The invention discloses an experimental apparatus for simulating an in-vivo
dissolution and absorption process of an
oral drug preparation. The experimental apparatus comprises a
dissolution pool, wherein a
drug basket frame is arranged inside the
dissolution pool in a suspending manner, a liquid inlet on the bottom of the dissolution
pool is communicated with an outlet of a confluence valve by virtue of a liquid inlet main path, a liquid outlet connector inserted in the dissolution pool transports a dissolution medium in the dissolution pool to a distribution valve in real time by virtue of aliquid outlet main path, the distribution valve is divided into two liquid outlet branches, one liquid outlet
branch is separately communicated with a sample collector (for implementing the online automatic
sample collection) and a waste liquid collection
bottle by virtue of a
sample collection three-way valve, the other liquid outlet
branch is communicated with one inlet of the confluence valveto form a circulating loop, another inlet of the confluence valve is communicated with a dissolution medium source by virtue of a medium input pipeline, the liquid inlet main path and the liquid outlet main path are respectively provided with a liquid inlet pump and a liquid outlet pump, and the flow rate of the liquid inlet is the same with an output amount of the liquid outlet connector. By adopting the experimental apparatus, the dissolution and absorption process of a
drug in a
living body can be simulated, and the synchronous evaluation of the dissolution and absorption of the
drug can berealized.