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Moxifloxacin oral preparation and preparation method thereof

A technology of moxifloxacin and preparations, applied in the field of moxifloxacin oral preparations and its preparation, can solve the problems of high cost and expensive lactose, and achieve the effects of easy purchase, good stability and cheap excipients

Active Publication Date: 2010-11-24
JIANGSU YABANG QIANGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the price of lactose is more expensive, and the cost of preparing moxifloxacin oral preparations according to the prescription of patent ZL99813124.5 is higher

Method used

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  • Moxifloxacin oral preparation and preparation method thereof
  • Moxifloxacin oral preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: (tablet is calculated on the basis of uncoated)

[0041] Moxifloxacin hydrochloride 437.9mg

[0042] Soluble starch 20.0mg

[0043] Pregelatinized starch 10.0mg

[0044] Microcrystalline Cellulose 160.0mg

[0045] Croscarmellose Sodium 25.0mg

[0046] Magnesium stearate 13.8mg

Embodiment 2

[0047] Embodiment 2: (tablet is calculated on the basis of uncoated)

[0048] Moxifloxacin hydrochloride 437.9mg

[0049] Soluble starch 35.0mg

[0050] Pregelatinized starch 15.0mg

[0051] Microcrystalline Cellulose 145.0mg

[0052] Croscarmellose Sodium 25.0mg

[0053] Magnesium Stearate 13.2mg

Embodiment 3

[0054] Embodiment 3: (tablet is calculated on the basis of uncoated)

[0055] Moxifloxacin hydrochloride 437.9mg

[0056] Soluble starch 45.0mg

[0057] Pregelatinized starch 45.0mg

[0058] Microcrystalline Cellulose 95.0mg

[0059] Croscarmellose Sodium 25.0mg

[0060] Magnesium Stearate 13.2mg

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PUM

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Abstract

The invention relates to an oral pharmaceutical preparation containing moxifloxacin, salts and / or hydrates of the moxifloxacin, soluble starch and pregelatinized starch. The preparation is characterized by containing 2.9%-14.5% of soluble starch and 1.4%-6.5% of pregelatinized starch, wherein all percents are calculated on the basis of the weight of the pharmaceutical preparation. The invention also relates to a preparation method of the preparation and an application of the preparation for treating or preventing bacterial infection of people or animals.

Description

technical field [0001] The invention relates to an oral pharmaceutical preparation containing moxifloxacin, its salt and / or hydrate, soluble starch and pregelatinized starch and a preparation method thereof. Background technique [0002] Moxifloxacin (moxifloxacin) is a new generation of fluoroquinolone antibacterial drugs, which has the advantages of broad antibacterial spectrum, strong antibacterial activity, and small toxic and side effects. It can be used to prevent or treat bacterial infections in humans or animals, such as upper and lower respiratory tract infections and skin infections. and soft tissue infections. The chemical name of moxifloxacin is: 1-cyclopropyl-7-[(S,S)-2,8-diazo-bicyclo[4.3.0]non-8-yl]-6-fluoro-1, 4-Dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid, the chemical structure is as follows: [0003] [0004] Bayer Company has described in Chinese patent (patent No. ZL89104574.0) containing moxifloxacin or its salt, microcrystalline cellulose, c...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/38A61K9/20A61K9/48A61K31/4709A61P31/04
Inventor 陈再新赵晓红葛育红孙海棠谢瑞丽毛白杨
Owner JIANGSU YABANG QIANGSHENG PHARMA
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