5 results about "Amino derivatives" patented technology

This application relates to the field of pharmaceutical technology, specifically disclosing a self-sampling mouthwash wash composition, a self-sampling mouthwash wash, and its application. The self-sampling mouthwash wash composition, based on the self-sampling mouthwash wash composition, comprises 0.1–2.5 wt% sodium hexadecyl sulfonate, 0.05–1.0 wt% guanidine derivative, and 0.05–1.0 wt% amino derivative. The raw materials of the self-sampling mouthwash wash include the self-sampling mouthwash wash composition. The application of the self-sampling mouthwash wash in oral self-collection of respiratory viruses. This application improves the elution ability of respiratory viruses, bacteria, and other pathogenic microorganisms in the oral cavity during self-sampling.

The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to an aminated 20 (S)-10, 11-difluoromethylenedioxy camptothecin derivative as well as a preparation method and application thereof. The derivative is a compound with a structure as shown in a formula (I), and in the formula (I), R is shown in the description; wherein X is an integer from 3 to 10, and n is an integer from 3 to 10; and Z is selected from (amido substitution). The novel aminated 20 (S)-10, 11-difluoromethylenedioxy camptothecin derivative provided by the invention has good in-vivo and in-vitro anti-tumor activity, and can be used for preparing and synthesizing camptothecin drugs for preventing or treating tumors, the preparation method is easy to operate, the post-treatment is simple and convenient, the initial raw materials of the reaction are cheap and easy to obtain, the designability of the reaction substrate is strong, and the method is suitable for industrial production. The reaction efficiency is relatively high, and the practicability is relatively high.

The invention provides compounds of formula (I), that are peptidase enhanced cytotoxics for use for use in the treatment of and / or prophylaxis of BCL2 inhibitor resistant or refractory acute myeloid leukaemia (AML). (Formula)

The invention discloses a coking inhibitor for delaying coking and a production process thereof, and belongs to the technical field of chemical additives. The anti-coking agent comprises an anti-coking agent intermediate, dioctyl zinc dithiophosphate and a high-boiling-point aromatic solvent, wherein the anti-coking agent intermediate is prepared through a Mannich reaction of a polyisobutylene succinimide amino derivative, benzaldehyde and 2, 6-di-tert-butylphenol under acid catalysis. The production process adopts a distributed control system automation control program and an SIS safety automation control program for linkage control, and comprises the steps of intermediate synthesis, compounding, quality monitoring, automatic filling and the like. The method has the advantages of high anti-coking efficiency, stable product quality, low temperature and low pressure in the production process, safety and controllability, and full-flow quality traceability, and is suitable for coking inhibition of an industrial scale delayed coking device.

The invention relates to a process and chemical plant for separating benzene and 1-methylbenzene from a stream comprising at least one pyrolysis oil produced from plastic waste and further converting the benzene or 1-methylbenzene into aromatic amines. These aromatic amines are suitable as precursors for diisocyanates and polyisocyanates based on benzene or 1-methylbenzene produced from plastic waste. Furthermore, polyurethanes, thermoplastic polyurethanes, polyisocyanurates and polyureas can be produced by the process according to the invention.