The application relates to the technical field of
traditional Chinese medicine preparations, and specifically discloses a wet eczema external washing formula and a preparation method thereof. The wet eczema external washing formula is composed of three raw medicinal materials, namely,
Sophora flavescens, Fructus Mume and
Smilax glabra. The preparation method is as follows: low-temperature segmented extraction of Fructus Mume is performed to obtain an acidic extract and residues; a part of the acidic extract is used to pretreat the residues, and then enzymolysis is performed to obtain a directional
polysaccharide extract; the remaining acidic extract is used to extract
Sophora flavescens and
Smilax glabra; the extract and the
polysaccharide extract are combined at a controlled speed to construct a non-covalent compound; after
nitrogen protection, segmented concentration and low-temperature curing and shaping, the product is obtained through filling, sterilization and the like. The wet eczema external washing formula can be used for wet eczema external washing treatment, active ingredients can form a sustained-release
colloid network, the
skin residence time is prolonged, and the
antipruritic and anti-inflammatory effects are long-lasting. In the preparation method, no exogenous acid and alkali and no chemical stabilizer need to be introduced, resource closed-loop utilization in the formula is realized, the
dissolution rate of active ingredients and the stability of the preparation are high, the process
controllability is good, and the preparation method is suitable for industrialized production.