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106 results about "Basilar membrane" patented technology

The basilar membrane within the cochlea of the inner ear is a stiff structural element that separates two liquid-filled tubes that run along the coil of the cochlea, the scala media and the scala tympani (see figure).

Frequency modulated stimulation strategy for cochlear implant system

InactiveUS20070239227A1Provide temporal informationReduce power consumptionElectrotherapyTectorial membraneBand-pass filter
A new speech processing strategy, termed Frequency Modulated Stimulation (FMS), is provided for use with a cochlear prosthetic. The FMS strategy advantageously mimics the neural firing patterns of the healthy cochlea by controlling when and where stimulation pulses are presented in the cochlea. The benefits of this approach are its simplicity and its ability to provide temporal information at relatively low power consumption. The stimulation that results has high temporal precision and a low pulse presentation rate. The power efficiency of the FMS strategy is three to six times greater than that of a CIS strategy with comparable thresholds. The FMS strategy depends on the probability that at any point along the basilar membrane the ganglion cells are most likely to respond during the upward motion of the basilar membrane, when the hair cells are pushed toward the tectorial membrane. At low frequencies, this probability accounts for phase locking of the neurons to each peak of the motion. At high frequency locations, phase locking occurs at integer multiples of the vibration cycles because the vibration of the membrane is faster than the refractory period of the neurons. The FMS strategy provided by the invention takes advantage of the natural behavior of the ganglion cells by outputting a biphasic pulse at the preset integer multiples of the vibration cycles. Integer multiples are determined by counting the positive-to-negative zero crossings, or equivalent frequency counting, at the output of the band pass filters that decompose the incoming audio signal(s).
Owner:ADVNACED BIONICS LLC

Method for preparing nanofiltration membrane by adopting layer-by-layer self-assembly method

The invention discloses a method for preparing a nanofiltration membrane by adopting a layer-by-layer self-assembly method, and relates to a preparation method of a nanofiltration membrane, aiming at solving the problems that a nanofiltration membrane prepared by adopting an existing method cannot have both good interception performance and high water flux. The method comprises the following steps: preparing a polyacrylonitrile solution, preparing a polyacrylonitrile basilar membrane, preparing a treated polyacrylonitrile basilar membrane, assembling a layer of polyethlenimine, assembling a layer of graphene oxide, and reassembling polyethlenimine and graphene oxide, thus obtaining the nanofiltration membrane. According to the method disclosed by the invention, a layer-by-layer self-assembly method is adopted, polyethlenimine and graphene oxide are adopted for modifying a PAN membrane, so that the hydrophilia and the pore size of the surface of the membrane are effectively adjusted; because the membrane is relatively thin, relatively large flux can be obtained, and the obtained nanofiltration membrane has good interception performance. The method can be applied to the fields of antibiotics separating, fruit juice concentrating and seawater desalting.
Owner:HARBIN INST OF TECH

Pigment-containing artificial skin detection model and preparation method thereof

The invention relates to a pigment-containing artificial skin detection model and a preparation method thereof. The artificial skin detection model is an epidermal layer structure with activity, which is constructed by compositely inoculating cutin formative cells and melanophores to the surface of a support membrane made from a biodegradable material through culture and comprises a stratum basale, a stratum spinosum, a stratum granulosum and a stratum corneum, and a basilar membrane structure is formed between the epidermal layer and the biodegradable material positioned below the epidermal layer. Compared with the conventional product, the invention can better simulate the pigment components of natural skin and more accurately reflect the whitening and sunscreen effect of cosmetics because of containing the melanophores, nourish the cutin formative cells by using the support membrane made from the biodegradable material as an enderonic layer, control the contraction of the epidermal layer with the strength and enhance the stability of the detection model and has low raw material cost, short manufacturing period and mass production; and in addition, the prepared artificial skin detection model can be directly used for the efficacy detection of the cosmetics and the skin irritation detection of textiles, the cosmetics and chemicals.
Owner:GUANGDONG BOXI BIO TECH CO LTD

Tissue engineered skin with basilar membrane and construction method thereof

The invention relates to the technical fields of tissue engineering and medical wound repair. At present, a living skin substitute constructed by using the materials of polylactic acid, polyglycolic acid, collagen, hyaluronic acid, and the like as a dermic bracket has the defects that on one hand, host materials are difficult to extract, the living skin substitute has complicated manufacturing technology and is expensive in cost and difficult to widely popularize and apply clinically; and on the other hand, the living skin substitute does not have a skin basilar membrane structure so that healed skin does not resist pressure and wear, and the living skin has unfirm adhesion to the epidermis and is easy to shed and break or form water blisters so that the structural and morphological development of the normal epidermis is influenced; and allogeneic acellular dermis is taken from cadaver skin and is limited in sources and expensive in cost, and thus clinical application is limited. The invention aims at providing a skin substitute which uses surface-finished and modified amnion as the basilar membrane and blood plasma as stroma, which has the advantages of wide material sources, low cost and simple preparation method. An animal experiment proves that the complete basilar membrane and hemidesmosomes can be retained in in-vivo transplantation, and the formation of an epidermal structural form is accelerated and promoted.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

NGF (nerve growth factor) chitosan microsphere and high-bionic stent slow releasing system and preparation method thereof

The invention discloses an NGF (nerve growth factor) chitosan microsphere and high-bionic stent slow releasing system, which is a cylindrical collagen and chitosan nerve stent. Chitosan microspheres buried with nerve growth factors are uniformly loaded in the stent. A preparation method of the stent includes firstly, preparing the chitosan microspheres buried with the nerve growth factors by an emulsification chemical-crosslink method; secondly, preparing the collagen and chitosan nerve stent with mutually parallel axial microtubules sample structures; and finally, compounding the chitosan microspheres onto the collagen and chitosan nerve stent via after-compounding technology and preparing the NGF chitosan microsphere and high-bionic stent slow releasing system. The stent structure is similar to a normal nerve basilar membrane structure, and the stent realizes an effect of physically guiding regeneration nerves to the greatest extent. Besides, the stent can slowly release the nerve growth factors with bioactivity for 12 weeks, can lead the nerve growth factors to be effectively released to a nerve injury portion for a long time, and accordingly achieves the purpose of promoting long nerve defect repair better and faster.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Method and system for multi-sound localization

The invention discloses a method and a system for multi-sound localization. The method comprises the following steps: acquiring an initial voice signal set; pre-processing each initial voice signal; dividing the pre-processed signals into a plurality of sub-bands via a basilar membrane filter; acquiring a cross-power spectral density functions of a same sub-band; fusing the cross-power spectral density functions of all sub-bands; acquiring a two-dimensional position/base frequency characteristic function of a microphone pair corresponding to each first voice signal; acquiring the two-dimensional position/base frequency characteristic function of each microphone pair; acquiring a fused weighted two-dimensional position/base frequency characteristic function; and confirming azimuth angles and base frequencies of various sound sources within a preset threshold range in accordance with a function value of the fused weighted two-dimensional position/base frequency characteristic function. According to the method and the system provided by the invention, mutual interference between sound signals is avoided and localization accuracy is improved. Moreover, the method and the system are relatively high in reverberation resistance, and locations of the various sound sources can be accurately estimated under a circumstance of strong reverberation.
Owner:TAIYUAN UNIV OF TECH

Gold nano-channel membrane for detecting atrazine and application thereof

The invention provides a chloride modified gold nano-channel membrane for detecting atrazine and a method for detecting the atrazine by using the gold nano-channel membrane. In the invention, polycarbonate membrane is taken as basilar membrane, Au nano-channel membrane with the diameter of 20-50 nm is prepared by using a chemical precipitation method, and chloride ions self-assembles to the pore wall of the gold nano-channel through a gold-chloride covalent bond. The detection method comprises the following steps of: placing the chloride modified gold nano-channel membrane between a sample injection pool and a transmission pool; adding a buffer solution containing atrazine antibody into the sample injection pool; adding a buffer solution into the transmission pool; maintaining a parallel liquid level of the two pools; applying voltage on the two pools and measuring basement currents; adding a buffer solution containing a sample to be tested into the sample injection pool and carrying out a current signal test through a electrochemical workstation, wherein if current undershoot occurs, the sample to be tested contains the atrazine. The invention has the advantages of high detectionefficiency, strong specificity, capability of measuring the atrazine with the concentration lower limit of 1.7*10-10 M, and better application prospect.
Owner:SHANGHAI NORMAL UNIVERSITY

Artificial cochlea acoustic nerve conductive electrode array capable of sensing music melodies

ActiveCN104013480APrecise deliveryImproved music perceptionEar treatmentProsthesisHarmonicBase frequency
The invention discloses an artificial cochlea acoustic nerve conductive electrode array capable of sensing music melodies. According to the base frequency of music notes, at the frequency sensing position of a human ear basilar membrane, the area between the top of a cochlea and the bottom of the cochlea is divided into frequency areas with specific stimulation signals according to a frequency band corresponding to a note with a half pitch; a specific electrode for conducting signals of the frequency band is arranged in each audio frequency area, namely the electrode is arranged at the frequency band corresponding to a possible base frequency and harmonic frequency of the music notes. The number of the electrodes is 80, and the electrodes correspond to the music audio frequency range of 60-6000 Hz. The artificial cochlea electrodes are distributed according to the scheme, harmonic features of music notes of various musical instruments within the range of 60-6000 Hz can be accurately transmitted in a relative complete mode, and subharmonic elements of each note can be accurately expressed; meanwhile, according to the electrode distribution scheme, the electrodes are distributed more densely than existing electrodes capable of sensing voice information, and voice feature information can still be transmitted accurately.
Owner:SHANDONG UNIV

Preparation method of nerve defect repair material of vessel basilar membrane imitating structure

The invention discloses a preparation method of a nerve defect repair material of a vessel basilar membrane imitating structure, and belongs to the fields of a tissue engineering technology and a biological material. On the basis of the arrangement of peripheral nerve collagen fibers and the structural characteristics of a nerve fiber vessel basilar membrane, the peripheral nerve defect repair material of the vessel basilar membrane imitating structure is prepared mainly from a high polymer material and a natural material in accordance with an electro-spinning technology and a pore-forming technology. Different from other nerve conduits, the cross section of the material is represented as a porous micro-tubular structure and fiber arrangement on the tube wall is highly oriented in a direction consistent with the moving direction of microtubule. The specific surface area of the tube wall of the material is significantly improved, and the structure of the microtubule is similar to that of the nerve fiber vessel basilar membrane; a plurality of nerve growth promoting substances can be added; and the tissue engineering peripheral nerve defect repair material is good in biocompatibility and convenient for the nerve fibers to grow in the direction of principal axis of the repair material, and the repair material has an application prospect.
Owner:GENERAL HOSPITAL OF PLA +1

Speaker recognition feature extraction method based on PSNCC (perception spectrogram Norm cochlea-filter coefficient)

InactiveCN106653004AImprove robustnessImproved temporal robustnessSpeech recognitionPattern perceptionBoundary detection
The invention discloses a speaker recognition feature extraction method based on a PSNCC (perception spectrogram norm cochlea-filter coefficient). The speaker recognition feature extraction method comprises the following steps: first, constructing a cochlea filter group conforming to traveling wave impulse response and nolinear frequency distribution of a cochlear basilar membrane; then carrying out speech enhancement and two-dimensional enhancement based on auditory perception features on voice, and carrying out two-dimensional boundary detection on a pure voice spectrum structure in continuous distribution, thus obtaining a perception spectrogram structure norm parameter PSN; finally, further normalizing all cochlea-filter coefficients output by the cochlea filter group in the time domain through the perception spectrogram structure norm parameter PSN, and extracting the PSNCC feature parameter. According to the PSNCC feature parameter extracted by adopting the method, the robust performance of the feature parameter is improved from two aspects, namely, the time domain and the frequency domain, and further, the recognition rate of a speaker recognition system under the noise environment with low signal to noise ratio is improved.
Owner:SUZHOU UNIV

Seamless laser graphic transfer technology between basilar membranes

InactiveCN101844480ALow price and low usageLow price usageDecorative surface effectsPattern printingMembrane configurationBasilar membrane
The invention discloses a seamless laser graphic transfer technology between basilar membranes, which comprises the following steps: coating: coating laser transfer paint on one side of a basilar membrane A by a coating machine, and then heating, drying and curing the paint; mould pressing: carrying out double-roll mould pressing on the basilar membrane A by a printing roller and a compression roller on a mould pressing machine, and then transferring the laser graphics on the printing roller after mould pressing onto the transfer basilar membrane A so as to reach the seamless effect; membrane combining: arranging the transfer basilar membrane A on a die assembly machine which overlaps with the transfer basilar membrane A and the basilar membrane B which are provided with seamless laser graphics on the surface, and then mould pressing the membranes together via a membrane combining compression roller; and stripping: stripping the transfer basilar membrane A and the basilar membrane B after combination by a cutting machine, the seamless laser graphic information on the transfer basilar membrane A is transferred to the surface of the basilar membrane B at this time, the seamless laser graphic information on the transfer basilar membrane A still exists, and the membrane combination and stripping processes can be repeated for many times. The technology can greatly reduce the use amount of the transfer membranes.
Owner:江苏中印印务集团有限公司

Lower opener for endoscope

The invention relates to the field of medical devices and discloses a lower opener for an endoscope. According to the lower opener, two opener heads are symmetrical to each other and are connected and matched with each other, and can be separated and drawn; when the two opener heads are drawn, a calabash shape with a circular blunt pointed end can be formed; during operation, the circular blunt pointed end punctures a basilar membrane, the edge of crevasse is fixed on the middle concave parts of the calabash-shaped opener heads, and the opener heads are separated to open and expand the crevasse to meet the operation requirements; and the puncturing and opening functions can be realized by using one machine; and the lower opener is simple in structural design and ensures that operation is easy and convenient to implement, and the operation effect is safe and effective. The inner sides of handheld handles are provided with tooth plates which are provided with multi-tooth lock catches matched with each other; and by fixing the positions of the handheld handles, the separating and drawing width of the opener heads can be controlled, the size of the opened mouth can be controlled conveniently, and the operation is convenient to implement. The lower opener is made of metal materials, so that the lower opener can be disinfected and sterilized at high temperature, cannot be damaged easily, can be used repeatedly, and reduces operation cost.
Owner:SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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