52 results about "Chitosan microsphere" patented technology

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.

The invention belongs to the technical field of soil organic matter improvers, and discloses a soil organic matter improver based on a compound microbial agent and a preparation method thereof, and the soil organic matter improver comprises the following components: a compound enzyme, a modified chitosan microsphere complex, a modified polyelectrolyte, an inhibitor L-methionine sulfoximine, a substrate, an auxiliary factor and the compound microbial agent. A compound enzyme system is used as a core, soil ammonium ions are circularly and efficiently assimilated through glutamine synthetase / glutamate synthetase, and the soil ammonium ions are converted into organic nitrogen; and energy guarantee is provided by virtue of polyphosphate kinase. The modified chitosan microsphere complex is used for protecting and slowly releasing enzyme and a substrate, and controlled release of the inhibitor L-methionine sulfoximine is realized through the modified polyelectrolyte, so that carbon-nitrogen balance of soil is regulated and controlled. The system has a synergistic effect with a compound microbial agent, the problem of soil organic matter reduction caused by excessive nitrogen application is effectively solved, meanwhile, the crop root biomass is remarkably increased, and the soil organic matter content is increased.

The invention provides a nasal delivery preparation for cerebral diseases as well as a preparation method and application of the nasal delivery preparation, and relates to the technical field of pharmaceutical preparations. The nasal delivery preparation for the cerebral diseases comprises gelatin derivative chitosan microspheres coated with stem cell exosomes, and the microspheres are prepared through the method that the stem cell exosomes are coated with gelatin derivatives of a specific structure and then cross-linked with chitosan. The gelatin derivative used in the invention has good surface activity, and can be well compatible with cells and active factors to form a stable inner core coating structure; meanwhile, the surface of the chitosan of which the outer layer is crosslinked with the gelatin derivative is positively charged and can be combined with anions in nasal mucus, so that the retention time of the microspheres in the nasal cavity can be effectively prolonged. Therefore, the nasal delivery preparation not only can slowly release the stem cell exosome, but also improves the absorption efficiency of the stem cell exosome by the nasal cavity, so that the stem cell exosome can reach the brain more effectively.

The invention discloses a probiotic chitosan microsphere and a preparation method thereof, and belongs to the technical field of probiotic embedding, and the method comprises the following steps: dissolving trehalose and L-glutamine in water, suspending lactic acid bacteria in the water, mixing with a chitosan solution to obtain a mixed solution, dropwise adding the mixed solution into a sodium tripolyphosphate solution, and stirring to obtain the probiotic chitosan microsphere. And washing insoluble substances, and performing freeze drying to obtain the probiotic chitosan microspheres. The trehalose and the L-glutamine are used as protective agents and nutrient substances of the probiotics at the same time, can synergistically improve the survival rate of the probiotics, are matched with other components, comprehensively improve the tolerance and activity of the probiotics, and are combined with a specific curing means and freeze drying, so that damage of high temperature to the probiotics can be avoided; the obtained microspheres have good probiotic protection capability, stability and appropriate release performance, can effectively improve the survival rate of the probiotics in storage and application processes, and can better play roles in improving intestinal flora and improving the health level of hosts.

The invention relates to the technical field of medical textile materials, in particular to an anti-static medical fabric and a preparation method thereof.The anti-static medical fabric comprises an outer layer, a middle layer, an inner layer and carbon fiber grids embedded into the outer layer and the inner layer, the outer layer is made of nanofibers prepared by electrostatic spinning and comprises polyvinylidene fluoride, an F-ZnO / TiO2 composite antibacterial agent, carboxylated carbon nanotubes and grafted quaternary ammonium salt; the middle layer is a chitosan enhanced polytetrafluoroethylene film, and the surface of the middle layer is sequentially coated with a chitosan / silk fibroin transition layer and a polypyrrole conducting layer; the inner layer is a blend fiber fabric and comprises hollow polyester fibers, chitosan microsphere modified cotton fibers and carbon nanotube grafted polyamide fibers; the carbon fiber grids are embedded into the outer layer and the inner layer in a warp knitting mode with the density of 20-24 pieces / cm. According to the antistatic fabric, a four-stage conductive network is formed by the outer-layer carbon nanotubes, the middle-layer polypyrrole, the inner-layer grafted carbon nanotubes and the carbon fiber grids, so that the antistatic performance of the fabric is greatly improved.

The application provides a long-acting, non-embolism filling monodisperse chitosan microsphere, the base material of the microsphere is cross-linked chitosan, the cross-linked chitosan is formed by cross-linking reaction of component A and a cross-linking agent, or formed by cross-linking reaction of component A, component B and the cross-linking agent; the component A is at least one of chitosan and modified chitosan, and the component B is at least one of hyaluronic acid, collagen and gelatin; the particle size of the microsphere is 20-120 mu m, and the variation coefficient of the microsphere particle size is not more than 5%. The application also provides a preparation method of the microsphere. The monodispersity of the microsphere is excellent, the degradation time is relatively longer, the water absorption performance is good, the embolism risk can be reduced, the filling effect maintaining time can be prolonged, and the effect of improving wrinkles can be increased, and the problems of short filling effect maintaining time and easy to cause blood vessel embolism of the filling hyaluronic acid product used in the existing medical and beauty field can be solved.

The application relates to the field of traditional Chinese medicine oral liquid preparations, in particular to a chitosan microsphere and a preparation method thereof and application of the chitosan microsphere in preparation of Baoyuan oral liquid preparations. The chitosan microsphere comprises, in weight parts, 80-120 parts of chitosan, 2-5 parts of an emulsifier and 30-40 parts of an oil phase; the chitosan microsphere is obtained by dissolving in an acid solution and then reacting with the emulsifier and the oil phase. The application adds a clarifying agent, i.e. a mixture of chitosan microspheres with different particle sizes, carries out flocculation adsorption, and adds a stabilizer sodium carboxymethyl cellulose CMC-Na; through the synergistic effect of the two, the quality and safety of the oral liquid are remarkably improved. The colloids after adsorption of the clarifying agent can be more stably dissolved in the medicinal liquid under the synergistic effect of the stabilizer sodium carboxymethyl cellulose, the preparation precipitation problem is solved, and the prepared Baoyuan oral liquid has good stability and immunoregulatory activity.

This invention provides a thiourea-tertiary amine bifunctional chitosan microsphere and its preparation method, belonging to the field of adsorption material technology. Through a stepwise functionalization and sequential crosslinking method, thiourea groups are first introduced onto the chitosan microspheres, followed by the introduction of tertiary amine groups and secondary crosslinking, successfully preparing chitosan microspheres possessing both thiourea and tertiary amine bifunctional groups. The thiourea and tertiary amine groups in the microspheres of this invention exhibit a synergistic adsorption effect on noble metal chloride anions, significantly improving the selective adsorption capacity and adsorption rate for noble metals such as palladium, platinum, and rhodium. Simultaneously, the dense three-dimensional network structure constructed through stepwise crosslinking greatly enhances the chemical stability and mechanical strength of the microspheres under strongly acidic environments, extending their service life. This preparation method is simple, mild, and environmentally friendly. The prepared adsorbent is particularly suitable for the efficient and selective recovery of noble metals from complex acidic wastewater or electronic waste leachates.

The invention belongs to the technical field of sterilization and disinfection materials, and particularly relates to a wrapped slow-release chlorine composition and a preparation method and application thereof.The composition is of a unique dual-wrapping structure, the core is a mixture of sodium chlorite and a stabilizer, the composition is primarily wrapped with hydrophobic modified chitosan microspheres and then combined with citric acid, and the wrapped slow-release chlorine composition is prepared. And finally, the metal coordinated polyethylene glycol hydrogel is used for outer layer coating to form a complete slow-release system. The preparation method comprises the following steps: firstly, preparing a microsphere carrier through hydrophobic modification and cross-linking curing of chitosan and lauric aldehyde; then, polyethylene glycol amine and a derivative of pyridinedicarbonyl chloride are subjected to cobalt ion coordination to form hydrogel; finally, the chlorine source components are combined and formed through adsorption, mixing and coating processes in sequence. The composition can effectively control the release rate of the chlorine component, has long-acting and stable sterilization and disinfection effects, and can be widely applied to the fields of water treatment, food preservation, medical instrument disinfection, agricultural disease control and the like.

This invention belongs to the field of traditional Chinese medicine fermentation technology, specifically involving a high-enzyme-active Liu Shen Qu (a type of fermented medicinal herb) and its fermentation process. The process first processes red beans, bitter almonds, artemisia annua, cocklebur, and polygonum hydropiper into a medicinal porridge, which is then mixed with wheat flour and a specific fermenting agent to form a soft mass. Its innovation lies in the use of a Bacillus subtilis trehalose protective agent complex and Aspergillus oryzae chitosan microspheres. These two fermenting agents are prepared by spray drying encapsulation and ionogel methods, respectively, significantly improving the survival rate and stability of the fermenting microorganisms during processing and storage. The soft mass undergoes two stages of precisely controlled temperature and humidity fermentation, and finally, after shaping and segmented drying, the finished product is obtained. This process effectively solves the problems of low enzyme activity and poor stability in traditional Liu Shen Qu fermentation, resulting in a Liu Shen Qu product with high digestive enzyme activity and stable, uniform quality.

The application discloses a degradable polymer-based bone repair 3D printing composite material and a preparation method and application thereof, and belongs to the technical field of bone repair material preparation.The raw material of the degradable polymer-based bone repair 3D printing composite material comprises a degradable polymer, a compatibilizer and hydroxyapatite and Mg(OH)2 co-loaded chitosan microspheres.The degradable polymer-based bone repair 3D printing composite material has good mechanical properties, biocompatibility, mineralization capacity, antibacterial and anti-inflammatory properties, can be used as a bone repair material, and is used for preparing a bone repair product through 3D printing after being prepared into a bone repair 3D printing wire material through extrusion molding, thereby providing a novel material solution for bone tissue regeneration and repair.The chitosan can adjust macrophage polarization and reduce the expression of inflammatory factors, so that the composite material has anti-inflammatory properties.

The application discloses a kind of soil remediation agent for environmental pollution and preparation method thereof, and relates to the technical field of soil regeneration.The preparation method comprises the following steps: first, iron sulfate and manganese sulfate are added to deionized water, stirred and dissolved to obtain a mixed salt solution;Then, chitosan microspheres are prepared;Chitosan microspheres are then added to the mixed salt solution for reaction to obtain chitosan-loaded iron-manganese composite oxides;Finally, chitosan-loaded iron-manganese composite oxides are added to a disodium ethylenediaminetetraacetate solution for reaction to obtain a soil remediation agent.The soil remediation agent is a special agent material for heavy metal environmental pollution treatment, can efficiently treat various heavy metals in soil, and has good adaptability to acidic and alkaline soils, thereby achieving soil regeneration.

The present application relates to the technical field of PET label, and particularly relates to a high-temperature-resistant waterproof PET label and a preparation process thereof. The present application obtains antibacterial modified chitosan microspheres by adding chitosan, nano titanium dioxide, span 80 and cinnamaldehyde; the antibacterial modified chitosan microspheres, isopropyl alcohol, epoxidized methylphenyl polysiloxane and a curing agent are mixed to obtain an epoxidized silicon coating. The epoxy resin is heated to be molten, and then hydrophobic silicon dioxide, a curing agent, dioctyl phthalate and acetone are added and uniformly stirred to obtain an adhesive. The epoxidized silicon coating is coated on the surface of a PET film, and then is left to stand and solidify to obtain a waterproof PET film; one side of the waterproof PET film is coated with the adhesive and is combined with a PET release base paper, and the other side of the PET film is coated with ink to obtain a finished product. The finished product prepared by the present application has excellent antibacterial performance and waterproof performance, and therefore has a wide application prospect in the technical field of PET label.

The invention discloses an antibacterial medical hydrocolloid pressure-sensitive adhesive tape and a preparation process thereof, and belongs to the technical field of adhesives, quaternary ammonium salt chitosan microspheres with an antibacterial effect and iodine elementary substances are loaded through charge transfer to form a composite antibacterial agent, and the composite antibacterial agent is used as a filler of the antibacterial medical hydrocolloid pressure-sensitive adhesive tape and can be used for preparing the antibacterial medical hydrocolloid pressure-sensitive adhesive tape. The long-acting antibacterial requirement of the pressure-sensitive adhesive tape can be met. The antibacterial medical hydrocolloid pressure-sensitive adhesive tape prepared by the invention has very high tensile strength and tear resistance, and the quaternary ammonium salt chitosan microsphere structure can disperse stress, so that the antibacterial medical hydrocolloid pressure-sensitive adhesive tape is not easy to damage and strong in cohesion in the use and activity processes, is integrally stripped when being uncovered, and does not break or leave sticky residual adhesive; the adhesive tape can be firmly adhered to dry skin, can bear a certain degree of body activity, is smooth in stripping during replacement due to high water absorption and softness, has small trauma to skin and new tissues, and is particularly suitable for sensitive skin and long-term application.

The invention relates to the field of medical auxiliary equipment, in particular to an inflatable foot drop corrective shoe and a preparation method thereof.The inflatable foot drop corrective shoe is prepared from, by mass, 75-80 parts of modified polyurethane rubber, 6-8 parts of a modified chain extender, 10-12 parts of modified chitosan microspheres, 5-7 parts of modified nano-silicon dioxide and the like. Through dynamic cross-linked network design, multi-stage antibacterial function integration and gradient mechanical regulation and control technologies, compared with the prior art, synergistic breakthrough of damage self-repairing, long-acting antibacterial protection and bionic comfortable supporting is achieved. An innovative material system can actively respond to a foot microenvironment, airtight stability is maintained under repeated mechanical stress, meanwhile, the infection risk is reduced through a molecular-level hydrophilic-antibacterial bifunctional interface, and the wearing safety and rehabilitation suitability are remarkably improved. The foot care solution is suitable for the field of chronic disease foot care and has wide clinical application prospects.

The invention discloses micro-plastic adsorption chewing gum for a digestive system and a preparation method thereof.The chewing gum comprises an oral cavity adsorption layer, a transition protection layer, an intestinal tract stabilizing layer and a bionic gastric mucosa core layer which are sequentially arranged from outside to inside, and the oral cavity adsorption layer is a film prepared from chitosan microspheres, gutta-percha and nano activated carbon; the transition protection layer is a film prepared from a hydroxypropyl methylcellulose phthalate ethanol solution, the intestinal tract stabilizing layer is a film prepared from PLGA and dichloromethane, and the bionic gastric mucosa core layer is an elastic film prepared from silicone rubber and aluminum hydroxide micro powder. Through the triple design of time-controlled dissolution of the transition layer, mechanical locking of the gum-based grid and physical bottom wrapping of the core layer, it can be ensured that microplastics adsorbed by the oral cavity layer are not released again even though the oral cavity layer is dissolved in the stomach, and the whole process from the oral cavity to discharge is safe.

The application discloses a preparation method of chitosan microspheres for cell immobilization and drug delivery, and relates to the field of chitosan microsphere preparation. The application carries out deacetylation on chitin through a microwave induction process technology combined with enzymes, carries out heavy metal green chelation on chitosan by using glutamic acid diacetic acid tetrasodium or citric acid, further improves the extraction and removal capacity of the chelating agent on residual metal ions by using a carbonate salt solubilization technology, and separates and hydrolyzes trace amounts of protein and lipids in the crude chitosan by selecting appropriate biological enzymes to obtain refined chitosan. Meanwhile, the refined chitosan is subjected to enzymatic molecular modification by applying transglycosylation or oxidase, and finally, the chitosan microspheres are prepared by using a green and environment-friendly spray drying method. The chitosan microspheres prepared by the application are smooth in shape, uniform in size, have a particle size of 1-250 mu m, and have a shell-core structure. The chitosan immobilized enzyme widens the application of chitosan in the fields of medicine, food and the like.

This invention relates to the field of pharmaceutical intermediate synthesis technology, and discloses a preparation process for diaminophenoxyethanol sulfate, comprising the following steps: Step S1, preparing chitosan-supported nickel nanoparticles: using chelated cross-linked chitosan microspheres to chelate nickel salt, and then adding a reducing agent to reduce nickel ions to obtain chitosan-supported nickel nanoparticles; Step S2, using 2,4-dinitrochlorobenzene and ethylene glycol as raw materials, synthesizing 2,4-dinitrophenoxyethanol under the action of an alkaline catalyst; Step S3, using 2,4-dinitrophenoxyethanol as raw material and 1,4-dioxane as solvent, the prepared chitosan-supported nickel nanoparticles have a higher loading capacity for nickel nanoparticles. As a catalyst, in the process of catalyzing the hydrogenation of 2,4-dinitrophenoxyethanol to prepare 2,4-diaminophenoxyethanol, the nickel nanoparticles are not prone to agglomeration, and after repeated use, they still maintain good catalytic activity and excellent stability.

The invention discloses a multi-channel micro-fluidic chip and a preparation method of monodisperse chitosan microspheres in the multi-channel micro-fluidic chip, and belongs to the technical field of chitosan microsphere preparation, the multi-channel micro-fluidic chip comprises an upper layer substrate, a middle layer substrate and a lower layer substrate, and further comprises a continuous phase channel assembly, a disperse phase channel assembly and a microsphere collection assembly, the upper-layer substrate, the middle-layer substrate and the lower-layer substrate are fixedly connected in sequence from top to bottom, the upper-layer substrate is connected with a continuous phase channel assembly, the middle-layer substrate is connected with a dispersed phase channel assembly, the lower-layer substrate is connected with a microsphere collecting assembly, and the continuous phase channel assembly, the dispersed phase channel assembly and the microsphere collecting assembly are connected with one another. Through the mode, the monodisperse chitosan microspheres with uniform size and controllable morphology can be prepared.

The invention discloses a chitosan microsphere-polyethylene glycol diamine composite aldehyde-sensitive intelligent indicating film and a method, and belongs to the technical field of active intelligent packaging. According to the indicating membrane, alcohol-soluble polyvinylpyrrolidone and ethyl cellulose are used as a composite matrix to construct a total ethanol phase membrane forming system, and polyethylene glycol diamine modified chitosan microspheres loaded with an indicator are introduced, so that the problem of dispersion of hydrophilic microspheres in a hydrophobic organic phase is solved. The indicating film is high in drying efficiency, good in component compatibility and high in transparency. The microspheres are uniformly dispersed in a continuous phase, so that the response sensitivity and mechanical strength to volatile aldehyde gas are greatly improved, and the freshness of perishable food can be quickly and nondestructively detected. The maturing and rotting states of fruits and vegetables can be visually reflected through color changes, and the material is high in thermal stability, high in water vapor barrier property, degradable, low in cost and suitable for intelligent packaging and fresh food circulation monitoring.

The present application relates to the technical field of Volvariella volvacea cultivation, and particularly relates to a Volvariella volvacea cultivation substrate and a cultivation method. The preparation raw material of the Volvariella volvacea cultivation substrate comprises the following components in parts by weight: extract / pectin@chitosan microspheres 3-5 parts, modified tannic acid-dextran 5-7 parts, rice straw 30-40 parts, corn cob 10-15 parts, bran 4-6 parts, and corn flour 3-5 parts. The present application utilizes the slow-release effect of the microspheres and the water storage network of the modified tannic acid-dextran to achieve synergistic effect, significantly improves the water retention rate, mycelial growth rate and biological efficiency of the cultivation substrate, and realizes high-yield and high-quality cultivation of Volvariella volvacea.

The invention relates to the technical field of preparation of natural antibacterial neutral agents, and discloses a preparation method of a natural antibacterial neutral agent based on a PLGA slow release mechanism, which comprises the following steps: taking polylactic acid PLGA as a carrier, mixing meloxicam polylactic acid microspheres, a chitosan solution and a cross-linking agent solution, adding a surfactant, and stirring to form a uniform emulsion; adding the emulsion into a hardening agent, and stirring until the cross-linking reaction is completed to obtain chitosan microspheres; the chitosan microspheres are washed with deionized water, and the surfactant and the cross-linking agent remaining on the surfaces are removed; and drying the chitosan microspheres in a ventilation drying chamber to obtain the natural antibacterial neutral agent based on the PLGA slow release mechanism. The meloxicam polylactic acid microspheres are prepared by taking PLGA as a carrier, so that the slow release effect of the medicine can be realized. The sustained release of the drug on the skin surface is facilitated, so that the balance of the pH value of the skin is maintained for a longer time, and the repair of the skin barrier and the maintenance of the microbial balance are promoted.

The application discloses a preparation method of ferroferric oxide chitosan microspheres and a protein immobilization method, wherein the preparation method of the ferroferric oxide chitosan microspheres comprises using glutaraldehyde with a specific concentration as a crosslinking agent to crosslink chitosan and ferroferric oxide, and chitosan uniformly and firmly wraps the ferroferric oxide particles, and finally forms round microspheres after incubation for a period of time; the protein immobilization method comprises microsphere modification and fusion protein modification; the microspheres take magnetic ferroferric oxide as the core, can be quickly separated from a reaction system by relying on external magnetic force of the system, and are convenient, fast, simple and efficient; the application establishes a fusion protein production method based on a tag ACP to provide mercapto, and the immobilization process is independent of the target protein, has the generality of protein immobilization, and can be convenient for co-immobilization of various related proteins (enzymes).

The application discloses a method for lime rock mine area soil reclamation, repair and improvement, which comprises the following steps: mixing citric acid, tartaric acid and water to obtain a first leaching agent; mixing rhamnolipid, quaternary ammonium salt modified chitosan microspheres and water to obtain a second leaching agent; mixing soluble starch, water, biochar powder, microbial inoculum, humic acid, algal powder and potassium dihydrogen phosphate, then adding the mixture into a mixed solution prepared by mixing liquid paraffin and span 80, and adding epichlorohydrin to react to obtain slow-release starch microspheres; and mixing the slow-release starch microspheres and water to obtain a soil improvement agent; ploughing the surface soil of the lime rock mine area, and sequentially using the first leaching agent, the second leaching agent and water for leaching treatment; and spraying the soil improvement agent into the surface soil. The application can effectively improve the acid-base property of the lime rock mine area soil, improve the soil fertility, and reduce the metal such as iron, copper and manganese and the toxic and harmful substances such as sulfate in the soil.

The application discloses a preparation method of a polymer modified spherical silica aerogel material. First, 3-(acryloyloxy)propyl-2-thiophene acrylate is synthesized through esterification and grafting reaction, and then is subjected to free radical polymerization with vinylpyridine under the action of an initiator and a chain transfer agent, and is subjected to proton acid doping and spray drying to obtain a conductive polymer. After hydrolysis of tetraethyl orthosilicate, the conductive polymer, phosphonated chitosan microspheres and a bridging agent are mixed, and pH and viscosity are adjusted to obtain a composite sol; after drop ball emulsification, gelation, ultrasonic template removal, gradient replacement and subcritical drying, the composite sol is subjected to pulse electrochemical doping and plasma annealing treatment. The prepared aerogel polymer has low charge transfer resistance and excellent conductivity, and has application potential in electrochemical energy storage devices such as supercapacitors.

The invention belongs to the technical field of medicine, and particularly relates to application of glycin in preparation of medicine for treating aortic valve calcification, micro-nano particles and a preparation method of the micro-nano particles, the micro-nano particles are of a core-shell structure, the core of the micro-nano particles is a glycin-loaded gel microsphere formed by hyaluronic acid methylacrylate through photo-crosslinking, and the core of the micro-nano particles is a chitosan microsphere formed by hyaluronic acid methylacrylate through photo-crosslinking. The shell covers the outside of the core and is formed by crosslinking calcium alginate ions; the particle size of the micro-nano particles is 90 to 110 [mu] m. According to the preparation method disclosed by the invention, a micro-fluidic chip technology is mainly adopted, and photo-crosslinking and ionic crosslinking are combined, so that the finally obtained GG-HAMA at SA has the characteristic of antagonizing aortic valve calcification.

The application provides a preparation method of glycerol butyrate, comprising the following steps: S1, mixing a lipase solution with a solid phase carrier and oscillating adsorption for 8-24 h; the solid phase carrier comprises at least one of mesoporous silica, macroporous adsorption resin, chitosan microspheres and bacterial cellulose membrane; S2, dispersing the product obtained in S1 in a solution A containing a crosslinking agent, and reacting at a temperature of 4-30 DEG C for 2-12 h to obtain an immobilized lipase; the pH of the solution A is 6.0-8.0; S3, mixing glycerol and butyric acid, then adding the immobilized lipase into the mixture, and reacting at 40-65 DEG C under a vacuum degree of 1-20 kPa for 6-24 h. The method uses the immobilized lipase as a catalyst to catalyze the esterification of food-grade glycerol and butyric acid to synthesize glycerol butyrate in an organic solvent-free system, the reaction condition can be accurately controlled, the product selectivity is high, and the immobilized lipase has high stability and can be efficiently recycled during the reaction process.

The application discloses a kind of strong waterproof high moisture-permeable jacket fabric and preparation method thereof, it is related to fabric technical field.The preparation includes the following steps: step 1: the preparation of TPU film: the spinning solution A and spinning solution B containing different porous chitosan microspheres proportion are formulated;Spinning solution A is spun, and inner layer is obtained;Aldehyde group modified porous chitosan microspheres solution is coated on one side thereof, with the coating surface as receiving layer, spinning solution B is spun on the surface thereof, and outer layer is obtained, dried to obtain composite base film;The composite base film is placed in keratinase solution, pretreated;Then 3-sulfopropyl acrylate potassium salt mixed solution is coated on the surface of outer layer, and ultraviolet light is irradiated at room temperature;Immersed in deionized water, dried to obtain TPU film;Step 2: TPU film is hot-pressed with shuttle fabric to obtain jacket fabric.

The application belongs to the technical field of biological medicine, and relates to a hemoperfusion adsorbent, a preparation method and application thereof. The hemoperfusion adsorbent is a microsphere structure, the carrier of the microsphere is a chitosan microsphere, the ligand is type I collagen, and the particle size of the microsphere is 250-1000 mu m. The hemoperfusion adsorbent provided in the application has the characteristics of large adsorption amount of bilirubin, high selective adsorption, small adsorption of albumin and the like based on the synergistic effect of collagen and chitosan, has excellent specific adsorption effect of bilirubin, is low in cost, and has good clinical application prospect.

The application discloses a special slow-release and controlled-release fertilizer for forests and grasses in desert and arid areas, and belongs to the technical field of agricultural fertilizers. The fertilizer solves the problems of too fast nutrient release, insufficient water retention and easy failure of trace elements of traditional slow-release fertilizers in a desert environment. The technical scheme points of the fertilizer are as follows: a three-layer coating structure is adopted, the core layer comprises mixed particles of ammonium biphosphate, potassium nitrate, magnesium sulfate, a trace element compound, amino acid chelated calcium and humic acid; the slow-release layer is a mixed coating of polylactic acid and ethyl cellulose, and the slow-release layer is inlaid with chitosan microspheres containing bacillus subtilis spores; the water-retaining layer comprises a porous adsorption layer formed by cross-linked sodium polyacrylate and diatomite; and the outermost layer is a carbonized rice husk protective layer. The fertilizer realizes slow nutrient release and long-term water retention through the synergistic effect of the core layer for providing nutrients, the slow-release layer for controlling the release rate, the water-retaining layer for adsorbing water and the carbonized rice husk layer for resisting wind erosion, so that the survival rate of forests and grasses is increased to more than 95%, the number of annual fertilization is reduced by 60%, and the fertilizer is especially suitable for cultivation of drought-tolerant plants such as coniferous trees in desert and arid areas.