161 results about "Male sexual dysfunction" patented technology

Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid side chain moieties, and are further characterized in that the metallopeptides preferably do not bind or significantly bind to a melanocortin receptor.

The present invention relates to the use of neutral endopeptidase inhibitors (NEPi) and a combination of NEPi and phosphodiesterase type 5 (PDE5) inhibitor for the treatment of male sexual dysfunction, in particular MED.

A cyclic peptide of the structural formula:

or a pharmaceutically acceptable salt thereof, wherein R₁, R₂, R₃, R₄, R₅, R₆, m and p are as defined. Further provided are compositions for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cyclic peptide including a C-terminus —OH group. Routes of administration include injection, oral, urethral, vaginal, nasal and mucosal administration.

Sildenafil, a known pharmaceutical chemical useful in treatment of male sexual dysfunction, is prepared by processes in which the final chemical intermediate is of significantly lower basicity than sildenafil itself, so that sildenafil can be extracted in substantially pure form from the organic reaction mixture in which it is made by adding an aqueous medium of appropriately chosen acidic pH and causing phase shift of the sildenafil to occur selectively into the aqueous phase.

Methods for the treatment of female sexual dysfunction, including treatment of associated postmenopausal symptoms, are provided using very low doses of 17β-[(1-methyl-1,4-dihydro-3-pyridinyl)carbonyloxy]estra-1,3,5(10)-trien-3-ol, also known as E₂-CDS, which do not elevate average steady-state peripheral estradiol levels to above about 50-60 pg/ml. Also, methods for the treatment of male sexual dysfunction are provided using very low doses of E₂-CDS which do not substantially elevate average peripheral estradiol levels to above average normal peripheral levels in the male mammal.

The invention relates to a composition for improving male sexual functions and resisting fatigue and a preparation method thereof. The composition for improving male sexual functions and resisting fatigue comprises the following raw materials in parts by weight: 5-30 parts of oyster peptide, 1-10 parts of milk polypeptide, 1-10 parts of ginseng powder, 1-10 parts of maca powder, 0-15 parts of common ginger powder, 1-10 parts of burdock root powder, 5-15 parts of mulberry powder, 5-15 parts of Chinese magnoliavine fruit powder, 5-15 parts of Chinese wolfberry fruit powder, 1-10 parts of dark plum powder, 10-50 parts of isomaltulose, and 0.1-0.5 part of sucralose. According to male sexual dysfunction generation mechanism, the oyster peptide is taken as a main raw material, supplemented witha composition capable of improving male sexual functions and resisting fatigue and including the milk polypeptide the ginseng powder, the maca powder, the common ginger powder, the burdock root powder, the mulberry powder, the Chinese magnoliavine fruit powder, the Chinese wolfberry fruit powder and auxiliary materials including the dark plum powder, the isomaltulose and the sucralose, so that thepurpose of improving male sexual functions and resisting fatigue is achieved.

The invention relates to a preparation method of an MACA extract. The preparation method comprises following steps: (1) extracting MACA with a solvent to obtain a primary MACA extract as a purification raw material; and (2) continuously performing purification to obtain the MACA extract being high in the content of MACAmide, wherein the purification is carried out in a column chromatography manner. The column chromatographic purification comprises following steps: (1) performing impurity washing to remove impurities; and (2) performing elution to obtain the MACAmide. The MACA extract is high in the content of the MACAmide so that the MACA extract is excellent in effects of enhancing male fertility and treating male sexual dysfunction. The preparation method is simple in extraction technology, is easy to operate, has a strong adaptability in production equipment and is easy to achieve industrialized production.

The invention relates to a novel use of ginsenoside Rg1, especially the use in preventing or treating male sexual dysfunction such as ejection dysfunction.

Disclosed are methods and compositions for treatment of male sexual dysfunction. A method of treating male sexual dysfunction includes administering a pharmaceutical composition effective to cause said male to sustain an erection. The composition is formulated based on diagnostic assessment and an individualized formulation test step. Also within the invention is a method of treating male sexual dysfunction in a population of subjects. The invention further provides kits for treatment of male erectile dysfunction.

A method of treating Alzheimer's disease, Parkinson's disease, sexual dysfunction or erectile dysfunction in a man by administration of a 5alpha reductase inhibitor together with a testosterone supplement is described. The method is also concerned with the use of the 5alpha reductase inhibiting compound and the testosterone supplement together with another agent useful for treating erectile dysfunction, including PDE V inhibitors; AGE (advanced glycation end-product) breakers; alpha 1 blockers; alpha 1A antagonists; alpha 2 antagonists; dopamine agonists; dopamine D4 agonists; melanocortin agonists; oxytocin agonists; prostaglandin; radical scavengers; rotamase inhibitors; aviptadil; nitroglycerine; and GPCR agonists for treating male sexual dysfunction or erectile dysfunction.

The invention relates to a synthetic method of MACAmide. The method includes following steps: with a fatty acid and benzylamine or m-methoxybenzylamine as reaction raw materials, mixing the raw materials in a dichloromethane solution in which HOAt, EDC.HCl and DIPEA are dissolved; performing a reaction with stirring; washing a reaction product with water; and drying a substance being undissolved in water to obtain the MACAmide. The method is simple in processes and the raw materials are easy to obtain. Operation conditions of the method are easy to control. The reaction product can reach a purity of 95% without purification. The invention provides basis for industrialized synthesis of the MACAmide. In addition, the MACAmide has effects of enhancing male reproductive ability and treating male sexual dysfunction. The invention provides market prospects to application of the MACAmide.

A negative pressure rehabilitation therapeutic instrument for controlling male ED function by means of electrocardio-synchronization is characterized in that an electrocardio-collector is connected with a single chip microcontroller which is then connected with a vacuum pump; the vacuum pump is again connected with a vacuum accumulator which is connected with an electromagnetic valve; the electromagnetic valve is connected with a vacuum tube; and the single chip microcontroller is respectively connected with a controller and a display screen. The negative pressure rehabilitation therapeutic instrument has the technical advantages of convenient use and simple structure. The single chip microcontroller collects signals in a heart systolic period on the basis of the electrocardio-collector, starts a vacuum generation device system when arterial blood is injected into the penis in the heart systolic period, controls a vacuum therapy tube to conduct intermittent actions synchronous with theheart, and causes the arterial blood with oxygen to be injected into the penis of a patient, thus achieving the effect of curing the male sexual dysfunction.

The invention relates to the field of health food, in particular to a health food for improving male sexual ability. The food is mainly composed of sea cucumber oligopeptides, oyster oligopeptides andraspberry extract which are capable of tonifying the kidney and invigorating yang, rose extract which is capable of soothing the liver and relieving depression, theanine which is capable of adjustingemotions, maca extract which is capable of improving prostate functions, and prepared licorice roots which are capable of tonifying qi and blood and reconciling the medicines. The food of the invention is safe, effective, non-toxic and harmless, and plays a role in conditioning and preventing diseases of male sexual dysfunction caused by kidney deficiency, liver depression and unhappy emotions. The formula can be made into a solid beverage or a tablet, and can be used as an oral liquid too.

A composition comprising a selective oxytocin antagonist for use in the treatment and/or prevention of a male ejaculatory disorder; which selective oxytocin antagonist is optionally admixed with a pharmaceutically acceptable carrier, diluent or excipient.

The invention discloses a tomato yeast tableting candy and a preparation process thereof. The candy is prepared from the following raw materials in percentages by weight: 17-25% of rape flower powder,16-24% of pumpkin seed powder, 3-9% of yeast powder, 4-10% of turmeric powder, 8-16% of tomato powder, 18-26% of isomalt, 6-14% of microcrystalline cellulose, 0.5-2% of magnesium stearate and 0.5-2%of hydroxypropyl methyl cellulose. The invention overcomes the deficiencies of the prior art, and with the scientific ratio and the mutual synergy of the rape flower powder, the pumpkin seed powder, the tomato powder, the turmeric powder and the yeast powder, the product has the functions of tonifying kidney, strengthening yang, preventing prostate diseases, urinary system and male sexual dysfunctions, improving men's reproductive ability, enhancing body's comprehensive immune functions, and helping prevent and treat other diseases. Moreover, all components are pure plant extracts, so that thecandy has no side effect, is convenient to eat, and has a large market prospect. Besides, a tableting method is used during production to retain the active ingredients of the raw materials to a maximum content.

The invention provides a penile size and stiffness measuring device, comprising power supply, lighting circuit, communication circuit, step motor drive circuit and size measuring system, stiffness measuring system and control computer, wherein the size measuring system and stiffness measuring system are respectively provided with a first digital camera and second digital camera and the digital video signal for measuring penile size and stiffness is connected to the control computer, the power supply is used for lighting circuit, communication circuit and step motor drive circuit. The realtime digital image processing is used, so as to reduce the contact with the penis and discomfort of patient, and the measuring time can be adjustable and the penile size and stiffness data can be automatically measured and stored, including length, width, height, diameter and stiffness data of penis. The digitized penile size and stiffness measuring device can satisfy the measurement of male sexual dysfunction degree and curative effect, with lower cost.

The invention discloses an application of patchouli alcohol in preparation of a drug or a health-caring product for male sexual dysfunction and discloses that the patchouli alcohol has a treating function on a vascular ED rat model, can significantly reduce an erection incubation period and increase erection times of ED rats and has a dose-dependent effect. Meanwhile, the invention discloses a mechanism of the patchouli alcohol in treatment of the male sexual dysfunction, namely, the patchouli alcohol can enhance a diastolic function of penis smooth muscle and can promote NO releasing level of penis vascular smooth muscle, thereby causing relaxation of cavernous body, which is different from other conventional medicine for treating the male sexual dysfunction. The invention provides a new medicinal application of the patchouli alcohol, provides a new medicine for the male sexual dysfunction and further provides a new preventing and treating approach for the male sexual dysfunction. In addition, the invention also proves that the patchouli alcohol not only is good in preventing and treating effect on the male sexual dysfunction but also is high in safety and practicability.

The invention relates to a pharmaceutical composition for treating male diseases. The pharmaceutical composition comprises, by mass, 10-30 parts of hot water extract of Maca, 10-30 parts of hot waterextract of eurycoma longifolia, 15-40 parts of hot water extract of semen cuscutae, 15-40 parts of hot water extract of Butea superba and 5-20 parts of powder of American ginseng. The pharmaceutical composition can significantly reduce prostate wet weight, a prostate index and prostate bulk density of a prostatic hyperplasia model rat and significantly reduce the T and EGF levels of the prostate homogenates of model rats. The non-formal clinical research result shows that the pharmaceutical composition can well treat prostatic hyperplasia. The pharmaceutical composition can improve the immunefunction, fast relieve fatigue, improve male vitality, improve reproductive ability and treat male sexual dysfunction and can be processed into related health products or drugs.

The invention relates to a rhein-arginine eutectic compound, and a preparation method, a purification method and application thereof in preparation of medicines for treating diabetic complications. The rhein-arginine eutectic compound is an eutectic substance formed by rhein and L-arginine, the mol ratio of the active medicine component of the rhein to the L-arginine is 1:1, and the X-ray diffractogram of the eutectic powder has the characteristic peaks of 9.22 degrees, 10.34 degrees, 12.28 degrees, 26.05 degrees, 26.58 degrees and 27.57 degrees 2theta. The medicines for treating diabetic complications are medicines for treating diabetic cardiopathy, medicines for treating diabetic macroangiopathy, medicines for treating diabetic nephropathy, medicines for treating diabetic orchiopathy, medicines for treating complicated male sexual dysfunction of diabetes, or medicines for treating diabetic impotence. The invention can increase the solubility and dissolution of the medicines, enhance the purity and stability of the rhein-arginine eutectic compound, reduce the impurity content and hygroscopicity, enhance the bioavailability and improve the release characteristic.

The composite medicine consists of emulsified transdermal Phentolaminum paste in oil-in-water preparation of 0.5-10 wt% concentration and emulsified transdermal Lidocaine paste in oil-in-water preparation of 1-20 wt% concentration. The preparation process is also disclosed. According to the features of male's sexual dysfunction, the present invention provides the medicine capable of treating bothimpotence and prospermia simultaneously through combining emulsified transdermal Phentolaminum paste and emulsified transdermal Lidocaine paste. The present invention has high curative effect and less side effect.

The invention relates to a substituted pyrrole chromone compound, which adopts the following structure: R1, R2, R3 and R4 are selected from hydrogen, halogen, C1-3 alkyl, C1-3 substituted alkyl, alkoxy, acyl, a carboxylic acid group, carboxylate radical, a nitrogen group, a phosphorous group or a sulfur group; R5 is selected from a substituted or non-substituted cyclic group; and R6 is selected from hydrogen or C1-3 alkyl, acyl, carboxylic acid group, carboxylate radical group, nitrogen group, phosphorous group or sulfur group. A type-5 phosphodiesterase inhibitor can be used for preparing medicine for curing diseases related to type-5 phosphodiesterase and is particularly suitable for preparing medicine for cuing male sexual dysfunction or pulmonary hypertension diseases.