274results about How to "Small side effects" patented technology

The invention provides a compound DOTA-HX2-DZ and application thereof, and belongs to the technical field of biological medicine. According to the invention, the molecular structure of DZ-HX2-DOTA is optimized, and a special connexon is designed and adopted, so that the problem of limited anti-tumor curative effect caused by poorer stability, fat solubility, tumor residence time and other properties of a radiolabeled drug in the prior art is solved. The compound provided by the invention can significantly reduce the risk of label removal of radioactive metal ions in an in-vivo environment, and ensures that the compound stably plays a role at a targeted part; the compound has excellent molecular lipid solubility, can penetrate cell membranes and vascular barriers more easily, improves the bioavailability of drugs, prolongs the in-vivo circulation time, prolongs the tumor residence time, and further improves the treatment efficiency. The DZ-HX2-DOTA disclosed by the invention has broad-spectrum tumor targeting property, and can be used for diagnosing and treating various types of malignant tumors.

The invention belongs to the technical field of biomedical materials, and particularly relates to a hydrogel wound dressing and a preparation method and application thereof. The hydrogel wound dressing disclosed by the invention can be matched with a sound-sensitive agent by utilizing the temperature-sensitive shrinkage performance of the temperature-sensitive compound monomer, and shows ultrasonic thermal response shrinkage performance, specifically, the hydrogel wound dressing can be rapidly heated and remarkably shrunk under the ultrasonic action to promote wound shrinkage, so that wound healing is accelerated. The obvious potential is embodied in the aspects of promoting the repair of the wound infected by the drug-resistant bacteria and the repair of the wound infected by the drug-resistant bacteria and diabetes mellitus. When the prepared hydrogel wound dressing is used, the contraction degree of the hydrogel wound dressing can be controlled by adjusting the ultrasonic time in the treatment process, and protection and treatment effects on drug-resistant bacteria wounds are achieved in a programmed mode. Meanwhile, the fixing structure of the hydrogel can anchor added drugs such as a sound-sensitive agent and the like, and the action time of the drugs is prolonged.

The invention provides an application of a recombinant XVII type humanized collagen or a composition containing the recombinant XVII type humanized collagen in preparation of a preparation for preventing and / or treating lupus erythematosus, which can overcome the defect that more adverse reactions are generated in treatment in the existing scheme.

The invention belongs to the technical field of food biology, and particularly relates to an antioxidant peptide derived from cantharellus cibarius sporocarp, an antioxidant peptide detection reagent and application, and the amino acid sequence of the antioxidant peptide is at least one of FPYPY, YPPYF, YYPF and MPWY. The antioxidant peptide provided by the invention is derived from chanterelle, is an enzymolysis product of chanterelle protein, and is derived from edible and medicinal fungus chanterelle, so that the antioxidant peptide is small in toxic and side effects and high in safety. Meanwhile, the antioxidant peptide disclosed by the invention has good biological activity and a relatively strong antioxidant effect, can remarkably scavenge free radicals, and can be applied to repair damage caused by oxidative stress.

The invention relates to the technical field of fire extinguishing agents, and discloses a fluoride-free anti-solubility foam fire extinguishing agent and a preparation method thereof.The fluoride-free anti-solubility foam fire extinguishing agent comprises a hydrocarbon surfactant, a carboxyl modified organosilicon surfactant, a foam stabilizer, a cosolvent, water and a pH regulator; the carboxyl modified organic silicon surfactant is obtained by modifying an organic silicon surfactant by using maleic anhydride; the foam stabilizer contains xanthan gum and a component A, according to the invention, the organosilicon surfactant is modified, so that the obtained carboxyl modified surfactant has good surface activity and water solubility; xanthan gum and a component A (polyethylene oxide-polypropylene oxide-polyethylene oxide and other substances) are compounded to serve as a foam stabilizer, so that the foam stability and the anti-dissolving performance can be improved, and the foam stabilizer also has temperature-sensitive-thermal response performance; under the combined action of the components, the fire extinguishing agent provided by the invention has excellent fire extinguishing performance and can quickly extinguish non-polar fuel and polar fuel.

The invention provides a nucleic acid aptamer agonist conjugate as well as a preparation method and application thereof. The nucleic acid aptamer agonist conjugate is prepared by coupling a nucleic acid aptamer, a connexon and an STING agonist, the nucleic acid aptamer agonist conjugate can be used as a medicine to recognize a target spot on the surface of a tumor cell in a targeted manner and enter the cell to start a cGAS-STING signal channel so as to realize an anti-tumor effect. The variety of STING agonists and the variety of connexons are also screened, so that the aptamer agonist conjugate not only has the advantages of easiness in transmembrane and cell entry, strong tumor permeability, long half-life period, small toxic and side effects and the like, but also has a strong inhibition effect on triple-negative breast cancer. The aptamer agonist conjugate can also be combined with an immune checkpoint blocking therapy to further realize long-acting and efficient inhibition of tumor growth.

The invention relates to the field of Wenchang chicken breeding methods, in particular to a Wenchang chicken breeding method capable of achieving multi-stage accurate feeding and disease early warning. The method comprises the following steps: S1, breeding in a chick transition stage: establishing a Wenchang chick transition room, S2, breeding in a growing period stage: adopting a mixed mode of free-range breeding and artificial feeding, and S3, breeding in an optimization period: selecting chickens for cage breeding; in the Wenchang chicken breeding process, the Wenchang chickens are bred in a multi-stage precise feeding mode, when chicks are introduced in the initial stage, a transition chamber is established, a nutritional agent containing rhizoma atractylodis macrocephalae, radix astragali, multivitamin powder and probiotics is added into feed, feeding is conducted in the Wenchang chicken breeding stage, the mixed mode of free-ranging and artificial feeding is adopted, and the breeding efficiency of the Wenchang chickens is improved. Nutritional agents containing multivitamin powder, probiotics, hawthorn fruit powder and medicated leaven are added in fixed-point feeding, good chickens are selected for cage culture in the optimization period of Wenchang chickens, traditional Chinese medicine agents are added, disease prevention and early warning can be conducted on the Wenchang chickens, and the Wenchang chickens are natural, small in toxic and side effect and easy to metabolize.

The invention belongs to the technical field of chemical drugs, and particularly relates to application of a polyphenol composition in preparation of drugs for treating inflammatory bowel diseases and the drugs. The polyphenol composition contains isorhamnetin, kaempferol, quercetin, ferulic acid and caffeic acid, and has an obvious anti-inflammatory effect on the inflammatory bowel disease; when the composition is used as a medicine for treating the inflammatory bowel disease, the treatment cost can be reduced, and the composition is effective in treating the inflammatory bowel disease and small in toxic and side effects after being taken for a long time.

The invention belongs to the technical field of food processing, and particularly relates to a sleep-aiding composition, a sleep-aiding aqueous extract and a preparation method and application of the sleep-aiding composition and the sleep-aiding aqueous extract. The invention provides a sleep-aiding composition. The sleep-aiding composition is prepared from the following components in parts by mass: 67.5 to 157.5 parts of semen ziziphi spinosae, 67.5 to 157.5 parts of Zanghuang jujubes, 0.3 to 0.7 part of konjac glucomannan, 10 parts of poria cocos and 6 parts of liquorice roots. All the components in the sleep-aiding composition are medicinal and edible medicinal materials, and food is used for treatment, so that the product has small toxic and side effects; meanwhile, the Zanghuang jujubes are added to be compounded with the spina date seeds, so that the obtained composition not only has rich red date fragrance and strong date flavor, but also can improve the content of sleep-aiding active substances, and has the effects of soothing the nerves and aiding sleep.

The invention belongs to the technical field of biological medicines, and particularly relates to application of gingerol compounds in preparation of products for treating hereditary intellectual and cognitive dysfunction diseases. The invention proves that the 6-gingerol can improve the neurogenesis of the fragile X-chromosome syndrome and correct the cognitive deficit, enriches the application of the 6-gingerol in neurodevelopment disorder diseases and the scientific connotation of the 6-gingerol in the aspect of disease treatment, and is suitable for industrial production and easy to popularize. The invention provides a new drug source for treating fragile X chromosome syndrome and related diseases caused by change and mutation of in-vivo X chromosome in a genetic process, and provides a new medicinal application of the gingerol compound.

The invention belongs to the technical field of chemical drugs, and particularly relates to application of a polyphenol composition containing gallic acid to preparation of drugs for treating inflammatory bowel diseases and the drugs. The polyphenol composition contains caffeic acid, ferulic acid, gallic acid, hesperidin, isoquercitrin, isorhamnetin, kaempferol, protocatechuic acid and quercetin, and has an obvious anti-inflammatory effect on the inflammatory bowel disease; when the composition is used as a medicine for treating the inflammatory bowel disease, the treatment cost can be reduced, and the composition is effective in treating the inflammatory bowel disease and small in toxic and side effects after being taken for a long time.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for improving osteothione as well as a preparation method and application thereof. The invention provides a composition for improving osteothione, which is prepared from the following components in parts by mass: 500 to 600 parts of folium cortex eucommiae, 300 to 350 parts of male flower of cortex eucommiae, 300 to 350 parts of wine-processed rhizoma polygonati, 300 to 350 parts of radix fici simplicissimae, 200 to 250 parts of maca, 90 to 120 parts of natto, 60 to 80 parts of calcined oyster shell and 0.5 to 1 part of ossein. The composition can increase the number of bone trabecula, increase bone density, bone volume fraction, the number of bone trabecula, bone trabecula thickness and bone surface area-to-tissue volume ratio, lower bone surface area-to-bone volume ratio and bone trabecula separation degree, enhance osteoblast activity, inhibit osteoclast maturation and differentiation and relieve inflammation, and is high in safety performance. In conclusion, the composition provided by the invention has a certain improvement effect on osteoporosis.

The invention discloses a wide-spectrum bacteriophage EFH2 capable of eliminating enterococcus faecalis suffering from humans and animals, and relates to the technical field of biology. The wide-spectrum bacteriophage is preserved in the China Center for Type Culture Collection on September 26, 2024, and the preservation number of the wide-spectrum bacteriophage is CCTCC NO: M 20242087. The wide-spectrum bacteriophage EFH2 is a newly found bacteriophage, has good tolerance under the conditions that the pH is 3-9 and the temperature is 4-60 DEG C, and has the titer as high as 2.31 * 10 < 8 > PFU / mL after being cultured for 8 hours under the condition that the MOI is 0.01. The wide-spectrum bacteriophage EFH2 is wide in antibacterial spectrum, short in incubation period, high in outbreak amount, capable of rapidly killing host bacteria, small in toxic and side effect, high in safety, wide in temperature and acid-base tolerance range, good in hydrophilicity and capable of well killing and disinfecting animals infected with multi-drug-resistant enterococcus and environments and food polluted by enterococcus.

The invention discloses a preparation process of a nano calcium nutrient, and relates to the technical field of nutrients. The preparation process comprises the following steps: S1, filling two cationic resin columns which are marked as a column 1 and a column 2, respectively soaking the column 1 and the column 2 in a saturated calcium chloride solution, washing the column 1 and the column 2 with the saturated calcium chloride solution until the pH value is 5-6, and washing the column 1 and the column 2 with purified water until the column 1 and the column 2 are neutral for later use; s2, adding a self-made milk hydrolyzed mixed amino acid sodium salt aqueous solution into the cationic resin column 1 prepared in the step S1 at normal temperature, slowly eluting and exchanging, and circularly exchanging the effluent for 3-5 times to obtain an effluent 1; s3, enabling the effluent 1 obtained in the step S2 to pass through a cationic resin column 2, and slowly eluting and exchanging to obtain effluent 2; and S4, carrying out vacuum decompression concentration on the effluent 2 obtained in the step S3, spraying the concentrated solution, feeding into a high-speed airflow chamber, further cutting the atomized solution by high-speed airflow, feeding into a freezing chamber, and freeze-drying to obtain the product. The nano mixed amino acid chelated calcium provided by the invention is small in toxic and side effects and good in safety.

The invention provides a composition with the effects of reducing uric acid and improving the renal function and a preparation method, application and a product of the composition, and belongs to the field of traditional Chinese medicine application. The composition is prepared from the following components: raw radix astragali, rhizoma smilacis glabrae, herba taxilli, radix salviae miltiorrhizae and rhizoma alismatis. According to the composition provided by the invention, the raw radix astragali, the rhizoma smilacis glabrae, the herba taxilli, the radix salviae miltiorrhizae and the rhizoma alismatis are combined for use, and the obtained composition can be used for treating hyperuricemia or related diseases thereof, and is remarkable in curative effect and small in toxic and side effects. The composition is used for post-treatment of hyperuricemia and is used for treating arthralgia and pain of joints and unfavorable flexion and extension. Meanwhile, the composition has a certain kidney protection effect and can reduce kidney inflammation and fibrosis.

The invention relates to a method for constructing strict anaerobic salmonella, the strict anaerobic salmonella constructed by using the method and application of the strict anaerobic salmonella in tumor treatment.

The invention discloses an enhanced anti-fluorescence quenching mounting medium as well as a preparation method and a mounting method thereof, particularly relates to the technical field of immunofluorescence, and aims to solve the problems that a fluorescent dye is rapidly attenuated under the irradiation of strong exciting light and the like in the prior art. Every 100 mL of the mounting medium comprises 15-30 mL of an acid-base buffer solution, 10-20 mL of a viscosity modifier, 0.5-5 g of a fluorescence quenching resistant compound, 1-15 mL of a synergist and the balance of distilled water, and the fluorescence quenching resistant compound comprises triethylene diamine and ethylenediaminetetraacetic acid. The mounting medium provided by the invention can enhance the overall fluorescence brightness and maintain the stability of fluorescence under excitation light, thereby realizing more accurate quantification of fluorescence signals.

The present invention provides a compound DOTA-HX2-DZ and its application, belonging to the field of biomedical technology. The present invention optimizes the molecular structure of DZ-HX2-DOTA, designs and adopts a special linker, and solves the problem of limited anti-tumor efficacy caused by the poor performance of radiolabeled drugs in the prior art, such as stability, lipid solubility and tumor retention time. The compound of the present invention can significantly reduce the risk of delabeling of radioactive metal ions in the in vivo environment, ensuring that it can stably play a role in the targeted site; the molecule has excellent lipid solubility and can more easily penetrate the cell membrane and vascular barrier, thereby improving the bioavailability of the drug, prolonging the in vivo circulation time, and prolonging the tumor retention time, thereby improving the treatment efficiency. The DZ-HX2-DOTA of the present invention has a broad spectrum of tumor targeting, and can be used for diagnosis and treatment of various types of malignant tumors.

The invention belongs to the technical field of cellular immune engineering, and particularly relates to a full-human-derived polypeptide for recognizing CLL-1 and application of the full-human-derived polypeptide. The polypeptide provided by the invention specifically recognizes CLL-1 and has good affinity performance, and the polypeptide specifically targeting CLL-1 provided by the invention can mark CLL-1 positive cells, can be combined with a CLL-1 antigen and the CLL-1 positive cells, and can be used as a detection reagent of CLL-1 molecules and an in-vivo tracing marking reagent. The polypeptide specifically targeting CLL-1 provided by the invention can also be used in an extracellular antigen recognition region of a chimeric antigen receptor, is used in an immune cell treatment drug targeting CLL-1, and is used for killing malignant tumors expressing CLL-1. The polypeptide for specifically recognizing the CLL-1 is a natural full-humanized antibody source, compared with a mouse antibody, a chimeric antibody and a humanized antibody, the immunogenicity of the polypeptide is greatly reduced, and the safety can be guaranteed to the maximum extent in clinical application.

According to the gel preparation and the preparation method thereof provided by the invention, the preparation does not use conventional stabilizers and antioxidants, and the PD-DP-008 gel preparation with better stability is obtained by optimizing the components of the gel preparation. The conventional lofting data of the preparation shows that the content change of the active substance PD-DP-008 is small, and the cumulative release amount can reach 76.005% at most after 8-hour in-vitro release. The prepared gel is uniform and fine in texture, is easy to coat after being unfolded, can form a transparent film on the surface of skin, has the advantages of high adhesiveness, quick drug release, long residence time, no irritation to skin and mucous membrane and the like, and is simple in preparation process, good in antibacterial effect and high in use value.

The present invention relates to a tartrate tyvalosin nanosuspension and a preparation method and application thereof. The raw materials for preparing the tartrate tyvalosin nanosuspension include: tartrate tyvalosin, a cosolvent, an alkaline reagent, a stabilizer, a crystallization aid and water; the crystallization aid includes any one of chitosan, povidone, polysorbate or sodium carboxymethyl cellulose or a combination of at least two thereof. The tartrate tyvalosin nanosuspension provided by the present invention is a new dosage form of tartrate tyvalosin, which can significantly improve the solubility, dissolution rate and bioavailability of tartrate tyvalosin, and has good application prospects in the preparation of drugs for treating respiratory and digestive tract diseases of poultry and livestock.

The application relates to a benzene ring-containing compound with analgesic efficacy, a preparation method and use thereof, and relates to the field of medicinal chemistry. The compound is a compound shown in formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or a prodrug thereof, or a metabolite thereof, or a deuterium derivative thereof. The analgesic effect of the compound is excellent, the compound is safe to use, has small toxic and side effects, and does not produce dependence during use. Therefore, the compound has a wide application prospect in the preparation of analgesic drugs, and provides a new selection for preparing drugs with analgesic action in the clinic.

The invention discloses a traditional Chinese medicine compound composition for treating functional dyspepsia and a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from 5-20 parts of gordon euryale seeds, 6-12 parts of Chinese yams, 10-30 parts of astragalus membranaceus, 10-30 parts of roasted rhizoma atractylodis macrocephalae, 10-20 parts of smoked plums, 3-15 parts of pericarpium citri reticulatae viride, 10-40 parts of malt, 6-12 parts of roasted endothelium corneum gigeriae galli, 10-20 parts of honey-fried licorice roots and the like. The traditional Chinese medicine composition is prepared according to the theory of treatment based on syndrome differentiation, has the functions of strengthening the spleen and stomach, promotes digestion and absorption, and has an exact treatment effect on related symptoms caused by dyspepsia. Most medicinal materials are medicinal and edible, have small toxic and side effects and are safe and reliable to take.

This invention provides a mulberry leaf and wolfberry composition, comprising aqueous extracts of wolfberry, mulberry leaves, astragalus, yam, kudzu root, and green tea. This invention also provides oral preparations and food products containing this composition. Furthermore, this invention provides the application of the composition or oral preparation in the preparation of health foods that help maintain healthy blood sugar levels and hypoglycemic drugs. The composition provided by this invention has the effect of lowering blood sugar, and the selected raw materials are highly safe, have few toxic side effects, and are widely available, possessing significant market value and development prospects.

The invention discloses application of vitexin (the molecular formula of the vitexin is C19H18O8, the molecular weight of the vitexin is 374.34, and the CAS number of the vitexin is 479-91-4) in preparation of antitumor drugs. The method comprises the following steps: firstly, treating esophageal cancer cell lines KYSE70 and KYSE450 with vitexin, detecting cell proliferation conditions after 0, 24 hours, 48 hours and 72 hours, and determining that the vitexin has an inhibiting effect on the esophageal cancer cell lines; the vitexin can inhibit cell proliferation of skin cancer cell lines SK-MEL-5 and SK-MEL-28 and ovarian cancer cell lines SKOV3 and TOV112D under the same concentration, and compared with a control group, the growth speed of tumor cells is remarkably reduced along with increase of the concentration of the vitexin, so that the vitexin has a remarkable effect on treating esophageal cancer, skin cancer and ovarian cancer; secondly, through a Pull down experiment, it is found that vitexin targets PRDX1, and it is indicated that vitexin can inhibit proliferation of tumor cells in vivo and in vitro by targeting PRDX1.

The invention belongs to the technical field of microorganisms, and particularly relates to a bacteriophage for splitting bovine-derived salmonella and application of the bacteriophage. The technical problem to be solved by the invention is to provide a new choice for treating infection of bovine-derived salmonella. According to the technical scheme, the invention relates to a bacteriophage Seoulvirus GX2401 for splitting bovine-derived salmonella, wherein the preservation number of the bacteriophage Seoulvirus GX2401 is CCTCC (China Center for Type Culture Collection) NO: M20241156. The bacteriophage is a wide host spectrum thallus, can split six different salmonella, has a wide antibacterial spectrum, and can be applied to preparation of drugs for preventing and treating bovine salmonella infection diseases.

The invention discloses a traditional Chinese medicine composition for treating diabetes and complications thereof, a preparation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the traditional Chinese medicine composition, the symptoms of liver-spleen disharmony, phlegm stagnation and qi stagnation and blood stasis are taken as main symptoms according to traditional Chinese medicine differentiation. The symptoms include dry and bitter mouth, impatience and irritability, dyspepsia, fatigue and hypodynamia, insomnia and dreaminess, chest and hypochondrium swelling pain, heavy body, obesity, medium and large tongue body, light red tongue, greasy fur, fine and smooth pulse and the like, and patients with abnormal blood glucose. The formula has the functions of improving insulin resistance, regulating blood sugar metabolism, improving microcirculation, protecting pancreas islet beta cells and the like, and can improve and enhance related organs of a human body after being taken persistently. The formula is more precise and appropriate in compatibility and takes all the components into consideration. The traditional Chinese medicine composition can widely play a main or auxiliary treatment role in diabetes with multiple situations at present. Compared with common blood-glucose-reducing western medicines and insulin, the traditional Chinese medicine preparation is small in toxic and side effects and free of obvious adverse effects after being taken for a long time.

The invention relates to a new application of a water-soluble tomato concentrate, and belongs to the technical field of medicines or health foods. The invention discloses a water-soluble tomato concentrate which has the effect of improving metabolism-related fatty liver and can be used for preparing products for preventing, relieving and / or treating metabolism-related fatty liver diseases. The water-soluble tomato concentrate is prepared through tomato extraction, is wide in source, small in toxic and side effects and high in safety, and has a wide application prospect.

The invention provides a foam hardener composition as well as a preparation method and application thereof, the foam hardener composition comprises polydocanol with single molecular weight and sodium hyaluronate in a volume ratio of 1: (0.1-5). The preparation method of the polydocanol with the single molecular weight comprises the following steps: reacting polyethylene glycol with the single molecular weight with 1-halogenated dodecane, separating and purifying to obtain the polydocanol with the single molecular weight. The foam hardener disclosed by the invention is higher in foam stability, better in drug effect and smaller in toxic and side effects, and can be widely applied to treatment of vascular related diseases, cystic diseases, tumors, gynecological and obstetrical diseases, inflammations or pains.

The invention relates to the technical field of chemical medicines, in particular to application of a compound 2-(4-methanoyl) anilino-4-(1H-indole-4-oxy)-5-trifluoromethylpyrimidine in inhibition of the activity of Aurora and JAK kinase families and in treatment of several tumors. On the basis of the research of 2-(4-methanoyl) anilino-4-amino-5-trifluoromethylpyrimidine derivative and application (patent application number: 202110571344.8) in the early stage, the compound is found to be capable of inhibiting the activity of FAK kinase and effectively inhibiting the family activity of Aurora and JAK kinase, and the inhibition effects are respectively 100 times and 5 times or more superior to those of the FAK kinase, so that the compound can be used for preparing a novel compound for inhibiting the activity of the FAK kinase. The compound can be used as a dual-effect anti-tumor inhibitor and can reduce proliferation of breast cancer, lung cancer, leukemia, thyroid cancer, prostate cancer, glioma, ovarian cancer and lymphoma cells, the activity is not observed in other FAK kinase inhibitors (such as Defactinib), and the compound can be used as a dual-effect anti-tumor inhibitor. The compound is applied to preparation of medicines for treating breast cancer, lung cancer, leukemia, thyroid cancer, prostate cancer, glioma, ovarian cancer, lymphoma and idiopathic pulmonary fibrosis.