90 results about "Tissue morphology" patented technology

A method and system for determining tissue type is provided. The system comprises an electronic control unit (ECU) configured to acquire a value of an electrical parameter between a first electrode electrically coupled with tissue and a second electrode. The ECU is further configured to identify a tissue type from a plurality of tissue types based at least on the acquired value, and in an exemplary embodiment, to generate a tissue morphology map comprising a marker representative of the identified tissue type. The method comprises acquiring a value of an electrical parameter between a first electrode electrically coupled with tissue and a second electrode. The method further comprises identifying a tissue type from a plurality of tissue types based on at least the acquired value of the electrical parameter, and in an exemplary embodiment, the method further comprises generating a tissue morphology map based on the identified tissue type.

A non-invasive subject-information imaging apparatus according to this invention includes a light generating unit which generates light containing a specific wavelength component, a light irradiation unit which radiates the generated light into a subject, a waveguide unit which guides the light from the light generating unit to the irradiation unit, a plurality of two-dimensionally arrayed electroacoustic transducer elements, a transmission / reception unit which transmits ultrasonic waves to the subject by driving the electroacoustic transducer elements, and generates a reception signal from electrical signals converted by electroacoustic transducer elements, and a signal processing unit which generates volume data about a living body function by processing a reception signal corresponding to acoustic waves generated in the subject by light irradiation, and generates volume data about a tissue morphology by processing a reception signal corresponding to echoes generated in the subject upon transmission of the ultrasonic waves.

The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.

Systems and methods treat hemorrhoids by introducing a treatment device into the anal canal to extend above a hemorrhoidal plexus and adjacent a tissue region containing blood vessels that feed the hemorrhoidal plexus. The systems and methods operate the treatment device to affect tissue morphology in the tissue region to occlude or otherwise reduce blood flow through the vessels.

An automatic contextual segmentation method which can be used to identify features in QCT images of femora, tibiae and vertebrae. The principal advantages of this automatic approach over traditional techniques such as histomorphometry are, 1) the algorithms can be implemented in a fast, uniform, non-subjective manner across many images allowing unbiased comparisons of therapeutic efficacy, 2) much larger volumes in the region of interest can be analyzed, and 3) QCT can be used longitudinally. Two automatic contextual segmentation algorithms relate to a cortical bone algorithm (CBA) and a whole bone algorithm (WBA). These methods include a preprocessing step, a threshold selection step, a segmentation step satisfying logical constraints, a pixel wise label image updating step, and a feature extraction step; with the WBA including whole bone segmentation, cortical segmentation, spine segmentation, and centrum segmentation. The algorithms are constructed to provide successful segmentations for known classes of bones with known topological constraints.

The present invention provides porous material of calcium phosphate of high strength whose open pores penetrate the porous body and have a size of 70 μm or more, preferably 100 μm or more, and are arranged in a three-dimensional network, whose porosity is sufficiently high for blood vessels to invade and perforate itself or for cells to infiltrate itself, whose chemical composition, in particular, Ca / P molar ratio can be freely changed within the range of 0.75 to 2.1, to which elements important for facilitating osteogenesis and producing resorbable effect can be added, and whose phase composition can be relatively easily changed. The invention is porous sintered compact of calcium phosphate which has artificially formed, penetrated open pores 70 μm to 4 mm in diameter, whose porosity is from 20% to 80%, and whose chief ingredient is calcium phosphate having a Ca / P molar ratio of from 0.75 to 2.1.

Systems and methods treat hemorrhoids by introducing a treatment device into the anal canal to extend above a hemorrhoidal plexus and adjacent a tissue region containing blood vessels that feed the hemorrhoidal plexus. The systems and methods operate the treatment device to affect tissue morphology in the tissue region to occlude or otherwise reduce blood flow through the vessels.

The invention provides a method for constructing tissue engineering skin. In the method, human epidermal stem cells and hypodermal fibroblasts are taken as seed cells, and a homologous acellular dermal matrix modified by a human placental type IV collagen is taken as a stent, so that active dual-layer engineering skin is compounded and constructed by using a gas-liquid interface separate culture method. The tissue engineering skin constructed by using the method is closer to the structure of natural skin; and as proved by histomorphology, the tissue engineering skin has an epidermal and hypodermal double-layer structure, wherein the hypodermal collagen stent has a complete structure, an epidermal layer is provided with a plurality of layers of cells of different differentiation degrees, and the morphological requirement of the tissue engineering skin is met.

A compensation circuit has a predetermined, known complex impedance and is located in a handle of a catheter or in a distal end of a cable that connects to the catheter. The compensation circuit is probed with a pilot signal produced by a compensation control that is external to the catheter, by way of an electrical connection through the connecting cable. The compensation control measures the complex impedance, which is the combination of the circuit's known impedance as well as that of the cable. The compensation control then determines the difference between the measured and the known complex impedances. The difference represents that which is attributable to the cable, and is used to compensate or cancel out such cable-related contributions to complex impedance in measurements made over other electrical connections in the same cable. In another aspect, an unknown tissue is identified as one of a plurality of possible tissue types such as regular myocardium, scar and fat based on the measured phase angle of the complex impedance of the unknown tissue.

The invention discloses a medical image holographic AR (augmented reality) display technology system in the medical field. The system comprises an image recognition device, a motion capture device, a man-machine interaction interface and a three-dimensional virtual image superposing system and is characterized in that the image recognition device and the motion capture device acquire a real medical image of a human body, the real medical image acquired after digital conversion is superposed with a three-dimensional virtual human body model and displayed on the man-machine interaction interface, and by means of the human-computer interface which is an interactive advanced human-computer interface of a computer, medical technicians can sense objective existence of organs and tissue morphology in the body of a real patient by combining a virtual reality system with medical images.

The invention provides a preserving fluid and a preserving method for maintaining high cell activity of a tissue sample, wherein the preserving fluid comprises the components: ion buffer solution components, carbohydrate components,, components avoiding the generation of ice crystals in and out solutions of tissue cells at a low temperature of 0-6 DEG C, components providing supplement, antioxidant and anti-apoptosis components for anabolism of the tissue cells; the preserving fluid has good biocompatibility, does not contain toxic or harmful components, and also does not contain components such as animal-derived protein, antibiotics and hormones influencing tissue gene expression. Different from traditional ultralow-temperature cryopreservation (-80 DEG C), the cryopreservation method disclosed by the invention can effectively realize low-temperature storage (0-6 DEG C) of fresh tissue samples of human beings and animals, maintains high cell activity of tissues, maintains tissue morphology, and is used for preservation and transportation of the tissue samples. Meanwhile, the nucleic acid integrity of the tissue and the stability of gene expression can be effectively maintained, the original state of the tissue is maintained, and the method can be used for gene detection, scientific research and other related experiments.

A compensation circuit has a predetermined, known complex impedance and is located in a handle of a catheter or in a distal end of a cable that connects to the catheter. The compensation circuit is probed with a pilot signal produced by a compensation control that is external to the catheter, by way of an electrical connection through the connecting cable. The compensation control measures the complex impedance, which is the combination of the circuit's known impedance as well as that of the cable. The compensation control then determines the difference between the measured and the known complex impedances. The difference represents that which is attributable to the cable, and is used to compensate or cancel out such cable-related contributions to complex impedance in measurements made over other electrical connections in the same cable. In another aspect, an unknown tissue is identified as one of a plurality of possible tissue types such as regular myocardium, scar and fat based on the measured phase angle of the complex impedance of the unknown tissue.

The invention discloses a method for obtaining aluminum oxide-based ternary melt grown ceramic tissue morphology, which comprises the following steps of: combining zone melting and liquid metal cooling, and performing directional solidification on a plurality of precast bodies formed by using aluminum oxide, yttrium oxide and zirconium oxide respectively; and taking the longitudinal sections and the transverse sections of the directional solidified precast bodies, performing conventional metallographic treatment, and performing surface metal spraying to obtain tissue morphology and interface morphology of the aluminum oxide-based ternary eutectic oxide melt grown ceramic at different growth rates. In the directional solidification, the withdrawing rate is 1 to 10,000mum / s, and the laser power is 200 to 1,500W. The obtained directional solidification tissues are greatly different from the tissues in a melting zone and have no obvious tissue transition zone, and the interface morphologyis preserved perfectly.

The invention discloses a high-carbon steel wire rod tissue grain size grading method. The method can finish high-carbon steel wire rod tissue grain size grading by the steps of manufacturing a sample, mechanically treating, chemically treating, observing and assessing and displaying results. The method disclosed by the invention achieves high-carbon steel wire rod tissue grain size grading by assessing the tissue grain size, namely the microscopy tissue morphology size. According to the method disclosed by the invention, an identical corrosion degree on the surface of a test sample is achieved by limiting nitric acid alcohol concentration and corrosion time; compared with a standard atlas, assessment errors can be reduced. According to the method disclosed by the invention, a supplementary effect among multiples is achieved by respectively grading tissue grade sizes under 100 times and 500 times. According to the method disclosed by the invention, four view fields and a core view field are chosen from on a detection ring of one fourth of the diameter of a high-carbon steel wire rod through observing positions and view field regulations; the choice of the observing positions and the view fields can reflect the tissue grain size situation of the whole cross section; thus, the obtained assessment results has strong representativeness, reality and validity.

Systems and methods treat hemorrhoids by introducing a treatment device into the anal canal to extend above a hemorrhoidal plexus and adjacent a tissue region containing blood vessels that feed the hemorrhoidal plexus. The systems and methods operate the treatment device to affect tissue morphology in the tissue region to occlude or otherwise reduce blood flow through the vessels.

The invention relates to the field of medical organ preservation and more particularly discloses a vitrification freezing and preserving fluid for preserving organs for a long term. The organ vitrification freezing and preserving fluid is characterized by comprising dimethyl sulfoxide, acetamide, glycerol, ethylene glycol, propylene glycol, cane sugar, polyethylene glycol and the like, wherein the concentrations of the dimethyl sulfoxide, the acetamide, the glycerol, the ethylene glycol, the propylene glycol and the cane sugar are 0.1-6 mol / L; the concentration of the polyethylene glycol is 1-20 mmol / L; and the pH value is in a range from 5.0 to 8.0. By implementing the vitrification preserving fluid for preserving organs, provided by the invention, the preserving fluid is in a glassy state rather than forming ice crystal in the cooling and freezing process to protect the tissue morphology and structure completeness, completely suppresses energy metabolism of tissue cells under a freezing condition and recovers biological functions of organs after anabiosis. The organ vitrification freezing and preserving fluid, disclosed by the invention, can be used for freezing and preserving kidney and also can be further widely applied to freezing and preserving of other organs for a long term for scientific research and clinic application.

According to the invention, a powder catalytic material Nd<3-x>CoxNbO7 (x being greater than or equal to 0.5 and less than or equal to 1) is prepared by adopting a supercritical hydrosynthesis method and a chemical vapor condensation and deposition method; a composite porous nanometer catalytic material Nd<3-x>CoxNbO7 (x being greater than or equal to 0.5 and less than or equal to 1) -zincosilicate molecular sieve is prepared by adopting an impregnating and baking method; and a novel photoelectrode Nd<3-x>CoxNbO7 (x being greater than or equal to 0.5 and less than or equal to 1) is prepared. The three novel materials are represented: tissue morphology analysis is performed by a transmission electron microscopy, and results show that catalyst particles are irregular in shape, with the average particle size of 150 nm; phase analysis is performed by an X-ray diffractometer, and results show that Nd2CoNbO7 has a single phase, and relatively high crystallinity; the chemical speciation of the surface of the catalyst and the elementary composition of a microcell as well as the structural characteristics of an electronic shell are discussed by an X-ray photoelectron spectroscopy; and a characteristic absorption edge of the Nd2CoNbO7 is determined by a UV-Vis diffuse reflection spectroscopy to obtain the band gap width of the Nd2CoNbO7 which is 2.412 eV. Finally, the catalyst is used for decomposing water to produce hydrogen, and carrying out catalytic degradation on organic pollutants such as microcystic toxins, methylene blue and sulfamethoxazole in a water body under visible light. Experimental results show that the catalyst prepared according to the invention is good in catalytic effect.

The invention relates to an experimental method and device for determining high temperature solidification phase transition rule, and belongs to detection instruments and meters. According to the invention, the solidification property of metal and alloy is determined at on-site cooling rate under a high-temperature condition so as to simulate real on-site working conditions; A phase transition temperature point is obtained by simulation determination of the high temperature solidification phase transition rule SPT; the whole phase transition process is observed; quantitative analysis of the phase transition is carried out; the phase transition rule is verified; and the transition rule is determined. According to the invention, a DTA differential thermal analyzer is used to determine the solidification phase transition point, liquidus line and solidus point of metal and alloy materials at different cooling rates; The cooling rate and the quenching temperature are determined based on the DTA results; with the method and device of the invention, a sample is melted and cooled to different quenching temperatures, and quenching is carried out by liquid nitrogen alcohol; the sample tissue morphology after quenching is observed; the contents of the first-precipitated phases in the high temperature tissue at different cooling rates are analyzed to obtain the high temperature solidification phase transition rule SPT of the sample; selection of an optimal solidification mode is realized at specific production requirements.

The analysis of the focal changes in the morphology of a tissue such as cartilage is completed through statistical parametric mapping by first detecting the amount of thickness changes; followed by the point by point estimation of the variance in the thickness delta estimation. Once the change and the variance are estimated, the z-map is computed. The z-map is used to compute single change parameters. i.e: volume significant change, area of significant change, average thickness of the significant changes, and D values from the probability distributions. That can be used for treatment decisions.

The invention relates a Pediococcus acidilactici strain BCC-1 capable of efficiently utilizing xylooligosaccharide and application thereof. The invention provides a Pediococcus acidilactici strain BCC-1 capable of efficiently utilizing xylooligosaccharide and application thereof based on the intestinal tract health problem which is likely to occur in modern livestock and poultry production. The invention also provides a feed additive comprising the Pediococcus acidilactici strain BCC-1 and xylooligosaccharide. The product can further improve the application effect of the lactobacillus strain, improve the intestinal tract tissue morphology of the anterior intestine of poultry, increase the content of short chain fatty acid in caecum, reduce the pH value in caecum, improve intestinal tract health of poultry, greatly increase the production performance of poultry, and realize green and health breeding.

The present invention belongs to the technical field of biological three-dimensional printing and particularly discloses a method for preparing artificial muscle tendons by using a biological three-dimensional printing and an electrospinning technology. The preparation steps are as follows: S1, seed cell culturing; S2, nano fiber membrane preparing; S3, cell coating layer preparing; and S4, nano fiber membrane / cell coating layer treating. The biological three-dimensional printing and the electrospinning technology are combined, the electrospinning method is used to obtain directional nano fiber membranes, the biological three-dimensional printing technology is used for printing on the nano fiber membranes to obtain lubricating cell coating layers to rapidly realize adhesion and colonization of seed cells and obtain the high polymer material artificial muscle tendons containing the cells and having good lubricating performance, the manufacture method is simple and convenient, better simulates tissue morphology, cell composition and lubricating performance of the natural muscle tendon tissues, and is conducive to muscle tendon repair and normal function recovery.

The invention discloses an experimental method of effects of DNA oxidative damage and bone cell apoptosis on avascular necrosis, the method comprises the following steps: experimental grouping and establishment of an animal model, preparation of specimens, histomorphology observation under a light microscope, observation by a transmission electron microscope, bone cell apoptosis situation detection by TUNEL (terminal dexynucleotidyl transferase(TdT)-mediated dUTP nick end labeling) method, bone marrow hematopoietic cell DNA oxidative damage detection by monoclonal antibody N45.1 immunohistochemistry method, and statistical analysis. According to the method, experiment animals are respectively killed in the second week and the fourth week after the last time of administration, and five animals are killed for each time in each group; bilateral femoral heads are taken for conventional fixed decalcification for stand-by testing, the number of vacant bone lacunas is counted by HE (hematoxylin-eosin) staining, the bone cell morphological change is observed by the electron microscope, the bone cell apoptosis situation is detected by the TUNEL method, the bone marrow hematopoietic cell DNA oxidative damage is detected by the immunohistochemistry method, and the relationship between SANFH ((steroid-induced avascular necrosis of femoral head)) and the bone marrow hematopoietic cell DNA oxidative damage and the bone cell apoptosis is explored, and provides new ideas for the further study of pathogenesis of the steroid induced avascular necrosis of femoral head.

The invention provides a method for processing form and elasticity information of a tissue and an elasticity detection apparatus. The method comprises the following steps of acquiring a form image and an elasticity image of the tissue, wherein the form characteristic information of the tissue is included in the form image; the elasticity characteristic information of the tissue is included in the elasticity image; fusing and displaying the elasticity image in the form image; determining a puncturing position according to the guide of a fused image, and puncturing the tissue for sampling. Through the elasticity detection apparatus, the elasticity characteristic information and the form characteristic information of the tissue can be acquired, so that the guide is jointly provided for the location of the puncturing position according to the additive fusion of the elasticity image and the form image; the accurate locating of a pathologic tissue can be realized, so that the reliability of aspiration biopsy is greatly improved.

The invention provides a continuous gradient bionic manufacturing method based on a pneumatic accurate control active cartilage scaffold. Based on sodium alginate SA ionic crosslinking and gelatin Gel low-temperature solidification forming mechanisms, SA, Gel, hydroxyapatite HA and cartilage cell suspension liquid are used as scaffold base materials, and according to the morphological characteristics of natural soft tissues, an extrusion deposition 3D printing technology based on high-pressure controllable gas is adopted to realize the preparation of an embedded living cell three-dimensional soft scaffold; and in the preparation process, the pressure applied to different charging barrels is dynamically and accurately regulated and controlled in real time, so that the accurate controllability of the component content is realized, then real-time dynamic mixing and continuous gradient laying of different component materials are realized through a dynamic mixing spray head, and the scaffold is crosslinked under the combined action of a CaCl2 solution and a low-temperature platform. The problems that an existing cartilage scaffold material is single in concentration, and the single material components of each layer in a layered structure do not conform to the anatomical characteristics of the continuous gradient of natural cartilage are solved.

The invention provides an analyzing and processing method and device for a tumor image. The method comprises the step of combining hardness information of ultrasonic imaging and blood oxygen information provided by photoacoustic imaging for analysis of the tumor image. In the specific embodiment of the invention, the hardness information of ultrasonic imaging and the blood oxygen information provided by photoacoustic imaging are combined for analysis of the tumor image, critical function and molecular imaging information provided by the photoacoustic technique can be importantly complementarywith tissue morphology and structure information provided by the ultrasonic technique, and overall observation of tumor structure and function is realized through combination of the photoacoustic technique and the ultrasonic technique.

Pretreating a tissue sample with an effective amount of collagenase results in increased immunodetection of collagen and enhanced preservation of tissue morphology. Such an improved method for immunodetection of collagen can be used in immunohistochemical studies of formalin-fixed, paraffin-embedded tissue sections.

The invention discloses a sample manufacturing method for representing the blade body performance of a thin-walled blade casting, which relates to the field of thin-walled blade testing, and is used for accurately and conveniently extracting a sample capable of representing the blade body performance of a thin-walled blade. The sample manufacturing method comprises the following steps: manufacturing a thin-walled blade including a thickened part, wherein the thickness of the thickened part is greater than the thickness of other parts of the thin-walled blade body; sampling from the thickened part; and processing the taken sample into a sample of a set shape. In the technical scheme, the thin-walled blade including the thickened part are manufactured before sampling the thin-walled blade; and the tissue morphology of the thickened part is the same or nearly the same as the tissue morphology of other parts of the thin-walled blade body. Then samples are taken from the thickened part andthen processed to the desired shape. The above technical scheme realizes sampling of the thin-walled blade, and the sample performance represents the performance of the blade body.

The invention provides a method for building psoriasis basic research models, and a gas-liquid level transmembrane device. The method utilizes a psoriasis streptococcal-induced mechanism and a T cell-mediated excessive proliferation mechanism, innovatively adopts a serum-free medium added with psoriasis peripheral blood T lymphocytes and hemolytic streptococcus antigens, and cultures psoriasis skin lesions in vitro. Characteristic tissue morphology of the psoriasis skin lesions can be maintained for as long as one week. The gas-liquid level transmembrane device used for culturing psoriasis in vitro skin lesions comprises the serum-free medium containing psoriasis peripheral blood T cells and the hemolytic streptococcus antigens in the method for building psoriasis basic research models, as well as sterilizing lens-wiping paper for manufacturing gas-liquid level, wherein tissue blocks and a gas phase are borne on the sterilizing lens-wiping paper; the gas phase is at 37 DEG C with 5 percent of CO2 saturation. The device not only can completely simulate gas-liquid junction environment for human skin growth, but also can reach the requirements of in vitro skin tissue culture. In addition, the device is easy to prepare, saves expenses, and has the advantages of repeatability, controllability and the like.