Double ion modified cellulose membrane and making method thereof

A cellulose membrane and dual-ion technology, applied in the field of dual-ion modified cellulose membrane and its preparation, can solve the problems of decreased membrane flux, harsh conditions, complicated processes, etc. good water effect

Active Publication Date: 2014-09-17
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods have the following limitations: 1) the process is complex and requires multi-step reactions, and generally requires the introduction of active groups before initiating polymerization; 2) the conditions are harsh, and oxygen must be removed during the operation; 3) this modification method is easy to cause Significant decrease in membrane flux

Method used

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  • Double ion modified cellulose membrane and making method thereof
  • Double ion modified cellulose membrane and making method thereof
  • Double ion modified cellulose membrane and making method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of double-ion modified cellulose membrane may further comprise the steps:

[0039] (1) Preparation of (3-carboxypropylbetaine propyl) trimethoxysilane

[0040] Dissolve β-propiolactone (1.799 g, 0.025 mol) in 20 mL of purified anhydrous acetone and add dropwise to purified anhydrous acetone of (N,N-dimethyl-3-aminopropyl)trimethoxysilane In the solution, the volume of (N,N-dimethyl-3-aminopropyl)trimethoxysilane is 5.68mL, under the protection of nitrogen, react at room temperature for 5 hours, and the white solid obtained is washed with anhydrous acetone , and then washed with anhydrous ether, and finally the solvent was removed under reduced pressure, vacuum freeze-dried, and the monomer was stored at 2-8°C.

[0041] 1 H-NMR(DMSO-6D,300MHz):δ0.5-0.6(t,2H,Si-C H 2 ),1.5-2.0(t,2H,C-C H 2 -C),2.5-3.0(m,2H,C-C H 2 -N),3.2-3.5(m,2H,N-C H 2 -C),3.0(s,6H,C H 3 -N-C H 3 ),2.5-2.6(t,2H,C H 2 -COO-),3.0-3.5(s,9H,C H 3 -O-Si).

[0042] E...

Embodiment 2

[0054] The preparation method of double-ion modified cellulose membrane may further comprise the steps:

[0055] (1) Preparation of (3-sulfopropylbetaine propyl) trimethoxysilane:

[0056] Add 7.5mL (N,N-dimethyl-3-aminopropyl)trimethoxysilane and 4.5g (3.23mol) 1,3-propane sultone to 37mL solvent-purified anhydrous acetone at 25°C Stir and react under the conditions for 12 hours, a white solid is formed, wash with acetone 4 times, filter with suction, dry under vacuum at 30°C, and store in a sealed container;

[0057] 1 HNMR(DMSO-6D,300MHz):δ0.4-0.6(t,2H,O-Si-C H 2 ),1.6-1.8(m,2H,C-C H 2 -C-Si),1.9-2.0(m,2H,S-C-C H 2 -C),2.4-2.5(t,2H,C-C H 2 -N),3.0(S,6H,C H 3 -N-C H 3 ),3.1-3.3(m,2H,N-C H 2 -C),3.3-3.4(m,2H,C-C H 2 -S),3.5(s,9H,C H 3 -O-Si).

[0058] Experiments have shown that the reaction in this step was stirred and reacted at 35°C for 8 hours, the number of times of washing with acetone was 2 times, and when the temperature of vacuum drying was 40°C, ...

Embodiment 3

[0069] The preparation method of double-ion modified cellulose membrane may further comprise the steps:

[0070] (1) Preparation of (3-sulfobutyl betaine propyl) trimethoxysilane:

[0071] Mix 7.5mL (N,N-dimethyl-3-aminopropyl)trimethoxysilane and 3.5mL 1,4-butane sultone evenly, raise the temperature to 60°C for 1 hour, cool to room temperature, and get The white solid was washed with anhydrous acetone, suction filtered, vacuum-dried, and sealed for storage;

[0072] 1 HNMR(DMSO-6D,300MHz):δ0.58(t,2H,O-Si-C H 2 ),1.6(m,2H,O-Si-C-C H 2 ),1.72(m,2H,N-C-C-C H 2 -C-S),2.08(S,2H,N-C-C H 2 ),2.4-2.5(t,2H,O-Si-C-C-C H 2 ),2.96(s,6H,C H 3 -N-CH3),3.16(m,2H,N-C H 2 ),3.43(m,2H,N-C-C-C-C H 2 -S),3.51(m,9H,Si-O-C H 3 ).

[0073] Experiments have proved that (3-sulfobutylbetaine propyl) trimethoxysilane can be obtained by reacting at 50°C for 2 hours in this example

[0074] (2) Take three containers, add 30mL of methanol and 1.67g of the product obtained in step (1)...

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Abstract

The invention discloses a double ion modified cellulose membrane and a making method thereof. The double ion modified cellulose membrane comprises a cellulose membrane, and a double ion polymer containing a siloxane group is grafted to the surface of the cellulose membrane through the hydrolysis condensation effect of a hydroxy group on the surface of the cellulose membrane and a double ion monomer containing the siloxane group. Compared with the raw material cellulose membrane, the double ion modified cellulose membrane has the advantages of similar membrane flux, good hydrophilicity while maintaining large flux, strong protein pollution resistance, good compatibility with blood, simple making method thereof, and realization of operation cost reduction without oxygen removal in the operation process.

Description

technical field [0001] The invention relates to a dual-ion modified cellulose membrane and a preparation method thereof. technical background [0002] Cellulose membrane is a widely used membrane material, which is widely used in biomedical fields, including medical devices, implant materials, tissue engineering and bioseparation. However, cellulose membranes have limited their applications due to their nonspecific protein adsorption and insufficient biocompatibility. Non-specific protein adsorption and poor bio(blood)compatibility on the membrane surface are extremely important issues when used as implanted biomaterials or for bioseparation and blood separation, since this may cause a series of problems, including bacterial infection, A series of unexpected biological reactions such as thrombus formation. [0003] In recent years, people have used surface modification to improve the anti-protein fouling ability and biocompatibility of the membrane surface. The commonly us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08L1/02C08G77/06
Inventor 孟建强徐明丽袁涛孙甜
Owner TIANJIN POLYTECHNIC UNIV
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