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Fasudic hydrochloride oral formulation

A preparation technology of fasudil hydrochloride, which is applied in the direction of pill delivery, medical preparations containing active ingredients, cardiovascular system diseases, etc., can solve the problems of complicated preparation process, difficult preparation production, inconvenient use, etc., and achieve the goal of using convenient effect

Active Publication Date: 2006-08-09
TIANJIN CHASE SUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art is inconvenient to use because it is a preparation for injection, and at the same time, because Fasudil hydrochloride is unstable in the solution, the preparation process is complicated, which brings difficulties to large-scale preparation production

Method used

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  • Fasudic hydrochloride oral formulation
  • Fasudic hydrochloride oral formulation
  • Fasudic hydrochloride oral formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Example 1 tablet

[0150] Fasudil Hydrochloride 80g

[0151] Lactose 150g

[0152] Hydroxypropyl Cellulose (HPC) 4g

[0153] water 560ml

[0154] Opadry AMB (Opadry) 12.5g

[0155] Sodium Carboxymethyl Starch (CMS Na) 12g

[0156] Talc powder 8g

[0157] Titanium dioxide 6g

[0158] Preparation:

[0159] Dissolve 80g of fasudil hydrochloride in 250ml of water to prepare an aqueous solution of fasudil hydrochloride. Dissolve 4g of hydroxypropyl cellulose in 150ml of water to form an aqueous solution of hydroxypropyl cellulose. Adopt the fluidized boiling granulation method, put 150g lactose and 12g carboxymethyl starch sodium into the fluidization chamber screen and be boiling state in the hot air of 60 ℃, spray into fasudil hydrochloride aqueous solution, the lactose and the boiling state The mixture of sodium carboxymethyl starch and the main ingredient starts to coalesce into granules, and after repeated spraying and drying, granules are obtained. Add 4 g of...

Embodiment 2

[0160] Embodiment 2 Granules

[0161] Fasudil Hydrochloride 80g

[0162] Lactose 150g

[0163] Hydroxypropyl Cellulose (HPC) 4g

[0164] water 560ml

[0165] Sodium Carboxymethyl Starch (CMS Na) 12g

[0166] The preparation method is:

[0167] Dissolve 80g of fasudil hydrochloride in 250ml of water to prepare an aqueous solution of fasudil hydrochloride. Dissolve 4g of hydroxypropyl cellulose in 150ml of water to form an aqueous solution of hydroxypropyl cellulose. Adopt the fluidized boiling granulation method, put 150g lactose and 12g carboxymethyl starch sodium into the fluidization chamber screen and be boiling state in the hot air of 60 ℃, spray into fasudil hydrochloride aqueous solution, the lactose and the boiling state The mixture of sodium carboxymethyl starch and the main ingredient starts to coalesce into granules, and after repeated spraying and drying, granules are obtained.

Embodiment 3

[0168] Embodiment 3 capsules

[0169] Fasudil Hydrochloride 80g

[0170] Lactose 150g

[0171] Hydroxypropyl Cellulose (HPC) 8g

[0172] water 560ml

[0173] Sodium Carboxymethyl Starch (CMS Na) 12g

[0174] Talc powder 8g

[0175] Ethanol 80ml

[0176] The preparation method is:

[0177] Dissolve 80g of fasudil hydrochloride in 250ml of water to prepare an aqueous solution of fasudil hydrochloride. Dissolve 4g of hydroxypropyl cellulose in 150ml of water to form an aqueous solution of hydroxypropyl cellulose. Adopt the fluidized boiling granulation method, put 150g lactose and 12g carboxymethyl starch sodium into the fluidization chamber screen and be boiling state in the hot air of 60 ℃, spray into fasudil hydrochloride aqueous solution, the lactose and the boiling state The mixture of sodium carboxymethyl starch and the main ingredient starts to coalesce into granules, and after repeated spraying and drying, granules are obtained. After granulation, the granules an...

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Abstract

The present invention relates to a fashudil hydrochloride oral preparation for curing ischemic cerebrovascular disease due to cerebrovascular spasm after subarachnoid hemorrhage. It can be made into tablet, capsule and granule preparation.

Description

Technical field: [0001] The invention relates to an oral pharmaceutical preparation, in particular to an oral pharmaceutical preparation of fasudil hydrochloride used for improving the symptoms of ischemic cerebrovascular diseases caused by cerebral vasospasm after subarachnoid hemorrhage. Background technique: [0002] Fasudil hydrochloride, English name: Fasudil, is a kind of protein kinase inhibitor namely intracellular calcium ion antagonist, it is a kind of medicine for the treatment of ischemic encephalopathy, and the existing pharmaceutical preparation for injection is on the market. Because the prior art is a preparation for injection, it is inconvenient to use, and at the same time, because fasudil hydrochloride is unstable in solution, the preparation process is complicated, which brings difficulties to large-scale preparation production. Invention content: [0003] According to the defects of the prior art, the present invention provides an oral preparation of f...

Claims

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Application Information

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IPC IPC(8): A61K31/551A61K9/20A61K9/16A61K9/48A61P9/10
CPCY02A50/30
Inventor 姚小青
Owner TIANJIN CHASE SUN PHARM CO LTD
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