24 results about "Male sexual dysfunction" patented technology

The invention discloses a composition based on an engineered stem cell exosome and application of the composition in treating male sexual dysfunction. The composition comprises a mesenchymal stem cell exosome modified by genetic engineering, and the surface of the mesenchymal stem cell exosome displays a bifunctional fusion polypeptide targeting TbetaR II and LOXL2. According to the fusion polypeptide, TbetaR-PEP and LOXL2-PEP are integrated through a flexible linker, and an HIV-TAT penetrating peptide and a self-assembly motif are introduced, so that nanoparticles are formed, and the half-life period is prolonged. In-vitro experiments show that the inhibition efficiency of the fusion polypeptide on TbetaRII and LOXL2 is obviously superior to that of a single peptide, and the fusion polypeptide can synergistically reverse fibrosis and promote angiogenesis. Animal experiments prove that the exosome loaded with the fusion polypeptide can significantly improve the erectile function of diabetic ED rats. According to the invention, a radical treatment scheme is provided for male sexual dysfunction through double-target cooperation, long-acting delivery and a multi-effect repair mechanism.

The invention provides a functional peptide with a yang tonifying effect, a seal penis peptide and a preparation method and application of the functional peptide and the seal penis peptide. The functional peptide comprises a peptide fragment pER and can promote testicular interstitial cells to secrete testosterone. Testosterone is steroid hormone and can be secreted by testicular interstitial cells through enzymatic reaction. The low testosterone level in serum can cause male testicular atrophy and low sperm survival rate, so that the male reproductive function is influenced, and the phenomena of poor sexual desire, premature ejaculation, erectile dysfunction and the like can also be caused. In addition, the testosterone also has the effects of maintaining muscle strength and quality, maintaining bone density and strength, refreshing, improving physical ability and the like. Therefore, the functional peptide provided by the invention has the effect of promoting the secretion of testosterone, which means that the functional peptide not only can effectively improve the male sexual function, but also can alleviate the damage of male sexual dysfunction to the body and spirit.

The present invention relates to the technical field of functional gel preparation, and in particular to a method for preparing a functional gel. The functional gel preparation steps provided by the present invention are as follows: 50 parts of 50°C water, 11 parts of carbomer, and 5 parts of xanthan gum are mixed and stirred at 150 rpm for 10 minutes to obtain material 1; material 1 is mixed with 6 parts of isopropyl palmitate and stirred at 200 rpm for 20 minutes to obtain material 2; material 2 is cooled to 23°C, mixed with 25 parts of 80% ethanol by volume, 13 parts of 50% n-butanol by volume, 14 parts of glycerol, and 3 parts of propyl paraben, and stirred at 200 rpm for 20 minutes; and the pH is adjusted to 5.4 using sodium carbonate as a pH adjuster to obtain a functional gel. The functional gel prepared by the present invention does not contain any pharmaceutical ingredients, is safe and non-irritating during use, and has excellent therapeutic effects on male sexual dysfunction, with the therapeutic effects comparable to those of existing drugs.

An apparatus for treating a sexually dysfunctional male patient is provided. The apparatus comprising an implantable vibrator adapted to be implanted within at least one corpus cavernosum of a human patient, wherein said vibrator is adapted to cause vibration in at least one of the corpus cavernosum for stimulating the sexually responsive tissue of the penis.

The application discloses a method for treating premature ejaculation by using high-frequency muscle-bone ultrasonic guiding razor needle to release the connective tissue of the dorsal nerve of penis, and belongs to the technical field of minimally invasive treatment of male sexual dysfunction. The method can accurately distinguish the course, branch and adjacent blood vessel level of the dorsal nerve of penis and mark the safe needle insertion area through real-time imaging of high-frequency muscle-bone ultrasound. A 0.4mm razor needle is used to perform longitudinal push-cut release in the interspace of the dorsal nerve of penis under the whole-process monitoring of ultrasound, so as to release the adhesion of the loose connective tissue under the skin and the high-tension structure. Then, transverse push-cut release is performed in the coronal sulcus area, so as to reduce the local sensory afferent excitability and prolong the ejaculation latency. The application realizes visual operation in the whole process, has small trauma and is controllable and accurate, does not damage the main stem of the nerve and the blood vessel, can stably improve the symptoms of premature ejaculation and is suitable for clinical standardization and popularization.

The application discloses a kind of compositions based on engineering stem cell exosome and its application in treating male sexual dysfunction.The composition includes mesenchymal stem cell exosome modified by genetic engineering, which displays bifunctional fusion polypeptide targeting TβRⅡ and LOXL2 on the surface. The fusion polypeptide integrates TβR-PEP with LOXL2-PEP through flexible linker, and introduces HIV-TAT penetrating peptide and self-assembly motif, forms nanoparticles to extend half-life. In vitro experiments show that the inhibition efficiency of the fusion polypeptide on TβRⅡ and LOXL2 is significantly better than that of single polypeptide, and can synergistically reverse fibrosis and promote angiogenesis. Animal experiments confirm that exosome loaded with fusion polypeptide significantly improves the erectile function of diabetic ED rats. The application provides a radical treatment scheme for male sexual dysfunction through double-target synergistic, long-acting delivery and multi-effect repair mechanism.

The application provides a preparation method of a stem cell exosome composition and application of the stem cell exosome composition in male sexual dysfunction, and the preparation method comprises the following steps: extracting stem cell exosomes; combining the stem cell exosomes with a stabilizing peptide; and preparing a stem cell exosome hydrogel; the stabilizing peptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The stem cell exosome composition obtained by the method can improve the stability of the exosomes, improve the in-vivo bioavailability, prevent and relieve testicular injury, and inhibit inflammatory reactions.

The invention provides a preparation method and application of a stem cell preparation for repairing male sexual dysfunction. The preparation method comprises the following steps: extraction and primary culture of mesenchymal stem cells; regulating and controlling secretion signals of the mesenchymal stem cells; and preparing the preparation. According to the preparation method of the stem cell preparation for repairing the male sexual dysfunction, the mitochondrial repair signal inducer is added in the mesenchymal stem cell culture stage, and the mitochondrial function repair promoting component is added into the preparation, so that the obtained stem cell preparation can repair the mitochondrial energy metabolism function; the mitochondrial quality control is promoted; the cavernous body tissue microenvironment is improved. The preparation method provided by the invention can achieve the beneficial effects of performing targeted repair on the focus of male sexual dysfunction and improving the treatment and repair efficiency.

The invention discloses a compound preparation based on traditional Chinese medicine extracts and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is prepared from the following raw materials in parts by weight: 10 to 20 parts of cortex eucommiae, 15 to 25 parts of poria cocos, 5 to 15 parts of gallnut, 10 to 20 parts of fructus cnidii, 15 to 25 parts of herba cistanche, 10 to 20 parts of herba epimedii, 10 to 20 parts of herba cynomorii, 5 to 10 parts of saffron crocus, 5 to 15 parts of fossil fragments, 5 to 10 parts of flos caryophylli and 10 to 20 parts of rhizoma chuanxiong. The traditional Chinese medicine extract is prepared into a spray; the traditional Chinese medicinal materials or decoction pieces are adopted as raw materials, effective components in the traditional Chinese medicinal materials or decoction pieces are extracted through a special extraction method and then prepared into different preparations such as sprays, and the traditional Chinese medicinal composition has a remarkable effect on male sexual dysfunction, has obviously fewer side effects than that of the traditional Chinese medicinal materials and the like, and is high in safety, definite in curative effect, low in cost and suitable for clinical popularization and application; meanwhile, the antibacterial effect is achieved, and safety and effectiveness are achieved.

The invention provides a penis external supporting device and method for assisting male sexual dysfunction, and belongs to the technical field of medical instruments. The device comprises a sleeve-shaped main body made of a flexible biocompatible material and a built-in plastic deformation metal structure supporting piece, the front end and the rear end of the main body are provided with a first opening and a second opening respectively, the front end opening ensures that the glans penis is exposed to maintain sensitivity, and the internal metal supporting piece can be bent and shaped manually; after shaping, the bottom opening ensures that the ejaculation channel is not pressed, and the supporting force required for maintaining erection of the penis is provided. By means of the composite structure with the soft outer portion and the rigid inner portion and the humanized design with the two ends open, erection is effectively assisted, meanwhile, the physiological comfort level, sensitivity and the normal ejaculation function of a user are guaranteed to the maximum degree, and a safe, non-invasive and effective physical auxiliary instrument is provided for an erectile dysfunction patient.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine compound for invigorating kidney and strengthening yang and improving and enhancing male sexual function and a preparation method thereof. The traditional Chinese medicine compound is prepared from the following components in parts by mass: 5 to 30 parts of black radix aconiti lateralis preparata, 10 to 40 parts of herba epimedii, 10 to 30 parts of fructus psoraleae, 3 to 15 parts of cortex cinnamomi, 5 to 35 parts of herba cistanche, 10 to 50 parts of actinolitum brevicompactum, 10 to 35 parts of radix rehmanniae preparata, 5 to 25 parts of radix morindae officinalis, 5 to 30 parts of deer-horn glue, 5 to 35 parts of radix salviae miltiorrhizae, 5 to 35 parts of fructus corni, 5 to 35 parts of fructus lycii, 6 to 25 parts of rhizoma curculiginis, 5 to 35 parts of cortex moutan and 10 to 40 parts of radix astragali seu hedysari. Through scientific compatibility, all the components cooperate with one another and jointly act on the male sexual dysfunction caused by kidney-yang deficiency, the traditional Chinese medicine can warm yang and tonify the kidney, meanwhile, yin injury caused by excessive heat can be avoided, blood circulation is promoted to remove blood stasis, and overall qi and blood circulation is improved.

The present application provides a kind of male sexual function monitoring and behavior training control method and system, monitor the penile root, glans penis pressure value in sexual behavior training, calculate ejaculation latency;Penile tumescence degree value and glans penis tumescence degree value are calculated;Real-time current unit time sexual excitement degree value Ls is calculated, and according to the change of Ls, corresponding control mode is adopted, ejaculation time point, ejaculation latency and ejaculation latency number are extended.The present application can feed back the sexual excitement degree data of training to the trainer in real time, and according to the change of sexual excitement degree in training, the sexual excitement degree is promoted and controlled, and the ejaculation is controlled, for male sexual behavior training, extend the penile erection and ejaculation latency length, so as to continuously improve the ejaculation control of trainer, improve the brain ejaculation threshold, improve the penile blood vessel blood supply time, treat premature ejaculation, erectile dysfunction and other male sexual dysfunction.

The invention discloses a traditional Chinese medicine composition for improving male sexual function and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The invention aims to solve the problems that the existing medicine for treating male sexual dysfunction is obvious in side effect, cannot be used for a long time and is unstable in curative effect by combining the traditional Chinese medicine theory and the modern medicine extraction technology through the compatibility of specific medicinal materials and optimizing process steps. The traditional Chinese medicine composition integrates the synergistic effects of various medicinal materials, can improve male sexual dysfunction and reduce the occurrence risk of side effects, and is suitable for long-term administration; meanwhile, the preparation method optimizes the extraction efficiency of active ingredients through a modern extraction technology, and has the characteristics of stable curative effect and high safety; the traditional Chinese medicine composition and the preparation method have innovativeness, effectiveness and practicability, are expected to become a powerful tool for improving the male sexual function, make important contributions to the health and welfare of vast males and promote the innovative development of related industries.

The invention provides a preparation method of a stem cell exosome composition and application of the stem cell exosome composition in male sexual dysfunction. The preparation method comprises the following steps: extracting stem cell exosomes; the stem cell exosome is combined with the stable peptide; stem cell exosome hydrogel is prepared; the stable peptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The stem cell exosome composition obtained by the method can improve the stability of the exosome, improve the in-vivo bioavailability, prevent and relieve testis injury and inhibit inflammatory response.

To provide a method for treating a sexual dysfunction.SOLUTION: The present disclosure relates to a method for treating female or male sexual dysfunction, the method comprising orally administering to a female or male subject an effective amount of 3,4-diaminopyridine or a pharmaceutically acceptable salt thereof. For example, a method for treating sexual dysfunction in a subject in need thereof is provided, the method comprising orally administering to the subject an effective amount of 3,4-diaminopyridine phosphate.SELECTED DRAWING: None

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition, a preparation method and application, and the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 10-12 parts of prepared rehmannia root, 6-8 parts of glossy privet fruit, 6-8 parts of rhizoma cibotii, 9-11 parts of euphorbia thymifolia, 6-8 parts of rhizoma polygonati, 6-8 parts of fructus rosae laevigatae and 4-5 parts of polygonum multiflorum. The traditional Chinese medicine composition disclosed by the invention starts from the root, overcomes the defect that western medicines treat symptoms but not root causes, and has a good prevention and treatment effect on male sexual dysfunction caused by cyclophosphamide.

This application discloses a composition, preparation method, application, and formulation for improving male sexual dysfunction. The composition includes Salvia miltiorrhiza root extract and Cnidium monnieri fruit extract. The Salvia miltiorrhiza root extract is obtained by hot reflux extraction and amylase hydrolysis of Salvia miltiorrhiza root followed by concentration. The Cnidium monnieri fruit extract is obtained by enzymatic hydrolysis of Cnidium monnieri fruit followed by cellulase and pectinase followed by concentration. This composition can be used as a raw material for topical application to improve male sexual dysfunction. This composition has no toxic effects, effectively improves male sexual dysfunction, and has restorative and nourishing effects on male sexual function. The composition can reverse the phenotypic transformation of penile cavernous smooth muscle cells under pathological conditions and maintain the normal relaxation and contraction function of smooth muscle.

The invention discloses application of cycloastragenol in preparation of a product for treating male sexual dysfunction, and relates to the technical field of biological medicine, sexual dysfunction of male mice caused by high-fat diet, medicine and aging is remarkably improved through intervention of cycloastragenol, the specific expression is that changes of body weight and testis weight are controlled, and the sexual dysfunction of the male mice caused by high-fat diet, medicine and aging is improved. The sperm motility rate is obviously improved, the hormone release level of testosterone and gonadotropin is increased, and the testicular tissue structure is improved.

Use of a mulberry extract in the preparation of a drug for treating and / or preventing male infertility. The extract comprises an alkaloid with a weight content of 3% or more, and / or a polysaccharide with a weight content of not more than 70%, and / or flavone with a weight content of not more than 10%, and / or an amino acid with a weight content of not more than 50%, and / or other components. The extract can be used for male infertility related to male sexual dysfunction and male reproductive dysfunction.

1. Name of the product in this design: Male Sexual Function Therapy Device. 2. Purpose of this design: For the treatment of male sexual dysfunction. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The application provides a composition for treating male sexual dysfunction and application thereof, which is composed of the following effective components in parts by weight: 1-3 parts of ginseng, 2-4 parts of oyster, 1-3 parts of oyster peptide, 0.1-0.3 parts of sea cucumber peptide, 2-4 parts of yam, 2-4 parts of steamed rhizoma polygonati, 2-4 parts of poria cocos, 2-4 parts of medlar, 2-4 parts of gordon euryale seed, 2-4 parts of raspberry, 2-4 parts of burdock root, 1-3 parts of cumin, 0.1-0.3 parts of leaf powder of damian grass, 0.1-0.3 parts of beetroot powder, 0.1-0.3 parts of gamma-aminobutyric acid, 2-4 parts of ophiopogon, 2-4 parts of licorice, 1-3 parts of mussel polysaccharide and 0.1-0.3 parts of yeast-beta-glucan. The traditional Chinese medicine composition is simple in preparation method, reasonable in compatibility and high in total effective rate in clinical experiment.

A phytotherapy formulation for preventing or treating sexual dysfunctions, and more specifically, a formulation containing standardized extract of Spilanthes acmella, is provided which is useful as an adjuvant in the prevention and treatment of female and male sexual dysfunctions, including hypoactive sexual desire disorder (HSDD).

The invention relates to the technical field of traditional Chinese medicine health preserving, and discloses a compound herbal multifunctional health preserving fragrant moxibustion, which comprises 48 traditional Chinese medicines such as agilawood, cistanche, cynomorium songaricum and the like, and is prepared by adopting superfine grinding, gradient mixing and low-temperature rolling processes. The fragrant moxibustion can simultaneously achieve the four effects of warming the kidney and strengthening yang, regulating qi and blood, clearing away heat and toxic materials and strengthening the spleen and stomach through acupuncture point moxibustion therapy, and is effective for male dysfunction, chronic fatigue syndrome, gastrointestinal dysfunction and the like.

An apparatus for treating a sexually dysfunctional male patient is provided. The apparatus comprising an implantable vibrator adapted to be implanted within at least one corpus cavernosum of a human patient, wherein said vibrator is adapted to cause vibration in at least one of the corpus cavernosum for stimulating the sexually responsive tissue of the penis; and a feedback device for sending feedback information from inside the patient's body to the outside thereof, the feedback information being related to at least one of a physiological parameter of the patient and a functional parameter related to the apparatus.