The invention discloses wine with effects of tonifying kidneys and strengthening bones and a method for preparing the wine. Medicinal compositions of the wine with the effects of tonifying the kidneys and strengthening the bones comprise, by weight, 20-30 parts of radix codonopsis, 10-30 parts of radix astragali, 10-30 parts of rhizoma atractylodis macrocephalae, 20-40 parts of radix glycyrrhizae, 10-30 parts of rhizoma dioscoreae, 10-30 parts of radix angelicae sinensis, 20-40 parts of radix rehmanniae preparata, 10-30 parts of radix polygoni multiflori, 10-30 parts of radix morindae officinalis, 10-30 parts of herba epimedii, 10-30 parts of fructus psoraleae, 10-30 parts of herba cistanches, 10-30 parts of herba cynomorii, 10-30 parts of semen cuscutae, 10-30 parts of cortex eucommiae, 20-40 parts of fructus lycii, 10-30 parts of radix ophiopogonis, 10-30 parts of rhizoma polygonati, 5-20 parts of cortex cinnamomi, 5-25 parts of radix aconiti lateralis preparata, 10-30 parts of poria, 10-30 parts of rhizoma alismatis, 20-40 parts of pericarpium citri reticulatae, 10-30 parts of cortex acanthopanacis, 10-30 parts of rhizoma cibotii, 10-30 parts of fructus corni, 10-30 parts of fructus rubi, 10-30 parts of fructus schisandrae chinensis, 10-30 parts of semen euryales, 10-30 parts of rhizoma chuanxiong, 10-30 parts of radix achyranthis bidentatae, 10-30 parts of radix salviae miltiorrhizae, 10-30 parts of flos carthami, 20-40 parts of concha ostreae, 20-40 parts of ossa draconis, 10-30 parts of radix scrophulariae, 10-30 parts of radix rehmanniae, 10-30 parts of radix dipsaci, 10-30 parts of rhizoma curculiginis, 5-25 parts of herba taxilli, 1-3 parts of cornu cervi pantotrichum and 1-3 parts of penis cervi. The wine and the method have the advantages that the wine and the method conform to traditional Chinese medicine differentiation ideology, and monarch, minister, assistant and guide medicines are distinct and are properly matched with one another; the wine comprises Chinese herbal medicines in the pharmacological test ranges, is high in safety and can be used for a long time, obvious curative effects can be realized, effects of tonifying the kidneys, strengthening the bones, relaxing muscles and tendons, removing obstruction from meridians and the like can be realized, kidney power can be increased, and immune functions of human bodies can be enhanced.