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327results about How to "Precision release" patented technology

Conveying device of covered stent

The invention discloses a conveying device of a covered stent. The conveying device of the covered stent comprises a guiding head which is provided with a hollow cavity in the axial direction, a guiding wire pipe which is communicated with the hollow cavity, a protective sleeve, an external pipe and a fixing device, wherein one end of the guiding wire pipe is fixedly connected with the rear end of the guiding head; the protective sleeve is sleeved outside the external wall of the guiding wire pipe and is capable of moving along the axial direction of the guiding wire pipe; one end of the protective sleeve is connected with the rear end of the guiding head; the external pipe is sleeved outside the external wall of the guiding wire pipe and is capable of sliding along the axial direction of the guiding wire pipe; the external pipe is sleeved outside at least partial of the external wall of the protective sleeve; and the fixing device is sleeved outside the external wall of the guiding wire pipe and is capable of moving along the axial direction of the guiding wire pipe. The conveying device of the covered stent is characterized in that a groove is formed on the external wall of the fixing device; a portion of the groove, which corresponds to the covered stent, is inserted into the fixing device and the front end of the insertion portion and the rear end of the insertion portion abut against the wall of the groove; space for accommodating the inserted potion is formed between the protective sleeve and the guiding wire pipe; and a position on the fixing device, which is provided with the groove, is arranged in the protective sleeve. The conveying device of the covered stent is applicable to conveying the covered stent into a body and performing releasing during an operation.
Owner:BEIJING PERCUTEK THERAPEUTICS CO LTD

Heart valve implantation device provided with anchoring device

ActiveCN104055604AGuaranteed needle exit anglePrecise positioningStentsHeart valvesAutologous tissueProsthesis
The invention relates to a heart valve implantation device provided with an anchoring device. The device comprises a heart valve prosthesis, at least two sets of anchoring pins and an anchoring pin releasing device, wherein an anti-disengagement end is arranged at the near end of each anchoring pin, the anchoring pin releasing device is detachably connected with the heart valve prosthesis and comprises a delivery pipe and a push rod, the far end of the anchoring pin releasing device is in a preset shape to enable the far end of the delivery pipe to be bent integrally or partially, the part, capable of being bent, of the delivery pipe is the bent section, a rigid section is arranged at the farthest end of the delivery pipe, the distance between the farthest end of the delivery pipe and the nearest end of the bent section of the delivery pipe is larger than or equal to one sixth of the perimeter of a circle formed by means of the minimum radius of the autologous valve tissue ring of a patient, the anchoring pins are pre-arranged in the far end of the delivery pipe and located at the far end of the push rod, and the anchoring pins can be made to move towards the far end of the delivery pipe by pushing the push rod to enable the heart valve prosthesis to be fixed between the autologous tissue and the anti-disengagement end. By the adoption of the device, accurate positioning and firm anchoring can be realized.
Owner:NINGBO JENSCARE BIOTECHNOLOGY CO LTD

Pharmaceutical formulation with enhanced solubility for the delivery of corticosteroids

Formulations have been developed to improve the solubility of corticosteroids such as fluticasone proprionate in a composition designed to achieve localized release of the drug in the small intestine and/or colon. In one embodiment, solid dispersions of fluticasone are prepared wherein the drug is blended with or coated onto a highly water soluble substrate such as nonpareil (sugar beads) then coated with a layer of polymer soluble in small intestinal fluid, then coated with an enteric coating. The inner polymer layer controls release of the drug, and the enteric coating, a pH sensitive polymer that is broken down in the ileum and colon, controls localized release of drug at various sites within the gastrointestinal tract. The multilayer pharmaceutical composition can be in the form of pellets, tablets compressed from pellets or pellets packed into capsules. The release profile of the drug can be manipulated by (1) altering size or shape (i.e., surface area) and solubility of the inert substrate; (2) the ratio of drug to polymer, the polymer composition and solubility, the porosity of the polymer; (3) the drug form (i.e., free base or salt, or which salt); and the thickness and/or surface area of the drug/polymer and/or enteric coating. In a preferred embodiment, the composition is administered orally. This may also be packaged to provide for an escalating or tapering dosage.
Owner:AURIGA LAB +1

Double sacculus device of expansion type bracket for bending section vascellum sacculus

A double sacculus device used for a curve section blood saccule expansible support comprises a pipe fitting, sacculus arranged on the pipe fitting, a dispersion stress pipe arranged on the back of the pipe fitting and a connecting piece. The pipe fitting comprises an inner sleeve and an outer sleeve, which respectively form a guiding cavity, a first filling cavity and a second filling cavity; the saccule on the pipe fitting comprises a center saccule and an extension saccule; the saccule has a design of three folds and is closely parceled; the center saccule is positioned in the extension saccule by which the center saccule is parceled; the tops of both the center saccule and the extension saccule are connected with the inner sleeve, but connection points are at different location; the ends of the inner sleeve are connected with the outer sleeves respectively; the cavities of the inner sleeve is communicated with the first filling cavity and the second filling cavity respectively; in the dispersion stress pipe and the connection piece, a double-layer cavity that is inosculated with each cavity in the pipe fitting. The invention solves problems of the prior art and changes an operating process by which both ends of a saccule are expanded first, which makes the center part of the complete saccule expand firstly and get a good adherence, and then the two end parts begin to expand.
Owner:SHANGHAI JIAO TONG UNIV

Message announcing system based on locating user behavior and method thereof

The invention discloses a message announcing system based on locating a user behavior and a method thereof. The invention is characterized in that the system comprises: a user behavior acquisition module for acquiring a user view behavior and building a user behavior matrix by analyzing a daily; a cluster counting engine module for clustering the user behavior matrix generated by the user behavior acquisition module to generate a user group behavior matrix with a clustering algorithm; a multicast group management module for distributing a message announcing multicast group to each user, receiving periodical query from a user terminal, and returning a message announcing multicast group address corresponding the user group to the user terminal; and a message announcing management module for remaining the feature user behavior matrix of a message announcing type, when announcing the message, counting the related coefficient between the message announcement and the user group, and distributing the message announcement to the user group with the related coefficient which is higher than a preset threshold value through a multicast information channel. The invention also discloses a message announcing method based on locating the user behavior.
Owner:ZHENGZHOU SEANET TECH CO LTD

Nano catalyst for tumor treatment, and preparation method and application thereof

ActiveCN110974978AImproving the Efficiency of Cancer TreatmentSmall toxicityHeavy metal active ingredientsDrug photocleavageNano catalystPtru catalyst
The invention provides a nano catalyst for tumor treatment, and a preparation method and application thereof. The nano catalyst provided by the invention comprises an erythrocyte membrane, and a composite nano enzyme and a photosensitizer which are coated in the erythrocyte membrane, wherein the composite nano enzyme comprises glucose oxidase and iron nanoparticles which are coated in an inner cavity of the glucose oxidase. The nano catalyst is preferentially accumulated at a target tumor site through targeted biomimetic delivery, and release of the composite nano enzyme is realized under irradiation of near infrared light. Based on high glucose uptake and a weakly acidic environment at the tumor site, glucose oxidase converts glucose into H2O2, induces iron nano particles to start an in-situ Fenton reaction, generates hydroxyl free radicals after sequential catalysis, induces tumor cells to be subjected to oxidative damage, and further kills the tumor cells. The nano catalyst not onlycan realize high-efficiency loading of the catalyst, but also can effectively prolong in-vivo circulation time, so that accurate and sustained release on a tumor focus part is realized, and a new thought and platform are provided for tumor treatment.
Owner:JINAN UNIVERSITY
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