The invention discloses a brewing method of dendrobium officinale and siraitia grosvenorii wine. The brewing method comprises the following steps of preparing dendrobium officinale homogenate; preparing siraitia grosvenorii homogenate; performing first-step fermentation, loading the siraitia grosvenorii homogenate into a fermentation tank, adding food grade ion exchange resin, and adding yeast for fermenting; performing second-step fermentation, then adding the dendrobium officinale homogenate, honey and traditional Chinese medicine leaching liquid for continuously fermenting, wherein the traditional Chinese medicine leaching liquid is prepared from the following components: rhizoma curculiginis, lucid ganoderma, cornu cervi pantotrichum, largehead atractylodes rhizome, rhizoma chuanxiong, liquorice root, fructus lycii and tangerine peel; treating after fermenting, and roughly filtering after the second-step fermentation to obtain wine liquid; adding alum powder, ageing, using a compound fining agent for fining; freezing, filtering and canning to obtain the dendrobium officinale and siraitia grosvenorii wine. The compound fining agent is prepared from the following components: polyvinylpyrrolidone hydrogel, silica sol, activated carbon, chitosan powder and lactic acid. According to the brewing method disclosed by the invention, effective ingredients of the dendrobium officinale and siraitia grosvenorii wine are fully extracted and fused; meanwhile, the content of total acid in the wine, the content of methanol, the content of fusel oil and the content of lead are reduced.