122 results about "Microtome" patented technology

A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.

The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.

A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.

The invention relates to a device and a method for detecting the retention performance of a liquid-phase solute of articular cartilage. The method comprises the following steps: adhering and fixing a treated cartilage on a perforated rubber plug; the cartilage pasted with the rubber plug is placed in a retention device with a perforated plate at the bottom, and water is added till the cartilage completely exceeds an overflow opening; the retention pressing rod provided with the rubber plug is pressed into the retention device, and whether liquid leakage exists or not is detected in advance; discharging the water, adding a solution required by a retention experiment, and pressing the retention pressure rod again; the retention device is arranged in the cylindrical base, and the screws on the two sides are fastened; the base of the device is fixed on a lower disc of a testing machine; a retention compression bar of the device is fixed on an upper disc of a testing machine; and setting expected pressure and time, starting to load experimental pressure, and then starting a cartilage retention experiment. And after the retention experiment is finished, observing the retention state of the fluorescent solute molecules by using a slicing machine and a laser confocal microscope. The cartilage liquid phase solute retention performance is effectively detected, the problem that sealing performance is difficult in a retention experiment is solved, a cartilage mass transfer research method is expanded, and the detection precision and stability are improved. The method is expected to be popularized to become a standard test technology of cartilage retention performance, and plays a positive role in promoting cartilage in-vitro experiments.

A method for positioning an article in a slicing machine having a discharge unit includes detecting actual position of the article on the discharge unit by an optical unit data-connected with a control of the slicing machine, automatically comparing the actual position with a predetermined target position by the control, and in the event of a discrepancy above a predetermined acceptance value, automatically displacing the article to the target position by a part of the discharge unit on which the article rests. A transverse position of the article is changed by moving a displacement belt of the discharge unit, and a rotational position of the article is changed by driving parts of the belt at different speeds. The displacement belt is a belt conveyor with belts controllable individually and independently of one another regarding running speed and / or deflecting pulleys displaceable individually and independently of one another in a transverse direction.

The invention provides a frozen section method for space transcriptomics analysis of mesentery and regenerative intestinal tract of stichopus japonicus, and belongs to the technical field of biotechnology. The method comprises the steps of sample treatment and embedding, pre-cooling by a freezing slicer, freezing and slicing, and flaking. According to the frozen section method for space transcriptome analysis of the mesentery and the regenerative intestinal tract of the stichopus japonicus, provided by the invention, a fresh material is directly embedded, and a plurality of thin tissue blocks with the same size are integrated into a standard tissue block of 1cm, so that the high coverage rate of a tissue cross section in a space transcriptome chip capture area is ensured; rNA degradation is effectively prevented, and finally, the cDNA library is successfully constructed and is used for subsequent analysis of a space transcriptome. The technical scheme has the characteristics of simplicity and convenience in operation and stable effect, and is particularly suitable for space transcriptomics frozen section preparation of thin film type tissues.

The present invention relates to an apparatus (10) configured and adapted to remove the flank bones (11) of a headless, slaughtered, preferably opened abdominal cavity fish (12), wherein the fish is conveyed in a conveying direction T with its tail forward and its spine (13) placed on a conveying saddle (14), the apparatus comprising at least: an upper bone guide (15) configured and adapted to guide the spine (13) from the dorsal side of the fish (12) to be processed; and a lower bone guide (16) configured and adapted to guide the ventral radii (44) of the fish (12) to be processed, the ventral radii being formed in the region from the tail to the abdominal cavity. The invention relates to a separation unit (17) for detaching fillets from the flank bones (11) surrounding the abdominal cavity of the fish (12) to be processed, wherein the separation unit (17) includes a separation mechanism (18) having a corresponding opposing unit (19) and capable of moving from a standby position to a working position and vice versa. The device (10) is characterized in that a detachment device (20) is located within the area of ​​the upper bone guide (15) and is configured and adapted to at least loosen the bone connections (21) between the individual flank bones (11) and the vertebrae (13) of at least some of the flank bones (11). The invention also relates to a corresponding slicer (40) having such a device (10) and a corresponding method.

The invention discloses a small-size biological sample laser slicing device and a laser slicing method, and belongs to the technical field of biological sample preparation. The laser slicing device comprises an ultrafast laser, a laser beam motion control assembly, a lens and a sample cabin, the sample cabin is a container which is composed of a frame and a replaceable transparent plastic or glass cabin wall and provided with an opening in the upper end, a small-size biological sample is fixed in the sample cabin, a matching medium needs to be added into a living body sample, and the matching medium is matched with the sample. And performing micro-damage cutting on the sample by using Gaussian light or Bessel light. According to the invention, laser is used for cutting the sample, so that the sample is not extruded and pulled during slicing, and the sample is not stuck and curled on the cutting blade, so that the experiment and sample loss are reduced, and the experiment efficiency and success rate are improved; the slicing machine is matched with a stereoscope for use, so that the dependence of a traditional slicing machine on the eyesight of operators can be relieved.

To improve sample cutting devices such as a microtome.SOLUTION: A device for cutting slicing a slice of a sample comprises: a sample holder configured to hold the sample to be cut and to move the sample in one or more directions; and a blade holder configured to move one blade in multiple directions to cut a sample. The device is configured or may be configured to move the sample holder relative to the blade holder in a first motion including a phase in which the sample is cut by the blade, and in a second motion including a retraction phase in which the sample holder moves away from and / or toward the blade. The two motions are performed to cut the sample in a predetermined direction, and the device shows whether or not it is in a retraction phase.SELECTED DRAWING: Figure 1

The invention relates to a following type slicing machine and a slicing method, the following type slicing machine comprises a conveying device and a cutting-off device, and further comprises a synchronous driving device, a position detecting device and a control system, the conveying device comprises a first conveying channel, a second conveying channel and a cutting-off station; a cutter of the cutting-off device is located above the second conveying channel, the cutter linearly moves up and down in the Z direction perpendicular to the X direction, and the synchronous driving device is connected with the cutting-off device and can drive the cutting-off device to linearly move back and forth in the X direction; the position detection device is in communication connection with the control system and comprises a detection light generator arranged on the side edge of the first conveying channel, the detection light generator can emit detection light rays towards the first conveying channel, the detection light rays emitted by the detection light generator are perpendicular to the X direction, and the detection light rays are smaller than the thickness of the cutter; and the control system is in control connection with the cutting device and the synchronous driving device.

The utility model discloses a slicer tool apron structure which comprises a tool apron, a plurality of evenly-distributed installation holes are formed in the tool apron, an installation base is fixedly installed in the tool apron through bolts, the top of the installation base is fixedly connected with a tool rest, the top of the tool rest is fixedly connected with a hydraulic cylinder, and the hydraulic cylinder is fixedly connected with the tool rest. The output end of the hydraulic cylinder is slidably connected with the tool rest, and the lower end of the output end of the hydraulic cylinder is fixedly connected with a connecting base. Through the design of the hydraulic cylinder, the output end of the hydraulic cylinder can drive the connecting base and the cutter to move, materials can be sliced through the contact of the cutter and the materials, and the relative positions of the cutter and the connecting base can be fixed under the insertion matching of the balls in the cutter and the grooves in the connecting base. And by moving the cutters, the balls are matched with the grooves in different positions in an inserted mode, the distance between the cutters can be adjusted, and the thickness of the slices can be adjusted conveniently.

An ultra-thin microtome (100, 1202) chuck includes a mounting portion (204) having mating surfaces (1406, 1606) operable to removably attach the mounting portion (204) to a sample (116, 126) slicing device (1100), and electrical contacts operable to electrically connect the mounting portion (204) to a power source; a sample receiving portion (202, 204, 210) coupled to the mounting portion (204), the sample receiving portion (202, 204, 210) having a sample receiving surface (206) sized to receive a sample (116, 126); a light source (1120, 116) coupled to the sample receiving portion (202, 204, 210), the light source (1120, 116) being operable to emit light from the sample receiving surface (206) and through a sample (116, 126) positioned along the sample receiving surface (206); and a circuit (516, 616) that electrically connects the light source (1120, 116) to the electrical contacts of the mounting portion (204).

A kind of device for the automatic screening of slicer powder, comprising a machine body shell, a roller, a blade, a screen and a transmission device. The transmission device in the machine body shell drives the rotation of the roller, the material enters from the top feed port, is cut by the blade, the powder is recycled to the bottom of the roller through the screen and the guide plate, and the sheet material is discharged through the discharge cylinder. The screen adopts a coaxial rotating structure of upper and lower screen plates, and the size of the screen hole is adjusted by the rotating shaft knob to adapt to the screening needs of different materials. The blade is connected to the roller shaft through the blade holder rod, and the contact angle with the roller can be adjusted. The device realizes automatic powder discharge through the inclined design of the slope plate screen, without manual intervention in the screening process. The utility model solves the problems of low efficiency and serious material waste in traditional manual separation of slicer powder, has the advantages of compact structure, adjustable screening precision, high automation degree, high material recycling rate, etc. and can be widely used in the slicing production of chemical industry, food industry and other fields.

It was difficult to create a thin bio sample embedded in an embedding material without using an expensive microtome. The present invention provides a medical device having a space for assisting in the embedding of a bio sample in an embedding material, the medical device being provided with a cover part and a base part having a recessed section in which the space is created by covering the cover part, wherein the base part is provided with a flow passage having an inlet section that is in fluid communication with the space, and the flow passage is configured such that when a force is applied to the medical device so that the volume of the space decreases, the embedding material flows out while preventing a positional misalignment of the bio sample inside the embedding material.

The utility model discloses a vertical turntable slicing machine which comprises a working table, a material frame, a cutter rest disc, a cutter, a rotary driving structure and a material pressing mechanism, and a blanking hole is formed in the working table; the material frame is arranged on the workbench, and a discharging opening communicating with an inner cavity of the material frame is formed in one side wall of the material frame. The tool rest disc faces the face and is spaced from the material frame, the lower portion of the tool rest disc is located in the blanking hole, and a plurality of cutting holes penetrating front and back are formed in the tool rest disc in the circumferential direction in an array mode; the number of the cutters is multiple, each cutter is installed in the corresponding cutting hole, the cutting edge of each cutter is exposed out of the corresponding cutting hole in the direction close to the material frame, and when the cutter rest disc rotates, each cutter can sequentially sweep over the right front of the corresponding cutting hole; the rotation driving structure is connected with the tool rest disc and used for driving the tool rest disc to rotate. The material pressing mechanism is connected with the material frame and used for tightly pressing the blocky medicinal materials in the material frame on the knife rest disc in a clearance mode. According to the vertical rotary table slicing machine, industrial injuries can be reduced, meanwhile, the production efficiency is improved, and the slicing consistency can be improved.

The utility model relates to the technical field of calibration and positioning devices, in particular to a paraffin section calibration and positioning device which comprises a frame, a plurality of connecting rods, a gradienter and two clamping assemblies. The clamping assembly comprises a side plate, a spring, a pull block, a guide rod and a clamping plate; when the paraffin slicing machine is used, the two clamping assemblies are used for clamping the frame on the sample clamp, a doctor obtains the position A of the bubble by observing the position of the bubble on the gradienter so as to obtain the position of the transverse axis and the position of the longitudinal axis of the sample clamp, and when slicing is needed on another paraffin slicing machine, the frame can be clamped on the sample clamp on the other paraffin slicing machine, so that the paraffin slicing machine is convenient to use. The positions of the sample clamps are adjusted until the bubble position on the gradienter moves to the position A, at the moment, it can be guaranteed that the positions of the two sample clamps are consistent, the angle tangent planes of the sample clamps of all the paraffin slicing machines can be kept consistent, and waste of materials due to incomplete tangent planes of paraffin blocks is avoided.

A real-time coaxial focusing system disclosed by the present invention comprises a slicing mechanism and a stabilizing structure, the slicing mechanism is composed of a vertical plate, a reference table, a blade, a solution tank, a connecting pipe and a lifting screw rod, the slicing mechanism is used for slicing a sample and providing a solution required by sample observation, the vertical plate is fixedly connected with the solution tank, and the stabilizing structure is fixedly connected with the vertical plate. The blade is in threaded connection with the lifting lead screw, the stabilizing mechanism is composed of a reflective mirror, a compressed air tank, a supporting leg, a supporting leg air pipe, a pneumatic clamp and a pneumatic branch pipe, the stabilizing mechanism is used for preventing the reflective mirror from deflecting, and the reflective mirror is rotationally connected with the reference table. By arranging the slicing mechanism, the device can control the thickness of a sample sliced by a blade by rotating a lifting screw rod, so that the device avoids the problem that imaging is affected due to the fact that the thickness of the sample sliced by other devices of the same kind cannot be controlled.

To provide a plurality of imaging and processing modalities to characterize sectioned tissue samples.SOLUTION: A preferred embodiment includes the following four main elements: (1) a vibrating knife microtome 64 capable of sectioning a thin (10 to 1,000 micron) slice from a tissue embedded in a tissue block, for example an agar block; (2) a suction manifold 110 capable of drawing buffer liquid with an equipped pump and refluxing it in a buffer tank, in which fluid force attracting the tissue slice 120 is generated by sucking buffer; (3) a material for transfer such as a porous conveyor belt 114, a tape, or a flexible material for transferring samples being driven around the suction manifold, the manifold operating like a pulley to change a moving direction of a conveying material or a belt; and (4) a collection station where tissue slices are placed.SELECTED DRAWING: Figure 4E

The invention discloses a preparation method of an addressable disc ultramicro electrode array for electrochemical imaging, which comprises the following steps of: 1, preparing a nanowire array by using an ultrathin slicing machine as processing equipment and a silicon wafer with a micron groove array structure as a template; 2, transferring the nanowire array to a silicon wafer, performing three-dimensional alignment on a molybdenum mask plate with a lead pattern and the nanowire array, and realizing lap joint of a lead and the nanowire array and preparation of the lead by combining a physical vapor deposition method; 3, resin is poured on the silicon wafer for normal-temperature curing, and the pattern is transferred to the resin; 4, macroscopic wire lap joint and packaging are carried out, a resin block with an embedded array structure is obtained, the end face is trimmed through an ultra-thin slicing machine, the dot array is exposed, and preparation of the addressable disc ultramicro electrode array is completed. According to the method, the addressable disc ultramicro electrode array which is high in consistency, high in spatial resolution and capable of being expanded at will can be prepared simply and efficiently at low cost.

A first aspect of the invention relates to a microtome comprising: one or more motor drives for moving a sample and for moving a knife, and comprising a user interface, the microtome being arranged to: acquire a position of the sample; collecting the position of the knife; obtaining adjustment information about the sample; adjusting information about the cutter is obtained; the microtome is tuned based on the acquired location, the tuning information, and the user interface command.

The utility model relates to the technical field of cutting equipment, in particular to a deviation rectifying device and a slicing machine. The utility model provides a deviation rectifying device. The deviation rectifying device comprises a wire arranging wheel, a wire winding roller, a first detector and a second detector. The wire arranging wheel is located above the wire winding roller, and the wire arranging wheel can be driven by the driving mechanism to do parallel reciprocating motion in the axial direction of the wire winding roller; when a diamond wire between the wire arranging wheel and the winding roller vertically sweeps through an induction area of the second detector, the position, detected by the first detector, of the wire arranging wheel is a calibration position P1, and in the running process of the wire arranging wheel, every time when the diamond wire between the wire arranging wheel and the winding roller sweeps through the second detector, the position, detected by the first detector, of the wire arranging wheel is a real-time position P2; by comparing the positions of P2 and P1, the inclined pulling information, the inclined pulling direction and the inclined pulling inclination amount of the diamond wire between the wire arranging wheel and the wire winding roller can be obtained, then the driving mechanism is controlled to drive the wire arranging wheel to transversely move in real time to eliminate inclined pulling, and real-time automatic deviation correction of the diamond wire is achieved.

The utility model relates to the technical field of linear cutting, in particular to a slicing machine and a feeding and discharging device thereof, and the feeding and discharging device comprises a transfer trolley, a feeding device and a discharging device, the conveying robot can be connected with the transfer trolley; the first end of the channel assembly can be connected with the slicing machine; and the conveying robot is provided with a second driving part, and the second driving part can drive the transfer trolley to at least reach the second end of the channel assembly. By means of the structure, the transfer trolley carrying the workpieces can be conveyed to the channel assembly through cooperation of the conveying robot and the transfer trolley, and therefore feeding work of the workpieces can be reliably achieved.

1. Name of the designed product: slicer. 2. Use of the designed product: for cutting meat. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The present invention belongs to the field of experimental instruments, and specifically provides an ultramicrotome and its knife table. The present invention aims to solve the problem that the section cut by the existing ultramicrotome has a short stroke and cannot meet the scientific research needs. To this end, the knife table of the present invention includes a knife table base fixedly connected to the base of the ultramicrotome, a knife table body slidably connected to the knife table base, a piezoelectric ceramic sheet provided on the knife table body, and a knife holder connected to the knife table body. Among them, when the piezoelectric ceramic sheet is energized, it can generate a deformation of 1 mm, and when the piezoelectric ceramic sheet is energized, it can drive the knife holder and the cutting tool mounted on the knife holder to move towards the sample arm and cut the sample on the sample arm. The section cut by the ultramicrotome with the above knife table of the present invention can reach 1 mm, meeting the needs of scientific research personnel.

A first aspect of this disclosure relates to a method for operating a microtome (100, 200) for a cutting process, the microtome (100, 200) having a knife (112) with a cutting edge (114) and having a sample (122) on a sample holder (120); said method comprising the following steps: - determining a light gap (300) which is defined in some sections by the cutting edge (114) and the sample (122), and - orienting the knife (112) and / or the sample (122) such that the light gap (300) has a predefined structure.

1. Name of the product of this design: Slicer (EP1406‑GS). 2. Purpose of the product of this design: used for cutting food. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

1. Name of the designed product: slicing machine (pole piece transfer coating). 2. Use of the designed product: for coating slicing machine. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The utility model belongs to the technical field of medical apparatus and instruments, concretely relates to a big organization embedding box suitable for the chuck of slicing machine, including standard embedding box, connecting portion and cross shape retention frame, the inside of connecting portion is the cavity that passes through up and down, and the cross section size of connecting portion is not greater than the cross section size of standard embedding box, cross shape retention frame is cross shape structure, and cross shape retention frame is openwork structure, the center of cross shape retention frame is connected standard embedding box through connecting portion, cross shape retention frame and standard embedding box are parallelly arranged, and the projection of standard embedding box towards cross shape retention frame all is located on cross shape retention frame. Compared with the prior art, the utility model solves the prior art in big organization embedding after slicing needs to cooperate the special specification slicing machine chuck, and easily holds too tight or too loose and leads to big wax block fragmentation. The scheme can adapt to the slicing chuck of uniform standard paraffin slicing machine, and simple operation does not exist and holds big wax block too tight or too loose and so on problem.

The present invention relates to a cutting operation device (200) for a microtome, the cutting operation device (200) having one of a knife holder and a sample holder (202), the cutting operation device (200) having a position adjustment mechanism (210) capable of moving one of the knife holder and the sample holder (202) in a return operation (R), the cutting operation device (200) having an additional position adjustment device (220) different from the position adjustment mechanism (210), and the cutting operation device (200) being configured so that the additional position adjustment device (220) allows the position adjustment mechanism (210) to at least partially perform the return operation (R). The present invention also relates to a microtome and a method for a microtome.