107 results about "Post-chemotherapy" patented technology

The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

The invention provides a medicinal composition for treating digestive system dysfunction. The medicinal composition is characterized by comprising the following components in parts by weight: 10-25 parts of ginseng, 10-25 parts of bighead atractylodes rhizome, and 12-25 parts of poria. The medicinal composition is particularly suitable for treating gastrointestinal dysfunction after radiotherapy or chemotherapy, is good in curative effect, and does not have toxic or side effect; the patients have good tolerance and can easily accept the medicinal composition; the treatment cost is low. The medicinal composition can be used for treating gastrointestinal dysfunction after radiotherapy or chemotherapy independently, and also can be used for treating malignant tumor diseases by combining radiotherapy or chemotherapy.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

The objective of the invention is to provide a traditional Chinese medicine granule for treating side effects on an alimentary canal after cancer chemotherapy and a preparation method thereof. The invention is characterized in that the granule is prepared from an active component, a binder and pharmaceutically acceptable adjuvant, and the active component is prepared from the traditional Chinese medicines consisting of 600 to 800 g of milkvetch root, 250 to 350 g of dwarf lilyturf tuber, 150 to 250 g of red ginseng, 150 to 250 g of white atractylodes rhizome fried with bran, 150 to 250 g of Poria cocos, 200 to 300 g of licorice, 200 to 300 g of radix scrophulariae, 200 to 300 g of Chinese angelica, 250 to 350 g of dark plum, 250 to 350 g of prepared pinellia tuber, 200 to 300 g of cablin patchouli herb, 200 to 300 g of dried orange peel and 200 to 300 g of curcuma rhizome. The granule is applicable to cancer patients who vomit or retch because of damage of both qi and yin and rising of stomach qi resulting from damage of the spleen and the stomach by anti-radiogenic cancer and chemotherapy drugs, and the granule can mitigate symptoms like no appetite, tiredness, hypodynamia, a red or light red tongue with little fluid and weak pulse.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors and stimulators of stem cell proliferation.

The invention discloses a Chinese medicinal composition for treating Qi-Yin deficiency symptom after radiotherapy and chemotherapy of malignant tumor. The Chinese medicinal composition is characterized in that the medicament is prepared from the following raw material medicaments in portion by weight: 4.5 to 5.5 portions of astragalus, 4 to 6 portions of dendrobium, 3.5 to 6.5 portions of ophiopogon, 3 to 5 portions of atractylodes and 0.5 to 2 portions of mint. The Chinese medicinal composition boosts Qi, nourishes Yin, is used for auxiliary treatment of the Qi-Yin deficiency symptom after the radiotherapy of the malignant tumor and has definite curative effect. The invention also discloses a method for preparing the Chinese medicinal composition.

The invention discloses a medicine for treating post-chemotherapy leucopenia and a preparation method thereof. The medicine consists of the following raw materials in part by weight: 2 to 20 parts of ginseng, 5 to 50 parts of astragalus, 5 to 50 parts of gensing, 5 to 50 parts of largehead atractylodes rhizome, 5 to 30 parts of epimedium, 5 to 20 parts of malaytea scurfpea fruit, 5 to 30 parts ofChinese angelica, 5 to 50 parts of suberect spatholobus stem, 5 to 50 parts of medlar, 5 to 30 parts of dwarf lilyturf tuber, 3 to 25 parts of bupleurum, 3 to 35 parts of largetrifoliolious bugbane rhizome and 1 to 15 parts of pangolin scales. According to the preparation method, the Chinese medicinal composition is prepared according to a method for the conventional preparation of Chinese medicines, wherein the conventional preparation comprises a water decoction, an oral liquid, granules, capsules or powder and the like. According to the medicine, a prescription for treating post-chemotherapy leucopenia is created on the basis of clinical experiences of multiple years, and a curative effect is obvious.

A γ-butyrolactone compound as shown in Formula (I) and pharmaceutical composition thereof: wherein X═N, O, S, Se; and A and B are selected from substituents having the following formula: wherein R1, R2, R3, R4, and R5 are selected from a hydrogen atom, a halogen atom, a hydroxyl group, a mercapto group, an amino group, an alkoxy group, and a nitro group. The γ-butyrolactone compound and pharmaceutical composition thereof butyrolactone have inhibitory effects on hepatoma, ovarian cancer, breast cancer, lung cancer, malignant glioblastoma or colorectal carcinoma, and are cytotoxic with high specificity to inhibit Paclitaxel-resistant tumour cells at later stage of chemotherapy without any damage on normal cells.

The invention discloses a complex probiotic preparation for reducing 5-hydroxytryptamine side effects after chemotherapy, the complex probiotic preparation is characterized in that the complex probiotic preparation is prepared by mixing the following probiotics: bifidobacterium breve, lactobacillus acidophilus, lactobacillus casei and Streptococcus thermophilus according to viable number proportion ratio of 1:1-3:1-3:1-3, and the total viable number of the composite probiotic preparation is 20 billion-80 billion; application of the complex probiotic preparation in preparation of drugs for preventing nausea and vomiting after the chemotherapy and application of the complex probiotic preparation in preparation of drugs for improving intestinal mucositis are disclosed.

This invention relates to a use of G-CSF dimer in the treatment of neutropenia. In particular, the recombinant human G-CSF of the present invention can enhance the differentiation and development of neutrophils in animal, and thus effectively reduce the severity of the severe neutropenia and shorten the time of severe neutropenia for the post-chemotherapy cancer patients. Serum half-life of G-CSF dimer of this invention is prolonged and the biological activity thereof is increased, providing a better effect in the treatment of neutropenia.

The present invention provides a kind of propolis dripping pill and its preparation process. The propolis dripping pill is prepared with propolis extract or pure propolis added with proper matrix. The medicine has simple production process and is suitable for industrial production. It has high bioavailability and fast acting, and is suitable for use in treating hyperlipemia, stomatocace after radiotherapy and chemotherapy of tumor and other diseases.

A method for predicting sensitivity of a cervical cancer patient subjected to paclitaxel and cis-platinum adopted chemotherapy comprises the steps: S1, preopreative examination is performed; S2, nidus analysis is performed; S3, mathematical statistics is performed; S4 sensitivity judgment is performed, namely serum SCC-Ag level analysis and post-chemotherapy MRI measurement are performed to judge chemotherapy sensitivity so as to determine whether a drug resistance rule is subjected to a postoperative pathological measurement result or not, it is confirmed that the patient is drug-sensitive if the drug resistance rule is subjected to the postoperative pathological measurement result, and it is confirmed that the patient is drug-resistant if the drug resistance rule is not subjected to the postoperative pathological measurement result. An experimental result of drug resistance analysis performed by means of the method for predicting the sensitivity of the cervical cancer patient subjected to the paclitaxel and cis-platinum adopted chemotherapy shows that change of the serum SCC-Ag level has close relationship with the sensitivity of cervical squamous cell neoadjuvant chemotherapy, important information can be provided for judgment on drug resistance of the patient, SCC-Ag and magnetic resonance imaging can be jointly and clinically utilized to assess the chemotherapy sensitivity, and the prediction accuracy is obviously higher than the prediction accuracy of an MRI imageology method widely and clinically used at present.

Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.

The invention discloses a medicine aiming at infection after chemotherapy of lymphoma and a preparation method thereof. The medicine comprises the following raw medicinal materials: herb of Christina loosestrife, clove, sappan wood, manyprickle acathopanax root, tree peony bark, thinleaf milkwort root-bark, rhizoma fagopyri dibotryis, pricklyash peel, coptis root, cape jasmine fruit, common leafflower herb, folium artemisiae argyi, honeysuckle flower, lucid ganoderma, platycodon root, safflower, liquorice root, artist's conk, cryptoporus volvatus, plantain herb, rose, heartleaf houttuynia herb and Chinese angelica. The invention also discloses a preparation method. The medicine has the effect of reducing infection after chemotherapy of lymphoma, has better curative effects aiming at infection and supplements with chemotherapy to achieve better effects.

The invention provides application of a SphK2 inhibiting agent ABC294640 in improving hematopoietic stem cell functions and treating hematopoietic dysfunction. The ABC294640 can be used for treating essential hematopoietic dysfunction, or radiation and chemical drug irritated hematopoietic dysfunction, and is capable of improving hematopoietic stem cell functions to improve the recovery rate and the survive rate of hematopoietic function of a patient after chemotherapy is carried out for a plurality of times. According to the drug, a new drug source is provided to treat essential or induced hematopoietic dysfunction diseases.

The invention relates to a method for preparing nanometer stewed corrected injection, and relative application. Wherein, it prepares the total extractive of stewed mutton with ginseng and astragalus and astragalus root, with some findings, into nanometer carriers, to be made into water injection, frozen dried, etc. The inventive product has significant target function, better solution, and stable property. And it has low excitation. The invention can reduce the ache of cancer patient. And it can improve immunity, etc.

The invention relates to a cell growth and / or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and / or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals. Further, the invention relates to antibodies against the peptides, inter alia for diagnostic use, for example, the diagnosis of stress-induced male infertility. The invention also relates to in vitro and in vivo methods for screening of drugs that affect the central nervous system, and are potential modulators of interactions between the “readthrough” form of acetylcholinesterase, AChE-R, the intracellular receptor RACK1 and the kinase PKC.

The invention discloses an application of a cordyceps militaris link extract to preparation of a health-care product or a medicament for prompting leucocyte proliferation of a breast cancer patient. In an extracting method of the cordyceps militaris link extract, water or an ethanol solution is adopted for extracting cordyceps militaris link. As proved by clinical test of a breast cancer chemotherapy patient, the extract has a good effect on prompting the leucocyte proliferation of the chemotherapy patient, and can be used for preparing a health-care food or a medicament for assisting in treating tumors. The invention discloses a novel clinical application of cordyceps militaris link after increase of leucocytes after chemotherapy on the breast cancer patient. The cordyceps militaris link extract plays a positive role in comprehensively utilizing and developing cordyceps militaris link.

Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.

Disclosed is a physiotherapy sleeve suitable for pressurizing and cooling fingertips of four limbs of a patient after chemotherapy. Firstly, an elastic sleeve belt and a sleeve body can be arranged on the wrist or the ankle of a patient in a sleeving mode, then a micro inflation and deflation pump can conduct inflation and deflation, expansion of a pressurization air bag can be regulated and controlled, and the pressurization effect on the fingertips of the patient is achieved; a semiconductor cooler can absorb heat to conduct refrigeration, a cooling sleeve bag can be cooled, the fingertips of the patient can be cooled, absorption of the four limbs of the patient to medicine is reduced, peripheral neurotoxic reaction is relieved, and complications of numbness of the hands and feet of the patient are effectively prevented; meanwhile, a timing relay is beneficial to control on and off time of the micro inflation and deflation pump and the semiconductor cooler; finally, an intelligent control assembly and a sleeve body assembly are convenient to disassemble, assemble and combine, when the sleeve body assembly needs to be replaced, only the intelligent control assembly and the sleeve body assembly need to be disassembled and separated, then a new sleeve body assembly is installed on the intelligent control assembly, and by means of the operation, the sleeve body assembly can be replaced, and the intelligent control assembly can be repeatedly used.

The present invention is medicine for treating thrombocytopenia and anemia and its preparation process and quality control method, and belongs to the field of Chinese medicine technology. The medicine is prepared with donkey-hide gelatin 3.5-6.5 weight portions, astragalus root 140-260 weight portions, angelica 105-195 weight portions, date 70-130 weight portions and antler gelatin 10.5-19.5 weight portions. It has the functions of invigorating qi, nourishing blood, and benefiting kidney and spleen, and is used in treating thrombocytopenia and anemia. It has also certain curative effect on leucopenia caused by radiotherapy and chemotherapy.

The invention discloses an application of dendrobium polysaccharide in preparation of drugs to prevent or restore reproductive injury after chemotherapy. The dendrobium polysaccharide applied to prevent and treat male reproductive injury caused by radiotherapy and chemotherapy has obvious therapeutic effect and small side effects, and can effectively reduce the damage caused by nitrogen mustard anticancer drugs to the reproductive system, which not only makes the sperm quantity of mice rise significantly, but also improves the sperm quality, and effectively improves the antioxidant activity ofmouse testicular tissue, and in mouse testicular tissue, the level of SOD, GPx, GSH and CAT is obviously increased while the level of MDA is obviously decreased. The dendrobium polysaccharide with wide source of raw materials is simple in extraction and purification method, high in sugar content and suitable for large-scale production and popularization and has a good prospect in the preparationand / or treatment of reproductive injury after chemotherapy.

The invention discloses an ointment formula for harmonizing the stomach and stopping vomiting and a preparation method and application thereof. The ointment formula for harmonizing the stomach and stopping vomiting is composed of the following ingredients (by weight): 40-60 parts of chicken's gizzard membrane, 130-170 parts of Chinese yam, 80-120 parts of clean haw, 30-70 parts of perilla stem, 30-70 parts of liquorice tablets, 10-50 parts of steamed dried orange peel, 50-85 parts of bamboo shavings, 30-70 parts of prepared pinellia tuber, 50-85 parts of Radix Ophiopogonis, 80-120 parts of fried Radix Codonopsis, 50-85 parts of dry dendrobium, 100-140 parts of Poria cocos, 130-170 parts of malt, 50-85 parts of bighead atractylodes rhizome, 10-50 parts of banksia rose, 10-50 parts of xylitol and 30-70 parts of ginger. The ointment formula for harmonizing the stomach and stopping vomiting can be combined with platinum-based chemotherapy to remarkably improve side effects after chemotherapy, such as inappetence, nausea and vomit, improve clinical symptoms and physical functions for later period tumor patients after chemotherapy and enhance life quality of the later period tumor patients. Meanwhile, the ointment formula for harmonizing the stomach and stopping vomiting has good safety, has good pharmacoeconomic advantages and is worthy of promotion and application.

The invention discloses application of spleen aminopeptide in preparation of a drug for treating leucopenia. The leucopenia is caused by chemotherapy drugs such as epirubicin hydrochloride; and the spleen aminopeptide is a spleen aminopeptide solution or spleen aminopeptide freeze-dried powder, can significantly improve myelosuppression condition of mice, and has the effect of treating the leucopenia caused by the chemotherapy drugs. By constructing an ICR mouse chemotherapy model, the spleen aminopeptide is verified to be capable of remarkably improving the myelosuppression condition of the mice, effectively relieving the leucopenia symptom of the mice after chemotherapy, and remarkably improving the survival condition of the mice, so that a new way and method are provided for treating the leucopenia.

The invention provides a traditional Chinese medicine marrow hematogenesis composition and an application thereof. The traditional Chinese medicine marrow hematogenesis composition is prepared from the following raw materials in parts by weight: 5-25 parts of human placenta, 5-25 parts of pseudo-ginseng, 15-50 parts of astragalus membranaceus, 10-30 parts of caulis spatholobi, 5-25 parts of radixpseudostellariae, 5-25 parts of glossy privet fruit, 5-25 parts of wolfberry and 5-25 parts of herba epimedii. The marrow hematogenesis composition with a better effect is obtained by combining humanplacenta capable of benefiting qi and nourishing blood, pseudo-ginseng capable of dissipating blood stasis and stopping bleeding, astragalus membranaceus capable of benefiting qi and raising yang, caulis spatholobi capable of promoting salivation and nourishing blood, radix pseudostellariae capable of benefiting qi and invigorating spleen, glossy privet fruit and wolfberry capable of nourishing liver and kidney, and herba epimedii capable of tonifying kidney yang. The traditional Chinese medicine marrow hematogenesis composition provided by the invention has the advantages that the symptom ofleucopenia of tumor patients after chemotherapy is very effectively improved, and the marrow suppression after chemotherapy is improved.