81 results about "Chitosan microsphere" patented technology

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.

The invention belongs to the technical field of soil organic matter improvers, and discloses a soil organic matter improver based on a compound microbial agent and a preparation method thereof, and the soil organic matter improver comprises the following components: a compound enzyme, a modified chitosan microsphere complex, a modified polyelectrolyte, an inhibitor L-methionine sulfoximine, a substrate, an auxiliary factor and the compound microbial agent. A compound enzyme system is used as a core, soil ammonium ions are circularly and efficiently assimilated through glutamine synthetase / glutamate synthetase, and the soil ammonium ions are converted into organic nitrogen; and energy guarantee is provided by virtue of polyphosphate kinase. The modified chitosan microsphere complex is used for protecting and slowly releasing enzyme and a substrate, and controlled release of the inhibitor L-methionine sulfoximine is realized through the modified polyelectrolyte, so that carbon-nitrogen balance of soil is regulated and controlled. The system has a synergistic effect with a compound microbial agent, the problem of soil organic matter reduction caused by excessive nitrogen application is effectively solved, meanwhile, the crop root biomass is remarkably increased, and the soil organic matter content is increased.

The invention discloses a deep fluorine removal agent and application thereof in wastewater in the photovoltaic industry, and belongs to the technical field of fluorine-containing wastewater treatment.The deep fluorine removal agent is obtained by conducting coordination on cross-linked hybrid chitosan microspheres and lanthanum ions to obtain composite microspheres and then synthesizing zirconium-based MOF on the composite microspheres through a hydrothermal synthesis method. The pore channels of the MOF facilitate the passing of fluorine ions but not the passing of sulfate ions, play a certain barrier role, facilitate the enrichment of the fluorine ions on the surfaces of the composite microspheres and the selective adsorption of the lanthanum ions on the fluorine ions, so that the fluorine ions are fixed, and the combination stability of the fluorine ions and the lanthanum ions is greater than that of the sulfate ions. The sulfate ions are in disadvantage when competitive adsorption with the fluorine ions, the selectivity of the deep fluorine removal agent to the fluorine ions is improved, the magnesium ions can be combined with the fluorine ions to generate complexes and can be combined with the sulfate ions to generate soluble magnesium sulfate, and interference of the sulfate ions is reduced through cooperation of the magnesium ions and the sulfate ions.

The invention provides a probiotic mixed fermentation method for enhancing a synergistic effect. Lactobacillus plantarum, bifidobacterium longum and clostridium tyrobutyricum are inoculated according to a volume ratio, and a pH-triggered two-stage fermentation process is adopted: the first stage is micro-aerobic to drive lactic acid bacteria to quickly produce acid, and the second stage is anaerobic to directionally improve butyric acid synthesis by pulse feeding of inulin-cysteine sustained-release particles. Physical isolation of flora is realized by using a double-layer gradient carrier, lactic acid bacteria are immobilized by sodium alginate-gelatin gel on the outer layer to form an acid barrier, and bifidobacterium and butyric acid producing bacteria are co-immobilized by chitosan microspheres on the inner layer to construct an anaerobic microenvironment. The technology breaks through the competitive inhibition bottleneck of multi-strain fermentation, the total number of viable bacteria is increased by 150% compared with a traditional technology, the yield of butyric acid is increased by 355%, and the technology is suitable for large-scale production of functional food and pharmaceutical preparations.

The invention provides a nasal delivery preparation for cerebral diseases as well as a preparation method and application of the nasal delivery preparation, and relates to the technical field of pharmaceutical preparations. The nasal delivery preparation for the cerebral diseases comprises gelatin derivative chitosan microspheres coated with stem cell exosomes, and the microspheres are prepared through the method that the stem cell exosomes are coated with gelatin derivatives of a specific structure and then cross-linked with chitosan. The gelatin derivative used in the invention has good surface activity, and can be well compatible with cells and active factors to form a stable inner core coating structure; meanwhile, the surface of the chitosan of which the outer layer is crosslinked with the gelatin derivative is positively charged and can be combined with anions in nasal mucus, so that the retention time of the microspheres in the nasal cavity can be effectively prolonged. Therefore, the nasal delivery preparation not only can slowly release the stem cell exosome, but also improves the absorption efficiency of the stem cell exosome by the nasal cavity, so that the stem cell exosome can reach the brain more effectively.

The invention discloses a probiotic chitosan microsphere and a preparation method thereof, and belongs to the technical field of probiotic embedding, and the method comprises the following steps: dissolving trehalose and L-glutamine in water, suspending lactic acid bacteria in the water, mixing with a chitosan solution to obtain a mixed solution, dropwise adding the mixed solution into a sodium tripolyphosphate solution, and stirring to obtain the probiotic chitosan microsphere. And washing insoluble substances, and performing freeze drying to obtain the probiotic chitosan microspheres. The trehalose and the L-glutamine are used as protective agents and nutrient substances of the probiotics at the same time, can synergistically improve the survival rate of the probiotics, are matched with other components, comprehensively improve the tolerance and activity of the probiotics, and are combined with a specific curing means and freeze drying, so that damage of high temperature to the probiotics can be avoided; the obtained microspheres have good probiotic protection capability, stability and appropriate release performance, can effectively improve the survival rate of the probiotics in storage and application processes, and can better play roles in improving intestinal flora and improving the health level of hosts.

The invention relates to the field of hydrometallurgy, and particularly discloses a technological method for extracting antimony from antimony sulfide through a wet method. A process method for wet extraction of antimony from antimony sulfide comprises the following steps: S1, mixing an antimony sulfide-containing material with a tetrafluoroborate ionic liquid, and adding water for slurrying to obtain ore pulp; s2, the ore pulp is added into a leaching tank with a two-way reaction structure, and leaching treatment is conducted under the nitrogen protection atmosphere; the lower part in the leaching tank is an ore pulp phase; during leaching, sodium sulfide, sodium hydroxide, modified chitosan microspheres and a catalyst are added into an ore pulp phase; s3, the organic phase obtained after leaching treatment is completed is eluted and filtered, and an antimony-containing solution is obtained; and S4, the antimony-containing solution is fed into an electrolytic bath to be subjected to electrodeposition treatment, and antimony is collected. By means of the method, the antimony leaching efficiency can be improved, and then the antimony recovery rate can be improved.

A method of manufacturing hemostatic particles involves heating and mixing a chitosan solution and a gelatin solution to form a chitosan / gelatin solution, adding the chitosan / gelatin mixture to oil containing an emulsifier / surfactant to form a combination of chitosan / gelatin and oil, heating and mixing the combination and then cooling and stirring the combination to form gelatin-chitosan microspheres (GCM), adding an aqueous solution of glutaraldehyde to the combination and stirring to cross-link the GCM, washing the GCM with emulsifier / surfactant to remove the oil, washing the GCM with a solvent to further remove excess oil, washing the GCM with alcohol to remove excess water, and drying the GCM.

The invention relates to the technical field of medical textile materials, in particular to an anti-static medical fabric and a preparation method thereof.The anti-static medical fabric comprises an outer layer, a middle layer, an inner layer and carbon fiber grids embedded into the outer layer and the inner layer, the outer layer is made of nanofibers prepared by electrostatic spinning and comprises polyvinylidene fluoride, an F-ZnO / TiO2 composite antibacterial agent, carboxylated carbon nanotubes and grafted quaternary ammonium salt; the middle layer is a chitosan enhanced polytetrafluoroethylene film, and the surface of the middle layer is sequentially coated with a chitosan / silk fibroin transition layer and a polypyrrole conducting layer; the inner layer is a blend fiber fabric and comprises hollow polyester fibers, chitosan microsphere modified cotton fibers and carbon nanotube grafted polyamide fibers; the carbon fiber grids are embedded into the outer layer and the inner layer in a warp knitting mode with the density of 20-24 pieces / cm. According to the antistatic fabric, a four-stage conductive network is formed by the outer-layer carbon nanotubes, the middle-layer polypyrrole, the inner-layer grafted carbon nanotubes and the carbon fiber grids, so that the antistatic performance of the fabric is greatly improved.

The application provides a long-acting, non-embolism filling monodisperse chitosan microsphere, the base material of the microsphere is cross-linked chitosan, the cross-linked chitosan is formed by cross-linking reaction of component A and a cross-linking agent, or formed by cross-linking reaction of component A, component B and the cross-linking agent; the component A is at least one of chitosan and modified chitosan, and the component B is at least one of hyaluronic acid, collagen and gelatin; the particle size of the microsphere is 20-120 mu m, and the variation coefficient of the microsphere particle size is not more than 5%. The application also provides a preparation method of the microsphere. The monodispersity of the microsphere is excellent, the degradation time is relatively longer, the water absorption performance is good, the embolism risk can be reduced, the filling effect maintaining time can be prolonged, and the effect of improving wrinkles can be increased, and the problems of short filling effect maintaining time and easy to cause blood vessel embolism of the filling hyaluronic acid product used in the existing medical and beauty field can be solved.

The application relates to the field of traditional Chinese medicine oral liquid preparations, in particular to a chitosan microsphere and a preparation method thereof and application of the chitosan microsphere in preparation of Baoyuan oral liquid preparations. The chitosan microsphere comprises, in weight parts, 80-120 parts of chitosan, 2-5 parts of an emulsifier and 30-40 parts of an oil phase; the chitosan microsphere is obtained by dissolving in an acid solution and then reacting with the emulsifier and the oil phase. The application adds a clarifying agent, i.e. a mixture of chitosan microspheres with different particle sizes, carries out flocculation adsorption, and adds a stabilizer sodium carboxymethyl cellulose CMC-Na; through the synergistic effect of the two, the quality and safety of the oral liquid are remarkably improved. The colloids after adsorption of the clarifying agent can be more stably dissolved in the medicinal liquid under the synergistic effect of the stabilizer sodium carboxymethyl cellulose, the preparation precipitation problem is solved, and the prepared Baoyuan oral liquid has good stability and immunoregulatory activity.

The invention provides an agricultural waste hydrolytic acidification method and a method for synthesizing medium-chain fatty acid, and belongs to the technical field of agricultural waste resource utilization. The invention provides an agricultural waste hydrolytic acidification method which comprises the following steps: after adjusting the solid content of agricultural waste, mixing the agricultural waste with short-chain AHLs and DPD-loaded chitosan microspheres to obtain a hydrolytic acidification system; and carrying out anaerobic fermentation on the hydrolytic acidification system to obtain a hydrolytic acidification product. According to the method, short-chain AHLs are added in the hydrolytic acidification process of the agricultural wastes to activate related genes of hydrolytic acidification bacteria, so that biofilm formation and extracellular enzyme secretion are promoted, the hydrolytic acidification efficiency of a substrate is improved, and substrate decomposition and short-chain fatty acid accumulation are promoted; dPD is released in a delayed manner in the metabolic peak period of acid-producing bacteria, the metabolic division of hydrolytic bacteria and acid-producing bacteria is coordinated, the activity of methanogens is inhibited, substrate competition is reduced, the degradation rate of agricultural waste cellulose is increased, and the yield of medium-chain fatty acid precursor substances such as acetic acid in fermentation substrates is increased.

This invention provides a thiourea-tertiary amine bifunctional chitosan microsphere and its preparation method, belonging to the field of adsorption material technology. Through a stepwise functionalization and sequential crosslinking method, thiourea groups are first introduced onto the chitosan microspheres, followed by the introduction of tertiary amine groups and secondary crosslinking, successfully preparing chitosan microspheres possessing both thiourea and tertiary amine bifunctional groups. The thiourea and tertiary amine groups in the microspheres of this invention exhibit a synergistic adsorption effect on noble metal chloride anions, significantly improving the selective adsorption capacity and adsorption rate for noble metals such as palladium, platinum, and rhodium. Simultaneously, the dense three-dimensional network structure constructed through stepwise crosslinking greatly enhances the chemical stability and mechanical strength of the microspheres under strongly acidic environments, extending their service life. This preparation method is simple, mild, and environmentally friendly. The prepared adsorbent is particularly suitable for the efficient and selective recovery of noble metals from complex acidic wastewater or electronic waste leachates.

The invention relates to the field of vanadium batteries, and discloses a method for preparing a vanadium battery electrolyte from an alkaline vanadium liquid in a short process, which comprises the following steps: adding an adsorbent into the alkaline vanadium liquid to remove impurities to obtain an impurity-removed vanadium liquid; wherein the adsorbent comprises sulfhydrylated chitosan microspheres; the impurity-removed vanadium liquid and a transforming agent are mixed and react, V (OH) 4 + in the impurity-removed vanadium liquid is transformed into VO < 2 + >, and transformed vanadium liquid is obtained; wherein the transforming agent comprises ascorbic acid and sulfite; and the converted vanadium liquid is adjusted to be acidic, a stabilizer is added to obtain a to-be-electrolyzed solution, the to-be-electrolyzed solution is electrolyzed, and an electrolyte containing V < 3 + > and VO < 2 + > is obtained. The preparation process of the electrolyte can be effectively shortened, impurity interference is avoided, and the current efficiency is improved.

The invention belongs to the technical field of sterilization and disinfection materials, and particularly relates to a wrapped slow-release chlorine composition and a preparation method and application thereof.The composition is of a unique dual-wrapping structure, the core is a mixture of sodium chlorite and a stabilizer, the composition is primarily wrapped with hydrophobic modified chitosan microspheres and then combined with citric acid, and the wrapped slow-release chlorine composition is prepared. And finally, the metal coordinated polyethylene glycol hydrogel is used for outer layer coating to form a complete slow-release system. The preparation method comprises the following steps: firstly, preparing a microsphere carrier through hydrophobic modification and cross-linking curing of chitosan and lauric aldehyde; then, polyethylene glycol amine and a derivative of pyridinedicarbonyl chloride are subjected to cobalt ion coordination to form hydrogel; finally, the chlorine source components are combined and formed through adsorption, mixing and coating processes in sequence. The composition can effectively control the release rate of the chlorine component, has long-acting and stable sterilization and disinfection effects, and can be widely applied to the fields of water treatment, food preservation, medical instrument disinfection, agricultural disease control and the like.

The invention relates to a skin antiallergic composition and a preparation method and application thereof, and the composition is prepared from the following raw materials: sodium cellulose, essence, propylene glycol, a coating solution, a nonionic surfactant and water, the coating solution is prepared by taking modified chitosan microspheres, ascophyllum nodosum extract, chamomile flower extract, centella asiatica extract, anthemis nobilis flower extract, glycerol and water as raw materials, and the modified chitosan microspheres are products obtained by grafting polylactic acid with chitosan. The modified chitosan microsphere can form a nano-micelle with a core-shell structure in a solvent, the ascophyllum nodosum extract, the chamomilla recutita extract, the centella asiatica extract and the anthemis nobilis extract are wrapped in the nano-micelle, the situation that the extracts are degraded or inactivated due to the external environment is avoided, a stable dispersion system can be formed in water, and the stability of the nano-micelle is improved. The plant extract is released after the body surface is coated, and the plant extract and other components synergistically improve the anti-allergic effect of the skin.

The invention discloses soybean phospholipids and an extraction method thereof, and belongs to the technical field of soybean phospholipids, the extraction method of soybean phospholipids comprises the following steps: selecting fresh soybean oil leftovers as an extraction raw material, carrying out centrifugation, acetone deoiling and ethanol extraction to obtain an ethanol extraction liquid, finally adding attapulgite composite cross-linked chitosan microspheres into the ethanol extraction liquid, and carrying out centrifugation, acetone deoiling and ethanol extraction to obtain the soybean phospholipids. And further removing impurity molecules to obtain the soybean phospholipid with high stability and high soybean lecithin content. According to the present invention, by using the multiple pore structures and the electrostatic interaction of the attapulgite composite cross-linked chitosan microspheres, the impurity macromolecules and the polar inositol phospholipid, cephalin and other compounds having competitive dissolution with the soybean lecithin are separated so as to increase the soybean lecithin content in the soybean lecithin; moreover, tea polyphenol is also grafted on the attapulgite composite cross-linked chitosan microspheres, so that free radicals can be cleared through a hydrogen supply mechanism, the phospholipid oxidation process is blocked, the dual functions of high stability and high antioxidant activity are realized, and the quality of the obtained soybean phospholipid is improved.

This invention belongs to the field of traditional Chinese medicine fermentation technology, specifically involving a high-enzyme-active Liu Shen Qu (a type of fermented medicinal herb) and its fermentation process. The process first processes red beans, bitter almonds, artemisia annua, cocklebur, and polygonum hydropiper into a medicinal porridge, which is then mixed with wheat flour and a specific fermenting agent to form a soft mass. Its innovation lies in the use of a Bacillus subtilis trehalose protective agent complex and Aspergillus oryzae chitosan microspheres. These two fermenting agents are prepared by spray drying encapsulation and ionogel methods, respectively, significantly improving the survival rate and stability of the fermenting microorganisms during processing and storage. The soft mass undergoes two stages of precisely controlled temperature and humidity fermentation, and finally, after shaping and segmented drying, the finished product is obtained. This process effectively solves the problems of low enzyme activity and poor stability in traditional Liu Shen Qu fermentation, resulting in a Liu Shen Qu product with high digestive enzyme activity and stable, uniform quality.

The application discloses a degradable polymer-based bone repair 3D printing composite material and a preparation method and application thereof, and belongs to the technical field of bone repair material preparation.The raw material of the degradable polymer-based bone repair 3D printing composite material comprises a degradable polymer, a compatibilizer and hydroxyapatite and Mg(OH)2 co-loaded chitosan microspheres.The degradable polymer-based bone repair 3D printing composite material has good mechanical properties, biocompatibility, mineralization capacity, antibacterial and anti-inflammatory properties, can be used as a bone repair material, and is used for preparing a bone repair product through 3D printing after being prepared into a bone repair 3D printing wire material through extrusion molding, thereby providing a novel material solution for bone tissue regeneration and repair.The chitosan can adjust macrophage polarization and reduce the expression of inflammatory factors, so that the composite material has anti-inflammatory properties.

The application discloses a kind of soil remediation agent for environmental pollution and preparation method thereof, and relates to the technical field of soil regeneration.The preparation method comprises the following steps: first, iron sulfate and manganese sulfate are added to deionized water, stirred and dissolved to obtain a mixed salt solution;Then, chitosan microspheres are prepared;Chitosan microspheres are then added to the mixed salt solution for reaction to obtain chitosan-loaded iron-manganese composite oxides;Finally, chitosan-loaded iron-manganese composite oxides are added to a disodium ethylenediaminetetraacetate solution for reaction to obtain a soil remediation agent.The soil remediation agent is a special agent material for heavy metal environmental pollution treatment, can efficiently treat various heavy metals in soil, and has good adaptability to acidic and alkaline soils, thereby achieving soil regeneration.

The present application relates to the technical field of PET label, and particularly relates to a high-temperature-resistant waterproof PET label and a preparation process thereof. The present application obtains antibacterial modified chitosan microspheres by adding chitosan, nano titanium dioxide, span 80 and cinnamaldehyde; the antibacterial modified chitosan microspheres, isopropyl alcohol, epoxidized methylphenyl polysiloxane and a curing agent are mixed to obtain an epoxidized silicon coating. The epoxy resin is heated to be molten, and then hydrophobic silicon dioxide, a curing agent, dioctyl phthalate and acetone are added and uniformly stirred to obtain an adhesive. The epoxidized silicon coating is coated on the surface of a PET film, and then is left to stand and solidify to obtain a waterproof PET film; one side of the waterproof PET film is coated with the adhesive and is combined with a PET release base paper, and the other side of the PET film is coated with ink to obtain a finished product. The finished product prepared by the present application has excellent antibacterial performance and waterproof performance, and therefore has a wide application prospect in the technical field of PET label.

The invention discloses a microbial fertilizer for treating citrus huanglongbing and a preparation method of the microbial fertilizer, and belongs to the field of agricultural biological control. 33 to 50 percent of sodium alginate-chitosan microspheres; 5 to 8% of hesperidin; 3-5% of nano zinc oxide; 2-4% of humic acid chelated boron; 2-4% of sucrose fatty acid ester; 2-4% of diatomite; wherein the preparation method of the sodium alginate-chitosan microspheres comprises the following steps: mixing sodium alginate with a microbial suspension, dropwise adding the mixture into a calcium chloride solution by using an injector, and standing and curing to form a microsphere core; and immersing the cured microspheres into a chitosan solution with the pH value of 6.0, taking out, and freeze-drying to obtain finished microspheres. Wherein the microbial suspension comprises trichoderma, bacillus and actinomycetes. The invention solves the problems of poor prevention and treatment effect of the existing Candidatus Liberobacter asiaticum, difficulty in colonization of the strain at phloem, short survival time and lack of targeted slow release function.

The invention discloses an antibacterial medical hydrocolloid pressure-sensitive adhesive tape and a preparation process thereof, and belongs to the technical field of adhesives, quaternary ammonium salt chitosan microspheres with an antibacterial effect and iodine elementary substances are loaded through charge transfer to form a composite antibacterial agent, and the composite antibacterial agent is used as a filler of the antibacterial medical hydrocolloid pressure-sensitive adhesive tape and can be used for preparing the antibacterial medical hydrocolloid pressure-sensitive adhesive tape. The long-acting antibacterial requirement of the pressure-sensitive adhesive tape can be met. The antibacterial medical hydrocolloid pressure-sensitive adhesive tape prepared by the invention has very high tensile strength and tear resistance, and the quaternary ammonium salt chitosan microsphere structure can disperse stress, so that the antibacterial medical hydrocolloid pressure-sensitive adhesive tape is not easy to damage and strong in cohesion in the use and activity processes, is integrally stripped when being uncovered, and does not break or leave sticky residual adhesive; the adhesive tape can be firmly adhered to dry skin, can bear a certain degree of body activity, is smooth in stripping during replacement due to high water absorption and softness, has small trauma to skin and new tissues, and is particularly suitable for sensitive skin and long-term application.

The invention relates to the field of medical auxiliary equipment, in particular to an inflatable foot drop corrective shoe and a preparation method thereof.The inflatable foot drop corrective shoe is prepared from, by mass, 75-80 parts of modified polyurethane rubber, 6-8 parts of a modified chain extender, 10-12 parts of modified chitosan microspheres, 5-7 parts of modified nano-silicon dioxide and the like. Through dynamic cross-linked network design, multi-stage antibacterial function integration and gradient mechanical regulation and control technologies, compared with the prior art, synergistic breakthrough of damage self-repairing, long-acting antibacterial protection and bionic comfortable supporting is achieved. An innovative material system can actively respond to a foot microenvironment, airtight stability is maintained under repeated mechanical stress, meanwhile, the infection risk is reduced through a molecular-level hydrophilic-antibacterial bifunctional interface, and the wearing safety and rehabilitation suitability are remarkably improved. The foot care solution is suitable for the field of chronic disease foot care and has wide clinical application prospects.

The invention discloses micro-plastic adsorption chewing gum for a digestive system and a preparation method thereof.The chewing gum comprises an oral cavity adsorption layer, a transition protection layer, an intestinal tract stabilizing layer and a bionic gastric mucosa core layer which are sequentially arranged from outside to inside, and the oral cavity adsorption layer is a film prepared from chitosan microspheres, gutta-percha and nano activated carbon; the transition protection layer is a film prepared from a hydroxypropyl methylcellulose phthalate ethanol solution, the intestinal tract stabilizing layer is a film prepared from PLGA and dichloromethane, and the bionic gastric mucosa core layer is an elastic film prepared from silicone rubber and aluminum hydroxide micro powder. Through the triple design of time-controlled dissolution of the transition layer, mechanical locking of the gum-based grid and physical bottom wrapping of the core layer, it can be ensured that microplastics adsorbed by the oral cavity layer are not released again even though the oral cavity layer is dissolved in the stomach, and the whole process from the oral cavity to discharge is safe.

The present invention discloses an adsorbent for removing excess hepcidin and a preparation method thereof. The adsorbent for removing excess hepcidin is made by using EDTA as a cross-linking agent to form cross-linked chitosan microspheres embedded with zirconium phosphate and / or zirconium oxide, and L-glutathione is bonded to the surface of the cross-linked chitosan microspheres. The adsorbent for removing excess hepcidin of the present invention uses chitosan microspheres as a carrier, and while the microspheres are cross-linked, further bonding ligands are introduced, eliminating the need for additional cross-linking agents and ligands. The reaction conditions are mild, the preparation method is simple, and the cross-linked microspheres have suspended carboxyl groups, which can be further coupled with peptides and amino acids to achieve functional modification. The microspheres can withstand high-temperature steam sterilization and effectively remove excess hepcidin and urea nitrogen from the blood.

The application discloses a preparation method of chitosan microspheres for cell immobilization and drug delivery, and relates to the field of chitosan microsphere preparation. The application carries out deacetylation on chitin through a microwave induction process technology combined with enzymes, carries out heavy metal green chelation on chitosan by using glutamic acid diacetic acid tetrasodium or citric acid, further improves the extraction and removal capacity of the chelating agent on residual metal ions by using a carbonate salt solubilization technology, and separates and hydrolyzes trace amounts of protein and lipids in the crude chitosan by selecting appropriate biological enzymes to obtain refined chitosan. Meanwhile, the refined chitosan is subjected to enzymatic molecular modification by applying transglycosylation or oxidase, and finally, the chitosan microspheres are prepared by using a green and environment-friendly spray drying method. The chitosan microspheres prepared by the application are smooth in shape, uniform in size, have a particle size of 1-250 mu m, and have a shell-core structure. The chitosan immobilized enzyme widens the application of chitosan in the fields of medicine, food and the like.

This invention relates to the field of pharmaceutical intermediate synthesis technology, and discloses a preparation process for diaminophenoxyethanol sulfate, comprising the following steps: Step S1, preparing chitosan-supported nickel nanoparticles: using chelated cross-linked chitosan microspheres to chelate nickel salt, and then adding a reducing agent to reduce nickel ions to obtain chitosan-supported nickel nanoparticles; Step S2, using 2,4-dinitrochlorobenzene and ethylene glycol as raw materials, synthesizing 2,4-dinitrophenoxyethanol under the action of an alkaline catalyst; Step S3, using 2,4-dinitrophenoxyethanol as raw material and 1,4-dioxane as solvent, the prepared chitosan-supported nickel nanoparticles have a higher loading capacity for nickel nanoparticles. As a catalyst, in the process of catalyzing the hydrogenation of 2,4-dinitrophenoxyethanol to prepare 2,4-diaminophenoxyethanol, the nickel nanoparticles are not prone to agglomeration, and after repeated use, they still maintain good catalytic activity and excellent stability.

The invention discloses a multi-channel micro-fluidic chip and a preparation method of monodisperse chitosan microspheres in the multi-channel micro-fluidic chip, and belongs to the technical field of chitosan microsphere preparation, the multi-channel micro-fluidic chip comprises an upper layer substrate, a middle layer substrate and a lower layer substrate, and further comprises a continuous phase channel assembly, a disperse phase channel assembly and a microsphere collection assembly, the upper-layer substrate, the middle-layer substrate and the lower-layer substrate are fixedly connected in sequence from top to bottom, the upper-layer substrate is connected with a continuous phase channel assembly, the middle-layer substrate is connected with a dispersed phase channel assembly, the lower-layer substrate is connected with a microsphere collecting assembly, and the continuous phase channel assembly, the dispersed phase channel assembly and the microsphere collecting assembly are connected with one another. Through the mode, the monodisperse chitosan microspheres with uniform size and controllable morphology can be prepared.

The invention discloses a chitosan microsphere-polyethylene glycol diamine composite aldehyde-sensitive intelligent indicating film and a method, and belongs to the technical field of active intelligent packaging. According to the indicating membrane, alcohol-soluble polyvinylpyrrolidone and ethyl cellulose are used as a composite matrix to construct a total ethanol phase membrane forming system, and polyethylene glycol diamine modified chitosan microspheres loaded with an indicator are introduced, so that the problem of dispersion of hydrophilic microspheres in a hydrophobic organic phase is solved. The indicating film is high in drying efficiency, good in component compatibility and high in transparency. The microspheres are uniformly dispersed in a continuous phase, so that the response sensitivity and mechanical strength to volatile aldehyde gas are greatly improved, and the freshness of perishable food can be quickly and nondestructively detected. The maturing and rotting states of fruits and vegetables can be visually reflected through color changes, and the material is high in thermal stability, high in water vapor barrier property, degradable, low in cost and suitable for intelligent packaging and fresh food circulation monitoring.