The invention relates to a digital loudspeaker drive method and a device based on quaternary code dynamic mismatch reshaping. The method comprises the steps of (1) conducting input format conversion, (2) conducting multi-bit sigma to delta modulation, (3) conducting thermometer code conversion, (4) conducting dynamic mismatch reshaping processing, (5) conducting channel data combination and mapping coding, (6) controlling metal-oxide-semiconductor field effect transistor (MOSFET) pipe of a full-bridge power amplifier network to conduct opening and closing status switching, and driving a digitalized loudspeaker load to produce sound. The device comprises a sound source (1), a digital format converter (2), a multi-bit sigma to delta modulator (3), a thermometer coder (4), a dynamic mismatch reshaper (5), a channel data combiner (6), a mapping coder (7), a multi-channel digital amplifier (8) and the digitalized loudspeaker load (9). The units are sequentially connected in order. According to the digital loudspeaker drive method and the device based on quaternary code dynamic mismatch reshaping, use efficiency of an amplifier pipe and the load is improved, development periods and hardware implementation cost are saved, and good immunity is provided for frequency response deviation of digital channels.