini, 3 to 13 parts of tortoise-shell glue, 2 to 12 parts of herba cistanche, 5 to 15 parts of radix rehmanniae praeparata, 3 to 15 parts of rhizoma polygonati, 3 to 13 parts of herba epimedii, 2 to 12 parts of fructus crataegi, 5 to 15 parts of arillus longan, 2 to 12 parts of fructus ligustri lucidi, 2 to 6 parts of fructus schisandrae chinensis and 1 to 5 parts of cortex cinnamomi. The traditional Chinese medicine composition has the main effects of replenishing qi, enriching blood, tonifying spleen and nourishing kidney, is used for rehabilitation after cancer surgery or chemotherapy and used for resisting cancer relapse, is particularly used for patients with spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy, and improves the problems of emaciation, insomnia, inappetence, mental fatigue and tiredness and the like of the patients with the patients with the spleen and kidney deficiency type cachexia after cancer surgery or chemotherapy.

The invention is suitable for the technical field of biological medicine, and provides application of 20 (S)-protopanaxatriol in preparation of a medicine for inhibiting tumor metastasis of liver cancer chemotherapy. According to the embodiment of the invention, a molecular mechanism of chemotherapy-induced liver cancer immunosuppression and metastasis increase is analyzed and studied, a key effect of an SHP2-PI3K / AKT signal axis in TAM M2 polarization is disclosed, a novel natural small molecule 20 (S)-protopanaxatriol capable of inhibiting the activity of SHP2 is provided, TAM is blocked from being polarized to an M2 type by inhibiting phosphorylation of SHP2 and activation of a downstream PI3K / AKT signal channel, and the activity of SHP2 is inhibited. Therefore, the tumor immune microenvironment after chemotherapy is improved, the tumor metastasis risk after chemotherapy is reduced, and the overall treatment effect is improved on the premise that safety is guaranteed.

The application provides a pharmaceutical composition for protecting intestinal injury caused by chemotherapy and use, and belongs to the field of medicines. The application also provides a pharmaceutical composition for protecting tight junction injury of intestinal mucosa caused by chemotherapy, which is prepared from raw medicinal materials in the following proportions by weight: 1-3 parts of astragalus polysaccharide and 1-3 parts of sanguisorba officinalis saponin I. The astragalus polysaccharide combined with the sanguisorba officinalis saponin I can not only improve the immunity of the body after chemotherapy, but also protect the intestinal mucosa injury caused by intestinal chemotherapy drugs, and solves the problem that there is no specific drug for intestinal injury after chemotherapy on the market. The drug efficacy test proves that the astragalus polysaccharide combined with the sanguisorba officinalis saponin I has a synergistic effect on protecting the tight junction injury of intestinal mucosa caused by chemotherapy. The composition of the application can protect the intestinal injury of pets caused by chemotherapy or diarrhea of young animals, maintain the integrity of the intestinal tissue morphology and structure, enhance the immunity of young animals, reduce economic losses, and reduce the use of antibiotics.

This invention relates to the field of special medical foods, and particularly to a special medical food formula for colorectal cancer patients, its preparation method, and its application. The raw materials, in parts by weight, include: 20-30 parts Codonopsis pilosula, 20-30 parts Rehmannia glutinosa (processed), 20-30 parts Astragalus membranaceus, 10-20 parts Coix lacryma-jobi (raw), 10-20 parts Atractylodes macrocephala, 10-20 parts Poria cocos, 10-20 parts Angelica sinensis, 10-20 parts Paeonia lactiflora, 10-20 parts Prunus persica, 3-6 jujubes, 3-15 parts Glycyrrhiza uralensis, 6-15 parts phycocyanin, and 6-15 parts citric acid. This formula can have anti-tumor effects, reduce the toxic side effects of chemotherapy, enhance the reticuloendothelial cell system, promote the enhancement of specific and non-specific immune functions in the body, thereby reducing tumor volume and inhibiting tumor proliferation and metastasis. The drug is encapsulated in Dunaliella salina exosomes and targeted modified to ensure accurate delivery to the lesion site, increasing bioavailability and reducing the drawbacks of a small therapeutic window and high toxicity.

The invention relates to an effect of ACSL6 in promoting colorectal cancer chemosensitization. According to clinical colorectal cancer patient specimens and queue follow-up F data, the expression level of ACSL6 in chemotherapy-tolerant colorectal cancer patient tissues is obviously reduced. The expression level of the ACSL6 shows obvious negative correlation with poor prognosis of a colorectal cancer patient after chemotherapy, so that the ACSL6 can be used for predicting the chemotherapy tolerance and sensitivity degree of the colorectal cancer, and early evaluation is provided for a scheme of preoperative treatment of the patient. The invention discloses a potential inhibitor for colorectal cancer chemotherapy resistance, which can be used for preparing a colorectal cancer chemotherapy sensitizing drug, and is beneficial to increasing the sensitivity of colorectal cancer cells to the chemotherapy drug so as to improve the treatment effect and prognosis of a colorectal cancer patient.

The application provides a kind of common solid tumor activity image evaluation method and medium in children abdomen, utilize 3D convolution neural network model, capture the change information of lesion on the image of plain scan and enhancement after intravenous period, carry out intelligentized silhouette generation lesion in the intensification area and intensification degree after chemotherapy, finally comprehensively all information is intelligently diagnosed, judge tumor activity, form abdominal solid tumor artificial intelligence auxiliary activity evaluation scheme after chemotherapy;The application utilizes the plain scan and enhanced CT image, realizes the automatic intensification degree quantitative evaluation of children hepatoblastoma, nephroblastoma and neuroblastoma by tumor automatic segmentation and registration subtraction image calculation, so as to extract lesion characteristics from multiple angles, fully excavate image information, which can significantly improve the accuracy and sensitivity of activity discrimination of children abdominal solid tumor after chemotherapy.

This invention discloses the application of Tiaoqi Jiedu Tongyou granules in the preparation of anti-esophageal cancer drugs targeting the IL1B / AHR / PSMD3 axis, belonging to the field of biomedical technology. Experiments have demonstrated that Tiaoqi Jiedu Tongyou granules can significantly downregulate the expression of IL1B, AHR, and PSMD3 proteins in cisplatin-induced esophageal cancer cells, inhibit cisplatin-induced treatment-related aging and aging-related secretory phenotypes, reduce the secretion of IL-6, IL-8, CXCL2, and TNF-α, and inhibit cell proliferation, migration, and invasion in a concentration-dependent manner. It can intervene in high-risk esophageal cancer patients identified by the IL1B / AHR / PSMD3 trigene prognostic model. This invention also discloses an anti-esophageal cancer drug containing the active ingredients of the granules and pharmaceutically acceptable excipients, which can intervene in high-risk esophageal cancer patients identified by the IL1B / AHR / PSMD3 trigene prognostic model. This invention provides a new drug intervention pathway for aging-related inflammation and recurrence after esophageal cancer chemotherapy, and has significant clinical application value.

This invention relates to the field of novel pharmaceutical applications, specifically to the application of traditional Chinese medicine (TCM) compositions and their compounding modifiers. The application of the TCM composition in the preparation of promoters that enhance the efficacy of chemotherapy drugs, wherein the active ingredients of the TCM composition, by weight, include 20-120 parts of Ganoderma lucidum, 10-90 parts of American ginseng or ginseng, 3-60 parts of fermented Cordyceps militaris powder and / or 3-90 parts of Cordyceps sinensis, and 10-60 parts of rose petals. This TCM composition can improve the efficacy of chemotherapy and, more importantly, alleviate the biochemical side effects caused by chemotherapy, further expanding the application of TCM compositions.

This invention belongs to the field of medical auxiliary device technology and discloses a chemotherapy support device for oncology. It includes a seat body, a respiratory status detection device, and a controller. The seat body is connected to armrests, a Neiguan acupoint massage component, a Zusanli acupoint massage component, an abdominal heat therapy component, a headrest, and a speaker. The Neiguan acupoint massage component includes a base, a motor, a fixed gear ring, a sun gear, planetary gears, and massage balls. The Zusanli acupoint massage component includes an air pump and an airbag. The abdominal heat therapy component includes a strap, a medicine storage box, a heat therapy bag, and an electric heating wire. The respiratory status detection device includes a pressure sensor. This invention utilizes the Neiguan acupoint massage component to stimulate and massage the Neiguan acupoint, the Zusanli acupoint massage component to compress the Zusanli acupoint, and the abdominal heat therapy component to provide heat therapy to the abdomen, effectively relieving symptoms such as nausea and vomiting, numbness in the hands and feet, and abdominal cold pain after chemotherapy.

The utility model relates to the field of medical instruments, in particular to an adjustable lower limb pressurizing device for preventing peripheral neuropathy after chemotherapy, which comprises a sock, a pressurizing component and a bandage. The pressurizing assembly comprises a first pressurizing air bag arranged on the upper area of the shank, a second pressurizing air bag arranged on the lower area of the shank and a third pressurizing air bag arranged on the ankle, and the first pressurizing air bag, the second pressurizing air bag and the third pressurizing air bag are fixed to the outer side of the sock cover and connected with an inflating device through inflating pipes. Massage silica gel is arranged at the position, coinciding with human body acupoint body surface projection, of the inner side of the sock cover, and positioning lines and positioning points corresponding to the physiological structure are arranged on the surface of the sock cover. And the at least two bandages are fixed outside the sock sleeve and the pressurizing air bag at intervals. The pressurizing force can be adjusted in different areas, the concentration distribution difference of chemotherapeutic drugs on lower limbs is matched, and the prevention effect is improved in combination with traditional Chinese medicine acupoint stimulation.

The present invention relates to a new application of 5-oxoproline in the preparation of a drug for preventing or treating cardiomyopathy, and particularly in the prevention or treatment of chemotherapy-induced cardiomyopathy in tumor patients. By means of further research on chemotherapy-induced cardiomyopathy in tumor patients, it has found that 5-oxoproline can partially restore reduced cardiac function, alleviate cardiomyocyte atrophy and myocardial tissue fibrosis, reduce myocardial tissue oxidative stress and cardiomyocyte apoptosis, and can be used for preventing or treating chemotherapy-induced cardiomyopathy in tumor patients, which addresses the currrent problem of no treatment means of small molecule metabolites for chemotherapy-induced cardiomyopathy in tumor patients, exhibits the potential to significantly reduce the mortality of tumor paitents due to cardiovascular disease, and has important significance for clinical prevention and treatment.

The utility model belongs to the technical field of medical apparatus and instruments, disclose a device for preventing peripheral nerve disorder after chemotherapy. The circulation and heat exchange efficiency of the fluid medium of the existing prevention device are limited, leading to small temperature regulating and pressurizing range, poor effect, leading to high chemotherapy interruption rate. The prevention device provided by the utility model places the main body structure of the wearing piece in the sealed box body containing the fluid medium, significantly increases the contact area of the wearing piece and the fluid medium, optimizes the flow path of the fluid medium, improves the circulation efficiency of the fluid medium, and effectively improves the heat conduction efficiency and pressurizing effect between the limbs and the fluid medium. The utility model realizes more rapid and more uniform temperature regulating and pressurizing effect, effectively enhances the prevention efficiency of peripheral nerve disorder after chemotherapy, and has significant clinical application value and market prospect.

The present application provides a ginsenoside-protein peptide complex for nutritional support of cancer patients, and a preparation method and application thereof, and belongs to the technical field of post-chemotherapy nutritional support.The present application comprises ginsenoside Rg3 5-7 parts, ginsenoside Rh2 2-4 parts, Compound K 0.5-1.5 parts, whey protein peptide 80-120 parts, marine fish scale peptide 25-40 parts, beta-glucan 8-12 parts, nano-curcumin 15-25 parts, HMB 20-30 parts, sodium butyrate 35-50 parts, N-acetylcysteine 40-60 parts, vitamin C 40-60 parts, and selenium yeast 0.6-1 part by weight.The present application can play an anti-tumor auxiliary role, provide nutritional support for cancer patients after chemotherapy, reduce the side effects of chemotherapy, and improve the quality of life.

The invention provides a composition for gastrointestinal mucosa protection after chemotherapy and a preparation method and application thereof, and belongs to the technical field of medicine preparation. The composition comprises a traditional Chinese medicine component, phosphatidylcholine and soybean oligosaccharide, the traditional Chinese medicine components comprise a cordyceps militaris extract, loropetalum chinense and Chinese yam. The composition can effectively protect gastric mucosa and repair gastrointestinal mucosa injury, and especially has a good repair effect on gastrointestinal mucosa injury caused by chemotherapy.

The invention provides application of clobetasol in neurotoxic injury treatment, and belongs to the technical field of biological medicine. The clobetasol is proved to be capable of effectively reversing or relieving demyelination, axonal injury, neuroinflammation and depression and anxiety-like behaviors caused by neurotoxic injury, a new treatment strategy is provided for neurotoxic injury occurring after cancer patients are subjected to chemotherapy, the living quality and treatment compliance of the patients can be improved, and the clobetasol can be used for treating neurotoxic injury caused by neurotoxic injury. Meanwhile, the clinical application range of clobetasol is expanded, and a new direction is provided for development of neuroprotective drugs.

According to the present invention, intestinal microbiota of patients diagnosed with colorectal cancer were analyzed, and intestinal microbiota following surgery and chemotherapy were compared and analyzed for the same patient. Through this, microorganisms that exhibited changes in enrichment before and after colorectal cancer treatment were selected, and intestinal microbial markers were selected by determining whether the selected microorganisms could be used to distinguish between a state in which colorectal cancer is present and a state in which colorectal cancer is absent. Therefore, the intestinal microbial marker according to the present invention can be used to determine the prognosis state of a colorectal cancer patient following surgery and chemotherapy.

This invention belongs to the field of medical devices, specifically relating to a positioning and marking device for breast tumor surgery. The device includes a guide needle, a tissue marker clip, a delivery component, and a flexible outer sheath fitted over the needle. The flexible outer sheath is made of a biocompatible shape memory polymer. At body temperature, it is in a first physical state, puncturing the tissue along with the needle. Upon gentle thermal stimulation, it transforms into a second physical state, significantly reducing friction with the needle, allowing the needle to be withdrawn independently, leaving the flexible outer sheath in place within the body, forming a stable guiding channel from the body surface to the marked location. The device can also integrate an intelligent temperature control unit, achieving closed-loop regulation through temperature sensor feedback to ensure safe and effective thermal stimulation. This invention solves the intraoperative positioning problem caused by lesion shrinkage after chemotherapy, combining long-term placement safety, puncture rigidity, and placement flexibility, significantly improving the accuracy and reliability of surgical positioning.

The invention relates to a detoxifying and synergistic chemotherapeutic drug carrier structure triglyceride composition as well as a preparation method and application thereof, belonging to the technical field of biology. The preparation method comprises the following steps: carrying out first ester exchange reaction on mixed oil 1 and lipase 1 to prepare a product 1; the mixed oil 2 and lipase 2 are subjected to a second ester exchange reaction, deodorization and enzyme deactivation are carried out, and a structure triglyceride composition is prepared; wherein the oil material 1 comprises highly unsaturated fatty acid and glycerol; the oil material 2 comprises the product 1, r-linolenic acid, nervonic acid and pinolenic acid. The triglyceride composition with the structure has the effects of detoxifying, improving leukocyte level, erythrocyte level and septicemia after chemotherapy, preventing alopecia and resisting tumors.

The invention relates to the field of medical biology, in particular to an AML (acute myelogenous leukemia) chemotherapy recurrent leukemia stem cell marker with a regulation function, and particularly relates to a PUF60 serving as the AML chemotherapy recurrent leukemia stem cell marker with the regulation function.

The invention discloses a light-operated cell membrane chimeric multi-unit drug-loaded liposome and an application thereof. The light-controlled multi-unit drug-loading liposome comprises a cell membrane, a light-sensitive element, a temperature-sensitive lipid material and a multi-unit drug-loading core, the multi-unit drug-loading core comprises a first drug-loading unit, a second drug-loading unit and a third drug-loading unit, wherein the first drug-loading unit is used for entrapping curcumin by taking vitamin E succinate-grafted-polylysine as a material, the second drug-loading unit is used for entrapping trabectedin by taking natural silk fibroin as a material, and the third drug-loading unit is used for compounding doxorubicin hydrochloride by taking dopamine-grafted-gamma-polyglutamic acid as a material. The light-operated cell membrane chimeric multi-unit drug-loaded liposome can reverse the immunosuppressive microenvironment of tumor tissues and improve the drug resistance problem of glioma after multiple chemotherapy, and has a wide application prospect in the aspect of tumor treatment.

The invention provides a compound preparation for gastrointestinal mucosa protection after chemotherapy and a preparation method thereof, and belongs to the technical field of medicine preparation. The compound preparation comprises a core active component, an energy supply component and an adjusting component, the core active component comprises a cordyceps militaris extract, loropetalum chinense, Chinese yam, phosphatidylcholine and soybean oligosaccharide; the energy supply component comprises amino acids and peptides; and the adjusting component comprises prebiotics. According to the invention, although only a few auxiliary materials are used, the tablet weight difference is small, the friability detection is qualified, and in a 6-month acceleration test, the retention rate of chlorogenic acid and cordycepin is greater than 90%, and the stability is good.

1. Name of the product in this design: Plasma Therapy Device. 2. Applications of this design: for anti-infection, wound healing and inflammation reduction; treatment of skin diseases, and adjuvant therapy after radiotherapy and chemotherapy for tumors. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for preventing and treating myelosuppression and leucopenia caused by tumor chemoradiotherapy and a preparation method and application of the traditional Chinese medicine composition. Comprising the following raw material medicines in parts by weight: 1-45 parts of astragalus membranaceus, 1-45 parts of rhizoma polygonati, 1-45 parts of radices trichosanthis, 1-45 parts of scalded rhizoma drynariae, 1-30 parts of wine-processed glossy privet fruit, 1-30 parts of roasted herba epimedii, 1-30 parts of radix pseudostellariae, 1-30 parts of bighead atractylodes rhizome, 1-20 parts of vinegar-processed radix bupleuri and 1-15 parts of pericarpium citri reticulatae. The composition disclosed by the invention not only can effectively increase the leukocyte count of a patient after radiotherapy and chemotherapy, but also can remarkably improve spleen-kidney deficiency related clinical symptoms, such as soreness and weakness of waist and knees, fatigue, intolerance of cold and cold limbs, reduced appetite and loose stool, accompanied by the patient, so that the dual goals of increasing leukocyte and improving life quality are achieved, and the defect that a traditional treatment medicine treats both symptoms and root causes is overcome.

The present application belongs to the technical field of traditional Chinese medicine composition, and discloses a traditional Chinese medicine composition for treating peripheral nerve toxicity after chemotherapy, which is composed of 10-20 parts of cassia twig, 10-20 parts of mugwort leaf, 5-15 parts of dried ginger, 5-15 parts of chuanxiong rhizome, 5-15 parts of red peony root, 5-15 parts of safflower, 5-15 parts of clematis, 20-40 parts of lonicera japonica, 5-15 parts of astragalus, 5-15 parts of rhabdophis, 5-15 parts of earthworm, 5-15 parts of scorpion and 1-5 parts of asarum, according to the weight component. The traditional Chinese medicine composition has the effects of warming yang and dispelling cold, promoting blood circulation and dredging collaterals, and dispelling wind and relieving pain, and is administered by fumigation and washing, so that the drug power and heat power are synergistic, directly reach the lesion site of the extremity periphery, and have rapid effect, and can effectively improve the nerve toxicity symptoms such as numbness, pain and paresthesia of the extremity caused by chemotherapy, and can be used for preparing a medicine for treating peripheral nerve toxicity caused by chemotherapy.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-induced cold-dampness encumbent spleen syndrome and improving intestinal epithelial cell injury after chemotherapy as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is a medicament prepared from the following raw material medicines in parts by weight: 1-20 parts of ginger processed pinellia, 1-10 parts of pericarpium citri reticulatae, 1-20 parts of poria cocos, 1-10 parts of fructus amomi, 1-20 parts of astragalus membranaceus, 1-10 parts of codonopsis pilosula and 1-10 parts of liquorice. In the preparation of the pharmaceutical composition, volatile component distillates are extracted from fructus amomi in a classified manner by a distillation method, and are included by beta-cyclodextrin; the pharmaceutical composition can be used for preventing / treating chemotherapy-induced cold-dampness obstructing spleen syndrome and improving intestinal epithelial cell injury after chemotherapy, and compared with other traditional Chinese medicines, 5-HT3 antagonist / NK-1 antagonist and dexamethasone, the pharmaceutical composition has the advantages that the effect is wider, and the characteristics of traditional Chinese medicines and comprehensive synergistic treatment and the thought of prevention before disease prevention are embodied.