2 results about "Tissue engineered skin" patented technology

The invention discloses in-vitro tissue engineering skin automatic cleaning equipment, and belongs to the technical field of cleaning equipment, the in-vitro tissue engineering skin automatic cleaning equipment comprises a cleaning tank, an ultrasonic cleaning module is arranged in the cleaning tank, the rear side of the cleaning tank is communicated with a liquid discharge pipe, a partition plate is mounted in an inner cavity of the cleaning tank, and the ultrasonic cleaning module is located at the top of the partition plate. According to the tissue engineering skin cleaning and rubbing device, the cleaning and rubbing effect on tissue engineering skin is improved through mutual circumferential movement of the pretreatment rollers on the two sides, the pretreated tissue skin falling into the surface of the conveying roller belt can be conveyed to the compaction mechanism on the rear side, and ultrasonic cleaning is conducted through ultrasonic waves emitted by the ultrasonic cleaning module in the cleaning tank in the compaction process; according to the in-vitro tissue engineering skin cleaning device, residual impurities of tissue skin are cleaned into a medium in the cleaning tank through ultrasonic waves, automatic cleaning of the in-vitro tissue engineering skin is achieved through pretreatment and compaction superposition cleaning, and cleaned materials can be conveyed to the tail section of the cleaning tank through a transmission roller to be conveniently taken and used.

The present application belongs to the technical field of biomaterials. The existing preparation process of composite injectable gel is complicated, and the prepared composite injectable gel has the problems of poor injectability, low swelling rate, low mechanical strength, low drug loading rate and high cytotoxicity. Based on this, the present application provides a method for preparing a composite injectable gel, which comprises: 1) dissolving hyaluronic acid and sodium chloride in an aqueous solution of NaOH or KOH; 2) adding a crosslinking agent 1,4-butanediol diglycidyl ether or genipin and mixing; 3) performing crosslinking reaction; 4) purifying the reaction product; 5) vacuum freeze-drying to obtain the final composite injectable gel. The method simplifies the preparation process, and the prepared composite injectable gel has significantly improved injectability, swelling rate, mechanical strength, drug loading rate, and lower cytotoxicity, and has good application prospect in the fields of drug delivery, tissue engineering, skin wound healing repair, medical cosmetology and the like.