78 results about "Tissue biopsy" patented technology

The invention discloses an early diagnosis marker for B-cell lymphoma, a cross-species screening method based on lamprey and application, and relates to the technical field of molecular diagnosis. In the prior art, tissue biopsy is strong in invasiveness, and a traditional marker is low in early detection rate; in order to solve the problems that a large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large-scale large- When the expression quantity of the gene in a sample is greater than or equal to 1.8 times of that of a normal B cell (HMY2. CIR), the lymphoma is judged to be positive, and the minimally invasive early diagnosis efficiency is remarkably improved.

The invention concerns methods for predicting changes in a tissue, comprising obtaining snap shot information on individual cells of at least one cell type in a section of a tissue biopsy, wherein the information comprises: (i) spatial localization, (ii) cell type and (iii) cell division state at a specific point in time; calculating cell division probabilities for each of said individual cells; determining cell population dynamics based on the cell division probabilities and predicting future changes in the tissue based thereon. Particularly, the method concerns predicting tissue dynamics in cancer biopsies relevant for prognosis, and assessment of response to therapy.

The invention discloses a marker for predicting the curative effect of tumor immunotherapy as well as application and a detection method of the marker, and belongs to the technical field of biomedicine. The marker is glycerophosphorylcholine (GPC) in peripheral blood, and under the condition that the GPC level of peripheral plasma is low, it is judged that ICIs immunotherapy is poor in curative effect response. Peripheral blood samples are simple and noninvasive to obtain, longitudinal curative effect monitoring can be realized, the method is independent of tissue biopsy and is not influenced by tumor heterogeneity, the cost is reduced, and application is facilitated; meanwhile, peripheral blood not only objectively reflects the systematic immune state of a host, but also is closely related to tumor immunity as an important ring in a tumor immune cycle, and in the aspect of accuracy, the efficiency of a prediction model constructed by GPC reaches 0.886 and is remarkably higher than that of PDL1.

The invention discloses stomach wall tissue biopsy forceps under a laparoscope, and belongs to the technical field of medical instruments. The biopsy forceps aim at solving the problems that existing biopsy forceps are low in sampling efficiency and inconvenient in angle adjustment. The device comprises a fixed pipe and a rotating pipe, a first pull rod is slidably connected into the fixed pipe, a second pull rod is slidably connected into the rotating pipe, an extension column is integrally formed at one end of the second pull rod, a limiting ball is integrally formed at one end of the extension column, and a limiting groove matched with the extension column and the limiting ball is formed in one end of the first pull rod; a connecting part is arranged between the fixed pipe and the rotating pipe and is used for connecting the fixed pipe and the rotating pipe; biopsy forceps are installed at the end, away from the fixed tube, of the rotating tube, and the biopsy forceps and the rotating tube rotate through a connecting part. The driving part is arranged at one end of the fixing tube and used for driving the first pull rod to move, a plurality of samples can be taken through one-time insertion, angle adjustment is flexible, operation is labor-saving, and the device is used for stomach wall tissue sampling under a laparoscope.

The present application relates to the field of medical equipment, and in particular to an endoscopic imaging device, an imaging system, and a method thereof having a diagnostic imaging device. The device comprises: a diagnostic imaging device, an external control device, and an ingestible capsule endoscope. The external control device is used to control the position and / or posture of the capsule endoscope within a target area; the diagnostic imaging device is disposed within the capsule endoscope and is used to perform diagnostic imaging of the target area under the control of the external control device. The endoscopic imaging device and the imaging method thereof provided in the present application utilize a diagnostic imaging device to examine the target area without the need for a tissue biopsy, thereby not only improving the accuracy of the examination of the lesion area, but also reducing the risk of infection in the patient.

The utility model relates to the field of temporary storage devices, in particular to a pathological tissue biopsy temporary storage device. The utility model provides a pathological tissue biopsy temporary storage device which can eject pathological tissues out of a temporary storage cylinder and is convenient for workers to take. A pathological tissue biopsy temporary storage device comprises a temporary storage barrel, a first spring, a mounting frame and a storing and taking mechanism, the middle of the temporary storage barrel is slidably and rotatably connected with the mounting frame, the first spring is connected between the mounting frame and the temporary storage barrel through a gasket, and the storing and taking mechanism capable of fixing and rapidly taking pathological tissues is arranged on the mounting frame. When diseased tissue needs to be taken out, the limiting piece is pulled to move to be separated from the upper portion of the mounting frame, so that the first spring rebounds, the mounting frame is driven to move upwards, the diseased tissue moves upwards, and the effects that the diseased tissue can be ejected out of the temporary storage barrel, and workers can take the diseased tissue conveniently are achieved.

The utility model discloses a pair of multi-angle adjustable endoscopic biopsy forceps, and relates to the technical field of medical instruments, in particular to a pair of multi-angle adjustable endoscopic biopsy forceps which comprises a handle assembly, an inner sliding groove is formed in the middle of the handle assembly, and a rack buckle is arranged above the handle assembly. One side of the rack buckle is in sliding connection with a pliers movable traction block, the other side of the rack buckle is in sliding connection with a pliers rotating traction block, and a transition connecting sleeve is fixedly installed at the end of the handle assembly. According to the multi-angle adjustable endoscopic biopsy forceps, the front head bend, the rotating cylinder and the forceps mounting shaft are arranged in a matched mode, so that the multi-angle adjustable endoscopic biopsy forceps have the effects that the head end can independently rotate, tissue biopsy can be better carried out, and the efficiency is improved; therefore, the multi-angle adjustable endoscopic biopsy forceps have the effect of conveniently controlling the bending of the tail end of the biopsy forceps.

Provided herein, among other things, is a method of treating a cancer patient without the need for a tissue biopsy. In some embodiments, the method may comprise (a) performing or having performed a sequencing assay on cell-free DNA (cfDNA) from a sample of blood from the patient to determine if the cell-free DNA comprises actionable and / or non-actionable sequence variations in one or more target genes, and (b) treating the patient using the following method: i. administering a therapy that is targeted to an actionable sequence variation if the patient is identified as having the actionable sequence variation, and ii. administering a non-targeted therapy in the absence of any follow-up genetic testing on DNA extracted from a tissue biopsy if one or more non-actionable sequence variations and no actionable sequence variations are identified.

The invention relates to an application of maximum allele mutation abundance in prediction of a mismatch repair protein complete metastatic colorectal cancer immunotherapy effect. The invention particularly relates to application of the maximum allele mutation abundance and a reagent or system for detecting the maximum allele mutation abundance in preparation of a system for predicting the immunotherapy effect of the mismatch repair protein complete metastatic colorectal cancer. According to the method, the baseline ctDNA maxVAF is used as the immunotherapy curative effect prediction marker for the first time, the blank in the field is filled, clinical individualized treatment, use of a peripheral blood sample and calculation of the maximum allele mutation abundance of peripheral blood circulation are better guided, sample acquisition is convenient, invasive tissue biopsy is not needed, and patient acceptance is high.

Methods are provided for detecting gene deletions and driver mutations using tumor-specific methylation patterns from cell-free DNA and tissue biopsies. The methods exploit the mutual exclusivity between tumor-specific methylation and homozygous gene deletion, enabling detection through absence of expected methylation signals. Applications include detection of MTAP, PTEN, and RB1 deletions, as well as prediction of EGFR single nucleotide (SNV) and small (up to 50 base pair) insertions and deletions (indel) driver mutations, enabling identification of patients eligible for targeted therapies.

A novel portable, and attachable device allows precise positioning of micro-tissues, tumor spheroids, and other biological samples during bioprinting. The device features an interchangeable connector for handling samples of various sizes and uses a manually adjustable pressure system for suction and deposition. A programmable control unit coordinates pressure and positioning based on input commands, enhancing accuracy and consistency in tissue handling. Compatible with multiple bioprinter systems and supporting both manual and automated operation, it streamlines workflows and improves user experience. This device addresses challenges in high-throughput biological positioning, critical for tissue engineering, clinical, pharmaceutical, and research applications. It supports advancements in customized medicine, biological models, and environmental monitoring, meeting the growing demand for precise biologic handling in the multi-billion-dollar bioprinting and biopsy markets. The device offers superior control over tissue biopsy positioning compared to current manual devices reliant on operator skill.

The invention provides a nucleic acid aptamer specifically combined with endometriosis cells and application of the nucleic acid aptamer, and belongs to the technical field of biology. The nucleic acid aptamer capable of being specifically combined with the endometriosis cells is screened out through the Cell-SELEX technology with living cells as screening objects, and the nucleic acid aptamer has the advantages of being high in specificity, high in affinity, high in specificity, high in specificity and high in specificity. The probe can be used for early diagnosis of endometriosis, tissue biopsy, ectopic endometrial tissue excision guided by fluorescence, targeted drug development and the like.

The invention discloses a cardiovascular lesion tissue biopsy sampling device, and relates to the technical field of biopsy sampling, the cardiovascular lesion tissue biopsy sampling device comprises a cannula, a cannula body is fixed in the cannula, and the cannula and the cannula body are provided with gaps; the piston plate is arranged in the pipe body in a sliding mode, and a plurality of round holes are formed in the side wall of the piston plate; the sealing assembly is in sliding connection with the piston plate, and the sealing assembly is used for sealing the circular hole; and the supporting assembly is fixed in the pipe body, and the supporting assembly is connected with the piston plate. By means of movement of the piston plate and cooperation with work of the sealing assembly, negative pressure can be generated at the notch so that diseased tissue can enter the tube body through the notch, normal saline can be injected into the middle end of the tube body through the supporting assembly and the transmission assembly, the cut diseased tissue can be output out of the tube body, and therefore the diseased tissue can be conveniently cut. And the next sampling work can be carried out.

Various embodiments may relate to a tissue biopsy instrument according to various embodiments. The tissue biopsy instrument may include a hollow tube having a distal end portion and a proximal end portion. The tissue biopsy instrument may further include a cutting device held within a distal end portion of the hollow tube.

The invention provides a genome kit capable of identifying and diagnosing pulmonary nodules, which comprises the following steps: taking 21-gene panel as a molecular marker, detecting and calculating tumor mutation load of 21-gene in peripheral blood of a pulmonary nodule patient by adopting EV DNA in the peripheral blood, and calculating the tumor mutation load of 21-gene in the peripheral blood of the pulmonary nodule patient. A benign and malignant pulmonary nodule diagnosis scoring system is established by combining four clinical factors (gender, smoking condition, age and nodule diameter), and malignant pulmonary nodules are identified and diagnosed according to diagnosis scores. The 21-gene panel is used as the molecular marker for judging benign and malignant pulmonary nodules, and compared with CT and tissue biopsy, the 21-gene panel has more remarkable recognition and prediction value on malignant pulmonary nodules and has important guiding significance for judging the progression of tumors to invasive adenocarcinoma.

Methods for determining genomic variant clonality using multi-region sequencing assays and algorithms are described. For example, the methods can include receiving, at one or more processors, sequence read data for a sample obtained from a subject. The sequence read data is obtained from nucleic acid molecules (extracted, e.g., via needle punch) from a plurality of target regions within the sample (e.g., spatially distinct regions of a tissue biopsy sample). For each target region within the sample, a set of reads from the sequence read data associated with the respective target region is identified, then a presence of a candidate genomic variant within the target region is detected based on the set of reads. A total number of target regions in which the presence of the candidate genomic variant is compared to a first predetermined threshold. Based on the comparison, clonality of the candidate genomic variant is determined.

The present invention provides a method for detecting benign and malignant breast tumors and its application. Taking body fluid exosomes as samples, the present invention uses liquid chromatography tandem mass spectrometry to obtain the protein phenotypes of patients with benign and malignant breast tumors, establish a detection and / or prediction model for benign and malignant breast tumors based on proteomics, and provides a kit or chip for detecting benign and malignant tumors, as well as the application of protein markers for benign and malignant breast tumors in the preparation of the kit and / or chip. Compared with traditional detection methods such as tissue biopsy, the present invention has the characteristics of non-invasive and convenient detection, and can accurately distinguish whether the sample to be detected is a sample of benign or malignant breast tumor.

The utility model discloses an umbrella opening type pleura biopsy device, which relates to the field of pleura tissue biopsy, and comprises an inner sleeve, an annular groove, a needle cylinder groove and a hook-shaped groove which are distributed in the inner sleeve from top to bottom, and a push rod which is assembled in the inner sleeve in a sliding manner, through the designed limiting unit, fastening unit and sampling unit, in the process of obtaining a pleural tissue sample, the limiting unit is used for limiting the push rod and controlling the push rod to slide in the puncture needle, so that the sampling is more convenient; meanwhile, the to-be-sampled part and the biopsy device are stabilized under the action of the fastening unit, so that the instrument is prevented from shaking in the sampling process; and finally, under the action of the sampling unit, umbrella-shaped sampling can be performed on the sample, so that the condition that the sampling is incomplete or the sample is not taken is avoided, and great clinical significance is achieved.

The invention relates to a non-invasive vagina examination treatment device which comprises a handheld shell, a visual collection tube, a control bin and a flushing sleeve, an end mounting seat is arranged at the working end of the visual collection tube, a picture collection camera is arranged in the end mounting seat, an LED annular lamp is arranged on the peripheral side of the picture collection camera, and the LED annular lamp is connected with the visual collection tube. A flushing interlayer is formed between the flushing sleeve and the visual collection tube, and one of a secretion extraction assembly, a tissue biopsy extraction assembly, a foreign matter clamping assembly and a negative pressure suction assembly is arranged at the working end of the visual collection tube. The visual collection tube enters the vagina from the vaginal orifice of a patient to achieve real-time collection of images in the vagina, different operation assemblies are installed at the front end of the visual collection tube in a matched mode, secretion extraction, tissue biopsy extraction, foreign matter clamping and other operations are achieved, the diameter of the whole device does not exceed 0.7 cm, and the visual collection tube is used for collecting the images in the vagina. The principle of minimum invasion can be met as much as possible, and the discomfort of a patient is effectively reduced.

The application discloses a low-noise pneumatic air gun type biopsy needle convenient for single-hand loading, which comprises an inner needle, an outer needle, a connector, a mechanical valve, a firing mechanism, a loading mechanism, a needle cylinder, a needle cylinder shell, a first piston, a tension spring, a second piston and a compression spring. The inner needle is glued on the outer side of the front end of the needle cylinder, the outer needle is glued on one end of the connector and is sleeved on the outer side of the inner needle, and the other end of the connector is fixed with the elongated part of the second piston. The needle cylinder comprises a needle cylinder part one and a needle cylinder part two, and the needle cylinder and the needle cylinder shell are bonded into an integrated whole after being aligned. The second piston is fixedly connected with the compression spring and is located on the inner side of the front end of the needle cylinder, and the other end of the compression spring is sleeved on the protruding part on the inner side of the front end of the needle cylinder. The first piston is fixedly connected with the tension spring and is located on the inner side of the tail end of the needle cylinder, and the other end of the tension spring is bonded with the tail seat of the needle cylinder. The firing mechanism realizes button control of cutting and sampling of the outer needle. The loading mechanism realizes button control of returning and loading of the outer needle. The application reduces the dependence of surgical operation on the experience of doctors, reduces the noise generated in the surgical process, avoids the body displacement of patients due to the noise, improves the precision of tissue biopsy surgery, can realize single-hand operation and improves the convenience of surgical operation.

The invention relates to the technical field of biological medicine, in particular to application of an lnc81 related reagent in ovarian function impairment related products. The invention provides an application of an lnc81 related reagent in ovarian function impairment related products, and provides a new biomarker for detecting ovarian function impairment, the biomarker is lnc81, and by using the marker, the false positive risk can be reduced, the detection accuracy is improved, the trauma of tissue biopsy is avoided, and the risk of ovarian function impairment is reduced. The method is suitable for dynamically monitoring curative effect or relapse.

Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

The invention relates to devices and methods for depth-selective tissue biopsy and segregation, tubular stricture dilation, mucosal ablation and resurfacing, and clinical agent administration using balloon devices, including devices for selective access to different depths of a target tissue.

The invention relates to the field of medical treatment, in particular to a multifunctional tumor tissue biopsy sampler which comprises a shell, an inner sleeve is fixedly welded in the shell, a cavity is formed in the inner sleeve and filled with glycerol, and a sampling mechanism capable of cutting and sampling tumor tissue is fixedly mounted between the inner sleeve and the shell. A detection mechanism capable of detecting a sampled sample is fixedly installed between the upper end of the shell and the inner wall of the inner sleeve, two handles are fixedly connected to the outer wall of the shell through bolts, glycerin penetrates through a circular ring opening, a matching ring abuts against the inner wall of the circular ring opening after a movable circular ring stops, and the movable circular ring is reset after sampling. The movable sleeve is pushed by glycerol to slowly move upwards, the observation piece is driven by the pull rope to lengthen the corrugated sleeve, the tumor tissue is adsorbed into the corrugated sleeve by negative pressure generated inside, and after the tumor tissue is soaked in a 1% methylrosanilinium solution, medical staff can quickly judge whether the sample contains a tumor cell dense area or not according to the staining difference on the surface of the tissue, so that the diagnosis time is shortened.

The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to medical systems and methods configured to shield the sharpened distal end of needles, such as exchangeable biopsy needles. The biopsy needles may be used for tissue biopsy and sampling under radial ultrasound guidance.

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and / or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device / component delivery / insertion / implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

The invention discloses a kit for detecting circulating tumor DNA (deoxyribonucleic acid) of portal vein and branch vein blood of portal vein. The kit comprises: a nucleic acid extraction assembly comprising an optimized lysate and selectively bound magnetic beads; the library construction component comprises a terminal repair / tailing fusion enzyme and a Y-shaped linker with a molecular identifier; the targeted enrichment assembly comprises a specific primer group and a probe group and is used for enriching related gene targets of the abdominal organ tumors; and necessary reaction components. Through an optimized nucleic acid extraction method, an efficient library construction system and a precise targeted enrichment technology, high-sensitivity detection of low-abundance ctDNA in portal venous blood is achieved, and the lower detection limit reaches 0.1% of mutation allele frequency. The kit is particularly suitable for early diagnosis, curative effect monitoring and prognosis evaluation of abdominal organ tumors such as intestinal cancer, liver cancer and pancreatic cancer.

The application discloses a kind of methylation liquid biopsy model construction method and system of tuberculous granuloma and lung cancer based on multi-omics sequencing.Use the DNA and RNA data extracted from ex vivo lung tissue sample sequencing and combine blood data screening analysis to obtain methylation DNA data, then use machine learning classification model independent training to obtain methylation liquid biopsy model;System contains gene extraction equipment, second-generation high-throughput sequencer, blood testing equipment and computer, computer will be off data and blood data together into computer comprehensive screening to obtain methylation DNA data, then construct model and predict to obtain the biopsy result of tuberculous granuloma and lung cancer.The application can realize the high-precision, non-invasive detection of tuberculous granuloma and lung cancer, can be flexibly selected according to specific needs, has the stability and reliability characteristics of marker, avoids the invasive risk of tissue biopsy, has wide applicability, and has important application value.

The invention relates to the field of medical technical equipment, in particular to a puncture needle for muscular tissue biopsy, and aims to solve the problem that an existing device cannot meet the requirements of transverse and longitudinal puncture paths at the same time, the puncture needle comprises a needle shell, and further comprises a longitudinal sampling mechanism and a transverse sampling mechanism; the longitudinal sampling mechanism is slidably arranged at one end of the needle shell and used for obtaining tissue samples in the needle entering direction. The transverse sampling mechanism is movably arranged in the radial direction of the needle shell, and one end of the transverse sampling mechanism penetrates through the needle shell and is used for obtaining tissue samples in the direction perpendicular to the needle entering direction. Longitudinal sampling and transverse sampling can be achieved at the same time in the one-time puncture process of a diseased region, multi-point sampling is needed in some diseased regions due to heterogeneity, complex conditions of the diseased regions can be reflected more comprehensively, meanwhile, the puncture frequency is reduced, and discomfort of a patient is reduced. The transverse sampling enables the detection of the sample to be more comprehensive and three-dimensional, and the accuracy and reliability of tissue biopsy are further improved.

The utility model relates to the technical field of tissue biopsy forceps, in particular to portable tissue biopsy forceps which comprise a base, the top of the base is fixedly connected with the bottom of a positioning piece, the positioning piece comprises a positioning block, a reset spring, a sliding rod and a clamping block, and the outer wall of the positioning piece is movably connected with the inner wall of an adjusting piece in an inserted mode. The adjusting part is composed of an adjusting column, a mounting block, a rotating block, a mounting bin, a clamping plate and a display screen, the inner wall of the base is movably connected with the outer wall of the endoscopic part in an inserted mode, the inner wall of the base is movably connected with the outer wall of the sampling part in an inserted mode, the anti-falling cap is taken down from one side of the fixing block, and the endoscope and the sampling pipe are taken out from the endoscopic pipe and the fixing pipe respectively. And a sliding rod is pushed to pull out a clamping block from an adjusting column, so that people can take out the adjusting column from a positioning block, and a clamping rod is rotated to control a movable plate to be separated from the outer wall of the display screen, so that the device is disassembled, and convenience is brought to carry-on and sterilization and disinfection work of people.