Limonin-7-amino derivatives and preparation method and medicine application thereof

A pharmaceutical and alkyl technology, applied in the field of water-soluble limonin-7-amino and deoxylimonin-7-amino derivatives, can solve the problems of poor water solubility, low bioavailability, and impact on clinical use, and achieve Good analgesic and pain relief effect
CN104744558AActive Publication Date: 2015-07-01CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2015-07-01

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Abstract

The invention relates to the field of pharmaceutical chemistry and particularly relates to water-soluble limonin-7-amino derivatives (I) and (II) shown in the specification, and a preparation method and medicine application thereof. Pharmacological experiments prove that the compounds disclosed by the invention have the analgesic and anti-inflammatory effects and can be clinically used for relieving pain and inflammatory diseases.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to a class of water-soluble limonin-7-amino and deoxylimonin-7-amino derivatives, their preparation methods, and their analgesic and anti-inflammatory effects. Background technique

[0002] There are at least 100 million pain patients in my country. If the pain is not treated in time and effectively, it will seriously affect the daily quality of life and social stability. Analgesia has become an important task for medical workers. At present, the mainstream analgesics on the market can be mainly divided into opioid receptor agonists, non-steroidal anti-inflammatory drugs, and anticonvulsants according to their mechanism of action and structure. Although great progress has been made in the research of analgesics, both non-steroidal antipyretic analgesic and anti-inflammatory drugs for mild and moderate pain, and analgesics for moderate and severe pain all have their own side effec...

Claims

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