45 results about "Tumor Weight" patented technology

The invention relates to a novel medicine composition capable of synergistically enhancing the capacity of restraining tumor growth. The composition contains tetrandrine and chloroquine. Researches prove that the combined medication of the tetrandrine and the chloroquine with a certain concentration can effectively induce the death of tumor cells; a BALB / c nude mouse is vaccinated with a tumor cell of a person, a tumor is formed, a nude mouse heterograft model is established, and the monitoring on the growth curve of the tumor and the weight of the tumor indicates that the combined medication has the obvious effect of restraining the tumor growth. The invention confirms that the antitumor effect of the medicine combination containing the tetrandrine and the chloroquine is much better than that of the single tetrandrine or the single chloroquine, the medicine combination has an obvious synergistic effect, the basis of clinical combined application of the tetrandrine and the chloroquine for resisting the tumor is provided, and the medicine combination is a potential tumor medicine with high efficiency and low toxicity.

The present invention discloses c-MYC-siRNA formulation as a potential therapeutic target for cisplatin-resistant ovarian cancer. It is disclosed targeting c-MYC with small interfering RNA (siRNA) in the cisplatin-resistant ovarian cancer cell line inducing a significant cell growth arrest and inhibition of cell proliferation. Apoptosis and arrest of cell cycle progression were also observed after c-MYC-siRNA-based silencing of c-MYC. Furthermore, delivering nanoliposomal c-MYC-siRNA, decreased tumor weight and number of tumor nodules compared with a liposomal-negative control siRNA.

The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (PBMC) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells. The rice prolamin is gluten-free, thus will not trigger gastrointestinal allergic reaction, it also can decrease the tumor weight without changes in body weight and can inhibit the growth of peripheral blood leukocyte in leukemia mouse model.

The invention discloses a medicament for treating endoplasmic reticulum (ER) breast cancer and belongs to the technical field of pharmacy. The active ingredients of the medicament are arsenic trioxide and tamoxifen. Experiments show that after being used together, the arsenic trioxide and the tamoxifen have obvious effect. To inoculated BALB / c-nu female nude mice, the tumor volume inhibition ratio of the composite medicament is up to 77.42 percent and the tumor weight inhibition ratio of the medicament is up to 76.28 percent. In addition, the formulation of the medicament is also improved, namely the arsenic trioxide is wrapped through collagen and then is mixed with the tamoxifen; and after a proper amount of diluent is added into the mixture, the mixture is prepared into oral formulations, such as powder, pills or capsules and the like. A normally used food component, namely water-soluble collagen, serves as a carrier and has high entrapment efficiency to the arsenic trioxide; the in-vivo retaining time of the arsenic trioxide can be prolonged while the side effect of the arsenic trioxide on gastrointestinal tract is reduced; long-time effective blood concentration is maintained; and while the effect of the medicament is maintained, great convenience is brought to patients and the injection pains of the patients are relieved.

The invention discloses a heteropolyvanadate compound, the molecular formula is [NH 2 (CH 3 ) 2 ] 12 [(V 5 o 9 Cl) 6 (TATB) 8 ]; The preparation method is: VCl 4 and 4,4,4-triazine-2,4,6-tribenzoic acid were dissolved in 2mL N,N-dimethylformamide and 0.5 mL acetonitrile solution, stirred at room temperature; crystallized at 125~135°C for 40 ~60 hours; cool down, separate green crystals, wash, and dry at room temperature to obtain a heteropolyvanadate compound; the results of in vitro experiments show that the salt is effective on half of SMMC‑7721, MCF‑7, A549, HL‑60 cells The inhibitory concentrations were 0.67 μmol / L, 0.44 μmol / L, 0.48 μmol / L, and 2.09 μmol / L; in vivo experiments showed that the salt could reduce the tumor weight of Hep-A-22 liver cancer-bearing mice.

The invention belongs to the field of Chinese medicament, and in particular relates to a Chinese compound preparation for treating primary liver cancer and a preparation method thereof. The invention adopts a method for nourishing spleen and regulating qi according to a theory of strengthening health energy of Chinese medical science, takes szechwon tangshen root, largehead atractylodes rhizome and poria nourishing the spleen as monarch drugs, akebia fruit and bitter orange assisting the spleen to transporting qi as associate drugs, and oldenlandia softening hard lumps as a messenger drug to prepare the Chinese compound preparation. Experimental results show that the compound preparation has obvious anti-tumor effect on H22 liver cancer of experimental animals mice, has obvious inhibitingeffect on tumor weight, tumor volume and relative tumor volume of human liver cancer QGY7703 xenograft tumor in nude mice, and can improve quality of life of a patient suffering the liver cancer, improve cachexia and prolong lifetime of the patient.

The invention provides the application of a radiotherapy sensitizer of the lychee grass water extract. The invention uses the lychee grass water extract as a radiotherapy sensitizer to inhibit the growth of tumor tissues of colorectal cancer CT26 cell line tumor-bearing mice. The use of lychee grass water extract as a radiotherapy sensitizer significantly improved the general activity of CT26 cell transplanted tumor model mice, inhibited the growth of tumor tissue, reduced tumor weight, and had a significant inhibitory effect on the growth and proliferation of colorectal cancer. The mechanism of action is related to the down-regulation of the expression of VEGF and Survivin in tumor tissues of mice transplanted with CT26 cells. The invention further expands the application of the water extract of lychee grass, clarifies the effect of the radiotherapy sensitizer of the water extract of lychee grass on inhibiting colorectal cancer, and provides an effective means for clinical tumor treatment by adopting the method of assisting radiotherapy with traditional Chinese medicine.

The invention provides medicinal liquor for improving immunity. The medicinal liquor is obtained by soaking the following raw materials in parts by weight in grain liquor: 1-20 parts of codonopsis pilosula, 1-20 parts of cornua cervi pantotrichum, 1-20 parts of astragalus mongholicus, 1-20 parts of pseudo-ginseng, 1-20 parts of rehmannia glutinosa, 1-10 parts of cordyceps sinensis, 1-10 parts of yam, 1-10 parts of medlar, 1-10 parts of ginseng, 1-10 parts of carthamus tinctorius, 1-10 parts of eucommia ulmoides, 1-10 parts of lucid ganoderma, 1-10 parts of gecko, 1-10 parts of red date, 1-10 parts of sea horse, 1-10 parts of cistanche, 1-10 parts of herba epimedii, 1-10 parts of radix polygonati officinalis and the like. The medicinal liquor has the advantages of remarkably improving the tumor weight inhibition ratio and the NK (Natural Killer) cell activity, reducing the TNF (tumor necrosis factor) alpha content in the serum and promoting the IFN (Interferon) gamma and IL-2 (interleukin-2) contents to rise, so that the medicinal liquor is capable of boosting the humoral immunity and cell immunity of the human body with remarkable effect; and at the same time, the medicinal liquor is obtained by soaking natural animal and plant ingredients as well as pure traditional Chinese medicine materials, so that the color of the liquor is natural amber, no toxic or side effects are caused and the preparation is convenient.

The present invention discloses thymopentin modified by heterocyclic carboxylic acid represented by general formula I, wherein RCO is 1,2,3,4-tetrahydro-β-carboline-3-formyl, β-carboline ‑3‑formyl, 1,2,3,4‑tetrahydroisoquinoline‑3‑formyl, isoquinoline‑3‑formyl, 1‑methyl‑1,2,3,4‑tetrahydro‑ β-carboline-3-formyl, 1-methyl-β-carboline-3-formyl and 4,5,6,7-tetrahydro-3H-imidazo[4,5-C]pyridine-6- Formyl, disclosed their preparation method, disclosed their anti-tumor cell proliferation activity in vitro, further disclosed their activity of inhibiting tumor weight gain in S180 tumor mice, and clarified their application in the preparation of anti-tumor drugs. RCO‑Arg‑Lys‑Asp‑Val‑Tyr I.

The present invention relates to the field of gene therapy, and provides a method for knocking out the high-risk human papillomavirus (Human papillomavirus, HPV) E6E7 gene by using zinc finger nuclease, which is based on the high-risk HPV E6E7 gene sequence, and designs a targeting specific site The ZFNs expression vector of ZFNs targets the HPV E6E7 gene sequence in cells, and then knocks out the target gene, which can obviously induce apoptosis and inhibit proliferation in cells infected with the corresponding subtype of HPV, while positive for other subtypes of HPV Cells and HPV-negative cells had no effect. Transfection of ZFNs expression vector in the subcutaneous tumor model of HPV-positive cervical cancer cells can significantly inhibit the growth rate of subcutaneous tumors and reduce tumor weight. The method of knocking out the high-risk HPV E6E7 gene by using zinc finger ribozyme can effectively destroy the viral oncogene at the DNA level, and cause apoptosis and proliferation inhibition of HPV-infected cells. Precancerous lesions such as internal neoplasia have great therapeutic value.

The invention relates to application of spirulina platensis polysaccharide, which is applied to preparing preparations for restraining tumor growth, preparations with antioxygenation functions to cells and nuclear factor kappa (NF-KB) immune preparations. A spirulina platensis washing gavage administration method has restraining functions on S180 tumors. After administration, spirulina platensis water is used for extracting washing polysaccharide of 100mg / kg, and T / C% is 58.95%. Compared with a control group, the weight of a tumor is obviously different (rho (0.05). Spleen cells of a mice immune organ are used for multiplication experiments of immune cells. Results show that 40, 200 and 1000 ug / ml of spirulina platensis polysaccharide all have functions of promoting multiplication of spleen cells, and when the T / C% is respectively 148.96%, 166.89% and 182.99%, and the T / C% is obviously different from a medicine-free group (rho (0.05). 0.2mol / l of spirulina platensis, 8ug / ml of Nacl elution polysaccharide and 40ug / ml of the Nacl elution polysaccharide have effects on promoting multiplication of spleen cells, and when the T / C% is respectively 19.88% and 202.81%, the T / C% is obviously different from the medicine-free group (rho (0.05).