419results about How to "Small side effects" patented technology

The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.

An anticancer kaurane-type diterpenoid for suppressing esophagus cancer and liver cancer cells is extracted from the stem of soursop through drying in air, pulverizing, extracting in alcohol concentrating, extracting in chloroform, chromatography, eluting, chromatography and eluting. Its advantages are high effect, low toxic by-effect, broad spectrum and high activity.

The invention discloses a fluoroquinolone acetal isoniazone, of which the chemical structure general formula is disclosed as Formula I shown in the description, wherein R1 is hydrogen atom or methyl group; R2 is hydrogen atom or amino group; R3 is hydrogen atom, methyl group, ethyl group, formacyl group, acetyl group, aroyl group or sulfonyl group; R4 is hydrogen atom or methyl group; and X is oxygen atom or sulfur atom. The fluoroquinolone isoniazone disclosed by the invention implements complementarity between the two anti-tuberculosis medicines fluoroquinolone and the isoniazide, lowers the toxic and side effect of the fluoroquinolone and the isoniazide, reduces the generation probability of drug resistance of Mycobacterium tuberculosis for the double-effect antimicrobial agent, and can be used as an anti-Mycobacterium tuberculosis medicine for brand-new structure development of medicinal active substances.

The present invention provides a paris total saponin extract for resisting tumor metastasis and a pharmaceutical preparation thereof. The pharmaceutical preparation is composed of paris total saponin extract as the active component and medicinal auxiliary materials; wherein, the weight percentage of paris total saponin extract in the total weight of the pharmaceutical preparation is 60 to 98 percent. The paris total saponin extract for resisting tumor metastasis and the pharmaceutical preparation provided by the present invention have good inhabitation on the metastasis of animal transplanted tumor cells, demonstrated in (1) significant anti-metastasis function for inbred mice and nude mice metastasis model of vaccinated mouse lung adenocarcinoma, human lung cancer, human gastric cancer, human intestinal cancer, human liver cancer and other tumor strains; (2) significant effect on relative albumen metastasis; (3) significant effect on relative gene metastasis and no obvious toxicity on major viscera. In addition, the main active component of the pharmaceutical preparation is a Chinese medicine extract, so compared with chemical drugs, the present invention has the advantage of small toxicity.

The present invention provides a lactam compound, a sugar transport enhancement agent containing this compound as an active ingredient, an agent for the prevention and/or treatment of diabetes mellitus, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macrovascular disease, glucose tolerance anomaly, obesity and the like. In addition, the present invention also provides a preparation method for the novel lactam compound, and a preparation intermediate thereof.

The invention relates to an antitumor traditional Chinese medicinal composition, which comprises the following bulk drugs by weight: 5-15 of Radix Astragali; 10-20 of ginseng; 5-10 of Coleus forskohli; 5-15 of ganoderma; 10-25 of barbed skullcap herb; 5-25 of hedyotis diffusa; and 5-10 of dried orange peel. The traditional Chinese medicinal composition of the invention has an obvious tumor inhibition effect, and is suitable for treating various malignant canceration including liver cancer, stomach cancer, kidney cancer, esophageal cancer, lung cancer, leukemia and the like.

A freeze-dried nano-suspension of nimodipine for intravenous injection with low stimulation and high curative effect and stability contains nimodipine, surfactant and scaffolding agent. Its preparing process and application are also disclosed.

The invention provides a targeted tumor active oxygen responsive medicine carrying nano-micelle, a preparation method and application of the medicine carrying nano-micelle, a medicine carrying nano-micelle intermediate RGD-PEG-thioketal-anthracene ring chemotherapy medicine conjugate and a preparation method of the conjugate. The nano-micelle, the conjugate as well as the preparation methods and application thereof have the beneficial effects that laser irradiates for activating porphyrin type photosensitive molecules; a large number of active oxygen radicals are triggered to be generated; further, thioketal in the medicine carrying nano-micelle system is induced to fracture; the controlled release of the anthracene ring chemotherapy medicine in the tumor position is realized; the medicinecurative effect is enhanced; the toxic and side effects of the medicine are reduced; PDT is combined with chemotherapy; the prominent synergistic interaction effect is achieved; the alone antitumor effect of a photodynamic therapy is improved; the toxic and side effects of the anthracene ring chemotherapy medicine on important visceral organs are also reduced.

The invention relates to an ecological antibacterial high-sensitivity polyester fiber and a method for producing the same. The method includes particular steps of (1), preparing ecological antibacterial high-sensitivity master batch from efficient antibacterial agents, modified bamboo charcoal powder and polyethylene glycol by the aid of double-screw melt blending extrusion processes; (2), preparing ecological antibacterial high-sensitivity polyester fibers, to be more specific, spinning and extruding conventional polyester chips by the ecological antibacterial high-sensitivity master batch prepared at the step (1) by the aid of melt blending spinning processes via spinning assemblies, cooling virgin fibers by means of circular air blowing, applying oil to clusters and carrying out drawing, heat-setting and winding to obtain the ecological antibacterial high-sensitivity polyester fiber. The ecological antibacterial high-sensitivity master batch is used as a modification auxiliary at the step (2). The ecological antibacterial high-sensitivity polyester fiber and the method have the advantages that the antibacterial performance of the ecological antibacterial high-sensitivity polyester fiber include that the antibacterial rate of the ecological antibacterial high-sensitivity polyester fiber for staphylococcus aureus is higher than 90%, and the antibacterial rate of the ecological antibacterial high-sensitivity polyester fiber for Escherichia coli is higher than 92%; the far infrared emittance of the ecological antibacterial high-sensitivity polyester fiber is higher than 85%.

The invention provides a taxol and CDKS kinase inhibitor anti-tumor combined pharmaceutical composition. The pharmaceutical composition comprises active components and pharmaceutically acceptable auxiliary materials, and is characterized in that the active components comprise taxol and a CDK4/6 kinase inhibitor or pharmaceutically salt; and the mass ratio of the taxol to the CDK4/6 kinase inhibitor or pharmaceutically salt in the active components is (2-8):1. The pharmaceutical composition is high in anti-tumor efficacy and low in toxic and side effect; and as the CDK4/6 kinase inhibitor has sensibility for the taxol, the combination of the CDK4/6 kinase inhibitor and taxol has a synergistic effect, the clinical dose of xeloda is reduced, toxic and side effect caused by the use of large dose of xeloda is reduced, the clinical treatment safety index is improved, and the pharmaceutical composition has a good clinical application prospect.

The invention provides a Paclitaxel liposome and process for preparation, wherein the components include Paclitaxel 1-30%, phosphatides 1-95%, cholesterin 0-30%, thermo-sensible auxiliary material D 0-50%, auxiliary material G 0-50%, freeze-drying protecting agent 0-80%, octadecyl amine 0-10%, anti-oxidant 0.001-50% and right amount of buffer salt.

The invention discloses a tussah silk protein adriamycin sustained release microsphere and a preparation method thereof. The tussah silk protein adriamycin sustained release microsphere takes calcium ions as an inducer, natural tussah silk proteins as a shell and adriamycin as nano particles of a core, is uniform in distribution of particle sizes, has the diameter of about 500 nanometers and is biodegradable. According to the tussah silk protein adriamycin sustained release microsphere and the preparation method disclosed by the invention, as the preparation environment of the tussah silk protein adriamycin sustained release microsphere is in a neutral and normal pressure and temperature state, an organic solvent is avoided, and the utilization degree of a medicament is increased; with the tussah silk proteins as an embedding material of the adriamycin, the tussah silk protein adriamycin sustained release microsphere has an RGD sequence and is capable of promoting cells to identify the tussah silk protein adriamycin sustained release microsphere and improving the targeting property of an adriamycin medicament; compared with free adriamycin, the adriamycin embedded in the tussah silk protein microsphere is obvious in sustained release property, expresses pH sensitivity, is obvious in sustained release effect in the environment with a pH value of 5.2, is small in releasing speed under the neutral condition, is convenient for a medicament to be released after entering cancer cells and is capable of remarkably lowering the toxic and side effects in normal cells.

The invention provides a medicine composite used for embolotherapy and acesodyne and a preparation method thereof. The medicine composite comprises a biocompatibility macromolecular compound containing hydroxy, a monomer containing unsaturated double bond and anion group, a polymer, and local anesthetic containing amino group, wherein the polymer is generated through a polymerization reaction of an optional vinyl monomer and the polymerization reaction is initiated by free radicals, and the local anesthetic is combined to an anion group of the generated polymer. In the invention, lidocaine hydrochloride is combined to a polymer carrier; which can give full play to the acesodyne effect of the local anesthetic in the embolotherapy; the anion part of the polymer can properly combine with the local anesthetic containing the amino group, which can both realize higher medicine loading capacity and enable the medicine in an emboliaztion agent to be exchanged by cations in vivo and then slowly released. Moreover, the polymer emboliaztion carrier has simple technology, low cost, and suitability for large scale industrial production.

The invention discloses a pharmaceutical composition for treating senile dementia, comprising the following components by weight: 20-40 parts of herba cistanche, 20-40 parts of astragalus mongholicus, 20-40 parts of radix salviae miltiorrhizae, 20-40 parts of herba epimedii, 20-40 parts of polygala tenuifolia, 10-20 parts of ligusticum wallichii, 10-20 parts of fructus alpiniae oxyphyllae, 10-20 parts of Chinese angelica, 10-20 parts of atractylodes rhizome, and 10-20 parts of poria cocos. The pharmaceutical composition for treating senile dementia provided by the invention has the characteristics of good treatment effect, small toxic and side effect, and simple preparation method, so that the pharmaceutical composition is beneficial to clinical application.

The invention discloses a medicament for treating uterus cancer, which comprises raw materials: ganoderma, bighead atractylodes rhizome, red paeony root, amur corktree bark, radix bupleuri, costus root, safflower, peach kernel, angelica, centipede, scorpion, pillworm, honeysuckle, finger citron, caulis spatholobi, oldenlandia diffusa, Chinese lobelia, gecko, Indian strawberry, paris rhizome, purple flower violet, fructus forsythiae, sparganium root, zedoary rhizome, corydalis tuber, wined rhubarb, ground beetle, poria, pseudo-ginseng, bletilla, motherwort, oriental wormwood, houttuynia cordata, fried pangolin scale, immature bitter orange, salvia chinensis, field thistle, garden burnet, wolfberry seed, astragalus, privet fruit, spica prunellae and licorice root. The medicament consists of pure nature Chinese medicinal herbs, does not have toxic side effect, is used for treating uterus cancer under the conditions of eliminating pathogenic factors without hurting original immunity and strengthening body resistance without boosting pathogenic factor growth in a discrimination manner, and can be used by weak patients in early period, middle period as well as late period. Nourishing ingredients in the prescription can improve the self immunity function of human bodies. When the medicament is used during chemoradiotherapy, the toxic side effect of the chemoradiotherapy can be relatively alleviated.

The invention provides a traditional Chinese medicine immune preparation for improving the immune function of grass carp. The traditional Chinese medicine immune preparation comprises the following raw materials of grifola, acanthopanax, atractylodes macrocephala koidz, ginseng leaves, cordate houttuynia, eucommia ulmoides, eclipta, rhizoma drynariae, cassia twig, isatis root, hawthorn, endothelium corneum gigeriae galli, campsis grandiflora, Chinese yam, caulis spatholobi, spina gleditsiae, dogwood, peach juvenile branchlet, fructus cnidii, Chinese-date, radix stemonae, semen euryales, fructus galangae, areca-nut, pittosporm root and horseweed herb. The traditional Chinese medicine immune preparation provided by the invention has lots of advantages such as high efficiency, low toxic and side effects, high safety and low residual, and is wide in source and low in cost; the traditional Chinese medicine immune preparation is capable of adjusting the immune system of fish, improving the anti-stress and immune functions of aquatic livestock, thus preventing and treating fish diseases.

The invention discloses a broad spectrum type influenza vaccine and a preparation method thereof. The vaccine comprises a conjugate formed by chemically coupling a carrier protein with a highly conserved antigen segment M2e or HA218-72 with a prevention and protection effect in an influenza virus. The broad spectrum type influenza vaccine prepared by the conjugate is easy for large scale production and preparation, has long effective period, can be subjected to bulk stock and overcomes the defect of the development and production technical route of the traditional influenza vaccine, thereby realizing real-time and effective control on epidemic situation caused by various influenza viruses.

The invention relates to stasis eliminating powder for treating soft tissue injury and cervical spondylosis. The stasis eliminating powder is prepared from the following raw material drugs in parts by weight: 1150 to 1350 parts of dandelion, 400 to 600 parts of rhubarb, 400 to 600 parts of myrrh, 400 to 600 parts of pseudo-ginseng, 400 to 600 parts of Chinese polyphaga, and 725 to 925 parts of geranium wilfordii. The invention also provides application of the stasis eliminating powder. The stasis eliminating powder has the advantages that: the stasis eliminating power is compatible with a principle of Chinese medicament 'monarch, minister, assistant and guide', and has the remarkable effects of dissipating blood stasis to promote menstruation, and alleviating pain and removing stagnation.The stasis eliminating powder is suitable for treating pains, swelling and inflammations caused by cervical spondylosis, osteoarthritis, lumbar muscle strain, lumbar disc herniation, rheumatoid arthritis, hyperosteogeny, gout and scapulohumeral periarthritis, and also can be used for treating symptoms of traumatic injuries, blood stasis, undispersed abdominal stasis and joint stasis. The stasis eliminating powder has less toxic and side effects and good curative effect, contains few medicaments and is suitable for long-term administration, and thus the stasis eliminating powder is a safe and effective medicament.

The present invention relates to a traditional Chinese medicine for treating male sterility, which consists of polygonatum canaliculatum, Chinese yam, ginseng, semen euryales, Cordyceps sinensis, plantain seed, raspberry, epimedium, dodder, medlar, broomrape, antler, dogwood fruit, gecko, colla corii ashili and shizandra. The composition treats the male sterility due to sexual disorder or low sperm survival percent, according to the theories of nourishing yin, tonifying kidney, strengthening yang and producing sperm of the traditional Chinese medicine, through the synergism of the active principles of the raw material medicines. The present invention also discloses a preparation method for the traditional Chinese medicine composition.

The invention relates to a synthesis method which comprises the steps of taking uridine as a principal raw material, treating with iodine and dilute nitric acid, obtaining 5-iodine uridine, treating with acetic anhydride to form 2',3',5'-O-trioxide acetyl-5-iodine uridine, allowing 2',3',5'-O-trioxide acetyl-5-iodine uridine to react with 2-(tributyl stannane) furan or thiophene by the action of triphenyl phosphine palladium chloride to form an intermediate, deprotecting by stirring in an ammonia methanol saturated solution at the room temperature by the action of phosphorus pentasulfide, and obtaining 5-(2-furyl or thienyl)-4-sulfur-bearing uridine. The compound has absorption at 363nm, and higher sensitivity to ultraviolet A, can enter inner cells of a tissue and act on cancer cells selectively, and overcomes the disadvantages that a photosensitive reagent for optic treatment at present is not gathered in nuclei and cannot selectively act on the cancer cells. The compound belongs to a novel base sulfur-bearing nucleoside compound, absorption light waves of the compound are in a long wavelength region, and the compound can selectively act on the inner cancer cells of the tissue, has a potential pharmaceutical value, and enters the inner cells of the tissue easily.

The invention discloses a traditional Chinese medicinal preparation for treating wet-rot-type tinea pedis. The traditional Chinese medicinal preparation comprises the following herbal raw materials: radix sophorae flavescentis, scutellaria baicalensis, sappanwood, dandelion, alum, radix saposhnikoviae, pawpaw, pericarpium zanthoxyli, fructus cnidii, gallnut, raw liquorice, atratylodes rhizome, honeysuckle flower, fructus forsythiae, yam rhizome, cyathula officinalis, raw pearl barley, fructus kochiae, radix stemonae, golden cypress, cortex dictamni, talcum, polygonum aviculare, cortex pseudolaricis, chaulmoogra, evodia lepta and alseodaphne hainanensis.The traditional Chinese medicinal preparation has the advantages as follows: the traditional Chinese medicinal preparation has the effects of clearing away heat and toxic materials, removing swelling and stopping pains, and dispelling wind, removing dampness and stopping itching, is simple and convenient in preparation process, small in toxic and side effects, convenient to administer and easy to prepare, and is a low-cost new medicine; through a solution, a lotion and other therapies, discomfort of a patient can be greatly relieved; herbal medicines with different properties are scientifically formulated to achieve a desired therapeutic effect; the traditional Chinese medicinal preparation is safe, small in toxic and side effects and short in healing time, and can directly reach a lesion; and the wet-rot-type tinea pedis does not reoccur after being cured.

The invention discloses use of catechin for preparing retrovirus integrase inhibitors; the catechin is added in the retrovirus integrase inhibitors; the retrovirus integrase inhibitors can be combined in the vicinity of flexible ring of integrase of AIDS virus, human T-lymphotropic virus or other retrovirus so as to influence processing function and chain transfer function; furthermore, the catechin can be combined in the vicinity of divalent metal of integrase so as to influence the combination of integrase and divalent metal and reduce the activity; and the catechin can interfere combination of integrase and cofactor, and reduce probability of integrating the retrovirus into host gene. Simultaneously, the integrase does not have highly homologous protein structure in human body, thus the inhibitor thereof has little side effect. The catechin is used for preparing the medicine for treating the diseases such as AIDS, leukemia T-cell prolymphocytic caused by retrovirus; and the medicine has good treating effects, low cost and little side effect.

The invention discloses a preparation method of an proanthocyanidin extract in grapes, which comprises the following steps: (1) preparation of grape skin and grape flesh: removing grape seeds from grapes to obtain grape skin and grape flesh; (2) extraction of proanthocyanidin: preparing a mixed solution composed of methanol, ethanol and a water solution, mixing the mixed solution with the grape skin and grape flesh prepared in the step (1), and reacting; (3) carrying out solid-liquid separation on the reaction product to obtain an extracting solution, carrying out freeze thawing on the extracting solution under negative pressure, and concentrating; (4) microwave extraction of proanthocyanidin: treating the extracting solution under the conditions of 550W microwaves, and centrifugating; and (5) concentration: concentrating the centrifugated supernate to obtain the concentrated proanthocyanidin extract. The method has higher extraction efficiency; and the extracted proanthocyanidin compound has the effects of resisting aging and the like, and is applicable to antiaging beauty treatment industry.

The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of traditional Chinese medicines. The invention aims at providing the medicine for treating the cardiovascular and cerebrovascular diseases, which has small side effect and obvious therapeutic effect. The invention discloses the medicine for treating the cardiovascular and cerebrovascular diseases, which is characterized in that: the medicine is prepared from the following pharmaceutical raw materials in parts by weight: 800 parts of ginkgo leaves, 500 parts of radix paeoniae alba, 500 parts of liquorice, 500 parts of witloof, 200 parts of radix notoginseng, 100 parts of lychee seeds and 100 parts of lumbricus. The medicine has the following beneficial effects: a pharmaceutical composition in the invention has small side effect and obvious therapeutic effect; when the medicine is adopted, the experimental carotid artery thrombosis time of a rat can be obviously prolonged, and the platelet aggregation of the rat can be obviously inhibited; and the medicine has the obvious therapeutic effects of resisting thrombosis, and treating thrombotic diseases, ischemic cardiovascular and cerebrovascular diseases, blood circulation obstacles and the like.

The invention discloses a traditional Chinese medicine composition for treating chronic bronchitis, which is characterized by being prepared from the following raw materials of medicines in parts by weight: 20 of astragalus root, 15 of radix sileris, 20 of white atractylodes rhizome, 10 of honeysuckle, 10 of weeping forsythia, 15 of dahurian angelica root, 5 of Chinese ephedra, 15 of radix glehniae, 5 of tendrilleaf fritillary, 30 of oldenlandia diffusa, 20 of cordate houttuynia, 10 of dahurian rhododendron leaf, 15 of radix rehmanniae, 12 of yam, 5 of dogwood, 10 of herba epimedii, 8 of radix codonopsis pilosulae and 5 of licorice. The invention takes the natural traditional Chinese medicines as the raw materials and has small toxic or side effect, definite curative effect and little possibility of relapse, and the total effective rate of treating the chronic bronchitis by the traditional Chinese medicine composition is 95.3%.

The invention discloses a traditional Chinese medicine composition used for treating melancholia, comprising the following raw material medicines: 4-12 parts of hypericum perforatum by weight, 4-12 parts of radix bupleuri by weight, 3-9 parts of stir-fried gardenia by weight, 3-9 parts of radix curcumae by weight, 5-15 parts of silktree albizzia bark by weight and 3-9 parts of licorice moxibustion senega by weight. The traditional Chinese medicine composition has the effects of calming the liver, relieving the depressed liver, reducing fever, relieving restlessness, tranquilizing and allaying excitement and is used for the light and moderate melancholia belonging to people with stagnation of qi and fire transmission. The symptoms comprise mental depression, vexation, discomposure, impatience, testiness, chest distress, costal swelling, insomnia, amnesia, reddened tongue and vein weakness.

The invention belongs to the technical field of biomedical polymer materials and nano-biotechnology and particularly relates to a targeting ligand modified reduction-responsive magnetic nano carrier and a preparation method thereof; the nano carrier is of typical core-shell structure, using superparamagnetic Fe3O4 nanoparticles to form a core wrapped in a reduction-responsive amphiphilic polymer; the reduction-responsive amphiphilic polymer is formed by linking hydrophobic groups to a hydrophilic polymer through linkers with reduction-sensitive bonds; the amphiphilic polymer forms the shell structure of the nano carrier, and target ligands are attached to the surface of the shell under the action of electrostatic adsorption. The carrier is used for carrying hydrophobic antitumor drugs and carrying out MRI (magnetic resonance imaging). The carrier and the preparation method thereof have the advantages that the carrier is able to target at multiple tumors, antitumor efficiency is improved, and toxic and side effects on normal tissues and organs are lowered; the targeting ligands are adsorbed via electrostatic adsorption, no chemical reaction is required, and time and cost are saved; the carrier may respond quickly to tumor high-GSH (high glutathione) microenvironment, allows a drug to be released quickly in tumor cells, and provides enhanced tumor inhibitory action.

The invention relates to a gemcitabine or gemcitabine salt nano-emulsion injecta and a preparation method of the gemcitabine or gemcitabine salt nano-emulsion injecta. The injecta specifically includes gemcitabine or a gemcitabine salt, oil for injection, a surface active agent and water for injection, wherein the weight ratio of gemcitabine or the gemcitabine salt to the oil for injection to thesurface active agent is 1:(10-100):(10-100), and the average particle size of an emulsion droplet in the emulsion is 1-100nm. The injecta provided by the invention is high in entrapment efficiency and stability and low in side effect.

The invention provides grouper feed and a preparing method thereof. The grouper feed is prepared from Peru fish meal, silkworm chrysalis meal, peameal, sweet potato flour, straw powder, salvinia natans powder, peanut straw powder, dried swine feces, spirulina powder, cotton seed meal, peanut meal, sesame-seed cakes, corn germ cakes, chalk, sleeve-fish liver powder, shrimp shell meal, beer yeast powder, calcium hydrophosphate, methionine, choline chloride, auxin, salt and additives. The grouper feed has the advantages that multiple microelements and microorganisms are matched, and the feed is environmentally friendly, small in toxic and side effect, high in safety, capable of resisting and killing bacteria, inhibiting viruses, substantially improving the organism immunity of grouper, increasing the growth speed and the survival rate and making grouper meat fresher, tenderer and richer in nutrition, low in cost, convenient to process, free of drug resistance, small in drug residual and remarkable in effect and greatly increases economic benefits of farmers.

The invention discloses ACE inhibiting peptide and application thereof. The amino acid sequence of ACE inhibiting peptide is CI or CK. Dipeptide CI or CK has the continuously-stable inhibiting effect on the activity of ACE, and it is found through animal experiments that dipeptide CI has the good blood pressure reducing effect in the body of a rat, and a reference is provided for synthesizing hypertension treating medicine.