26 results about "Amino derivatives" patented technology

The invention relates to a colored flame-retardant polyester fiber with efficient flame-retardant characteristic and a preparation method thereof.The preparation method comprises the steps that firstly, a PDI derivative with the end group being-NH2 is added into ethyl alcohol dispersion liquid of alpha-ZrP, alpha-ZrP-PDI colored efficient flame-retardant molecules obtained through a reaction are blended with a polyester chip powder matrix, and colored efficient flame-retardant master batches are obtained; and finally, blending the colored high-efficiency flame-retardant master batch and polyester chips, and carrying out melt spinning to obtain the colored flame-retardant polyester fiber. The limit oxygen index of the colored flame-retardant polyester fiber is greater than or equal to 32%, the vertical combustion grade is V0, the breaking strength is greater than or equal to 4.7 cN / dtex, and the washing color fastness at 60 DEG C is above grade 4. The alpha-ZrP and the PDI amino derivative react to form an ordered layered stacking structure, so that the flame-retardant effect is remarkably improved; the prepared colored flame-retardant polyester fiber not only has excellent flame retardance, but also has uniform color distribution and good mechanical strength.

The invention relates to a preparation method of anti-dripping colored flame-retardant polyester fibers. The preparation method comprises the following steps: firstly, carrying out reaction on alpha-ZrP subjected to micromolecule amine pre-supported intercalation treatment and a PDI amino derivative to obtain alpha-ZrP-PDI anti-dripping colored flame-retardant molecules; then blending the alpha-ZrP-PDI anti-molten-drop colored flame-retardant molecules with a polyester chip powder matrix to obtain anti-molten-drop colored flame-retardant master batches, finally blending the anti-molten-drop colored flame-retardant master batches with polyester chips, and performing melt spinning to obtain the anti-molten-drop colored flame-retardant polyester fiber. And the PDI amino derivative is a PDI derivative with a terminal group of-NH2. According to the preparation method, the alpha-ZrP is subjected to pre-supporting intercalation treatment by adopting small molecule amine to increase the interlayer spacing of the alpha-ZrP, and then the pretreated alpha-ZrP reacts with the PDI amino derivative to form alpha-ZrP-PDI molten-drop-resistant colored flame-retardant molecules, so that the flame retardance and the molten-drop resistance of the polyester fiber are remarkably improved.

The invention relates to application of Nogo-B protein in preparation of a medicine serving as an anti-osteosarcoma target spot. The invention discloses an alpha-hydroxyl / alkoxy / amino-beta-amino derivative, a synthesis method thereof and application of Nogo-B protein serving as a new osteosarcoma target, an osteosarcoma diagnostic reagent and a small-molecule inhibitor 4v serving as an osteosarcoma targeting drug. A diazo compound, water / alcohol / amide and imine are used as raw materials, rhodium acetate is used as a catalyst, a product is obtained in an organic solvent through a one-step reaction with high selectivity and high yield, then the small-molecule inhibitor 4v is obtained through osteosarcoma cell surface screening, a new osteosarcoma target Nogo-B is proposed based on a proteomics analysis technology, and the new target Nogo-B is used for inhibiting osteosarcoma. The effects of inhibiting cell proliferation and migration and tumor growth can be achieved through experiments such as knockout of Nogo-B protein. The invention discloses a novel application of Nogo-B protein. The Nogo-B protein is used for preventing, relieving and treating osteosarcoma and osteosarcoma-related complications of individuals in need. Also disclosed are methods of diagnosing, treating, and monitoring osteosarcoma or methods of inhibiting osteosarcoma, and methods of screening for osteosarcoma inhibitors.

This invention belongs to the field of organic optoelectronic materials and specifically discloses a method for preparing the helical chiral luminescent molecule DNP-DA by dimerizing azaperylene (NP). This molecule has a twisted 1,6-diazacyclopyrimidine (DA) core skeleton, with conjugated high-luminescent azaperylenes at both ends, resulting in excellent chiral luminescence properties and supramolecular responsiveness. Through a simple synthetic process, the chiral luminescent molecule DNP-DA is obtained by dimerizing an azaperylene amino derivative in a single step. The DNP-DA preparation method provided by this invention is simple, easy to operate, and highly universal, allowing it to be applied to the construction of other chiral molecules. The product has broad application prospects in the field of organic circularly polarized optoelectronic materials.

The invention relates to the technical field of new materials, and discloses thiophene polyamide and a preparation method thereof, a nanofiber membrane and a preparation method and application of the nanofiber membrane, and the thiophene polyamide contains a structural unit shown in the formula (I); wherein X and Y are respectively and independently selected from hydrogen, alkyl, halogen, amino and amino derivatives. The nanofiber membrane prepared by taking the thiophene polyamide as a raw material has the characteristics of high mechanical strength, high heat resistance, high hydrophobicity and antibacterial property, can be used for a long time under a high-temperature working condition, and has a wide application prospect in the fields of water treatment, automobile fuel filter screens, new energy batteries, automobile air conditioner filter screens, medical protective articles and the like.

The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 1 (LPA1), particularly the invention relates to compounds that are Ami do cyclohexane acid derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

The present invention discloses an integrated diagnostic and therapeutic ERαPROTACs compound for detecting and degrading ERα, and its preparation method and application, which belong to the field of medical technology. The structure of the integrated diagnostic and therapeutic PROTAC compound of the present invention is shown in general formula (I), and the OBHSA containing a carboxyl linker is respectively reacted with a WUN29654 amino derivative with a different linker as a raw material to prepare the ERαPROTAC compound by a one-step amide reaction. Cytotoxicity, immunoblotting analysis and optical properties showed that the integrated diagnostic and therapeutic PROTAC compound of the present invention has significant anti-MCF-7 cell and mutant strain activity, ERα protein degradation activity, and a significant fluorescence emission signal at 400-500nm, which can be used to prepare anti-breast cancer drugs and / or breast cancer diagnostic drugs.

The present invention discloses an α-amino BODIPY derivative, a preparation method, and an application thereof. The invention overcomes the defect in the prior art that only alkylamines are feasible in the oxidative cross-dehydrogenation coupling reaction for constructing α-amino BODIPYs, while aniline, as a weak nucleophile, is not suitable for this reaction. The structure of the α-amino BODIPY derivative is shown in Formula 3 and Formula 4, wherein Ar1 is an aryl group, Ar2 is an aryl group or a heterocyclic aryl group, and X is selected from one of C, N, O, and S. The α-amino BODIPY derivative has a novel structure, and can be directly functionalized and synthesized into α-amino BODIPY through base-promoted oxidative cross-dehydrogenation coupling, thereby realizing the installation of weak nitrogen nucleophiles such as aniline and heteroaryl aniline. The synthesis method is simple and efficient, and the preparation method has the advantages of mild conditions and simple operation.

The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.

This application relates to the field of pharmaceutical technology, specifically disclosing a self-sampling mouthwash wash composition, a self-sampling mouthwash wash, and its application. The self-sampling mouthwash wash composition, based on the self-sampling mouthwash wash composition, comprises 0.1–2.5 wt% sodium hexadecyl sulfonate, 0.05–1.0 wt% guanidine derivative, and 0.05–1.0 wt% amino derivative. The raw materials of the self-sampling mouthwash wash include the self-sampling mouthwash wash composition. The application of the self-sampling mouthwash wash in oral self-collection of respiratory viruses. This application improves the elution ability of respiratory viruses, bacteria, and other pathogenic microorganisms in the oral cavity during self-sampling.

The present invention relates to compounds of formula (I) that inhibit transforming growth factor-beta (TGF-beta) type 1 receptor (ALK5), methods for preparing such compounds, pharmaceutical compositions containing them, and therapeutic uses thereof. The compounds of the present invention are useful for treating diseases or conditions in mammals associated with dysregulation of the ALK5 signaling pathway.

The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to an aminated 20 (S)-10, 11-difluoromethylenedioxy camptothecin derivative as well as a preparation method and application thereof. The derivative is a compound with a structure as shown in a formula (I), and in the formula (I), R is shown in the description; wherein X is an integer from 3 to 10, and n is an integer from 3 to 10; and Z is selected from (amido substitution). The novel aminated 20 (S)-10, 11-difluoromethylenedioxy camptothecin derivative provided by the invention has good in-vivo and in-vitro anti-tumor activity, and can be used for preparing and synthesizing camptothecin drugs for preventing or treating tumors, the preparation method is easy to operate, the post-treatment is simple and convenient, the initial raw materials of the reaction are cheap and easy to obtain, the designability of the reaction substrate is strong, and the method is suitable for industrial production. The reaction efficiency is relatively high, and the practicability is relatively high.

The invention provides compounds of formula (I), that are peptidase enhanced cytotoxics for use for use in the treatment of and / or prophylaxis of BCL2 inhibitor resistant or refractory acute myeloid leukaemia (AML). (Formula)

The present invention relates to a process and a chemical plant for separating benzene and 1-methylbenzene from a liquid stream comprising at least one pyrolysis oil which is manufactured from plastic waste and further converting said benzene and 1-methylbenzene into aromatic amines. The aromatic amines are suited as a precursor for di- and poly-isociyanate derivatives of benzene and 1-methylbenzene which are based (at least a portion thereof) on benzene and 1-methylbenzene manufactured from plastic waste. Furthermore, polyurethanes, thermoplastic polyurethanes, polyisocyanurates and polyureas can be manufactured by the process according to the present invention.

The present invention relates to a colored flame-retardant polyester fiber with high-efficiency flame-retardant properties and a preparation method thereof. First, a PDI derivative having an NH2 terminal group is added to an ethanol dispersion of α-ZrP, and the α-ZrP-PDI colored high-efficiency flame-retardant molecules obtained by the reaction are blended with a polyester chip powder matrix to obtain a colored high-efficiency flame-retardant masterbatch; finally, the colored high-efficiency flame-retardant masterbatch is blended with the polyester chips and melt-spun to obtain a colored flame-retardant polyester fiber; the colored flame-retardant polyester fiber has a limiting oxygen index of ≥32%, a vertical burning grade of V0, a ​​breaking strength of ≥4.7 cN / dtex, and a color fastness to water washing at 60°C of grade 4 or above. The present invention significantly improves the flame retardant effect by reacting α-ZrP with a PDI amino derivative to form an ordered layered stacking structure; the obtained colored flame-retardant polyester fiber not only has excellent flame retardant properties, but also has uniform color distribution and good mechanical strength.

The present invention relates to a process and a chemical plant for separating benzene and 1-methylbenzene from a stream comprising at least one pyrolysis oil which is manufactured from plastic waste and further converting said benzene or 1-methylbenzene into aromatic amines. The aromatic amines are suited as a precursor for di- and poly-isocyanates which are based on benzene or 1-methylbenzene manufactured from plastic waste. Furthermore, polyurethanes, thermoplastic polyurethanes, polyisocyanurates, and polyureas can be manufactured by the process according to the present invention.

The invention discloses double-network hydrogel based on host-guest interaction and amino-imide reaction and a preparation method and application thereof, and relates to the field of intelligent hydrogel materials, the preparation method comprises the following steps: S1, grafting a beta-cyclodextrin amino derivative to polysuccinimide to obtain a polysuccinimide derivative with a host unit for later use; s2, amantadine is grafted to polysuccinimide, and a polysuccinimide derivative with a guest unit is obtained; and S3, mixing the polysuccinimide derivative with the host unit, the polysuccinimide derivative with the guest unit and an amino donor compound with deionized water, adjusting the pH value of the mixed system to be greater than 7, and reacting to obtain the dual-network hydrogel. The hydrogel is endowed with intelligence through the participation of the subject-object interaction of cyclodextrin and adamantane, the mechanical property of the hydrogel is guaranteed through the clamping of the covalent bond interaction, and the problem that the mechanical property and the intelligence of a conventional hydrogel material are not considered at the same time is solved.

The invention discloses an AR-CBD PROTAC compound as well as a preparation method and application thereof in treating breast cancer, and relates to the technical field of biological medicines. The preparation principle of the AR-CBD PROTAC compound provided by the invention is that an AR-CBD inhibitor D2 carboxylic acid derivative and an E3 ligand amino derivative with different linkers are respectively subjected to one-step amidation reaction to prepare the AR-CBD PROTAC compound. The AR-CBD PROTAC compound provided by the invention has the advantages that the activity of resisting MCF-7 cells and mutant strains of the MCF-7 cells is obvious, the AR degradation activity is obvious, and the AR-CBD PROTAC compound can be used for preparing the anti-breast cancer medicine.

The invention discloses a coking inhibitor for delaying coking and a production process thereof, and belongs to the technical field of chemical additives. The anti-coking agent comprises an anti-coking agent intermediate, dioctyl zinc dithiophosphate and a high-boiling-point aromatic solvent, wherein the anti-coking agent intermediate is prepared through a Mannich reaction of a polyisobutylene succinimide amino derivative, benzaldehyde and 2, 6-di-tert-butylphenol under acid catalysis. The production process adopts a distributed control system automation control program and an SIS safety automation control program for linkage control, and comprises the steps of intermediate synthesis, compounding, quality monitoring, automatic filling and the like. The method has the advantages of high anti-coking efficiency, stable product quality, low temperature and low pressure in the production process, safety and controllability, and full-flow quality traceability, and is suitable for coking inhibition of an industrial scale delayed coking device.

The invention discloses a tetraphenylethylene derivative assembled in specific tumor cell mitochondria and inducing tumor cell death as well as a synthesis method and application thereof. The synthesis method comprises the following steps: preparing a pyridine modified tetraphenylethylene derivative by utilizing a coupling reaction; the preparation method comprises the following steps: synthesizing a brominated amino derivative from single Boc ethylenediamine and bromoacetyl bromide; synthesizing a target compound precursor by utilizing a nucleophilic substitution reaction of pyridine; and removing a protecting group by using trifluoroacetic acid to obtain the amino-modified tetraphenylethylene derivative. Through an organic synthesis strategy, an amino group is introduced to the tail end of a tetraphenylethylene derivative cationic compound. The compound can be selectively enriched in tumor cell mitochondria, can be enriched in lysosome in normal cells, and can be self-assembled in tumor mitochondria to inhibit proliferation. The anti-tumor effect can be further improved under the irradiation of white light due to the aggregation-induced enhanced active oxygen generation capability. In-vivo experiments prove that the compound can effectively inhibit tumor growth and shows synergistic treatment potential.

The invention relates to a process and chemical plant for separating benzene and 1-methylbenzene from a stream comprising at least one pyrolysis oil produced from plastic waste and further converting the benzene or 1-methylbenzene into aromatic amines. These aromatic amines are suitable as precursors for diisocyanates and polyisocyanates based on benzene or 1-methylbenzene produced from plastic waste. Furthermore, polyurethanes, thermoplastic polyurethanes, polyisocyanurates and polyureas can be produced by the process according to the invention.

The invention discloses a dicyanoisophorone-pyrazole fluorescent probe, which is synthesized by carrying out nucleophilic addition-elimination reaction on an amino derivative of dicyanoisophorone and aldehyde group modified phenyl pyrazole, and the chemical structure of the dicyanoisophorone-pyrazole fluorescent probe is as follows: # imgabs0 #. The probe shows fluorescence quenching response to Cu < 2 + >, and Cu < 2 + > recognition is achieved. The probe has high specific recognition capability on Cu < 2 + >.

The application relates to the technical field of biological medicines, in particular to a folate-targeted black phosphorus quantum dot nanocomposite as well as a preparation method and application thereof. The nanocomposite comprises black phosphorus quantum dots, the surface of the black phosphorus quantum dots is grafted with folate-modified polyethylene glycol amino derivatives, and the black phosphorus quantum dots are loaded with tirapazamine. The folate is used for targeting tumor cells with high expression of folate receptors. The preparation method comprises the following steps: black phosphorus raw materials are subjected to ice bath ultrasonic peeling and centrifugation in an organic solvent to obtain black phosphorus quantum dots; the black phosphorus quantum dots are reacted with folate-modified polyethylene glycol amino derivatives to obtain folate-modified polyethylene glycol grafted black phosphorus quantum dots; and then the folate-modified polyethylene glycol grafted black phosphorus quantum dots are incubated with tirapazamine for loading and centrifugation. The nanocomposite has good dispersion stability and active targeting capability, can exert photodynamic and photothermal effects under laser irradiation, and can promote the hypoxic activation of tirapazamine, realizes synergistic effect, and can be used for preparing a tumor treatment.

The invention discloses a trigger type self-degradation polycoumarin monomer molecule and a synthesis method thereof, the monomer molecule comprises a 7-hydroxy coumarin derivative and a 7-amino coumarin derivative, the structures of the 7-hydroxy coumarin derivative and the 7-amino coumarin derivative respectively contain polymerizable hydroxy / amino derivative groups, and the 7-hydroxy coumarin derivative and the 7-amino coumarin derivative are synthesized through multi-step functional group modification. Two types of coumarin derivative monomers are designed and synthesized by combining a classical small-molecular fluorophore with a novel trigger type self-degradable polymer through a high-molecular synthesis means, and a polycarbonate type polycoumarin structure is successfully prepared. The triggering type self-degradation process of polycoumarin macromolecules under the action of an irritant F <-> is explored, the target of a novel triggering type self-degradation polymer structure with classical fluorescent micromolecule coumarin as a main chain skeleton is preliminarily achieved, and the detection sensitivity of a micromolecule fluorescent probe to an analysis object is improved through a chemical method. The construction of a novel molecular amplification analysis method provides guidance and help.

The application relates to a preparation method of anti-dripping colored flame-retardant polyester fibers. First, a small-molecule amine is used to pre-expand and intercalate alpha-ZrP to react with a PDI amino derivative to obtain alpha-ZrP-PDI anti-dripping colored flame-retardant molecules. Then, the alpha-ZrP-PDI anti-dripping colored flame-retardant molecules are blended with polyester chip powder matrix to obtain anti-dripping colored flame-retardant master batches. Finally, the anti-dripping colored flame-retardant master batches are blended with polyester chips to be melt spun to obtain the anti-dripping colored flame-retardant polyester fibers. The PDI amino derivative refers to a PDI derivative with a terminal group of -NH2. In the application, the small-molecule amine is used to pre-expand and intercalate the alpha-ZrP to increase the layer spacing, and then the pretreated alpha-ZrP is reacted with the PDI amino derivative to form the alpha-ZrP-PDI anti-dripping colored flame-retardant molecules, so that the flame-retardant performance and the anti-dripping performance of the polyester fibers are significantly improved.

The present invention relates generally to compounds (I) (hereinafter referred to as ALK5 inhibitors) that inhibit transforming growth factor beta (TGF beta) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic uses thereof. The compounds of the invention are useful, for example, in the treatment of a number of diseases, disorders or conditions associated with the ALK5 signaling pathway.