7 results about "Moxifloxacin" patented technology

The invention relates to a method for detecting six second-line antituberculous drugs by high performance liquid chromatography. The method comprises the following steps: providing an internal standard stock solution and a standard stock solution of six second-line antituberculosis drugs; preparing an internal standard working solution and a standard curve working solution by utilizing the diluent; preparing a solution of a product to be detected by using the Tianlongitudinal sample extraction liquid TZ-002; a liquid chromatograph is used for detection, and the conditions are as follows: a mobile phase A is a Tianlongitudinal sample releasing agent TZ-D004; a mobile phase B is acetonitrile; a mobile phase C is water; and gradient elution. According to the method, the plasma concentration of the second-line antituberculous drug taken by a tuberculosis patient is measured by applying the reversed-phase high-performance liquid chromatography, the cost is relatively low, the analysis time is short, the sensitivity is high, and the accuracy is high. The kit can be used for simultaneously detecting the blood concentration of six second-line antituberculosis drugs such as isopropylthioamide, levofloxacin, linezolid, moxifloxacin, deramanib and bedaquiline in human serum, and is expected to provide a more reliable basis for clinicians to adjust the dosage of the antituberculosis drugs.

The invention discloses a sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst and a preparation method and application thereof.The sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst is a sulfur-doped cobalt cerium composite oxide, and in the sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst, the Co element content is 20-24 wt%, the Ce element content is 50-56 wt%, the O element content is 20-22 wt%, and the balance is a carrier. The content of the S element is 1-4 wt%. According to the sulfur-doped bimetallic cobalt cerium oxide Fenton-like catalyst disclosed by the invention, peroxyacetic acid is activated to generate organic oxygen free radicals, and 90.5% of moxifloxacin can be degraded within 15 minutes; and the composite material has a good degradation effect on pollutants of polycyclic aromatic compounds such as ofloxacin, gatifloxacin, norfloxacin, tetracycline, o-nitrophenol, naproxen and the like.

The invention discloses a moxifloxacin hapten, antigen and antibody as well as a preparation method and application thereof, and belongs to the technical field of small molecule immunodetection.The moxifloxacin hapten, antigen and antibody are obtained by introducing an alkyl connecting arm-(CH2) n-NH2 with a specific length to a secondary amino group, away from a quinolone mother nucleus, of moxifloxacin, according to the present invention, the carbostyril is introduced into the molecule so as to endow the molecule with chemical operability on the premise of not disturbing the pharmacophore of the quinolone mother nucleus, such that the molecule can efficiently couple the carrier protein and induce the generation of the high affinity and high specificity antibody so as to finally construct the immunodetection system suitable for the treatment drug monitoring and the bedside instant detection scene;

This invention discloses the application of *Gastrococcus xanthophylloides* in regulating intestinal bile acid metabolism disorders, including *Gastrococcus xanthophylloides* (… Ruminococcus flavefaciens The application of this invention in the preparation of compositions for regulating intestinal bile acid metabolism disorders, wherein the compositions promote the conversion of primary bile acids to secondary bile acids, wherein the primary bile acids include cholic acid and chenodeoxycholic acid, and the secondary bile acids include deoxycholic acid and lithocholic acid; wherein the intestinal bile acid metabolism disorders include metabolic disorders caused by antibiotics, wherein the antibiotics include one or more of moxifloxacin and metronidazole; wherein the compositions can be health products, pharmaceuticals, or feed; and wherein the active ingredient of the compositions includes xanthospirococcus flavus.

The invention discloses a moxifloxacin nano drug delivery system as well as a preparation method and application thereof, and the moxifloxacin-loaded infected microenvironment lipase response nano drug delivery system is constructed on the basis of a comprehensive strategy of drug-assistant synergistic sensitization and antibiosis, improvement of permeability of a bacterial outer membrane, inhibition of activity of a bacterial efflux pump and removal of a biofilm. The sensitivity of moxifloxacin to multi-drug-resistant pseudomonas aeruginosa is enhanced, the pathogenicity of bacteria is reduced, and the risks of infection recurrence and drug resistance are reduced while the infection clearance rate is increased. And the antibiotic adjuvant adopts natural biodegradable epsilon-polylysine, so that the side effect of lung inhalation is reduced, and the biological safety of the nano-drug delivery system is improved.

The application relates to a high-activity electrode and a preparation method thereof and application of the electrode in sewage treatment. The preparation method is as follows: Sn source, Sb source and Tb source are configured into a mixed solution, the Tb-Sn-Sb sol is obtained after ultrasonic treatment and standing and aging, the Tb-Sn-Sb sol is uniformly coated on the surface of an electrode substrate, and the high-activity titanium-based tin dioxide-antimony electrode is prepared through heat treatment at a specific temperature. The application finds that, for the first time, the rare earth element Tb is doped in the Ti / SnO2-Sb electrode, the conductivity of the Ti / SnO2-Sb electrode can be greatly improved, and the treatment capacity of the Ti / SnO2-Sb electrode for wastewater containing organic pollutants can be greatly improved. The removal rate of the Ti / SnO2-Sb-Tb electrode for moxifloxacin reaches more than 84%, while the removal rate of the conventional Ti / SnO2-Sb electrode for moxifloxacin is only 58.4%, and the removal rate of the Ti / SnO2-Sb-Ho electrode doped with other rare earth elements for moxifloxacin is 74.1%, which further shows that the doping of the rare earth element Tb in the Ti / SnO2-Sb electrode can greatly improve the treatment capacity of the electrode for wastewater containing organic pollutants.

The application discloses a colorimetric copper ion fluorescent probe and synthesis and application thereof, which has a fluorophore and a copper ion recognition group, wherein the copper ion recognition group is one of commercial drugs of norfloxacin, levofloxacin, moxifloxacin and gatifloxacin. The copper ion fluorescent probe can be used for qualitative and colorimetric detection of copper ions, and is especially used in the fields of solution / cell / tissue / living body imaging, biological labeling or sensing.