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419results about How to "Small side effects" patented technology

Ecological antibacterial high-sensitivity polyester fiber and method for producing same

The invention relates to an ecological antibacterial high-sensitivity polyester fiber and a method for producing the same. The method includes particular steps of (1), preparing ecological antibacterial high-sensitivity master batch from efficient antibacterial agents, modified bamboo charcoal powder and polyethylene glycol by the aid of double-screw melt blending extrusion processes; (2), preparing ecological antibacterial high-sensitivity polyester fibers, to be more specific, spinning and extruding conventional polyester chips by the ecological antibacterial high-sensitivity master batch prepared at the step (1) by the aid of melt blending spinning processes via spinning assemblies, cooling virgin fibers by means of circular air blowing, applying oil to clusters and carrying out drawing, heat-setting and winding to obtain the ecological antibacterial high-sensitivity polyester fiber. The ecological antibacterial high-sensitivity master batch is used as a modification auxiliary at the step (2). The ecological antibacterial high-sensitivity polyester fiber and the method have the advantages that the antibacterial performance of the ecological antibacterial high-sensitivity polyester fiber include that the antibacterial rate of the ecological antibacterial high-sensitivity polyester fiber for staphylococcus aureus is higher than 90%, and the antibacterial rate of the ecological antibacterial high-sensitivity polyester fiber for Escherichia coli is higher than 92%; the far infrared emittance of the ecological antibacterial high-sensitivity polyester fiber is higher than 85%.
Owner:ZHEJIANG JINXIA NEW MATERIAL TECH CO LTD +1

Tussah silk protein adriamycin sustained release microsphere and preparation method thereof

The invention discloses a tussah silk protein adriamycin sustained release microsphere and a preparation method thereof. The tussah silk protein adriamycin sustained release microsphere takes calcium ions as an inducer, natural tussah silk proteins as a shell and adriamycin as nano particles of a core, is uniform in distribution of particle sizes, has the diameter of about 500 nanometers and is biodegradable. According to the tussah silk protein adriamycin sustained release microsphere and the preparation method disclosed by the invention, as the preparation environment of the tussah silk protein adriamycin sustained release microsphere is in a neutral and normal pressure and temperature state, an organic solvent is avoided, and the utilization degree of a medicament is increased; with the tussah silk proteins as an embedding material of the adriamycin, the tussah silk protein adriamycin sustained release microsphere has an RGD sequence and is capable of promoting cells to identify the tussah silk protein adriamycin sustained release microsphere and improving the targeting property of an adriamycin medicament; compared with free adriamycin, the adriamycin embedded in the tussah silk protein microsphere is obvious in sustained release property, expresses pH sensitivity, is obvious in sustained release effect in the environment with a pH value of 5.2, is small in releasing speed under the neutral condition, is convenient for a medicament to be released after entering cancer cells and is capable of remarkably lowering the toxic and side effects in normal cells.
Owner:SUZHOU UNIV

Medicament for treating uterus cancer

The invention discloses a medicament for treating uterus cancer, which comprises raw materials: ganoderma, bighead atractylodes rhizome, red paeony root, amur corktree bark, radix bupleuri, costus root, safflower, peach kernel, angelica, centipede, scorpion, pillworm, honeysuckle, finger citron, caulis spatholobi, oldenlandia diffusa, Chinese lobelia, gecko, Indian strawberry, paris rhizome, purple flower violet, fructus forsythiae, sparganium root, zedoary rhizome, corydalis tuber, wined rhubarb, ground beetle, poria, pseudo-ginseng, bletilla, motherwort, oriental wormwood, houttuynia cordata, fried pangolin scale, immature bitter orange, salvia chinensis, field thistle, garden burnet, wolfberry seed, astragalus, privet fruit, spica prunellae and licorice root. The medicament consists of pure nature Chinese medicinal herbs, does not have toxic side effect, is used for treating uterus cancer under the conditions of eliminating pathogenic factors without hurting original immunity and strengthening body resistance without boosting pathogenic factor growth in a discrimination manner, and can be used by weak patients in early period, middle period as well as late period. Nourishing ingredients in the prescription can improve the self immunity function of human bodies. When the medicament is used during chemoradiotherapy, the toxic side effect of the chemoradiotherapy can be relatively alleviated.
Owner:何玉伟

Stasis eliminating powder for treating soft tissue injury and cervical spondylosis

The invention relates to stasis eliminating powder for treating soft tissue injury and cervical spondylosis. The stasis eliminating powder is prepared from the following raw material drugs in parts by weight: 1150 to 1350 parts of dandelion, 400 to 600 parts of rhubarb, 400 to 600 parts of myrrh, 400 to 600 parts of pseudo-ginseng, 400 to 600 parts of Chinese polyphaga, and 725 to 925 parts of geranium wilfordii. The invention also provides application of the stasis eliminating powder. The stasis eliminating powder has the advantages that: the stasis eliminating power is compatible with a principle of Chinese medicament 'monarch, minister, assistant and guide', and has the remarkable effects of dissipating blood stasis to promote menstruation, and alleviating pain and removing stagnation.The stasis eliminating powder is suitable for treating pains, swelling and inflammations caused by cervical spondylosis, osteoarthritis, lumbar muscle strain, lumbar disc herniation, rheumatoid arthritis, hyperosteogeny, gout and scapulohumeral periarthritis, and also can be used for treating symptoms of traumatic injuries, blood stasis, undispersed abdominal stasis and joint stasis. The stasis eliminating powder has less toxic and side effects and good curative effect, contains few medicaments and is suitable for long-term administration, and thus the stasis eliminating powder is a safe and effective medicament.
Owner:XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Sulfur-bearing uridine anticancer drug, intermediate and synthesis method

InactiveCN103467549ASmall side effectsHigh value for development research and clinical applicationSugar derivativesEnergy modified materialsAcetic anhydrideLight wave
The invention relates to a synthesis method which comprises the steps of taking uridine as a principal raw material, treating with iodine and dilute nitric acid, obtaining 5-iodine uridine, treating with acetic anhydride to form 2',3',5'-O-trioxide acetyl-5-iodine uridine, allowing 2',3',5'-O-trioxide acetyl-5-iodine uridine to react with 2-(tributyl stannane) furan or thiophene by the action of triphenyl phosphine palladium chloride to form an intermediate, deprotecting by stirring in an ammonia methanol saturated solution at the room temperature by the action of phosphorus pentasulfide, and obtaining 5-(2-furyl or thienyl)-4-sulfur-bearing uridine. The compound has absorption at 363nm, and higher sensitivity to ultraviolet A, can enter inner cells of a tissue and act on cancer cells selectively, and overcomes the disadvantages that a photosensitive reagent for optic treatment at present is not gathered in nuclei and cannot selectively act on the cancer cells. The compound belongs to a novel base sulfur-bearing nucleoside compound, absorption light waves of the compound are in a long wavelength region, and the compound can selectively act on the inner cancer cells of the tissue, has a potential pharmaceutical value, and enters the inner cells of the tissue easily.
Owner:DALIAN UNIVERSITY

Traditional Chinese medicinal preparation for treating wet-rot-type tinea pedis and preparation method thereof

The invention discloses a traditional Chinese medicinal preparation for treating wet-rot-type tinea pedis. The traditional Chinese medicinal preparation comprises the following herbal raw materials: radix sophorae flavescentis, scutellaria baicalensis, sappanwood, dandelion, alum, radix saposhnikoviae, pawpaw, pericarpium zanthoxyli, fructus cnidii, gallnut, raw liquorice, atratylodes rhizome, honeysuckle flower, fructus forsythiae, yam rhizome, cyathula officinalis, raw pearl barley, fructus kochiae, radix stemonae, golden cypress, cortex dictamni, talcum, polygonum aviculare, cortex pseudolaricis, chaulmoogra, evodia lepta and alseodaphne hainanensis.The traditional Chinese medicinal preparation has the advantages as follows: the traditional Chinese medicinal preparation has the effects of clearing away heat and toxic materials, removing swelling and stopping pains, and dispelling wind, removing dampness and stopping itching, is simple and convenient in preparation process, small in toxic and side effects, convenient to administer and easy to prepare, and is a low-cost new medicine; through a solution, a lotion and other therapies, discomfort of a patient can be greatly relieved; herbal medicines with different properties are scientifically formulated to achieve a desired therapeutic effect; the traditional Chinese medicinal preparation is safe, small in toxic and side effects and short in healing time, and can directly reach a lesion; and the wet-rot-type tinea pedis does not reoccur after being cured.
Owner:段妤

Medicine for treating cardiovascular and cerebrovascular diseases

The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of traditional Chinese medicines. The invention aims at providing the medicine for treating the cardiovascular and cerebrovascular diseases, which has small side effect and obvious therapeutic effect. The invention discloses the medicine for treating the cardiovascular and cerebrovascular diseases, which is characterized in that: the medicine is prepared from the following pharmaceutical raw materials in parts by weight: 800 parts of ginkgo leaves, 500 parts of radix paeoniae alba, 500 parts of liquorice, 500 parts of witloof, 200 parts of radix notoginseng, 100 parts of lychee seeds and 100 parts of lumbricus. The medicine has the following beneficial effects: a pharmaceutical composition in the invention has small side effect and obvious therapeutic effect; when the medicine is adopted, the experimental carotid artery thrombosis time of a rat can be obviously prolonged, and the platelet aggregation of the rat can be obviously inhibited; and the medicine has the obvious therapeutic effects of resisting thrombosis, and treating thrombotic diseases, ischemic cardiovascular and cerebrovascular diseases, blood circulation obstacles and the like.
Owner:南通市通州区平潮镇新坝卫生院

Targeting ligand modified reduction-responsive magnetic nano carrier and preparation method thereof

ActiveCN106729727AImprove anti-tumor efficiencySmall side effectsInorganic non-active ingredientsNMR/MRI constrast preparationsSide effectAnti-Tumor Drugs
The invention belongs to the technical field of biomedical polymer materials and nano-biotechnology and particularly relates to a targeting ligand modified reduction-responsive magnetic nano carrier and a preparation method thereof; the nano carrier is of typical core-shell structure, using superparamagnetic Fe3O4 nanoparticles to form a core wrapped in a reduction-responsive amphiphilic polymer; the reduction-responsive amphiphilic polymer is formed by linking hydrophobic groups to a hydrophilic polymer through linkers with reduction-sensitive bonds; the amphiphilic polymer forms the shell structure of the nano carrier, and target ligands are attached to the surface of the shell under the action of electrostatic adsorption. The carrier is used for carrying hydrophobic antitumor drugs and carrying out MRI (magnetic resonance imaging). The carrier and the preparation method thereof have the advantages that the carrier is able to target at multiple tumors, antitumor efficiency is improved, and toxic and side effects on normal tissues and organs are lowered; the targeting ligands are adsorbed via electrostatic adsorption, no chemical reaction is required, and time and cost are saved; the carrier may respond quickly to tumor high-GSH (high glutathione) microenvironment, allows a drug to be released quickly in tumor cells, and provides enhanced tumor inhibitory action.
Owner:CHINA PHARM UNIV
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