13 results about "Male sexual dysfunction" patented technology

An apparatus for treating a sexually dysfunctional male patient is provided. The apparatus comprising an implantable vibrator adapted to be implanted within at least one corpus cavernosum of a human patient, wherein said vibrator is adapted to cause vibration in at least one of the corpus cavernosum for stimulating the sexually responsive tissue of the penis.

The application discloses a method for treating premature ejaculation by using high-frequency muscle-bone ultrasonic guiding razor needle to release the connective tissue of the dorsal nerve of penis, and belongs to the technical field of minimally invasive treatment of male sexual dysfunction. The method can accurately distinguish the course, branch and adjacent blood vessel level of the dorsal nerve of penis and mark the safe needle insertion area through real-time imaging of high-frequency muscle-bone ultrasound. A 0.4mm razor needle is used to perform longitudinal push-cut release in the interspace of the dorsal nerve of penis under the whole-process monitoring of ultrasound, so as to release the adhesion of the loose connective tissue under the skin and the high-tension structure. Then, transverse push-cut release is performed in the coronal sulcus area, so as to reduce the local sensory afferent excitability and prolong the ejaculation latency. The application realizes visual operation in the whole process, has small trauma and is controllable and accurate, does not damage the main stem of the nerve and the blood vessel, can stably improve the symptoms of premature ejaculation and is suitable for clinical standardization and popularization.

The application discloses a kind of compositions based on engineering stem cell exosome and its application in treating male sexual dysfunction.The composition includes mesenchymal stem cell exosome modified by genetic engineering, which displays bifunctional fusion polypeptide targeting TβRⅡ and LOXL2 on the surface. The fusion polypeptide integrates TβR-PEP with LOXL2-PEP through flexible linker, and introduces HIV-TAT penetrating peptide and self-assembly motif, forms nanoparticles to extend half-life. In vitro experiments show that the inhibition efficiency of the fusion polypeptide on TβRⅡ and LOXL2 is significantly better than that of single polypeptide, and can synergistically reverse fibrosis and promote angiogenesis. Animal experiments confirm that exosome loaded with fusion polypeptide significantly improves the erectile function of diabetic ED rats. The application provides a radical treatment scheme for male sexual dysfunction through double-target synergistic, long-acting delivery and multi-effect repair mechanism.

The application provides a preparation method of a stem cell exosome composition and application of the stem cell exosome composition in male sexual dysfunction, and the preparation method comprises the following steps: extracting stem cell exosomes; combining the stem cell exosomes with a stabilizing peptide; and preparing a stem cell exosome hydrogel; the stabilizing peptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The stem cell exosome composition obtained by the method can improve the stability of the exosomes, improve the in-vivo bioavailability, prevent and relieve testicular injury, and inhibit inflammatory reactions.

The invention provides a preparation method and application of a stem cell preparation for repairing male sexual dysfunction. The preparation method comprises the following steps: extraction and primary culture of mesenchymal stem cells; regulating and controlling secretion signals of the mesenchymal stem cells; and preparing the preparation. According to the preparation method of the stem cell preparation for repairing the male sexual dysfunction, the mitochondrial repair signal inducer is added in the mesenchymal stem cell culture stage, and the mitochondrial function repair promoting component is added into the preparation, so that the obtained stem cell preparation can repair the mitochondrial energy metabolism function; the mitochondrial quality control is promoted; the cavernous body tissue microenvironment is improved. The preparation method provided by the invention can achieve the beneficial effects of performing targeted repair on the focus of male sexual dysfunction and improving the treatment and repair efficiency.

The invention provides a penis external supporting device and method for assisting male sexual dysfunction, and belongs to the technical field of medical instruments. The device comprises a sleeve-shaped main body made of a flexible biocompatible material and a built-in plastic deformation metal structure supporting piece, the front end and the rear end of the main body are provided with a first opening and a second opening respectively, the front end opening ensures that the glans penis is exposed to maintain sensitivity, and the internal metal supporting piece can be bent and shaped manually; after shaping, the bottom opening ensures that the ejaculation channel is not pressed, and the supporting force required for maintaining erection of the penis is provided. By means of the composite structure with the soft outer portion and the rigid inner portion and the humanized design with the two ends open, erection is effectively assisted, meanwhile, the physiological comfort level, sensitivity and the normal ejaculation function of a user are guaranteed to the maximum degree, and a safe, non-invasive and effective physical auxiliary instrument is provided for an erectile dysfunction patient.

The present application provides a kind of male sexual function monitoring and behavior training control method and system, monitor the penile root, glans penis pressure value in sexual behavior training, calculate ejaculation latency;Penile tumescence degree value and glans penis tumescence degree value are calculated;Real-time current unit time sexual excitement degree value Ls is calculated, and according to the change of Ls, corresponding control mode is adopted, ejaculation time point, ejaculation latency and ejaculation latency number are extended.The present application can feed back the sexual excitement degree data of training to the trainer in real time, and according to the change of sexual excitement degree in training, the sexual excitement degree is promoted and controlled, and the ejaculation is controlled, for male sexual behavior training, extend the penile erection and ejaculation latency length, so as to continuously improve the ejaculation control of trainer, improve the brain ejaculation threshold, improve the penile blood vessel blood supply time, treat premature ejaculation, erectile dysfunction and other male sexual dysfunction.

The invention discloses a traditional Chinese medicine composition for improving male sexual function and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The invention aims to solve the problems that the existing medicine for treating male sexual dysfunction is obvious in side effect, cannot be used for a long time and is unstable in curative effect by combining the traditional Chinese medicine theory and the modern medicine extraction technology through the compatibility of specific medicinal materials and optimizing process steps. The traditional Chinese medicine composition integrates the synergistic effects of various medicinal materials, can improve male sexual dysfunction and reduce the occurrence risk of side effects, and is suitable for long-term administration; meanwhile, the preparation method optimizes the extraction efficiency of active ingredients through a modern extraction technology, and has the characteristics of stable curative effect and high safety; the traditional Chinese medicine composition and the preparation method have innovativeness, effectiveness and practicability, are expected to become a powerful tool for improving the male sexual function, make important contributions to the health and welfare of vast males and promote the innovative development of related industries.

The invention provides a preparation method of a stem cell exosome composition and application of the stem cell exosome composition in male sexual dysfunction. The preparation method comprises the following steps: extracting stem cell exosomes; the stem cell exosome is combined with the stable peptide; stem cell exosome hydrogel is prepared; the stable peptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The stem cell exosome composition obtained by the method can improve the stability of the exosome, improve the in-vivo bioavailability, prevent and relieve testis injury and inhibit inflammatory response.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition, a preparation method and application, and the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 10-12 parts of prepared rehmannia root, 6-8 parts of glossy privet fruit, 6-8 parts of rhizoma cibotii, 9-11 parts of euphorbia thymifolia, 6-8 parts of rhizoma polygonati, 6-8 parts of fructus rosae laevigatae and 4-5 parts of polygonum multiflorum. The traditional Chinese medicine composition disclosed by the invention starts from the root, overcomes the defect that western medicines treat symptoms but not root causes, and has a good prevention and treatment effect on male sexual dysfunction caused by cyclophosphamide.

This application discloses a composition, preparation method, application, and formulation for improving male sexual dysfunction. The composition includes Salvia miltiorrhiza root extract and Cnidium monnieri fruit extract. The Salvia miltiorrhiza root extract is obtained by hot reflux extraction and amylase hydrolysis of Salvia miltiorrhiza root followed by concentration. The Cnidium monnieri fruit extract is obtained by enzymatic hydrolysis of Cnidium monnieri fruit followed by cellulase and pectinase followed by concentration. This composition can be used as a raw material for topical application to improve male sexual dysfunction. This composition has no toxic effects, effectively improves male sexual dysfunction, and has restorative and nourishing effects on male sexual function. The composition can reverse the phenotypic transformation of penile cavernous smooth muscle cells under pathological conditions and maintain the normal relaxation and contraction function of smooth muscle.

1. Name of the product in this design: Male Sexual Function Therapy Device. 2. Purpose of this design: For the treatment of male sexual dysfunction. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The application provides a composition for treating male sexual dysfunction and application thereof, which is composed of the following effective components in parts by weight: 1-3 parts of ginseng, 2-4 parts of oyster, 1-3 parts of oyster peptide, 0.1-0.3 parts of sea cucumber peptide, 2-4 parts of yam, 2-4 parts of steamed rhizoma polygonati, 2-4 parts of poria cocos, 2-4 parts of medlar, 2-4 parts of gordon euryale seed, 2-4 parts of raspberry, 2-4 parts of burdock root, 1-3 parts of cumin, 0.1-0.3 parts of leaf powder of damian grass, 0.1-0.3 parts of beetroot powder, 0.1-0.3 parts of gamma-aminobutyric acid, 2-4 parts of ophiopogon, 2-4 parts of licorice, 1-3 parts of mussel polysaccharide and 0.1-0.3 parts of yeast-beta-glucan. The traditional Chinese medicine composition is simple in preparation method, reasonable in compatibility and high in total effective rate in clinical experiment.