492 results about "Sexual function" patented technology

Systems and methods use an implantable pulse generator system for neuromodulation stimulation to treat sexual dysfunction by the unilateral or bilateral stimulation of the left and / or right branches of the dorsal genital nerves using one or more leads and electrodes implanted in adipose or other tissue in the region at or near the pubic symphysis. A neuromodulation stimulation waveform includes at least a variable frequency component and / or a variable duty cycle component and / or a variable amplitude component and / or a variable pause component to ward off habituation.

The present invention is concerned with compounds of the general Formula I: and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such, compounds of the present invention are useful for the treatment or prevention of obesity or eating disorders associated with excessive food intake and complications thereof, osteoarthritis, certain cancers, AIDS wasting, cachexia, frailty (particularly in elderly), mental disorders stress, cognitive disorders, sexual function, reproductive function, kidney function, locomotor disorders, attention deficit disorder (ADD), substance abuse disorders and dyskinesias, Huntington's disease, epilepsy, memory function, and spinal muscular atrophy. Compounds of formula I may therefore be used in the treatment of these conditions, and in the manufacture of a medicament useful in treating these conditions. Pharmaceutical formulations comprising one of the compounds of formula (I) as an active ingredient are disclosed, as are processes for preparing these compounds.

The present invention is concerned with compounds of the general Formula I: and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such, compounds of the present invention are useful for the treatment or prevention of obesity or eating disorders associated with excessive food intake and complications thereof, osteoarthritis, certain cancers, AIDS wasting, cachexia, frailty (particularly in elderly), mental disorders stress, cognitive disorders, sexual function, reproductive function, kidney function, locomotor disorders, attention deficit disorder (ADD), substance abuse disorders and dyskinesias, Huntington's disease, epilepsy, memory function, and spinal muscular atrophy. Compounds of formula I may therefore be used in the treatment of these conditions, and in the manufacture of a medicament useful in treating these conditions. Pharmaceutical formulations comprising one of the compounds of formula (I) as an active ingredient are disclosed, as are processes for preparing these compounds.

The present invention aims at extracting, separating and purifying the active components of Maka as one natural plant to obtain extractive with several medicinal and health care values. Fresh or dried Maka root material is extracted and separated to obtain active components and extracted residue. The active components includes glucosinolate and its decomposed product isothiocynate in 10-90 wt%,Maka amide and Maka olefin 5-70 wt% and sterol 2-30 wt%. The active components may be further prepared into capsule, tablet, and delayed releasing forms, and the prepared medicine and health food have the functions of treating climacteric syndrome, strengthening male's and female's sexuality, improving sexual function, etc.

Systems and methods use an external and / or implantable pulse generator system for neuromodulation stimulation to treat sexual dysfunction by the unilateral or bilateral stimulation of a target nerve A and / or a target nerve B using one or more leads and electrodes implanted in tissue in the pelvic region. The electrical stimulation waveform may be conveyed to the target nerve A electrode for a first predetermined amount of time, and conveyed to the target nerve B electrode for a second predetermined amount of time.

Systems and methods use an external and / or implantable pulse generator system for neuromodulation stimulation to treat sexual dysfunction by the unilateral or bilateral stimulation of a target nerve A and / or a target nerve B using one or more leads and electrodes implanted in tissue in the pelvic region. The electrical stimulation waveform may be conveyed to the target nerve A electrode for a first predetermined amount of time, and conveyed to the target nerve B electrode for a second predetermined amount of time.

The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment, beneficial substances may be delivered, according to certain embodiments, through the stratum corneum of the skin into the body. Beneficial substances include, but are not limited to, pharmaceutical agents, drugs, vitamins, co-factors, peptides, dietary supplements, and others. The beneficial effects disclosed include, for instance, relief of pain and inflammation, prevention and healing of ulcers of the skin, relief of headache, improved sexual function and enjoyment, growth of hair on the scalp, improving muscle size and / or function, removing body fat and / or cellulite, treating cancer, treating viral infections and others. A hostile biophysical environment may also be used in conjunction with systems and methods for increasing local blood flow, according to one set of embodiments. For example, by using a nitric oxide donor such as L-arginine, local blood flow may be increased, e.g., by transdermally delivering the nitric oxide precursor. The nitric oxide donor may be the sole cause of increased blood flow, or it may be supplemented with an adjunct such as theophylline.

The invention discloses a maca, ginseng and medlar composition and an application thereof. The composition is prepared by mixing the following components in percentage by weight: 30-85% of maca, 10-40% of ginseng and 5-30% of medlar. The composition is added with edible accessory and prepared into tablets, hard capsules, granules, soft capsule, medicinal liquor, oral liquid and beverage. According to the composition disclosed by the invention, the maca, ginseng and medlar are matched and combined according to the functional characteristics thereof; the ginseng has the effects of nourishing and strengthening and tonifying middle and replenishing qi, the maca has the effects of improving sexual function, reducing benign prostatic hyperplasia and improving the fertility, and the medlar has the effects of preventing consumptive disease, essence deficiency, impotence, spermatorrhea and the like; and the three complement one another and realize a synergistic effect in improving the sexual function, reducing benign prostatic hyperplasia and improving the fertility.

The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment, beneficial substances may be delivered, according to certain embodiments, through the stratum corneum of the skin into the body. Beneficial substances include, but are not limited to, pharmaceutical agents, drugs, vitamins, co-factors, peptides, dietary supplements, and others. The beneficial effects disclosed include, for instance, relief of pain and inflammation, prevention and healing of ulcers of the skin, relief of headache, improved sexual function and enjoyment, growth of hair on the scalp, improving muscle size and / or function, removing body fat and / or cellulite, treating cancer, treating viral infections and others. A hostile biophysical environment may also be used in conjunction with systems and methods for increasing local blood flow, according to one set of embodiments. For example, by using a nitric oxide donor such as L-arginine, local blood flow may be increased, e.g., by transdermally delivering the nitric oxide precursor. The nitric oxide donor may be the sole cause of increased blood flow, or it may be supplemented with an adjunct such as theophylline.

The present invention is concerned with compounds of the general Formula I:and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such, compounds of the present invention are useful for the treatment or prevention of obesity or eating disorders associated with excessive food intake and complications thereof, osteoarthritis, certain cancers, AIDS wasting, cachexia, frailty (particularly in elderly), mental disorders stress, cognitive disorders, sexual function, reproductive function, kidney function, locomotor disorders, attention deficit disorder (ADD), substance abuse disorders and dyskinesias, Huntington's disease, epilepsy, memory function, and spinal muscular atrophy. Compounds of formula I may therefore be used in the treatment of these conditions, and in the manufacture of a medicament useful in treating these conditions. Pharmaceutical formulations comprising one of the compounds of formula (I) as an active ingredient are disclosed, as are processes for preparing these compounds.

The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment, beneficial substances may be delivered, according to certain embodiments, through the stratum corneum of the skin into the body. Beneficial substances include, but are not limited to, pharmaceutical agents, drugs, vitamins, co-factors, peptides, dietary supplements, and others. The beneficial effects disclosed include, for instance, relief of pain and inflammation, prevention and healing of ulcers of the skin, relief of headache, improved sexual function and enjoyment, growth of hair on the scalp, improving muscle size and / or function, removing body fat and / or cellulite, treating cancer, treating viral infections and others. A hostile biophysical environment may also be used in conjunction with systems and methods for increasing local blood flow, according to one set of embodiments. For example, by using a nitric oxide donor such as L-arginine, local blood flow may be increased, e.g., by transdermally delivering the nitric oxide precursor. The nitric oxide donor may be the sole cause of increased blood flow, or it may be supplemented with an adjunct such as theophylline.

The invention relates to a maca health-care wine and a preparation method thereof. The maca health-care wine is prepared from the following components in parts by mass: 2-10 parts of maca functional extract, 0.1-5 parts of kudzu root functional extract and 85-97.9 parts of wine. The preparation method comprises the following steps: by using maca and kudzu root as raw materials, preparing maca andkudzu root functional extracts by a normal-temperature ultrasonic extraction technique, proportionally adding the extracts into wine in the form of solid dry powder or concentrated solution, filtering, sterilizing, and filling. The method is suitable for preparing maca health-care wines from white wine, yellow wine, wine, beer and fruit wine, and has the advantages of simple production technique and quantitative and controllable effective components; and the maca health-care wine not only performs the multiple health-care functions of maca, but also reduces the injury of alcohol on the human body by using the effective components in kudzu root. The maca health-care wine provided by the invention has the effects of relieving fatigue, resisting pressure, resisting radiation, improving the immunity, enhancing the sexual function, adjusting the incretion, improving the sleep, lowering the blood fat, postponing senility, protecting the liver and the like. The maca and kudzu root functionalextracts enhance the bioavailability of the respective functional components, and therefore, the maca health-care wine has wide application prospects in the aspect of preventing and improving sub-health.

The invention provides a preparation method for high-activity lepidium meyenii extract. The preparation method is characterized by comprising the following steps of: crushing fresh or dry lepidium meyenii roots, and performing primary ultrasonic reinforced extraction, primary solid-liquid separation and primary low-temperature supernatant concentration under the conditions of certain liquid / solid ratio and 20 to 50 DEG C by taking water as a solvent; performing secondary ultrasonic reinforced extraction, secondary solid-liquid separation and secondary low-temperature supernatant concentration on filter residues under the conditions of certain liquid / solid ratio and 20 to 50 DEG C by using an ethanol-water solution; and mixing the two concentrated solutions, and drying the mixture at low temperature or quickly to obtain powdery lepidium meyenii extract. The preparation method has the characteristics of high speed, high efficiency, completeness of functional component extraction, capability of preventing the damage of heat-sensitive functional components of lepidium meyenii, high bioactivity of the extract, low energy consumption, low cost and the like. The lepidium meyenii extract prepared by the preparation method provided by the invention has the effects of eliminating fatigue, resisting pressure, improving immunity, alleviating climacteric syndromes, resisting prostatic hyperplasia, enhancing sexual function, and the like.

The present invention is aimed at strengthening physique and raising sexual function via nourishing Yin, filling life essence and strengthening Yang. The comdposite medicine for treating impotence is prepared with ten kinds of Chinese medicinal materials including dodder seed, wolfberry fruit, schisandra, cnidium fruit, cherokee rose fruit, etc. The pharmacological test shows that the medicine of the present invention can raise the excitement of the penis of emasculated rat to external stimulation, shorten the period for the penis to erect and raise level of testosterone in serum.

The present invention provides a kit comprising, in separate compartments of a container, the following components (a) and (b): (a) a combination of apomorphine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable excipient or carrier; and (b) a solution which comprises a diluent and a pH modifying agent; the components being presented such that they can be combined at the point of use into a formulation which is adjusted to a pH ranging from mildly acidic to alkaline and which is suitable for buccal administration. The formulation is useful in treating Parkinson's disease and in promoting sexual function.

The invention provides a Lepidium meyenii. health product, which is made by uniformly mixing the raw materials of Lepidium meyenii., rhodiola rosea and Chinese angelica according the weight proportions of Lepidium meyenii. 15-30, rhodiola rosea 6-10 and Chinese angelica 3-6. The invention has the functions of adjusting human body immunity, improving sexual function, enriching blood, regulating blood, resisting oxidation and delaying aging, and is suitable for long term and proper amount taking.

A health-care food contains Maka (15-85%), Chinese-medicinal materials (5-70%), taurine (0-20%) and auxiliary (10-30%). It is prepared through pulverizing Maka and Chinese-medicinal materials, sieving by 60 meshes, proportioning, adding auxiliary, and loading in capsules. It features its health-care function of relieving fatigue and improving immunity and sexual function.

The invention relates to a series of derivatives (I) of isopentenyl flavonoid and preparation methods and uses thereof. The pharmacology experiments show that: the compounds can inhibit cGMP specific phosphodiesterase, in particular to selectively inhibiting phosphodiesterase V (PDE5), and have wide application in the treatment and prevention of sexual function trouble and the improvement of vascoconstriction related diseases.

A system and device for measuring sexual function includes an adjustable ring forming an opening to receive a penis, at least one diagnostic sensor positioned on an inner surface of the adjustable ring, wherein the ring automatically couples the diagnostic sensor to the penis throughout a range of ring diameters, and a microcontroller in communication with the at least one diagnostic sensor. The at least one diagnostic sensor measures data during sexual activity and communicates the data to the microcontroller. In fact, in an example, the device is configured to be worn by a user during sexual activity.

The kidney invigorating and yang strengthening Chinese medicine preparation is prepared with morinda root, malaytea scurfpea fruit, cnidium fruit, pilose antler, ursine seal's penis and testes and other 16 kinds of Chinese medicinal materials. It has the function of mildly reinforcing kidney yang, strengthening sexual function, raising sperm quality, etc.

The invention relates to health-care medicinal liquor capable of tonifying the kidney, strengthening yang and enhancing immunity and a preparation method thereof. The medicinal liquor is characterized by being prepared by soaking the following traditional Chinese medicines with white spirit: wild ginseng, cordyceps sinensis, pilose antler powder, deer penis, deer tendons, sea otters, hippocampus japonicus, gecko, glossy ganoderma, herba epimedii, cistanche deserticola, saffron crocus, dogwood, morinda officinalis, rehmanniae praeparatum, schisandra chinensis, gastrodia elata, cinnamomum cassia, rhizoma cibotii, fructus psoraleae, rape pollen, fructus ziziphi jujubae, the bark of eucommia, radix astragali powder and medlar. According to the theory of the traditional Chinese medicine that the kidney is the root of congenital constitution, the health-care medicinal liquor is mainly used for tonifying the kidney and strengthening yang. The medicinal liquor is prepared by adopting a fine scientific technology and carrying out four times of soaking, filtration, preparation and ageing on 20 various of precious traditional Chinese medicines which are capable of prolonging the life span ofhuman body cells. The medicinal liquor has a good effect and specific functions of enhancing of physical strength and sexual function when being drunk, and is particularly suitable for crowns with diseases such as deficiency of the kidney, impotence, premature ejaculation, lumbago, lacking in strength, prematurely senile and the like.

The invention discloses a health-care full-price feed for improving semen quality and sexual desire of a breeding boar. The health-care full-price feed comprises the following components in parts by weight: 43-74 parts of corns, 5-20 parts of wheat brans, 10-30 parts of bean pulps, 2-5 parts of fish powder, 2-4 parts of corn protein powder, 1-5 parts of corn germ meal, 0.2-0.5 part of lysine hydrochloride (98.5 percent), 0.2-0.4 part of salt, 0.2 part of a plurality of vitamins, 0.2 part of a plurality of mineral substances, 0.3-0.5 part of calcium hydrophosphate, 0.6-0.9 part of mountain flour, and 0.6 part of Chinese herbal medicine powder. The Chinese herbal medicine has the functions of warming the kidney yang, nourishing the kidney yin, benefiting semen blood, strengthening the bones and muscles, improving a sex function, adjusting immunization, promoting growth of osteoblast, resisting stress, resisting oxidization, delaying senescence and facilitating hematopoiesis, and can improve the semen quality of the breeding boar and increases the sexual desire of the breeding boar.

The invention relates to the field of wines, and particularly relates to a maca healthcare wine and a preparation method thereof. The maca healthcare wine comprises the following raw materials in parts by weight: 0.9-6 parts of maca powder, 0.45-3 parts of medlar, 0.75-5 parts of Chinese-date, 1.2-8 parts of momordica grosvenori, 0.15-1 part of liquorice, 0.12-0.8 parts of root of kudzu vine, 0.15-1 part of rhizoma polygonati, 0.6-4 parts of hawthorn, 0.15-1 part of semen cassia, 0.75-5 parts of tuckahoe and 0.75-5 parts of mulberry. The maca healthcare wine is prepared by the following technologies such as mixing, soaking, settling, primary filtering, ageing, freezing, secondary filtering and packaging, the condition that nutrient substances of the brewed wine are not destroyed is ensured by selecting the raw materials by means of reasonable process treatment and adding of auxiliary materials, the maca healthcare wine is comfortable in taste and has the advantages that the immunity of a human body can be improved, the sexual function is enhanced, blood fat and blood pressure are regulated, the immunity is enhanced, and digestion is facilitated. The maca healthcare wine has a certain regulating effect on female climacteric syndrome and ageing resistance, and is suitable for being drunk for a long period of time.

The invention provides methods of reducing the side effects of tramadol. Accordingly, in one embodiment, the invention provides a method of reducing the incidence of newly-discovered side effects related to sexual function in human males taking a tramadol material. The method comprises administering a phosphodiesterase inhibitor to a male taking the tramadol material. The invention also provides pharmaceutical compositions. In one embodiment, the composition comprises a tramadol material and a phosphodiesterase inhibitor. The invention further provides kits. In one embodiment, the kit comprises a tramadol material and a phosphodiesterase inhibitor.

Improved delivery systems and delivery methods for supporting and promoting healthy sexual function, for preventing sexual dysfunction, or for treatment of sexual dysfunction. A compositions including one or more cGMP-specific PDE5 inhibitors and / or dopaminergic agonists is administered in the form of a breath-care strip, mint or lozenge, or a food or beverage product. The cGMP-specific PDE5 inhibitor comprises an ingredient selected from the group consisting of sophoflavescenol, vardenafil, tadalafil, and sildenafil. The dopaminergic agonist comprises apomorphine. Vitex agnus-castus extract, and one or more of lipoic acid, L-Arginine, folic acid, trimethylglycine, policosanol, carnitine, biotin, and acetyl L-Carnitine may also be included in the delivery vehicle.

The invention discloses a health-care food for males and a preparation method thereof. The health-care food is prepared according to a traditional Chinese medicine theory and the respective health-care efficacies and characteristics of maca, cistanche and liquorice; maca has the efficacies of resisting fatigues, improving sexual functions, increasing the number of sperms, improving the quality of the sperms, reducing benign prostatic hyperplasia, enhancing fertility and the like; traditional Chinese medicine cistanche has the efficacies of benefiting essence and blood, tonifying the kidney and reinforcing yang as well as lubricating intestines and smoothing bowels and can have health-care effects on kidney deficiency and impotence, spermatorrhea and premature ejaculation, coldness and pain of a waist and knees and the like; liquorice is a tonifying Chinese herbal medicine and can coordinate drug properties as well as tonify spleen and benefit qi. By virtue of a nanotechnology, the bioavailability of bioactive molecules in maca, cistanche and liquorice is improved; by virtue of fine processing, maca, cistanche and liquorice are prepared into the health-care food for males; the health-care food is safe and effective, nontoxic and harmless, and has synergistic effects on improvement of sexual function, enhancement of fertility, regulation of internal secretion, reduction of prostate diseases and improvement of the immunologic function of an organism.

Disclosed are instant functional maca coffee and a production method thereof. The instant functional maca coffee comprises, by weight, 5-40% of functional maca extract, 50-80% of instant coffee powder, 1-10% of white granulated sugar, 0.5-5% of non-dairy creamer, 1-10% of zinc lactate, and 0.1-2% of vitamin B1. The instant functional maca coffee retains coffee taste and gives full play to functions of maca, such as fatigue relief, radiation proofing, immunity enhancement, hormone balancing, benign prostatic hyperplasia proofing and sexual function enhancement. Bioavailability of functional components of the functional maca extract is improved, and accordingly the instant functional maca coffee has broad application prospect in terms of preventing and improving sub-health.

The invention relates to a lycium-rehmannia pill and capsule with thirty six types of raw materials, belonging to the field of homology of medicine and food of animals and plants. The invention is prepared by alcohol extraction and water boiling extraction of radix rehmanniae preparata, siberian solomonseal rhizome, raidx astragali, Chinese magnoliavine fruit, common cnidium fruit, platycladi seed, barbary wolfberry fruit, Chinese dodder seed, seed of tuber onion, herba epimedii, Chinese angelica, white paeony root, ginseng, cordyceps sinensis, raspberry, mulberry, cortex cinnamomi, prepared common monkshood daughter root, sharpleaf galangal fruit, gordon euryale seed, fried yam, twotooth achyranthes root, medicinal indianmulberry root, desertliving cistanche, cynomorium coccineum, thinleaf milkwort root-bark, liquoric root, cornu cervi pantotrichum, deer kidney, donkey kidney, beef kidney, dog kidney, jackass penis, dog penis, american ginseng and sea horse. The product can improve immunity, tonify Qi of the kidney, calm the five internal organs, resist fatigue, prevent impotence and premature ejaculation, sexual function decline, low sexual desire of male and female, has obvious effect and is convenient in use.

The invention discloses a traditional Chinese medicine compound capable of improving immunity, resisting fatigue and improving sexual function. The traditional Chinese medicine comprises the following raw materials by part of weight: 25-35 parts of maca, 1-6 parts of herba epimedii extractive, 5-15 parts of rhodiola rosea extractive, 1-10 parts of cistanche extractive, 5-15 parts of acanthopanax extractive and 5-20 parts of pallas pit viper extractive. According to animal experiments, the traditional Chinese medicine compound has the obvious effect of improving immunity, resisting fatigue and improving sexual function and can be prepared into various medicines, health care products, food and the like together with excipient, additives and the like for improving immunity, resisting fatigue and improving sexual function.

The invention relates to a traditional Chinese medicine composition for relieving fatigue as well as a preparation method and application of the composition. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1-50 parts of fruit of Chinese wolfberry, 1-30 parts of rhizoma polygonati, 1-30 parts of Chinese yam, 1-30 parts of chrysanthemum, 1-15 parts of liquorice, 1-15 parts of smoked plum and 1-8 parts of pericarpium citri reticulatae. The preparation method disclosed by the invention comprises the following steps: adopting a water extracting process; applying the technologies such as centrifugation and membrane separation, so as to obtain traditional Chinese medicine concentrated liquor; or carrying out spray drying to obtain traditional Chinese medicine extract powder; adding auxiliary materials to prepare beverage, oral liquid, granula or tablets. The traditional Chinese medicine composition disclosed by the invention has the effects of relieving physical fatigue and visual fatigue, and helping improvement of memory and sexual function, and is accurate in effect, and safe and free of toxic and side effects.