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41results about How to "Precision release" patented technology

Traditional Chinese medicine fermented disaccharide encapsulated nano anti-dandruff, hair-growing and oil-controlling shampoo and preparation method thereof

PendingCN121754457AInhibit the inflammatory responseprevent proliferationCosmetic preparationsHair cosmeticsBiotechnologyTremella
The invention provides traditional Chinese medicine fermented disaccharide encapsulated nano anti-dandruff, hair-growing and oil-controlling shampoo and a preparation method, and relates to the field of daily chemical products, and the shampoo comprises the following components: a compound fermentation product, lactobacillus crispatus, lactobacillus plantarum, a disaccharide activity protection system, a basic component and a nano oil-controlling component; the compound leavening is prepared from cacumen biotae, radix polygoni multiflori, radix ginseng, fructus cnidii and orchid; the disaccharide activity protection system comprises maltotetraose and trehalose; the disaccharide activity protection system wraps a fermented material formed by fermenting the compound fermentation product, the lactobacillus crispatus and the lactobacillus plantarum to form a disaccharide glassy state layer; the nano oil control component is prepared from calamine powder and chitosan-sodium alginate; the basic component is prepared from tea bran, radix sophorae flavescentis, herba ecliptae, radix notoginseng, fructus ligustri lucidi, tea saponin microcapsules and tremella polysaccharide. According to the invention, through fermentation conversion of the orchid, disaccharide glassy state protection and slow release of the nano calamine, activity enhancement, stable retention and accurate release are realized, and the effects of removing dandruff, relieving itching, controlling oil and growing hair are achieved.
Owner:HENGYANG AIMINKANG BIOTECHNOLOGY CO LTD

Mechanized high-strain guide hammering system

A mechanical high-strain guide hammering system comprises a vertical guide frame and a heavy hammer, the vertical guide frame is of a rectangular frame structure with an opening in the lower end, a hydraulic winch is fixedly mounted at the upper end of the vertical guide frame, a lifting seat is slidably mounted in the vertical guide frame, and the hydraulic winch is connected with the lifting seat through a steel cable; the lower surface of the lifting seat is connected with a hydraulic unhooking hook; a lifting point is arranged on the upper surface of the heavy hammer, the heavy hammer is connected with the hydraulic unhooking hook through the lifting point, the hydraulic unhooking hook achieves releasing and locking of the heavy hammer through a control oil way, and the heavy hammer moves up and down along an inner cavity of the vertical guide frame. A hinge seat is arranged on the side face of the vertical guide frame body, and the vertical guide frame body is connected with a mechanical arm of the excavator through the hinge seat. According to the utility model, the defects in the prior art are overcome, the accurate positioning of the heavy hammer in the hammering process can be effectively ensured, the heavy hammer is suitable for different detection environments, the risk of manual intervention is greatly reduced, and the working efficiency and the safety are improved.
Owner:SHANGHAI FAQI CONSTR ENG CO LTD +1

Full-automatic insert injection molding taking and packaging machine

ActiveCN224408265UAvoid affecting the injection molding effectavoid displacementThermal dilatationProcess engineering
The utility model discloses a full -automatic embedded part injection molding takes out piece packaging machine belongs to injection molding machine technical field, it includes work table, work table top fixed mounting has fixed mould, the fixed mould is buckled and is connected with embedded part main part, the sliding block with the guide rail sliding connection, the sliding block is located between the guide rail with the embedded part main part, the guide rail is the inclined structure, the utility model discloses through the heat absorption block absorption external heat like the heat source of mould processing, the heat transfer to first air cylinder, and the heated expansion gas (like nitrogen) in first air cylinder and second air cylinder expands in volume because temperature rises, and pressure increases, and the telescopic link of movable block outside pushes the sliding block and slides on the inclined guide rail, because the guide rail is the inclined structure, the sliding of sliding block will produce the component force along the guide rail direction, and then will embedded part main part extrude to the inboard of fixed mould, avoids in the injection molding process and causes the displacement of embedded part to influence injection molding effect.
Owner:SHANGHAI DEGUANG AUTOMATION TECH CO LTD

Pentaethylenehexamine-beta-cyclodextrin grafted folic acid-included cannabidiol nanospheres, methods of preparation and uses

The application provides a pentaethylenehexamine-beta-cyclodextrin grafted folic acid inclusion cannabidiol nanosphere, a preparation method and an application, the method first prepares a pentaethylenehexamine-beta-cyclodextrin grafted folic acid (PEHA-beta-CD-FA) targeting carrier, then cannabidiol (CBD) is mixed with the carrier in an ethanol-water mixed solvent in a certain proportion, a stable inclusion system is formed through ultrasonic-assisted inclusion + room-temperature light-avoiding stirring, and the system is purified through dialysis, freeze-drying or spray-drying, so that the spherical nanoparticles with uniform particle size of about 100 nm are obtained. The application solves the problems that CBD has extremely low water solubility, poor bioavailability and lacks targeted delivery, the obtained nanospheres have folic acid receptor active targeting, pH response drug release, high encapsulation rate and high colloidal stability, can significantly improve the solubility, dissolution rate and in-vivo targeted delivery efficiency of CBD, and are suitable for the fields of anti-inflammatory, neuroprotective and the like drugs, cosmetics and functional foods.
Owner:YUNNAN UNIV +1

Skill control method and apparatus, electronic device, and computer program product

The present disclosure relates to a skill control method and device, electronic equipment and computer program product, and belongs to the technical field of games. The method comprises: when a game character is in a skill release state of a target skill, in response to a targeting instruction, controlling to adjust the release direction of the target skill; determining a target game object from the game scene according to the release direction; and controlling to display the internal structure of the target game object in perspective and / or the game scene blocked by the target game object in perspective. The present disclosure can assist users in accurately releasing a line-of-sight-out skill when facing a complex scene space by displaying the three-dimensional perspective structure of the target game object, thereby improving the operation efficiency of the user.
Owner:NETEASE (HANGZHOU) NETWORK CO LTD

A ros-responsive trichoderma-derived composite nanoparticle, a preparation method thereof and application thereof in prevention and treatment of tomato botrytis cinerea

This invention discloses a ROS-responsive Trichoderma-derived composite nanoparticle in the field of plant biocontrol, its preparation method, and its application in controlling tomato gray mold. The aqueous solution of the nanoparticles contains: mesoporous silica (MSN), 6-pentyl-2H-pyran-2-one (6PP), and the plant-responsive protein Epl1. The aqueous solution of the nanoparticles uses the main metabolites of Trichoderma, 6PP and Epl1, as its core. Both 6PP and Epl1 have dual functions of broad-spectrum fungicidal activity and inducing plant immunity. MSN is synthesized using the Stöber method and modified with an S-containing backbone and surface amino groups, providing protection, slow release, and precise delivery of 6PP and Epl1. The 6PP in the aqueous solution of the nanoparticles can be rapidly released in response to low pH and high ROS conditions. The carrier works synergistically with the two components, significantly improving the induction of resistance and direct fungicidal effects on tomato plants and fruits compared to single-component methods. It is particularly suitable for foliar fungal diseases of vegetable crops in the field and has high practical value for widespread field application.
Owner:SHANGHAI JIAOTONG UNIV +1

Fire extinguishing microcapsules and microfluidic controllable preparation method thereof

PendingCN122273420AImprove mechanical propertiesavoid premature leaksLiquid fluorineMicrofluidics
This invention belongs to the field of fire extinguishing materials and their preparation technology, and provides a fire extinguishing microcapsule and its microfluidic controllable preparation method. The preparation method is characterized by the following steps: (1) preparing fluids of each phase, (2) preparing a dual emulsion using a microfluidic device, (3) collecting and sealing the dual emulsion in a collection container, controlling the axis of the collection container to be horizontal, and controlling the collection container to rotate around its axis for 1 to 15 minutes, applying light to solidify the outer shell of the dual emulsion droplets while maintaining the rotation of the collection container, cleaning, and drying to obtain the final product. The fire extinguishing microcapsule prepared by this method consists of an outer shell and a liquid fluorine-containing fire extinguishing agent encapsulated within the outer shell. The outer shell of the fire extinguishing microcapsule has a uniform thickness, and the eccentricity between the outer shell and the core is less than 0.1. The method of this invention can achieve precise customization of fire extinguishing microcapsules according to the differentiated fire characteristics of different application scenarios, and can improve the concentricity between the core and the outer shell of existing fire extinguishing microcapsules.
Owner:SICHUAN UNIV

Sulfhydrylated hyaluronic acid drug-loaded hydrogel preparation as well as preparation method and application thereof

PendingCN121943791AResistance to scourProlong local retentionOrganic active ingredientsNervous disorderMolecular Targeted TherapiesBiochemistry
The invention belongs to the field of pharmaceutical preparations, and particularly relates to a sulfhydrylated hyaluronic acid drug-loaded hydrogel preparation and a preparation method and application thereof, and the preparation method comprises the following steps: preparing isorhamnetin nanocrystalline ISO-NCs by adopting an anti-solvent precipitation method; the preparation method comprises the following steps: constructing thiolated hyaluronic acid HA-SH responded by GSH; and uniformly embedding the ISO-NCs into the HA-SH hydrogel, so as to prepare the sulfhydrylated hyaluronic acid drug-loaded hydrogel preparation ISO-NCs-coated Gel, and preparing the sulfhydrylated hyaluronic acid drug-loaded hydrogel preparation ISO-NCs-coated Gel. The drug-loaded hydrogel preparation constructed by the invention can be used for targeted therapy of colon cancer.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE +1

Termite monitoring, inducing and treating integrated device

The utility model relates to a termite monitoring, inducing and treating integrated device, which solves the problem of poor termite monitoring and killing effects caused by information transmission lag and poor environmental adaptability of equipment in the existing termite monitoring and killing technology, and adopts the technical scheme that a shell comprises an upper cover and a shell body which are detachably connected, and a through hole is formed in the side wall of the shell body; the monitoring module is arranged in the shell and used for collecting image information of the termites in real time; the signal transmission module is arranged outside the shell, is connected with the monitoring module and is used for wirelessly transmitting the monitoring data to an external upper computer; the killing module is arranged in the shell and can release an ant killing agent; and the inducing structure is bait for inducing termites and is arranged at the inner bottom of the shell.
Owner:ORIENTAL MIND (WUHAN) COMPUTING TECH CO LTD

Special equipment for testing ignition temperature of A2L hot surface

The utility model discloses an A2L hot surface ignition temperature test special device, which comprises a test box and a spraying type pipe arranged in the test box, the surface of one end of the spraying type pipe is fixedly connected with a refrigerant tank with a valve, one side of the refrigerant tank is provided with the valve which is communicated with the interior of the refrigerant tank through the spraying type pipe, and the other side of the refrigerant tank is provided with the spraying type pipe. A glass barrel is arranged on the peripheral side, close to one end, of the spraying type pipe, a metal disc is fixedly installed on the surface of the lower end of the glass barrel, a thermocouple is fixedly installed on the surface of one side of the metal disc, a heat insulation pad is fixedly connected to the peripheral side surface of the metal disc, and one side, extending to the heat insulation pad, of one end of the metal disc is fixedly connected with a heating plate; according to the utility model, through the arrangement of the spraying type pipe, stable conveying and controlled release of the refrigerant can be realized, the refrigerant can be accurately sprayed on the metal disc, and the refrigerant is fully contacted with the hot surface, so that the ignition temperature of the hot surface is tested, and the effect of accurate test result is achieved.
Owner:CQC INTIME TESTING TECH CO LTD

Preparation method and application of coumoxyl-modified chlorantraniliprole-loaded MOF nano-pesticide

PendingCN122074481Aprecision releasereduce lossesBiocideAnimal repellantsCoumaric acidp-Coumaric acid
This invention discloses a method for preparing and applying a coumaric acid-modified MOF nanopesticide loaded with chlorantraniliprole, belonging to the field of pesticide formulation technology. The nanopesticide comprises: an iron-based metal-organic framework carrier MIL-101(Fe); chlorantraniliprole loaded within the pores of the carrier; and coumaric acid modified on the surface of the carrier through electrostatic interactions. The preparation method includes three steps: MIL-101(Fe) carrier synthesis, chlorantraniliprole loading, and coumaric acid surface modification. The process is simple and the conditions are mild. This invention utilizes the alkaline environment of the fall armyworm's gut to trigger carrier degradation, achieving targeted and controlled release of active molecules. Simultaneously, the released MIL-101(Fe) is reduced under the action of GSH in the gut, generating reactive oxygen species through the Fenton reaction, forming a synergistic insecticidal effect with coumaric acid. Experiments have shown that this nanopesticide exhibits far superior insecticidal activity against fall armyworm compared to single agents or carriers, possessing excellent insecticidal activity and environmental compatibility, making it suitable for green agricultural production.
Owner:SANYA NATIONAL INSTITUTE OF SOUTHERN BREEDING CHINESE ACADEMY OF AGRICULTURAL SCIENCES +2

Preparation and application of bone targeting catechin-strontium metal polyphenol nanoparticles

PendingCN121891548AAchieve synchronous deliveryImplement sequential releaseSkeletal disorderPharmaceutical non-active ingredientsBone regenerationBone quality
The invention discloses a preparation method and an application of a bone targeting catechin-strontium metal polyphenol nano particle. The system takes a metal-polyphenol network (MPN) formed by coordination self-assembly of strontium ions and catechin as a core, and tetracycline is modified on the surface of the MPN to construct a bone targeting functional layer. The MPN structure can significantly enhance the loading efficiency and physiological stability of catechin, and the tetracycline modification on the surface endows the nanoparticles with excellent bone targeting ability. When reaching an osteoporosis focus, the nanoparticles can respond to a local weakly acidic microenvironment and controllably release catechin, and exert antioxidant and anti-inflammatory effects, thereby reversing a pathological microenvironment unfavorable for bone regeneration. Meanwhile, the MPN skeleton is gradually degraded in vivo, and the released Sr < 2 + > can promote proliferation and differentiation of pre-osteogenic cells, inhibit the activity of osteoclasts and promote formation of new bones. The system integrates bone targeting, microenvironment response drug release, immunoregulation and ion regulation treatment, and provides a new strategy for precise treatment of osteoporosis.
Owner:GUANGDONG NO 2 PROVINCIAL PEOPLES HOSPITAL +1

Nanoparticles for treating retinal ischemia-reperfusion injury, methods of making, pharmaceutical compositions, and uses thereof

PendingCN122499130Aprecision releaseImprove retention
This invention relates to the field of biomedical technology, specifically to nanoparticles for treating retinal ischemia-reperfusion injury, their preparation method, pharmaceutical composition, and uses. The nanoparticles consist of a zeolite imidazole ester-8 core encapsulating baicalin and a polydopamine shell coating its surface, prepared via in-situ self-polymerization. The nanoparticles utilize the polydopamine shell to scavenge reactive oxygen species and prolong intraocular residence time, while their core responsively degrades in a weakly acidic pathological microenvironment, precisely releasing baicalin, thereby synergistically exerting antioxidant, anti-inflammatory, and anti-apoptotic effects. Experiments show that these nanoparticles can effectively reduce oxidative damage and inflammation in the model retina, significantly inhibit ganglion cell apoptosis, and restore electroretinogram function, providing a novel multi-target therapeutic strategy for retinal ischemic diseases.
Owner:CHONGQING MEDICAL UNIVERSITY AFFILIATED THIRD HOSPITAL(FANGDA HOSPITAL) +1

Seaweed-based composite water-soluble fertilizer and preparation method thereof

The invention discloses a seaweed-based composite water-soluble fertilizer and a preparation method thereof, and belongs to the technical field of functional fertilizers, gel microspheres embedded with bacillus subtilis are adsorbed and fixed through a composite seaweed carbon porous carrier, so that the gel microspheres have a good slow-release effect, seaweed belongs to a renewable marine biomass resource and is wide in source and relatively low in cost, and the seaweed-based composite water-soluble fertilizer has a good slow-release effect. Meanwhile, the introduced bacillus subtilis functional component and castor oil polyether polyol are environment-friendly substances, so that the soil residue risk caused by chemical synthesis of an additive is avoided; the seaweed-based composite water-soluble fertilizer can achieve accurate release, on one hand, due to the water absorption swelling effect of the gel microspheres, release of bacillus subtilis in the gel microspheres can be promoted; on the other hand, the metal complex serving as the bridge is PH responsive, and can be matched with organic acid secreted by microorganisms in the soil in acid soil to promote structural collapse of the metal complex, so that the gel microspheres rapidly fall off and are released.
Owner:烟台绿云生物科技有限公司

Low-energy-consumption zone control deicing system and method

PendingCN121947768Alow gas consumptionreduce demandDe-icing equipmentsLeading edgeAirbag
The invention relates to a low-energy-consumption zone-control deicing system and a low-energy-consumption zone-control deicing method. Comprising a left / right wing compound distribution valve, an empennage compound distribution valve, a wing front edge deicing sleeve, an empennage front edge deicing sleeve and a controller, a plurality of sections of wing leading edge deicing sleeves are arranged on the leading edge of the left / right wing along the wingspan direction in a partitioned manner, and a plurality of sections of empennage leading edge deicing sleeves are arranged on two sides of the leading edge of the empennage along the wingspan direction in a partitioned manner; the air inlet ends of the left / right wing compound distribution valves are connected with engine air sources on the corresponding sides through deicing pipelines, and the one or more wing leading edge deicing sleeves are connected with the outlet ends of the compound distribution valves on the corresponding sides through the deicing pipelines; the air inlet end of the empennage compound distribution valve is connected with a left / right engine air source through a deicing pipeline, and one or more sections of empennage front edge deicing sleeves are connected with outlet ends of the empennage compound distribution valve through deicing pipelines; and the controller is in communication connection with the left / right wing compound distribution valve and the empennage compound distribution valve, opening and closing of outlet ends of the compound distribution valves are controlled according to a certain time sequence, segmented deicing is achieved, and the consumption demand caused by an engine is reduced. The air bag is driven to act mechanically in a form of extremely low power consumption, and'on-demand, accurate and instantaneous' release of deicing energy is realized.
Owner:WUHAN AVIATION INSTR

Baicalin carbon dot / silver-based metal organic framework composite material and drug delivery system

PendingCN121796582AGive full play to the synergistic antibacterial effect of photodynamic-photothermalefficient releaseAntibacterial agentsInorganic active ingredientsMetal-organic frameworkPharmaceutical Substances
The invention provides a baicalin carbon dot / silver-based metal organic framework composite material and a drug delivery system. The composite material B-CDs (at) Ag-MOF comprises a silver-based metal organic framework and baicalin carbon dots loaded on the silver-based metal organic framework; the drug delivery system comprises hydrogel and a composite material dispersed in the hydrogel, and the composite material is the B-CDs (at) Ag-MOF. According to the composite material and the drug delivery system provided by the invention, the problems that pure baicalin carbon dots are difficult to release in a controllable manner and the targeting property is insufficient can be solved.
Owner:CHINA AGRI UNIV

Artificial valve anchoring device, delivery system and transcatheter heart valve replacement system

ActiveCN224085503UAchieve progressive expansionprecise positioningHeart valvesProsthetic valveHeart valve replacement
The utility model relates to an artificial valve anchoring device, a delivery system and a transcatheter heart valve replacement system, the device can radially collapse and expand between a radial collapse structure and a radial expansion structure, and the device comprises a skirt edge part, a main body part and a plurality of connecting pieces; the skirt edge part extends outwards in the radial direction in an umbrella disc shape, and the small-diameter end of the skirt edge part is connected with the main body part; the main body part comprises a plurality of grid units which are connected with one another; the connecting piece is arranged at the far end of the skirt edge part and used for being connected with a conveying device. At least part of the section of the connecting piece is configured to be an elastic deformation section, the elastic deformation section can be in a straightened state in a conveying state and gradually recover to be in a preset nonlinear shape in a release state, and gradual release of the artificial valve anchoring device can be achieved through gradual deformation of the elastic deformation section.
Owner:SHANGHAI NEWMED MEDICAL CO LTD

Preparation method and application of collagen composite nano-carrier entrapped with probiotics

PendingCN122075444AImprove gel propertiesImprove thermal stability
The invention discloses a preparation method and application of a probiotic-entrapped collagen composite nano-carrier. The preparation method is characterized by comprising the following steps: mixing a fish gelatin protein solution and a polysaccharide solution, adjusting the pH value to be alkaline, heating to carry out glycosylation reaction, and purifying to obtain glycosylated fish gelatin protein. Mixing and emulsifying the glycosylated fish gelatin protein solution serving as a water phase and the oil phase by adopting a reversed-phase emulsification method to form a W / O type emulsion; adding a probiotic bacterial suspension, uniformly stirring, adding a cross-linking agent, carrying out a cross-linking reaction, carrying out solid-liquid separation, washing, and drying, so as to obtain the probiotic-entrapped collagen composite nano-carrier; the preparation method has the advantages that precise and slow-release release in intestinal tracts is realized, and the survival rate and bioavailability of probiotics are remarkably improved.
Owner:NINGBO UNIV

An mRNA delivery system, a preparation method thereof and application thereof

The present application relates to the technical field of pharmaceutical preparations, in particular to an mRNA delivery system, a preparation method and application thereof. The present application provides an mRNA delivery system, which comprises a reactive oxygen species (ROS) responsive ionizable lipid nanoparticle delivery unit and low molecular weight heparin coated on the surface of the reactive oxygen species (ROS) responsive ionizable lipid nanoparticle delivery unit. The mRNA delivery system provided by the present application can be targeted to deliver into macrophages in plaques, realize local expression of therapeutic RAC2 protein in the damage area, and play a role in treating atherosclerosis.
Owner:SHANDONG UNIV QILU HOSPITAL

Power assembly taking mechanism

ActiveCN121404751BOptimize space utilizationReasonable assembly timeConveyor partsMechanical conveyorsProcess engineeringReclaimer
The application relates to a power component taking-out and discharging mechanism, which comprises a rack, a conveying mechanism, a pin leg bending mechanism and a taking-out mechanism arranged on the rack. The conveying mechanism comprises at least two groups of conveying components capable of reversing the power components. The pin leg bending mechanism can complete pin leg bending in at least one conveying area. The taking-out mechanism can take out the power components on a carrier and then transfer the power components to the next work station. The conveying mechanism with different transfer surfaces in the same specified area can realize the conversion of the transfer direction of the power components in a relatively limited space, so that the equipment has good space utilization, and the whole equipment has higher production efficiency and better stability compared with the traditional power component production equipment.
Owner:SUZHOU ZHENGYI AUTOMATIC CONTROL TECH CO LTD

Lithium ion battery electrolyte flame retardant additive, application and lithium ion battery

PendingCN121839887Aimprove securityPrecise thermal response releaseSecondary cellsElectrolytic agentElectrical battery
The invention provides a lithium ion battery electrolyte flame-retardant additive, application and a lithium ion battery, Zn-MOF-74 is used as a carrier, triphenyl phosphate (TPP) is used as a flame-retardant active component, and the TPP is packaged in a porous framework of Zn-MOF-74 to form core-shell structure nanoparticles; the loading capacity of TPP in the additive is 10-40 wt%, and the particle size of particles is 300-700 nm; the flame-retardant additive accounting for 0.5-40% of the mass of the electrolyte is added into the basic electrolyte, ultrasonic dispersion is carried out for 25-45 min, and a flame-retardant electrolyte is formed; the basic electrolyte is a mixed system of 0.5-3 mol / L of lithium salt and a carbonic ester organic solvent; the carbonic ester organic solvent is a mixed solution of EC, DEC and EMC in a volume ratio of 1: 1: 1; the lithium salt is LiPF6; the flame-retardant electrolyte also contains 0.5-2wt% of a negative electrode film-forming additive, and the negative electrode film-forming additive is VC or FEC; the electrolyte is the flame-retardant electrolyte; the pole core is formed by winding or laminating a positive plate, a negative plate and a diaphragm; according to the lithium ion battery electrolyte flame-retardant additive, the application and the lithium ion battery, the effect of improving the safety performance of the battery can be achieved.
Owner:JIANGSU HIGHSTAR BATTERY MFG CO LTD +2

Rotary uncovering nasal dredging container

ActiveCN224061579Uprecision releaseThe opening angle is controllableNon-removalbe lids/coversPharmacy medicinePharmaceutical drug
The utility model relates to the technical field of portable aromatic product containers, in particular to a rotary uncovering nasal ventilation container, which comprises a first shell, a second shell, a first cover and a second cover, the second shell is internally provided with a storage cavity used for containing nasal dredging medicine, and a filter plate is fixed to an opening of the storage cavity; the second shell is hinged to the first shell through a rotating shaft, and the second shell can rotate around the rotating shaft relative to the first shell to achieve opening and closing; in the uncovered state, the second shell rotates into the rotating cavity of the first shell, and the fragrance of the nasal dredging medicine is released; and in the closed state, the first shell and the second shell are mutually covered. The scheme has the advantages of being convenient to operate, controllable in uncovering angle, stable in single-hand operation and accurate in fragrance release.
Owner:HANGZHOU ZHIXIANG BRAND MANAGEMENT CO LTD

A pH-responsive silk fibroin-doxorubicin prodrug nanoparticle, a preparation method and application thereof

PendingCN122499132AOvercome the shortcomings of sudden releaseImprove stabilityLithium bromideAdipic acid
This invention discloses a pH-responsive silk fibroin-doxacin prodrug nanoparticle, its preparation method, and its application. Silkworm cocoons are degummed, dissolved in a lithium bromide aqueous solution, and freeze-dried to obtain regenerated silk fibroin powder. The regenerated silk fibroin powder is then combined with succinic anhydride, a condensing agent, adipic dihydrazide, and doxorubicin hydrochloride, and treated multiple times with a composite solvent to prepare an aqueous solution of the silk fibroin-doxacin covalently bound. This solution is then added dropwise to an antisolvent under stirring to induce self-assembly into nanoparticles. After centrifugation purification and resuspension in water, the product is obtained. This invention completely overcomes the shortcomings of traditional physical encapsulation methods of silk fibroin, which are prone to burst release. The nanoparticles are extremely stable in physiological blood environments and can rapidly break hydrazone bonds for precise drug release in the slightly acidic environment of tumor cell endosomes. The antisolvent granulation mechanism promotes the flipping of unreacted polar groups to the surface, giving the nanoparticles a moderately negative potential and rich active sites, resulting in excellent colloidal stability and deep functionalization potential.
Owner:ZHEJIANG UNIV

Intelligent hydrogel for treating skin tissue injury, preparation method and medicine thereof and application thereof

PendingCN122499102AAchieve space-time controllable releaseOvercome burst release defectsSmart hydrogelsCD44
The application belongs to the field of biomedical polymer materials and regenerative medicine, and particularly relates to an intelligent hydrogel for treating skin tissue damage, a preparation method and a medicine thereof, and application thereof. The intelligent hydrogel comprises a hydrogel support and a functional module. The hydrogel support takes methacrylated gelatin as a matrix and forms a stable three-dimensional network structure through photo-crosslinking. The functional module comprises two core DNA chains, one of which is a ZnR-Cage chain with a sulfhydryl group directly or indirectly connected to one end of the chain, and the other is a CD44-link chain. The two chains form a non-active assembly through base complementary pairing. The intelligent hydrogel has many advantages such as strong spatiotemporal controllability, overcoming drug burst defects, efficient cascade repair, realizing targeted synergistic treatment, efficient integration, excellent stability and clinical transformation potential. It is particularly suitable for clinical treatment of complex wounds such as diabetic ulcers and infected wounds.
Owner:HUNAN UNIV +1

Prostate stent system and delivery device thereof

The utility model provides a prostate stent system and a delivery device thereof, the delivery device is used for placing the prostate stent into the prostate, the delivery device comprises a pushing tube, a pre-collection tube and a sheathing canal, the pushing tube and the pre-collection tube are movably arranged in the sheathing canal in a penetrating mode in the longitudinal direction, the pre-collection tube is coaxially arranged on the far side of the pushing tube, and the pre-collection tube is coaxially arranged on the far side of the pushing tube. The pushing tube is suitable for a traction rope to penetrate through, the pre-collecting tube is suitable for containing the near end of the stent body, and the prostate stent is contained in the sheathing canal under the pulling force of the pushing tube.
Owner:ZHEJIANG YIGAO MEDICAL TECH CO LTD

An umbrella-shaped anchored tumor marker and its implantation system

ActiveCN224421154Ueffective anchoringEffective developmentLaser etchingShape-memory alloy
This utility model relates to the field of interventional tumor diagnostic and treatment medical device technology, and discloses an umbrella-shaped anchored tumor marker and its implantation system. The umbrella-shaped anchored tumor marker includes an umbrella-shaped anchoring system composed of multiple umbrella ribs with shape memory properties. The proximal ends of the ribs converge to form an axial central tube. The surface of the ribs has micro-barb structures formed by laser etching. The umbrella-shaped anchoring system remains in a contracted state at temperatures below body temperature and autonomously unfolds into a three-dimensional umbrella-shaped anchoring form at body temperature. In this utility model, the distal end of the umbrella ribs integrates a platinum-iridium alloy imaging tip with gradient stiffness (rigid at the proximal end and flexible at the distal end). The barbs are spaced along the length of the umbrella ribs. The shape memory alloy is in one state during delivery at room temperature and can self-unfold in vivo, achieving effective anchoring and imaging, thus aiding in tumor marking.
Owner:昕科生物科技(苏州)有限公司

Preparation method of high-temperature-resistant synthetic roe for pets

The invention relates to the field of pet food, and particularly discloses a preparation method of high-temperature-resistant synthetic roe for pets. The preparation method of the high-temperature-resistant synthetic roe for pets comprises the following steps: uniformly mixing a curdlan solution and a sodium alginate solution to prepare a wall material solution; uniformly mixing the calcium liquid, the acid liquid, the emulsifier, the suspending agent and the nutrient substances to prepare a mixed glue solution, mixing the mixed glue solution with edible oil, and shearing to prepare a core material glue solution; dropwise adding the core material glue solution into the wall material solution to react for 5-10 minutes, separating, washing, sterilizing and packaging to obtain the synthetic roe. The synthetic roe provided by the invention can be used in wet cat food, hair paste, cat strips and other pet food, and has the advantages of high-temperature sterilization resistance, elasticity maintenance, no rupture, high antioxidant energy and high mechanical strength.
Owner:QINGDAO BRIGHT MOON SEAWEED GROUP

A method of manufacturing a heat preservation tube holder

PendingCN122500962AReduce construction resistanceLimit relative dislocation
This invention discloses a method for manufacturing an insulated pipe support. The mating surfaces of the semi-tube shell are machined into a stepped shape, comprising a first mating section and a second mating section. The first mating section is machined as a slope with a cutting depth gradually increasing from the side near the outer wall to the side near the inner wall, and a blind hole is correspondingly machined. An insert with a coefficient of linear expansion greater than that of the insulation material is inserted into the blind hole for mating. At room temperature, the insert and the blind hole have a clearance fit to reduce construction resistance, and a gap gradually narrows from the inside to the outside is formed between the first mating sections. Under high-temperature conditions, the radial thermal expansion of the insert is converted into an interference fit with the hole wall, and the resulting lateral extrusion force effectively restricts the relative misalignment of the semi-tube shell. Driven by this force, the insulation material around the hole wall is forced to undergo local extrusion deformation, protruding into the gap to actively absorb high-temperature thermal stress, mitigate the risk of cracking, and force the gap to close, establishing a tight thermal barrier.
Owner:ZHEJIANG SHANLIDE NEW MATERIAL TECH CO LTD