6708results about How to "Small side effects" patented technology

The present invention relates to a method capable of using natural and artificial synthetic isosulfocyanate compound or its derivative to prevent and cure prostatic diseases and skin carcinoma. The internal tests show that various isosulfocyanate compounds or their derivatives can induce prostatic cell II phase drug metabolic detoxication enzyme-glutathione transferase so as to can inhibit the hyperplasia of prostate and inflammation, and can prevent and cure prostatic carcinoma and skin carcinoma.

The invention discloses a layer feed containing a traditional Chinese medicine additive. The layer feed comprises the following components in parts by weight: 60-80 parts of corn powder, 8-10 parts of bran, 8-10 parts of bean pulp, 8-10 parts of fish meal, 8-10 parts of shell powder, and 2-12 parts of traditional Chinese medicine additive, wherein the traditional Chinese medicine additive comprises the crude drugs in parts by weight: 5-10 parts of dandelion, 3-5 parts of herba andrographitis, 3-5 parts of rhizoma atractylodis, 5-10 parts of honeysuckle, 5-10 parts of fructus cnidii, 10-15 parts of selfheal, 10-15 parts of baical skullcap root, 10-15 parts of astragalus root, 10-15 parts of Polygonum multiflorum Thunb, 5-10 parts of hawthorn, 0.5-1 part of lucid ganoderma, 10-15 parts of codonopsis pilosula, 10-15 parts of angelica sinensis, 5-10 parts of semen cuscutae, 5-8 parts of clove, 5-8 parts of pericarpium citri reticulatae, 5-8 parts of hawthorn and 5-8 parts of cinnamon. The immunoreactive substance can enhance the immune function of organism, improves the anti-stress ability and the disease resistance of the animal, improves the production performance of the animal, and simultaneously has the advantages of small toxic and side effects, no drug-resistance, no residue and the like; the survival rate of chicken is greatly improved; the lecithin content of the egg is obviously improved; the cholesterol content of the egg is reduced; and the nutritive value of the egg is improved.

The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.

The invention relates to a laying hen feed prepared from bran, salt, corn grit, fish meal, ground oyster shells, rice bran, bean dregs and a traditional Chinese medicine feed additive, wherein the traditional Chinese medicine feed additive comprises the following components: honeysuckle, common cnidium fruit, corydalis tuber, small fennel, motherwort, self-heal, houttuynia, baikal skullcap root, dyers woad leaf, dangshen, astragalus root, angelica sinensis, medical stone, eclipta, dodder, barbat skullcap and weeping forsythia. The feed additive provided by the invention has both medicinal and nutritional actions, can prevent diseases and can also improve the production performance; the feed additive can directly sterilize and inhibit bacteria, adjusts the immunity function of of the organism, has non-specific antibacterial action, and greatly improves the survival rate of chicken; and the feed additive eliminates chemical damage to the chicken, can effectively improve the production performance of animals, simultaneously has small toxic side effects and no drug resistance, can effectively improve the egg quality, achieves the requirements of purely natural green food, and can acquire good economic benefit.

The invention discloses a mixed feed of young broiler chickens and a preparation method of the feed. The mixed feed comprises various raw materials including corns, bean pulp, wheat bran, distillers dried grains with soluble (DDGS), wheat, rapeseed dregs, rice bran, soya-bean oil, three-worm powder, fish meal, wheat compound enzyme, salt and Chinese herbal medicine additives. The preparation method comprises the steps of crushing, burdening, granulating and spraying. The mixed feed has the beneficial effects that the disease resistance and the survival rate of the young broiler chickens can be improved, the nutritional requirements of the young broiler chickens can be met, the palatability and the digestibility are high, and the production performance of the young broiler chickens is improved.

The invention discloses a broiler chicken breeding method and special feed traditional Chinese medicine addition agents thereof. According to the breeding method, during the age of 1-10 days of broiler chickens, the feed traditional Chinese medicine addition agents improving immunity of the broiler chickens are added to feeding feed; during the age of 11-19 days of the broiler chickens, the feed traditional Chinese medicine addition agents preventing respiratory diseases of the broiler chickens are added to the feeding feed; during the age of 20-29 days of the broiler chickens, the anti-virus feed traditional Chinese medicine addition agents are added to the feeding feed; during the age of 30-42 days of the broiler chickens, the feed traditional Chinese medicine addition agents promoting growth of the broiler chickens are added to the feeding feed; and adding proportion of the addition agents in the feeding feed is 0.3-1% of the total weight of the feed. The broiler chicken breeding method and the special feed traditional Chinese medicine addition agents thereof have the advantages of using the traditional Chinese medicine feed in the whole process, improving disease-resistant capacity of the broiler chickens, promoting growth and development of the broiler chickens, and being low in production cost, simple to produce and use, remarkable in use effect, and free from drug residue and adverse effect.

The invention relates to a method of cleaning a boiler, in particular to a method of chemically cleaning a boiler, which comprises the following steps: caustic cleaning, acid cleaning, rinsing, passivating and liquid waste processing. The invention has the advantages that: 1. raw material adopted in the whole cleaning process has little toxic side effect and is environment-friendly. 2. Technological mistaken ideas on cleaning various prior boilers are overcome. 3. Sequential processing is easy according to cleaning solutions.

The invention discloses a human immunodeficiency virus (HIV) affinity adsorption column, comprising a column body and at least one activated affinity microsphere located in the column body, wherein the activated affinity microsphere is connected with a human immunodeficiency virus affinity protein, and the affinity protein can be bound with human immunodeficiency virus. The affinity protein comprises a main receptor CD4 molecule, a gp120 antibody, an auxiliary receptor CXC chemokine receptor 4 (CXCR-4) and a CC chemokine receptor 5 (CCR-5). The affinity microsphere may be a glass microsphere with the size of 1mm, a chitosan crosslinking microsphere with the diameter more than 500 microns, or a gluosan microsphere. The human immunodeficiency virus affinity adsorption column disclosed by the invention is applicable for eliminating the human immunodeficiency virus in the blood of HIV patients, and relieving and treating the immunodeficiency syndrome of HIV patients; and compared with the traditional treatment methods, the immunoadsorption column has high safety, good specificity, small toxic or side effects and good operation simplicity.

The invention relates to a green, economical and sustainable method for preparing nanocellulose fibrils. The preparation method comprises the following steps that 1, a cellulose raw material is added to a citric acid solution to be heated, stirred and hydrolyzed; 2, treated cellulose and hydrolysate are separated through methods of centrifugal sedimentation and the like, and precipitated cellulose is centrifugally washed with water multiple times and diluted into a cellulose suspension; 3, the separated hydrolysate can be directly recycled at least once, citric acid is recovered from the recycled hydrolysate, and the citric acid obtained through recovery can be recycled continuously; 4, the natural structure of the cellulose suspension obtained in the second step is further destroyed through a high pressure homogenizer or ultrasonication or physical mechanical treatment of a disc mill, and the colloidal nanocellulose fibrils are obtained. According to the method for preparing the nanocellulose fibrils, a catalyst is not adopted, the reaction condition is relatively mild, the reaction is easy to control, operation is easy, and the method is friendly to environment.

An anticancer kaurane-type diterpenoid for suppressing esophagus cancer and liver cancer cells is extracted from the stem of soursop through drying in air, pulverizing, extracting in alcohol concentrating, extracting in chloroform, chromatography, eluting, chromatography and eluting. Its advantages are high effect, low toxic by-effect, broad spectrum and high activity.

The invention discloses feed for postpartum sow in a lactation period of 1-20 days and a preparation method thereof. The feed comprises the following raw materials: maize, wheat bran, soybean meal, egg yolk, powdery black fungus, soybean oil, table salt, a microelement premix and a traditional Chinese medicine additive. The feed has the benefits that based on the treatment principle of ferrum supplementing, spleen strengthening, qi invigorating and hematopoiesis, the traditional Chinese medicine additive contained in the feed cooperates with other raw materials to together act, so that the demand of the sow in the lactation period for nutrition is satisfied, and the feed has the advantages of high efficiency, low toxic and side effects, no residue, no medicine resistance, no pollution to the environment, enhancement of organism resistance, short treatment period, and no repeatability on the treatment of piglets suffering an iron-deficiency anemia disease.

The invention discloses a fluoroquinolone acetal isoniazone, of which the chemical structure general formula is disclosed as Formula I shown in the description, wherein R1 is hydrogen atom or methyl group; R2 is hydrogen atom or amino group; R3 is hydrogen atom, methyl group, ethyl group, formacyl group, acetyl group, aroyl group or sulfonyl group; R4 is hydrogen atom or methyl group; and X is oxygen atom or sulfur atom. The fluoroquinolone isoniazone disclosed by the invention implements complementarity between the two anti-tuberculosis medicines fluoroquinolone and the isoniazide, lowers the toxic and side effect of the fluoroquinolone and the isoniazide, reduces the generation probability of drug resistance of Mycobacterium tuberculosis for the double-effect antimicrobial agent, and can be used as an anti-Mycobacterium tuberculosis medicine for brand-new structure development of medicinal active substances.

The invention belongs to the technical field of medicinal and edible formula foodstuffs, and specifically relates to a special diet edible for patients with kidney yin deficiency. Kidney yin means yin-qi and yin-fluid of kidney self, is the yin basis all over the body, and has effects of cooling, moistening, soggy nourishing and limiting excess yang-heat on the whole body. According to the special diet, traditional Chinese medicines with characteristics of whole grains, homology of medicine and food, and new resource foodstuffs are combined together, diet and health preserving are organically combined, so that kidney yin deficiency is conditioned, prevented and resisted. According to the special diet, disease treatment methods as motherland traditional Chinese medicine treasures are inherited, probiotics is creatively utilized as a pioneer and is promoted in propagation, so that microecological balance in intestines is regulated, splenic and gastric motility is enhanced, and drug absorption is accelerated. Probiotics is abundant in multiple active factors, biological immune factors and multiple vitamins. Also according to constitution characteristics of the patients with kidney yin deficiency, multiple natural original-ecological medicinal and edible food materials are added, so that the special diet of the invention has the unique advantage of integration of triple-efficacy comprising dietotherapy, prevention and conditioning.

The invention relates to a novel veterinary antibacterial agent and in particular relates to a lauroyl arginine ethyl ester ion pair compound derivative which is prepared from lauroyl arginine ethyl ester LAE and an organic acid through reactions. As a livestock aquatic animal antibacterial agent, the derivative is capable of preventing and treating duckling riemerella anatipestifer diseases caused by riemerella anatipestifer, is capable of treating peritonitis diseases caused by escherichia coli and staphylococcus aureus, is capable of preventing and treating fish septicemia caused by aeromonas sobria, and has remarkably improved prevention and treatment effects when being compared with a conventional LAE veterinary antibacterial agent. The derivative can be completely degraded in human bodies and animal bodies and is small in toxic and side effect, environment drug resistance bacteria caused by residual antibacterial agents discharged into the environment can be avoided, and small adverse environment influence can be caused while an effective antibacterial effect is achieved.

The invention belongs to the technical field of medicine, particularly relates to a heterocyclic nitrogen compound which acts as a tyrosine kinase inhibitor and is represented by a general formula (I) as well as a deuterated material, pharmaceutically acceptable salt or stereisomer thereof. In the general formula (I), X, W, R1, R2, R3, L1, L2, a, b, c, d, e, p, q, a ring A and a ring B are defined in specification. The invention further relates to a preparation method of the compounds, a pharmaceutic preparation containing the compounds, and important actions of the compounds in treatment of leukemia (such as B cell chronic lymphocytic carcinoma and non-hodgkin lymphoma) related to B cell, and autoimmune diseases (such as rheumatoid arthritis and systemic lupus erythematosus).

The invention provides a medicine eluting balloon catheter. The medicine eluting balloon catheter has the characteristics of simple structure, simple production process, less loss of medicines in a conveying process, and less medicine residue amount on a balloon after interventional operation. The medicine eluting balloon catheter has a simple structure and is also suitable for large-scale production.

The invention relates to synthesis and application of an indole hemicyanine dye, which belongs to the synthesis of a functional dye and the application of the functional dye as a fluorescent dye in the field of fine chemistry industry. Indole quaternary ammonium salts and the corresponding aldehyde are condensed to form compounds with the advantages of large molar extinction coefficient, good light stability, easy synthesis and the like. The molecules have pH probe property, solid-state fluorescent property and binding property with biomacromolecules according to different substituents and anions. Being used as a pH probe, the compound can adjust the pKa of the probe according to the different substituents, and can be used for two-color living cell imaging; being used as a solid-state emission dye, the compound can adjust the solid-state emission wavelength according to different substituents and anions; being used as a biological molecule probe, the compound has good very response to the biological molecule, and living cell membrane permeability ability, can be used for cell staining, can prevent the interference of biomass autofluorescence because of longer absorption and emission wavelengths, and can also reduce the damage of exciting light to cells or biological tissues.

The present invention provides a paris total saponin extract for resisting tumor metastasis and a pharmaceutical preparation thereof. The pharmaceutical preparation is composed of paris total saponin extract as the active component and medicinal auxiliary materials; wherein, the weight percentage of paris total saponin extract in the total weight of the pharmaceutical preparation is 60 to 98 percent. The paris total saponin extract for resisting tumor metastasis and the pharmaceutical preparation provided by the present invention have good inhabitation on the metastasis of animal transplanted tumor cells, demonstrated in (1) significant anti-metastasis function for inbred mice and nude mice metastasis model of vaccinated mouse lung adenocarcinoma, human lung cancer, human gastric cancer, human intestinal cancer, human liver cancer and other tumor strains; (2) significant effect on relative albumen metastasis; (3) significant effect on relative gene metastasis and no obvious toxicity on major viscera. In addition, the main active component of the pharmaceutical preparation is a Chinese medicine extract, so compared with chemical drugs, the present invention has the advantage of small toxicity.

The invention relates to the technical field of medicine, which is a preparation of a taxane drug for intravenous drug delivery, consisting of two parts of drug solution and an emulsion. The drug solution is composed of paclitaxel or docetaxel, a pH regulator and a solvent for injection, wherein, the solvent for injection is an organic solvent; the emulsion comprises a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When in use, the drug solution can be added and evenly mixed in the emulsion for direct intravenous drip according to the clinical drug dosage and can also be firstly added in the emulsion with the volume that is not less than 5 times of the volume of the drug solution according to the clinical drug dosage and then added with a certain amount of physiological saline or glucose injection for intravenous drip. The preparation of the invention does not contain solubilizer and has the advantages of little toxicity, safety, effectivity, stability and economy. The fat emulsion can also be taken as a nutrition replenisher for a patient, thus achieving better treatment effects. The physiological saline or the glucose injection can also replace a certain amount of the emulsion, so the storage and the transportation are convenient, and the preparation is more economical.

The invention belongs to the technical filed of medicines, and concretely relates to optically pure benzyl-4-chlorophenyl C-glucoside derivatives represented by formula (II) and formula (III), a method for preparing the above compounds and intermediates thereof, a medicinal preparation and a medicinal composition containing the compounds, and an application of the optically pure benzyl-4-chlorophenyl C-glucoside derivatives in the preparation of medicines for treating and/or preventing insulin-dependent diabetes, non-insulin dependent diabetes, insulin resistance diseases or obesity, various diabetes and relevant diseases as a sodium-glucose cotransporter (SGLT) inhibitor.