The embodiment of the present invention relates to the technical field of nano-medicine, and specifically discloses a conjugated compound, a preparation method, a nano-targeted drug, and an application. The conjugated compound includes the following raw materials: octahedral ceria, hydroxyl-containing Anti-inflammatory components of M2-type macrophage polarization and 3‑aminopropyltriethoxysilane. The conjugated compounds provided in the examples of the present invention have excellent anti-inflammatory effects, and can regulate The immune differentiation of macrophages enables them to have a good effect on eliminating inflammation, and can also repair tissue damage caused by inflammation, which solves the problem that existing ceria-based nano-medicines cannot repair damaged periodontal inflammation while inhibiting periodontal inflammation. The problem of periodontal tissue damage is simple, the preparation method is simple, the biosafety is high, and it has broad market prospects.