An umbrella-shaped anchored tumor marker and its implantation system

Abstract

This utility model relates to the field of interventional tumor diagnostic and treatment medical device technology, and discloses an umbrella-shaped anchored tumor marker and its implantation system. The umbrella-shaped anchored tumor marker includes an umbrella-shaped anchoring system composed of multiple umbrella ribs with shape memory properties. The proximal ends of the ribs converge to form an axial central tube. The surface of the ribs has micro-barb structures formed by laser etching. The umbrella-shaped anchoring system remains in a contracted state at temperatures below body temperature and autonomously unfolds into a three-dimensional umbrella-shaped anchoring form at body temperature. In this utility model, the distal end of the umbrella ribs integrates a platinum-iridium alloy imaging tip with gradient stiffness (rigid at the proximal end and flexible at the distal end). The barbs are spaced along the length of the umbrella ribs. The shape memory alloy is in one state during delivery at room temperature and can self-unfold in vivo, achieving effective anchoring and imaging, thus aiding in tumor marking.

Description

Technical Field

[0001] This utility model relates to the field of interventional tumor diagnosis and treatment medical device technology, and in particular to an umbrella-shaped anchored tumor marker and its implantation system. Background Technology

[0002] Tumor markers play a crucial role in the field of tumor diagnosis and treatment. These markers are either characteristically hidden inside malignant tumor cells, or generated by abnormal metabolism of tumor cells, or produced by the host's immune system in response to tumor stimulation. They can directly reflect the entire process of tumor development from inception, growth, invasion to metastasis. Furthermore, they can effectively monitor treatment response during various treatment methods such as surgery, radiotherapy, chemotherapy, and targeted therapy, providing key evidence for doctors to adjust treatment strategies in a timely manner.

[0003] Metallic marker clips are typically made of inert metals such as titanium alloys and are placed at the surgical site after tumor resection. Due to their excellent imaging properties, they are clearly visible on X-rays and CT scans, helping doctors accurately locate the surgical area, assess the effectiveness of tumor resection, and detect any recurrence. This is crucial for surgical evaluation and postoperative follow-up. Liquid markers, such as solutions containing fluorescent substances or radioactive isotopes, can circulate in the bloodstream. Their specific substances can bind to receptors on the surface of tumor cells or components of the tumor microenvironment. For example, liquids containing fluorescent markers, when injected into the body and excited by specific light, will emit light... With the help of imaging equipment, doctors can clearly observe the tumor boundary during surgery. Radioactive isotope-labeled liquids can be tracked by detection instruments, which is beneficial for early tumor diagnosis and the detection of metastases. Spherical markers are generally made of biodegradable materials into small spheres with targeting molecules on the surface. After being injected into the human body, they can specifically bind to tumor cells. Some spherical markers are filled with magnetic or special optical substances, such as superparamagnetic iron oxide nanoparticles. During MRI examination, they can change the signal intensity of the tumor site, making the tumor clearer, helping doctors to judge the tumor condition, and assisting in the formulation of precise treatment plans.

[0004] Current metal marker clips have a displacement rate as high as 12% to 18%, provide only single-point marking, cannot define the three-dimensional lesion boundary, and have blurred ultrasound imaging (due to comet tail artifacts). Liquid markers require the injection of 3 to 5 mL of viscous fluid, pose a risk of diffusion (morphological variation rate >25% within 30 days), cannot provide mechanical anchoring, and rely on tissue fibrosis for fixation. Spherical markers have smooth surfaces that lead to rotational displacement (MRI detection rotation error >5°), and the imaging components are singular (containing only metal marker points), making CT / MRI registration difficult. Therefore, an umbrella-shaped anchored tumor marker and its implantation system are proposed to solve the above problems. Utility Model Content

[0005] To overcome the above shortcomings, this invention provides an umbrella-shaped anchored tumor marker and its implantation system, aiming to improve the problems of high marker displacement rate, inability to accurately define lesion boundaries, poor imaging effect and unstable anchoring in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] An umbrella-shaped anchored tumor marker includes an umbrella-shaped anchoring system. The umbrella-shaped anchoring system is composed of multiple umbrella ribs with shape memory properties. The proximal ends of each umbrella rib converge to form an axial central tube. The surface of the umbrella ribs is provided with micro-barb structures formed by laser etching. The umbrella-shaped anchoring system remains in a contracted state in an environment below body temperature and autonomously unfolds into a three-dimensional umbrella-shaped anchoring form in a body temperature environment.

[0008] As a further description of the above technical solution:

[0009] The distal end of the umbrella rib is integrated with a platinum-iridium alloy developing tip, and the umbrella rib itself has gradient stiffness.

[0010] As a further description of the above technical solution:

[0011] The barbs are 50-200 μm high and are arranged at intervals along the length of the umbrella ribs.

[0012] An implantation system for delivering the umbrella-shaped anchored tumor marker includes a housing and a fixing housing. A fixing cylinder is fixedly connected to the front end of the housing, a rotating block is threadedly connected to the outside of the fixing cylinder, a movable column is slidably connected inside the housing, a sliding block is fixedly connected to the top end of the movable column, and a pushing column is fixedly connected to the rear end of the movable column.

[0013] As a further description of the above technical solution:

[0014] The rotating block has a sliding groove inside, and the outside of the sliding block is slidably connected to the inside of the sliding groove;

[0015] As a further description of the above technical solution:

[0016] The fixed cylinder has a sliding groove on its outside, and the sliding block is slidably connected to the inside of the sliding groove.

[0017] As a further description of the above technical solution:

[0018] The movable column is slidably connected to the outside of the fixed cylinder, and the pushing column is slidably connected to the outside of the fixed shell.

[0019] As a further description of the above technical solution:

[0020] The outer surface of the push column contacts the outer surface of the multiple umbrella ribs, and the outer surface of the rotating block is provided with anti-slip grooves.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this invention, the umbrella-shaped anchoring system of the umbrella-shaped tumor marker is composed of multiple umbrella ribs with shape memory properties. The proximal ends of each umbrella rib converge to form an axial central tube, and the surface is provided with a laser-etched micro-barb structure. The umbrella-shaped anchoring system remains in a contracted state at temperatures below body temperature and autonomously unfolds into a three-dimensional umbrella-shaped anchoring form at body temperature. The distal end of the umbrella rib integrates a platinum-iridium alloy imaging tip, which has gradient stiffness, i.e., rigid at the proximal end and flexible at the distal end. The barbs are arranged at intervals along the length of the umbrella rib. Its shape memory alloy is in one state when transported at room temperature and can self-unfold in vivo, which can achieve effective anchoring and imaging, and is helpful for tumor marking.

[0023] 2. In this utility model, when marking the lesion site of a patient, medical staff first insert the fixed shell at the front end of the marker into the lesion site, and then rotate the rotating block. The rotation of the rotating block causes it to move on the externally connected component, which drives the sliding block connected to it to slide in a specific track, thereby pushing the moving column to slide. The moving column then pushes the pushing column, ultimately causing the umbrella rib to slide out of the fixed shell and into the patient's body. Medical staff can also fine-tune the pushing position of the umbrella rib by slowly rotating the rotating block to accurately release the marker, which greatly improves the convenience and accuracy of the operation and ensures that the marker can be accurately placed at the lesion site. Attached Figure Description

[0024] Figure 1 This is a three-dimensional schematic diagram of an umbrella-shaped anchored tumor marker and its implantation system proposed in this utility model.

[0025] Figure 2 This is a schematic diagram of the structure of the fixation shell of the umbrella-shaped anchored tumor marker and its implantation system proposed in this utility model.

[0026] Figure 3 This is a schematic diagram of the structure of the umbrella-shaped anchored tumor marker and its implantation system proposed in this utility model.

[0027] Figure 4 for Figure 3 Enlarged view of point A in the middle.

[0028] Legend:

[0029] 1. Housing; 2. Fixed cylinder; 3. Rotating block; 4. Sliding block; 5. Moving column; 6. Pushing column; 7. Sliding groove; 8. Sliding groove; 9. Fixed shell; 10. Umbrella rib; 11. Platinum-iridium alloy developing tip; 12. Axial center tube. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0031] Example 1:

[0032] Reference Figure 1 This utility model provides an embodiment of an umbrella-shaped anchored tumor marker, comprising an umbrella-shaped anchoring system. The umbrella-shaped anchoring system is composed of multiple umbrella ribs 10 with shape memory properties. The proximal ends of each umbrella rib 10 converge to form an axial central tube 12. The surface of the umbrella ribs 10 is provided with a micro-barb structure formed by laser etching to ensure the stability of the marker's position in the body. The umbrella-shaped anchoring system remains in a contracted state in an environment below body temperature and autonomously unfolds into a three-dimensional umbrella-shaped anchoring form in a body temperature environment, achieving an automatic unfolding effect. The distal end of the umbrella ribs 10 integrates a platinum-iridium alloy imaging tip 11, and the umbrella ribs 10 themselves have gradient stiffness. The barb height is 50-200μm and is arranged at intervals along the length direction of the umbrella ribs 10. The unfolded diameter of the umbrella ribs 10 is 8mm (contracted state) to 25mm (fully unfolded). The shape memory alloy phase transition temperature is 25℃ (room temperature delivery) to 37℃ (in vivo self-unfolding). The gradient stiffness design of the umbrella ribs 10 is (proximal rigidity / distal flexibility).

[0033] Example 2:

[0034] Reference Figures 2 to 4This embodiment discloses an implantation system for implanting an umbrella-shaped anchored tumor marker as mentioned in Embodiment 1, comprising a housing 1 and a fixing shell 9. A fixing cylinder 2 is fixedly connected to the front end of the housing 1. A rotating block 3 is threadedly connected to the outside of the fixing cylinder 2. The rotating block 3 is a key component in the operation of the entire implantation system. Medical personnel release the marker by rotating the rotating block 3. The inner thread of the rotating block 3 is connected to the outside of the fixing cylinder 2. This threaded connection allows the rotating block 3 to move axially along the fixing cylinder 2 during rotation, facilitating the subsequent pushing of the umbrella rib 1. 0 provides power. Inside the housing 1, there is a sliding connection of a movable column 5. The movable column 5 plays the role of transmitting power during the entire conveying process. The movable column 5 converts the rotation of the rotating block 3 into linear motion, thereby pushing the umbrella rib 10 to release. The top of the movable column 5 is fixedly connected to a sliding block 4. The sliding block 4 is connected to both the rotating block 3 and the fixed cylinder 2. The sliding block 4 plays a key guiding and transmission role during the movement of the rotating block 3. The rear end of the movable column 5 is fixedly connected to a push column 6. The push column 6 is in direct contact with the umbrella rib 10 and is the direct power source for pushing the umbrella rib 10 to slide out from inside the fixed housing 9.

[0035] The rotating block 3 has a sliding groove 7 inside, and the sliding block 4 is slidably connected to the inside of the sliding groove 7. The sliding groove 7 provides a sliding track for the sliding block 4, so that the rotation of the rotating block 3 can drive the sliding block 4 and the moving column 5 to move in a straight line. The fixed cylinder 2 has a sliding groove 8 outside, and the sliding block 4 is slidably connected to the inside of the sliding groove 8. The sliding groove 8 guides the movement of the sliding block 4, ensuring that the moving column 5 can slide stably along the fixed cylinder 2, improving the accuracy and stability of the entire conveying process. The moving column 5 is slidably connected to the inside of the fixed cylinder 2, pushing the column... The external sliding connection of the push column 6 is inside the fixed shell 9. The sliding of the push column 6 inside the fixed shell 9 directly pushes the umbrella ribs 10 out of the fixed shell 9, completing the delivery of the marker. The external of the push column 6 is in contact with the external of multiple umbrella ribs 10. This contact method can evenly transmit the thrust of the push column 6 to each umbrella rib 10, ensuring that the umbrella ribs 10 slide out of the fixed shell 9 synchronously. The external of the rotating block 3 is provided with anti-slip grooves. The anti-slip grooves can increase the friction between the hands of medical staff and the rotating block 3, avoiding slippage when rotating the rotating block 3, making the operation more stable and reliable.

[0036] Working principle: When medical staff need to mark the lesion site of a patient, they insert the outside of the fixing shell 9 into the lesion site. Then, by rotating the rotating block 3, as the rotating block 3 moves outside the fixing cylinder 2, the sliding block 4 is compressed and slides inside the sliding groove 7. At the same time, the sliding block 4 slides under the guidance of the sliding groove 8, causing the moving column 5 to slide outside the fixing cylinder 2. This causes the moving column 5 to push the pushing column 6 to slide inside the fixing shell 9, ultimately causing the umbrella rib 10 to slide out from inside the fixing shell 9 and into the patient's body, completing the installation of the marker. By slowly rotating the rotating block 3, medical staff can fine-tune the pushing position of the marker to achieve precise release, avoiding pushing too much or too little, thus improving the convenience and accuracy of the operation.

[0037] The marker itself includes a platinum-iridium alloy imaging tip 11 and multiple umbrella ribs 10. When the marker enters the lesion site of the patient, its shape memory alloy will automatically unfold due to the influence of the patient's body temperature, so that the entire marker unfolds in the body. At the same time, the surface of the umbrella ribs 10 is provided with micron-level barbs to ensure that the anchoring position will not be deviated, and it integrates imaging components of at least two different imaging modes.

[0038] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. An umbrella-shaped anchored tumor marker, comprising an umbrella-shaped anchoring system, characterized in that: The umbrella-shaped anchoring system is composed of multiple umbrella ribs (10) with shape memory characteristics. The proximal ends of each umbrella rib (10) converge to form an axial central tube (12). The surface of the umbrella ribs (10) is provided with a micro barb structure formed by laser etching. The umbrella-shaped anchoring system remains in a contracted state in an environment below body temperature and autonomously unfolds into a three-dimensional umbrella-shaped anchoring form in a body temperature environment.

2. The umbrella-shaped anchored tumor marker according to claim 1, characterized in that: The distal end of the umbrella rib (10) is integrated with a platinum-iridium alloy imaging tip (11), and the umbrella rib (10) itself has gradient stiffness.

3. The umbrella-shaped anchored tumor marker according to claim 1, characterized in that: The barbs are 50-200 μm high and are arranged at intervals along the length of the umbrella rib (10).

4. An implantation system for implanting the umbrella-shaped anchored tumor marker according to any one of claims 1-3, comprising a housing (1) and a fixation shell (9), characterized in that: A fixed cylinder (2) is fixedly connected to the front end of the housing (1), and a rotating block (3) is threadedly connected to the outside of the fixed cylinder (2). A moving column (5) is slidably connected inside the housing (1), and a sliding block (4) is fixedly connected to the top end of the moving column (5). A pushing column (6) is fixedly connected to the rear end of the moving column (5).

5. An implantation system according to claim 4, characterized in that: The rotating block (3) has a sliding groove (7) inside, and the sliding block (4) is slidably connected to the inside of the sliding groove (7).

6. An implantation system according to claim 4, characterized in that: The fixed cylinder (2) has a sliding groove (8) on its outside, and the sliding block (4) is slidably connected to the inside of the sliding groove (8).

7. An implantation system according to claim 4, characterized in that: The movable column (5) is slidably connected to the outside of the fixed cylinder (2), and the push column (6) is slidably connected to the outside of the fixed shell (9).

8. An implantation system according to claim 4, characterized in that: The outside of the push column (6) is in contact with the outside of the multiple umbrella ribs (10), and the outside of the rotating block (3) is provided with anti-slip grooves.

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