Pharmaceutical composition for treating male diseases and preparation method and use thereof

A male disease and composition technology, which is applied in the field of pharmaceutical composition for treating male diseases and its preparation, can solve problems such as large side effects, cardiovascular and cerebrovascular system, immune system harm, and easy dependence, so as to relieve fatigue and cure Male sexual dysfunction, the effect of enhancing male vitality

Inactive Publication Date: 2018-06-01
HAIWEN HEALTH TECH SHENZHEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages of drug treatment for benign prostatic hyperplasia include: large side effects, easy to produce dependence, and great harm to the cardiovascular and cerebrovascular system and immune system after long-term use

Method used

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  • Pharmaceutical composition for treating male diseases and preparation method and use thereof
  • Pharmaceutical composition for treating male diseases and preparation method and use thereof
  • Pharmaceutical composition for treating male diseases and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment one: the preparation of pharmaceutical composition

[0025] 1.1 Components of the pharmaceutical composition

[0026] The dosage form of the pharmaceutical composition in the present embodiment is a capsule (hereinafter referred to as a drug capsule), and the drug capsule includes the following components in parts by mass: 18.75 parts of Maca hot water extract, Tongkat Ali hot water extract 18.75 parts, 25 parts of Cuscuta hot water extract, 25 parts of Butea baicalensis hot water extract, 12.5 parts of American ginseng powder.

[0027] Specifically, each drug capsule in this embodiment weighs 0.4g, which contains 0.075g of Maca hot water extract, 0.075g of Tongkat Ali hot water extract, 0.1g of Buteba superbae hot water extract, and Cuscuta hot water extract Extract 0.1g, American ginseng powder 0.05g.

[0028] 1.2 The preparation method of each component in the pharmaceutical composition

[0029] Briefly describe the preparation process of each component...

Embodiment 2

[0042] Embodiment two: experimental process (material and method)

[0043] 2.1 Animals: 60 male SD rats, clean grade, weighing (280±20) g, 8 months old, provided by the Experimental Animal Center of Kunming Medical University.

[0044] 2.2 Experimental drugs

[0045] ①Drug capsule: specification: 0.4g / capsule; before use, use normal saline to prepare a suspension containing 0.4g / mL of patented medicine. The concentration in the group is 0.8g / mL (twice the normal dose) containing proprietary drugs, and the concentration in the high-dose group is 0.12g / mL (three times the normal dose) containing proprietary drugs;

[0046]②Longbishu Capsules: Specification: 0.3g / capsule, produced by Shijiazhuang Kedi Pharmaceutical Co., Ltd., batch number 010601; prepared into a suspension containing 0.03g / mL of patent medicine before use;

[0047] ③ Testosterone Propionate Injection: Specification 25mg / 1mL, produced by Tianjin Jinyao Amino Acid Co., Ltd.;

[0048] ④ Testosterone (T) assay ki...

Embodiment 3

[0061] Example Three: Results and Discussion

[0062] 3.1 Effects on prostate weight, prostate index and gland density in benign prostatic hyperplasia model rats

[0063] The drug capsules in Example 1 were tested by the method in Example 2, and the effects of drug capsules on prostate weight, prostate index and gland density in benign prostatic hyperplasia model rats were tested. The experimental results are shown in Table 1.

[0064] Table 1 The effect of drug capsules on the wet weight of the prostate gland, the prostate index and the density of the gland in the rat model of benign prostatic hyperplasia ( n=10)

[0065]

[0066] Note: Compared with the blank group, ** P△△ P<0.01

[0067] It can be seen from Table 1 that compared with the blank group, the wet weight, prostate index and glandular density of rats in the model group increased significantly (P<0.01), indicating that the rats in the model group had obvious hyperplasia of the prostate gland, and the model w...

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Abstract

The invention relates to a pharmaceutical composition for treating male diseases. The pharmaceutical composition comprises, by mass, 10-30 parts of hot water extract of Maca, 10-30 parts of hot waterextract of eurycoma longifolia, 15-40 parts of hot water extract of semen cuscutae, 15-40 parts of hot water extract of Butea superba and 5-20 parts of powder of American ginseng. The pharmaceutical composition can significantly reduce prostate wet weight, a prostate index and prostate bulk density of a prostatic hyperplasia model rat and significantly reduce the T and EGF levels of the prostate homogenates of model rats. The non-formal clinical research result shows that the pharmaceutical composition can well treat prostatic hyperplasia. The pharmaceutical composition can improve the immunefunction, fast relieve fatigue, improve male vitality, improve reproductive ability and treat male sexual dysfunction and can be processed into related health products or drugs.

Description

technical field [0001] The invention relates to the field of drugs for treating male diseases, in particular to a pharmaceutical composition for treating male diseases, its preparation method and application. Background technique [0002] Prostatic hyperplasia (BPH) is one of the common diseases of middle-aged and elderly men, and its incidence is increasing with the aging of the global population. The incidence of benign prostatic hyperplasia increases with age, but there may not be clinical symptoms when there are hyperplasia lesions. The urban incidence rate is higher than that in the rural areas, and racial differences also affect the degree of proliferation. Prostatic hyperplasia is known as the "four major killers" of elderly men. Many elderly men have suffered from such diseases. Prostatic hyperplasia seriously endangers the physical and mental health of elderly men. The occurrence of benign prostatic hyperplasia must have two important conditions of age growth and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P37/04A61P39/00A61P15/00A61P15/08A61P13/08
CPCA61K36/185A61K36/258A61K36/31A61K36/39A61K36/43A61K36/48A61K2236/331A61K2236/51A61K2300/00A61K2236/00A61P13/08A61P15/00A61P15/08A61P37/04A61P39/00
Inventor 张南钟荣
Owner HAIWEN HEALTH TECH SHENZHEN CO LTD
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