84 results about "Arachnoid Membrane" patented technology

A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and / or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and / or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

The invention relates to a cerebrospinal fluid dynamic monitoring management method. Comprising the following steps: performing mode identification by using dynamic characteristics of cerebrospinal fluid pressure and flow velocity; by monitoring the flow velocity and pressure fluctuation of cerebrospinal fluid in real time, a comparison library of a normal mode and an abnormal mode is established; deep learning is carried out by using a fluid mechanics model and a neural network, and abnormal points of non-linear change are identified; through combination of a pressure sensor array and a flow velocity sensor, dynamic flow changes are captured in different areas of a cerebrospinal fluid system including a ventricle and a subarachnoid space, and abnormal fluctuations are identified through continuous analysis of time sequence data; by analyzing the interaction between the intracranial flow mode of cerebrospinal fluid and the compression expansion effect of brain tissues, an intelligent adjustment mechanism based on the flow pressure coupling effect is introduced; under the influence of cerebrospinal fluid pressure changes, deformation of brain tissue including ventricular expansion influences blood flow and tissue pressure in other intracranial areas.

A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g., a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and / or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

The application discloses a lumbar puncture auxiliary mechanism and a use method thereof. The lumbar puncture auxiliary mechanism comprises a main body assembly, a supporting shell fixed to one side of a positioning disc, and a puncture needle penetrating through the positioning disc and the supporting shell. The main body assembly is provided with an adjusting assembly in the supporting shell. The adjusting assembly comprises a driving element arranged on one side of the positioning disc, a transmission element arranged on one side of the driving element, and an adjusting element arranged on one side of the transmission element. The adjusting element comprises a limiting shell fixed to the inner wall of the supporting shell, a rack sliding in the limiting shell, and a first spring fixed to the end of the rack. The adjusting assembly can intermittently supply the puncture needle, so that the puncture needle can smoothly break through the yellow ligament without improper force. The puncture process can be judged, so that the time when the puncture needle enters the epidural space and the subarachnoid space can be accurately grasped, and the accidental damage to the human body is reduced.

The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

This utility model discloses an anesthesia puncture needle, including an outer needle tube and a needle hub connected to one end of the outer needle tube; it also includes an inner needle body nested inside the outer needle tube, with one end extending to the outside through the opening of the outer needle tube, and the other end extending into the needle hub. The protruding end of the inner needle body is conical, and at least one collection hole is opened on its outer wall near the end. This utility model relates to the field of medical anesthesia technology. This anesthesia puncture needle, through the cooperation of the inner needle body and the outer needle tube, can facilitate the puncture needle to enter the subarachnoid space. At the same time, it can pull the piston collector to draw cerebrospinal fluid from the end of the inner needle body and store it in the internal cavity of the piston collector, so that it can be mixed with the colorimetric solution injected through the colorimetric branch tube, thereby enabling colorimetric treatment of the cerebrospinal fluid, facilitating rapid diagnosis by medical personnel. In this process, the colorimetric solution will not come into contact with the human body, avoiding harm to the human body.

The lumbar puncture auxiliary mechanism comprises a main body assembly, the main body assembly comprises a positioning disc and a supporting shell fixed to one side of the positioning disc, and a puncture needle penetrates through the positioning disc and the supporting shell; the adjusting assembly is arranged in the supporting shell and comprises a driving piece arranged on one side of the positioning disc, a transmission piece is arranged on one side of the driving piece, an adjusting piece is arranged on one side of the transmission piece and comprises a limiting shell fixed to the inner wall of the supporting shell, a rack slides in the limiting shell, and a first spring is fixed to the end of the rack. By arranging the adjusting assembly, intermittent supply can be conducted on the puncture needle, so that the puncture needle can smoothly break through the ligamentum flavum, and the situation of improper force exertion is avoided; the puncture process can be judged, so that the opportunity that the puncture needle enters the epidural space and the subarachnoid space is accurately grasped, and accidental injuries to the human body are reduced.

This invention relates to the field of microfluidic chip technology, specifically to a dynamic microfluidic chip device, its preparation method, and its applications for studying CAR-T therapy for gliomas. The preparation method includes: fabrication of the microfluidic chip; reconstruction of neural tissue; reconstruction of the blood-brain barrier; and simulation of the glioma microenvironment. The dynamic microfluidic chip device includes a microfluidic chip; the microfluidic chip includes, from left to right, a vascular channel, a brain parenchyma channel, a tumor channel, and a subarachnoid channel; each of the vascular channel, brain parenchyma channel, tumor channel, and subarachnoid channel includes a cell culture chamber with an inlet on one side; the cell culture chambers of the vascular channel and the subarachnoid channel have corresponding outlets on the other side. The applications include: CAR-T cell infusion; observation of transmembrane migration; and detection of biomarkers. This invention, through the dynamic microfluidic chip device, its preparation method, and its applications, aims to achieve more accurate in vitro evaluation of CAR-T cell therapy.

The invention is a non-invasive intracranial pulse wave monitor and method for measuring pulsating cerebrospinal fluid pressure in the subarachnoid space of the optic nerve in real-time.

The invention relates to a device (1) for draining cerebrospinal fluid, wherein the device (1) has a shaft (2) that can be implanted into a skull bone (14) of a human or animal, wherein the device (1) is suitable for draining cerebrospinal fluid from the subarachnoid space and / or a cerebral ventricle (15) into the diploë of the skull bone (14), and the shaft (2) has radially extending outlet openings (4), wherein a valve (17) is arranged inside the shaft (2) which connects a first chamber to a second chamber, wherein the second chamber has a fluid connection with the outlet openings (4), and a tube (5) opens into the shaft (2) at the distal end face of the shaft (2), or a tube (20) is arranged at the distal end face of the shaft (2) to which a tube (5) is connected.wherein the tube (5) in its proximal section or the pipe (20) is in fluid communication with the first chamber and the tube (5) has at least one distal inlet opening (8) for cerebrospinal fluid, wherein the inlet openings (8) can be placed in the subarachnoid space and / or in the region of a cerebral ventricle (15) and the tube (5) has a lumen (9) into which a wire (6) can be inserted, wherein the wire (6), when inserted, protrudes from the proximal end face of the device (1). The invention allows the treating physician to position and adjust the device (1) according to the requirements for draining the cerebrospinal fluid into the diploë of the skull bone (14). Placement is possible under local anesthesia.

The invention provides application of IL-33 in preparation of a medicine for treating and / or relieving brain injury after subarachnoid hemorrhage, and belongs to the technical field of medicine. The invention clarifies a mechanism that IL-33 plays a role in neuroprotection in a rat subarachnoid hemorrhage model, verifies that exogenous IL-33 treatment can activate an ST2 receptor, further promotes M2-type polarization of microglial cells, plays a role in neuroprotection in the progress of subarachnoid hemorrhage, can improve prognosis after subarachnoid hemorrhage, and has a good application prospect in treatment of subarachnoid hemorrhage. The compound can be applied to preparation of drugs for treating and / or relieving brain injury after subarachnoid hemorrhage.

In some embodiments, disclosed herein are systems and methods of treating a patient that can include the steps of accessing the sphenopalatine fossa, and cannulating the inferior orbital fissure from the sphenopalatine fossa to access the retro-orbital space. The sphenopalatine fossa can be accessed via various routes, including percutaneously. Accessing the sphenopalatine fossa can include the step of inserting a needle-catheter system into the sphenopalatine fossa. Integrated needle-catheter systems as described herein can also be configured to access the trigeminal ganglion, epidural space, intrathecal space, and other desired anatomical locations.

The invention belongs to the technical field of medical instruments, and particularly relates to a lumbar puncture auxiliary positioning device which comprises a backrest plate, the lower end of the backrest plate is rotationally connected with a hip supporting plate, a pillow plate is fixedly mounted at the upper end of the backrest plate, an open groove is formed in the backrest plate, and a sliding groove is formed in the inner wall of one side of the open groove; a through groove is formed in the inner wall of the other side of the backrest plate in a penetrating mode, a first sliding plate is arranged in the sliding groove in a sliding mode, a second sliding plate is arranged in the through groove in a sliding mode, and the end of the second sliding plate is fixedly connected with a circular ring located on the outer side of the backrest plate. The hip joints, knee joints, the head and the neck of a patient are bent through the arrangement of the backrest plate and the hip supporting plate, then puncture points are conveniently found, adjustment of the puncture angle and depth is achieved through rotation of the rotating block and the threaded pipe, then a needle head can penetrate through the intervertebral space and enter the epidural space or the subarachnoid space, and a cerebrospinal fluid sample is rapidly obtained.

The invention belongs to the field of biological medicines, and particularly relates to a medicine for treating meningeal metastasis of malignant tumors with NTRK and / or ROS1 mutations and a preparation method, and the medicine is a freeze-dried powder preparation or injection for subarachnoid space injection of NTRK / ROS1-TKIs. The invention also provides an application of the NTRK / ROS1-TKIs in preparation of a medicine for treating meningeal metastasis of malignant tumors with NTRK and / or ROS1 mutation. The prepared NTRK / ROS1-TKIs injection can be directly injected into the subarachnoid space of a patient, the drug concentration in cerebrospinal fluid of the patient is greatly improved, the cerebrospinal fluid / plasma concentration ratio can reach 20 times or more, the problem of insufficient dosage caused by the blood-brain barrier after the targeted drug is orally taken can be completely solved, and the drug has the advantages of fast effect taking, no toxic or side effect and no toxic or side effect. The treatment effect on meningeal metastasis of malignant tumors such as lung cancer can be obviously improved.

This utility model discloses a lumbar puncture needle with monitoring function, comprising: a needle body, with a puncture needle main body internally connected to the needle body. The puncture needle main body is used to detect puncture depth and monitor cerebrospinal fluid pressure. The puncture needle main body includes an outer needle and an inner needle, with the inner needle located inside the outer needle. A gap is reserved between the outer and inner needles. A signal receiving mechanism is provided at the top of the outer needle. Both the outer and inner needles are electrically connected to the signal receiving mechanism via a point-to-line connection. This utility model provides a lumbar puncture needle with monitoring function, consisting of a system and a puncture needle main body. It can issue an alarm when the puncture needle tip contacts the cerebrospinal fluid in the subarachnoid space of the lumbar spine, and can monitor the cerebrospinal fluid pressure in real time during cerebrospinal fluid collection. Through precise puncture depth feedback and real-time cerebrospinal fluid pressure monitoring, doctors can more accurately locate the puncture point, reduce surgical errors, and improve the success rate of surgery. Real-time monitoring of cerebrospinal fluid pressure helps to detect abnormal intracranial pressure in a timely manner, prevent serious complications such as brain herniation, and ensure patient safety.

The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and / or modulating of the media or tissue surfaces.

The application discloses a method, device and equipment for evaluating the width and narrowness degree of the subarachnoid space of the optic nerve, and the method comprises the following steps: collecting a target image corresponding to a target position of the optic nerve, and obtaining the resolution of the target image, wherein the target position is any one of a plurality of preset positions on the optic nerve; dividing the subarachnoid space of the optic nerve in the target image into at least two regions by using at least one division line, the division line passes through the centroid of the optic nerve sheath in the target image, and the target circle central angle is bisected, the target circle central angle is the central angle of a circle with the centroid as the center and an arbitrary length as the radius; evaluating whether the target image meets the first evaluation standard based on the images of the at least two regions and the resolution of the target image; in this way, the defect that the MR image cannot be effectively judged whether it can be used for evaluating the width and narrowness degree of the subarachnoid space of the optic nerve can be solved, and the subarachnoid space of the optic nerve can be equally divided to the maximum extent, so that the final evaluation result is more accurate and more persuasive.

Methods for planning endovascular procedures intended to access extravascular spaces are disclosed herein for measuring anatomical distances and assessing such distance relative to anatomical screening criteria specified for a procedure to improve patient safety and procedural success, for example, when planning a procedure for navigating a delivery catheter through a blood vessel wall to a location within the intracranial subarachnoid space.

A method of performing a ventriculostomy includes creating an access site in a lumbar region. A guidewire is inserted into the access site. A sheath is introduced over the guidewire, into the access site, and the tip of the sheath is positioned in a subarachnoid space. A first catheter and a second catheter are introduced through the access site. The first catheter and the second catheter are guided proximate to a ventricle membrane of a ventricle. A hole is created in the ventricle membrane and at least one of the first catheter or the second catheter are advanced through the hole. The hole in the ventricle membrane is dilated. Contrast is injected into the ventricle to confirm cerebrospinal fluid is draining into a subarachnoid cistern.

The present invention relates to the technical field of bypass tubes, and specifically to a subarachnoid bypass tube that is convenient for accurately controlling the depth of side holes, comprising a bypass tube body, an outer wall of the bypass tube body is provided with a connecting assembly, an inner wall of the connecting assembly is provided with a bullet-shaped connecting tube, the bypass tube body and the bottom of the connecting tube are both provided with a bullet-shaped connecting tube, a plurality of side holes are opened on the outer wall of the bullet-shaped connecting tube, a marking point is fixedly connected to the outer wall of the bullet-shaped connecting tube on one side close to the plurality of side holes, the connecting assembly comprises a connecting shell located on the outer wall of the bypass tube body, the bypass tube that is convenient for accurately controlling the depth of the side holes solves the problem that the existing drainage tubes cannot be adjusted according to the specific conditions of the patient due to their fixed length by extending the drainage tube, and avoids the problem that the drainage tubes of inappropriate length may lead to poor surgical results, or even require a second operation to replace the appropriate drainage tube.

The invention belongs to the field of biological medicine, and particularly relates to a medicine for treating EGFR mutation non-small cell lung cancer meningeal metastasis, application, a medicine box and a preparation method of the medicine, the medicine is a freeze-dried powder preparation or injection of EGFR-TKIs for subarachnoid space injection, the amount of EGFR-TKIs per person in the medicine is 0.01-5 mg, and the amount of EGFR-TKIs in the medicine is 0.01-5 mg. The injection method comprises any one of lumbar puncture, bridge forebay indwelling catheter injection and Ommaya capsule injection. The prepared EGFR-TKIs injection can be directly injected into the subarachnoid space, the drug concentration in cerebrospinal fluid of a patient is greatly improved, the cerebrospinal fluid / plasma concentration ratio of the EGFR-TKIs injection is increased from far less than 1 to more than 2 times and even can reach more than 10 times, and the EGFR-TKIs injection can completely solve the problem of insufficient dosage caused by a blood-brain barrier after oral administration of a targeted drug and has a good application prospect. The medicine takes effect quickly, and the treatment effect on lung cancer meningeal metastasis can be remarkably improved.

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

The utility model relates to the technical field of medical experiments, in particular to an auxiliary device for subarachnoid space injection or sampling, which comprises a spine clamping component and an indwelling hose detachably connected with the spine clamping component. The pipe penetrating through hole is used for allowing the indwelling hose to penetrate through. The device overcomes the defects that in the prior art, when cerebrospinal fluid is extracted from the subarachnoid space of a mouse or medicine is injected, mouse tissue needs to be cut open for multiple times, so that the experiment time and cost are increased, and the mouse is injured, and the device is arranged above the exposed spinal cord of the mouse, so that tissue adhesion can be effectively prevented; besides, injection or sampling operation can be directly performed through the indwelling hose, tissue does not need to be cut open again to expose the spinal cord, the experiment efficiency can be improved, and further damage to the mouse caused by multiple times of cutting open of the damaged part can be avoided.

This invention discloses a cerebrospinal fluid external filtration and dialysis device for the purification and treatment of cerebrospinal fluid in diseases such as central nervous system infections and subarachnoid hemorrhage. The device includes a dual-lumen drainage tube, comprising an outflow pipe and an inflow pipe. The outflow pipe is connected to the inlet of the filtration and dialyzer via a suction-side connecting pipe. The suction-side connecting pipe passes through a peristaltic pump and is equipped with a sampling pipe, on which a detachable timed sampler is mounted. The first outlet of the filtration and dialyzer is connected to a storage bag via a suction connecting pipe, and the second outlet is connected to the inflow pipe via a return connecting pipe. Pressure sensors are installed on both the suction-side and return connecting pipes, and a flow meter is installed on the return connecting pipe. These components form a feedback control loop with a control processor to adjust the pump speed and valve opening and closing, achieving safe and controllable flow and pressure. This device can filter / dialyze pathogens and inflammation-related substances in cerebrospinal fluid and return them, while simultaneously performing timed sampling for dynamic monitoring.

A method for the in vitro diagnosis of the risk of delayed cerebral ischemia (DCI) following subarachnoid hemorrhage from a ruptured aneurysm (aSAH) which includes the following steps: collection of a blood sample from the patient; quantitative determination of 8-iso-prostaglandin F2α (F2-IsoP) concentration in plasma; comparison of the concentration thereof in plasma with the reference value; collection of at least one further blood sample; quantitative determination of the concentration of endothelial nitric oxide synthase (eNOS) and / or nicotinamide adenine dinucleotide phosphate (NADPH) in plasma; comparison of the concentration thereof in plasma with the reference value; analysis of the obtained results and establishing diagnosis. A marker substance for the in vitro diagnosis of the risk of occurrence of DCI selected from 8-iso-prostaglandin F2α (F2-IsoP), endothelial nitric oxide synthase (eNOS), nicotinamide adenine dinucleotide phosphate (NADPH) and combinations thereof and the use thereof as a screening test for the in vitro diagnosis of DCI following aSAH.

The present invention provides a pharmaceutical composition, which is an aqueous solution containing Compound (I) (also known as U0126) or a pharmaceutically acceptable salt thereof at a concentration of 50-200 μM, further comprising 0.2-1.0% (v / v) polyoxyethylene castor oil. The composition is particularly useful in treating ischemic injury (particularly subarachnoid hemorrhage) in human patients by direct injection into the brain. Uses of the composition, unit doses containing the composition, and methods of using the composition are also disclosed. [Formula 1] TIFF2026501344000012.tif40159

The present invention provides a pharmaceutical composition which is an aqueous solution comprising Compound (I) (also known as U0126) or a pharmaceutically acceptable salt thereof at a concentration of 50 [mu] M to 200 [mu] M, and wherein the solution further comprises 0.2% to 1.0% (v / v) polyoxyethylated castor oil. The compositions are particularly useful for the treatment of ischemic injury, in particular subarachnoid hemorrhage, in human patients by direct injection into the brain. Uses of the compositions, unit doses containing the compositions and methods of using the compositions are also disclosed. # imgabs0 #

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

The embodiment of the invention provides a cerebrospinal fluid venous imbedding drainage device and an operation method thereof, and relates to the field of medical instruments. The cerebrospinal fluid venous imbedding drainage device comprises a drainage pump body, a ventricular drainage tube and a venous catheter. In the operation process, a power source can be provided by the drainage pump body, so that cerebrospinal fluid accumulated in the ventricle can be led out through the ventricle drainage tube and led into veins through the venous catheter for metabolism, and then the effects of treating cerebrospinal fluid accumulation, intracranial pressure rise, cognitive function decline and senile dementia caused by cerebrospinal fluid lesion are achieved. The traditional Chinese medicine composition can treat and improve the problems of intracranial hemorrhage, subarachnoid hemorrhage, other intracranial non-infectious inflammatory metabolites, immune complexes, intracranial hemorrhage, subarachnoid hemorrhage and the like, so that the traditional Chinese medicine composition can be used for treating long-term and repeated illness conditions, and the treatment effect is improved.