69 results about "Acute toxicity testing" patented technology

The invention discloses a traditional Chinese medicine composition with the effects of benefiting qi, nourishing blood, invigorating the spleen and tonifying the kidney and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: cistanche, ginseng, American ginseng, astragalus membranaceus, medlar, rhizoma polygonati, oyster peptide, angelica sinensis, radix rehmanniae preparata, donkey-hide gelatin, fructus amomi, pericarpium citri reticulatae, hawthorn, folium cortex eucommiae, radix puerariae, liquorice and the like. The preparation method comprises the following steps: respectively crushing the medicinal materials, dissolving the colla corii asini, mixing, adding water, granulating and the like. The composition can be prepared into various dosage forms such as granules, capsules, tablets, oral liquid and the like. Experiments show that the traditional Chinese medicine composition can effectively improve the symptoms of deficiency of qi and blood (increasing erythrocyte count and hemoglobin content), weakness of spleen and stomach (increasing body weight and improving pepsin activity) and kidney deficiency (reducing creatinine and urea nitrogen content and improving SOD activity), and acute toxicity experiments show that the toxicity is slightly reversible under high dosage, and the safety is good under therapeutic dosage. The traditional Chinese medicine composition has potential application value in the aspect of preparing medicines for benefiting qi, nourishing blood, invigorating spleen and tonifying kidney.

The invention discloses a water pollution event index screening method and device, electronic equipment and a storage medium. The method comprises the steps that a historical monitoring data set and real-time monitoring flow data of a water body are collected, and the data are preprocessed; calculating an initial entropy weight of each monitoring index, and screening out a high-sensitivity candidate index set according to a preset threshold value; for pollutants in the candidate index set, fusing acute toxicity and bio-enrichment risk of the pollutants, constructing a toxicity coefficient, performing normalization processing, and dividing toxicity grades based on the toxicity coefficient; measuring the correlation strength of the initial entropy weight sorting and the normalized toxicity weight sorting, and calculating the self-adaptive comprehensive weight of each candidate index in combination with a reference toxicity contribution threshold value based on a risk threshold value and a water body function correction factor calculated based on a water body national standard limit value; and verifying the decision coefficient of the comprehensive weight and the actual risk entropy so as to screen out a final early warning perception index. The method has no empirical parameters, results can be reproduced, and the method is suitable for various water bodies.

The invention discloses application of ursolic acid in resisting fish ichthyophthiriasis. The ursolic acid has a remarkable killing effect on ichthyophthirius multifilis in an in-vitro stage, and the 4-hour half effective insecticidal concentration (4h-EC50) of the ursolic acid on a grazing body is 0.3774 mg / L; and the 22-hour half effective insecticidal concentration (22h-EC 50) on the capsule is 4.931 mg / L. An acute toxicity test shows that the 96-hour median lethal concentration (96h-LC50) of ursolic acid to goldfish is 9.358 mg / L, the therapeutic index (TI = 96h-LC50 / 4h-EC50) is up to 24.8, and the safety of ursolic acid is remarkably superior to that of a traditional medicine. Ursolic acid used in the invention is a plant-derived active component, has the characteristics of high environmental compatibility and low biological accumulation, meets the development requirements of green fishery, and has an industrialization basis for being developed into eco-friendly aquatic products.

The invention discloses an ecological risk assessment method for organic pollutants in a natural water body, and belongs to the field of ecological risk assessment of the natural water body, and the method comprises the steps: building a quantitative structure-activity relationship toxicity prediction model of species based on a machine learning and feature screening method; predicting and obtaining biotoxicity data in a to-be-predicted water body by using the quantitative structure-activity relationship model, establishing a species sensitivity distribution model of pollutants in the water body according to the biotoxicity data, and calculating predicted non-effect concentration; on the basis of database retrieval, acute toxicity experiments and an inter-species relationship prediction model, collecting, predicting and supplementing toxicity data of species in the water body, and evaluating the harmfulness of pollutants in the water body by using a risk entropy method and a comprehensive scoring method respectively. According to the method, ecological risk assessment is carried out by utilizing a machine learning method, the toxicity of the persistent organic pollutants in seawater and fresh water can be effectively assessed, and the ecological risk of the organic pollutants in the water body can be effectively assessed.

The invention discloses a pill for treating qi-blood deficiency and a preparation method thereof, and belongs to the technical field of Chinese patent medicine preparation. Comprising 80-90 parts of wall-broken ginseng rootlets, 140-160 parts of freeze-dried Chinese wolfberry fruits, 190-210 parts of fried Chinese yam powder, 110-130 parts of fermented Chinese date powder, 50-70 parts of donkey-hide gelatin beads, 80-100 parts of black sesame seed powder, 45-55 parts of maltitol, 15-25 parts of giant knotweed rhizomes, 10-14 parts of red peony roots and 0.5 part of a compound enzyme preparation. The medicine is small in packaging size, convenient to carry and low in cost; the traditional Chinese medicine composition has the advantages of scientific formula, wide application range, stable process and controllable quality, and embodies the traditional Chinese medicine theory advantages of simultaneous treatment of vital qi and pathogen and simultaneous regulation of qi and blood. Acute toxicity tests show that LD50 is larger than 20 g / kg, and the traditional Chinese medicine is free of liver and kidney dysfunction after being taken for a long time and suitable for long-term conditioning.

The invention relates to an aromatic heterocyclic compound and / or a salt thereof, a preparation method and application thereof, and an insecticidal and acaricidal agent. The aromatic heterocyclic compound has a structure as shown in a formula (I). The aromatic heterocyclic compound provided by the invention can have an acaricidal effect when being used at a low concentration content, meanwhile, the provided compound has relatively good safety, and in a rat acute toxicity test, part of the compound does not show obvious toxicity under the administration dosage of 1,000 mg / kg. # imgabs0 #

The invention discloses a high-throughput evaluation method for chemical hematopoietic toxicity based on a zebra fish model, and relates to the field of chemical toxicity evaluation technology and toxicology risk screening. According to the method, a transparent zebra fish strain marked by blood cells is constructed, an acute toxicity test is combined to determine a chemical concentration range, and an automatic imaging technology and a flow cytometry technology are utilized to perform high-throughput analysis on the number change of the blood cells, so that the hematopoietic toxicity of the chemicals is identified and evaluated. The method is low in cost, high in flux, high in reliability and suitable for large-scale toxicity screening and risk management and control of chemicals.

The invention discloses application of betulinic acid 28-O-beta-D-glucoside in medicines, and particularly relates to application of betulinic acid 28-O-beta-D-glucoside in preparation of medicines for treating or preventing inflammatory bowel diseases. The invention discloses application of betulinic acid 28-O-beta-D-glucoside (BA-6) in prevention and treatment of inflammatory bowel diseases for the first time aiming at the problems that existing medicines for treating the inflammatory bowel diseases (IBD) are limited in curative effect, slow in effect taking, multiple in side effects, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreactions and the like. The technical progress of obviously improving the acute colitis symptom is realized. Results of a cytotoxicity experiment and an acute toxicity experiment show that the betulinic acid 28-O-beta-D-glucoside (BA-6) does not have obvious biotoxicity on a cellular level or an animal level.

The invention discloses a water quality on-line biotoxicity detection method and a water quality on-line biotoxicity detection device through a lactic acid bacteria PH inhibition method. The detection method comprises the following steps: preparing a first water sample and a second water sample; acquiring initial PH voltage values of the first water sample and the second water sample; performing constant-temperature culture on the first water sample and the second water sample; respectively acquiring PH voltage values of the first water sample and the second water sample after culture; and performing biotoxicity analysis calculation on the to-be-detected water sample. According to the method disclosed by the invention, the size of harmful substances in water is determined by monitoring the pH change caused by lactic acid bacteria metabolite lactic acid; pH is detected based on a mature glass electrode electrochemical principle method, and the detection precision is not influenced by water turbidity; the detection method provided by the invention has high consistency with a photobacterium method in the prior art for detecting the biotoxicity, and meets the related technical requirements in the determination of the acute toxicity of the water quality.

The invention discloses bacillus velezensis B116 and a preparation method of the bacillus velezensis B116. The bacillus velezensis B116 is prepared from bacillus velezensis, bacillus velezensis and bacillus velezensis. Belongs to the technical field of microbial technologies and animal probiotic preparations. The bacillus velezensis B116 obtained by screening has relatively strong biofilm forming ability, intestinal toxin-producing escherichia coli inhibiting activity, good self-aggregation and co-aggregation ability, excellent acid resistance, bile salt resistance, high temperature resistance and artificial gastrointestinal fluid characteristics, has no hemolysis and gelatinase activity, and does not carry drug-resistant genes and virulence genes. Animal experiments show that the strain has no acute toxicity to mice, does not influence visceral organ indexes, blood biochemical indexes and intestinal tissue structures, can significantly reduce the death rate of the mice after ETEC challenge and regulate the intestinal inflammatory factor level, has good probiotic effects and safety, and is suitable for development of feed additives or veterinary probiotics or veterinary drug products.

The invention relates to a photo-thermal agent, a preparation method thereof and application of the photo-thermal agent in treating tumors by combining a mild photo-thermal therapy with abesilib. The photo-thermal agent has excellent photo-thermal effect and light stability, and when the photo-thermal agent is used for mild photo-thermal-abelsilib combined treatment, tumor cells are induced to age through abelsilib, then fragile and aged cancer cells are accurately hit by using a mild photo-thermal therapy, and a double-hit effect is formed. According to the therapy, the treatment effect is remarkably improved, meanwhile, side effects are reduced, and the combination therapy has higher targeting property due to the fact that mild photo-thermal energy is low; in addition, treatment is carried out step by step, aging is induced firstly, then photo-thermal treatment is carried out, the scheme can be adjusted according to the reaction of a patient, safety and controllability are improved, and the acute toxicity risk is reduced. According to the invention, drug-induced aging and physical treatment are innovatively combined, and a new treatment approach is provided for refractory or recurrent cancers.

The invention discloses a liposome vaccine adjuvant and a preparation method thereof, and belongs to the technical field of vaccine adjuvants. The adjuvant comprises hydrogenated soybean phospholipids, cholesterol, a saponin adjuvant QS-21, a membrane function lipid and a stabilizer. The preparation method comprises the following steps: dissolving a lipid component in an organic solvent to form a film, hydrating by using a buffer solution containing a stabilizer, carrying out high-pressure homogenization to form blank liposome, purifying, incubating with a QS-21 solution for drug loading, and finally purifying and sterilizing to obtain the product. Through synergistic cooperation of the components and the process, the technical problems of low encapsulation efficiency, poor storage stability, high hemolytic property and the like when QS-21 is encapsulated by traditional liposome are successfully solved, and the prepared liposome vaccine adjuvant passes strict acute toxicity and local irritation tests, is good in biological safety and has good application prospects. The important clinical application value is realized.

The invention discloses a rapid preliminary screening evaluation method for chemical prevention and control active components of meadow moth, which comprises the following steps: (1) evaluating the activity of chemical prevention and control active components to be detected on larvae of meadow moth moth through indoor bioassay to obtain basic score data of the chemical prevention and control active components to be detected; (2) selecting other farmland pests which are damaged with the meadow moth in the same period, and evaluating the activity of the chemical prevention and control active components to be detected through indoor bioassay to obtain additional score data; (3) selecting a main environmental non-target organism, and determining acute toxicity data of the to-be-detected effective component to the environmental non-target organism through public database query or test to obtain score deduction data; (4) comprehensively scoring the chemical prevention and control active components to be detected; and (5) grading according to the comprehensive score, and giving a recommendation conclusion to the chemical prevention and treatment active components to be detected. By means of the evaluation method, the efficient and low-toxicity emergency chemical prevention and control active ingredients of the meadow moth can be rapidly and preliminarily screened, and therefore the purpose of guiding emergency chemical prevention and control of the meadow moth is achieved.

The present application relates to the field of environmental monitoring and biosensing technology, and particularly relates to a detection method and system for new pollutants in ecological environment, comprising the following steps: S100: culturing specific effector cells in a biosensing channel, and collecting trans-epithelial electrical resistance (TEER) signals of the effector cells in real time; S200: monitoring a change rate of the TEER signals, and generating an enrichment triggering instruction when the change rate exceeds a preset threshold; S300: in response to the enrichment triggering instruction, introducing a fluid to be tested, which generates the change rate, into a surface-enhanced Raman scattering (SERS) detection cavity, and starting an active enrichment unit to in-situ concentrate the fluid to be tested, so that the volume of the fluid to be tested is contracted to a detection area of a SERS substrate; the present application uses impedance response of effector cells as a preliminary screening "sentinel", realizes targeted capture of only abnormal samples with acute toxicity, avoids ineffective detection of a large number of non-toxic water samples, and significantly improves monitoring efficiency.

The invention belongs to the technical field of plant molecular biology, and particularly discloses a diatom RNA extraction method and a method for evaluating influence of pollutants on diatom gene expression. The invention firstly provides a diatom RNA extraction method, RNA is extracted by virtue of a cell homogenate physical crushing method and according to an improved TRIzol method, the release amount of RNA is high, and the purity reaches the standard. The invention also provides a method for evaluating the influence of pollutants on gene expression of diatom, which is based on the diatom RNA extraction method, takes Tubulin as a reference gene, takes one or more of iron redox protein, ferrithionein, ketoacyl coenzyme A thiolase, ethanol dehydrogenase, lipoprotein and acetyl coenzyme A carboxylase as target genes, and evaluates the influence of pollutants on gene expression of diatom. The relative expression level of a target gene is detected through qPCR and can be used for evaluating the acute toxicity of pollutants. The method effectively solves the problems that diatom RNA is difficult to extract, the diatom gene expression level is difficult to detect through qPCR, and the molecular mechanism of pollutant action is difficult to evaluate.

The application discloses a group of low-toxicity broad-spectrum antibacterial peptides containing a central PXXP hinge structure and application thereof. The low-toxicity broad-spectrum antibacterial peptides are obtained by using a head design method, using positively charged lysine (Lys, K) and hydrophobic tryptophan (Trp, W), symmetrically arranging the two kinds of amino acids alternately and repeatedly, and introducing a PXXP hinge structure containing proline into the symmetry center of the antibacterial peptide sequence. The structural general formula is (KW) n PXXP(WK) n wherein XX=KK, n=2-4 or XX=WK, n=2-3. In-vitro antibacterial experiments show that the antibacterial peptides have broad-spectrum antibacterial activity; the preferred antibacterial peptides have the advantages of low hemolytic toxicity and high serum stability. Induced drug resistance experiments show that the preferred antibacterial peptides have the characteristics of low drug resistance occurrence. In-vivo acute toxicity experiment results show that, compared with a control drug Polymyxin B, the preferred antibacterial peptides have higher in-vivo safety. Therefore, the antibacterial peptides have good application prospects in the preparation of clinical antibacterial drugs and are expected to become new antibiotic candidate drugs.

The invention discloses a 2-[2-(thiophenyl) benzothiazole-6-yl] acetamide compound with antimicrobial activity and / or pharmaceutically acceptable salt and application thereof, and relates to the technical field of chemical and pesticide chemical development. The 2-[2-(thiophenyl) benzothiazole-6-yl] acetamide compound with antimicrobial activity and / or the pharmaceutically acceptable salt thereof provided by the invention are / is obtained by carrying out structure optimization on the basis of benzothiazole active compounds in black ants. The compound provided by the invention has a certain inhibition effect on plant pathogenic fungi and animal pathogenic bacteria, and realizes broad-spectrum antimicrobial activity by inhibiting succinate dehydrogenase (SDH), and an acute toxicity test shows that the compound is good in safety. The 2-[2-(thiophenyl) benzothiazole-6-yl] acetamide compound with antimicrobial activity and / or the pharmaceutically acceptable salt thereof provided by the invention can be prepared into a bactericidal pesticide, and can also be used as a structure precursor of an antituberculosis drug.

The present invention provides the use of sodium percarbonate in the preparation of a product that reduces acute toxicity in fish, relating to the technical field of schistosomiasis control. The present invention uses sodium percarbonate to reduce the acute toxicity of niclosamide to fish. This novel application can, to a certain extent, resolve the conflict between schistosomiasis control and aquaculture, and can serve as an emergency protection measure during drug snail control in aquaculture areas.

The application discloses a branched antibacterial peptide with double fatty acid tails and application thereof, and has the structure of taking Lys as a branched core, using Arg and Trp as two kinds of amino acids to replace the C-terminal of Lys, e -amino, α -amino, to obtain a branched peptide structure. The same length of saturated fatty acid tail chains are introduced into two N-terminal ends of the branched peptide structure to obtain the branched antibacterial peptide with double fatty acid tails, and the structure general formula is Cn-Z-K(Y-Cn)-X, which is marked as XYZn, wherein K is Lys, X, Y and Z are end-point amino acids Arg or Trp, Cn is a saturated fatty acid chain, and n is the number of carbon atoms of the fatty acid chain. The antibacterial peptide structure is novel, simple to synthesize, and has the advantages of broad-spectrum antibacterial activity, low toxicity and high safety in in-vitro antibacterial experiments and toxicity tests. Serum stability experiments show that the antibacterial peptide has excellent stability in mouse serum, and acute toxicity experiments show that the antibacterial peptide has high safety. Therefore, the antibacterial peptide has a good application prospect in preparation of clinical antibacterial drugs.

The invention relates to the technical field of precious metal extraction, and particularly discloses a low-toxicity environment-friendly precious metal extracting agent which comprises the following components in percentage by mass: 20-40% of an alkaline thiourea component, 30-50% of a thiocyanate component, 2-8% of an anionic surfactant A, 2-8% of an anionic surfactant B, 5-15% of an alkaline regulator and 0.1-2% of a stabilizer, the alkaline thiourea and thiocyanate dual coordination system in the extracting agent can synergistically generate an active ligand with mixed coordination of-SC (NH2) 2 and SCN-in an alkaline medium, cyano contained in the extracting agent is stably combined in a thiourea or thiocyanate skeleton in a covalent bond form and does not exist in a free CN-form, and the leakage risk and acute toxicity are greatly reduced. In addition, the system can be broken and reduced into non-toxic small molecules in a natural environment or wastewater in several weeks through microbial action, chemical hydrolysis and other ways, design degradation is achieved, and long-term environmental accumulation and ecological toxicity are effectively reduced.

The invention discloses a 2-(2-phenethyl) chromone compound with COX-2 and 5-LOX dual-targeting inhibitory activity as well as a preparation method and application of the 2-(2-phenethyl) chromone compound, and belongs to the technical field of natural pharmaceutical chemistry. According to the compound, 2-(2-phenethyl) chromone is taken as a skeleton, and a functional group capable of being specifically combined with COX-2 and 5-LOX enzymes is introduced through chemical modification, so that double-target synergistic inhibition on two inflammatory mediators is realized. The invention also provides a synthesis method of the compound, which comprises the following steps: selecting high-purity 2-(2-phenethyl) chromone as an initial raw material, carrying out structural modification under the action of a catalyst, introducing key functional groups such as acrolein and acrylic acid into specific positions of a chromone ring, synthesizing a target compound through a multi-step reaction, and carrying out purification treatment on a reaction product. An in-vitro experiment result shows that IC50 (half maximal inhibitory concentration) of COX-2 is 1.12 [mu] M, and IC50 of 5-LOX is 1.18 [mu] M; and an acute toxicity experiment LD50 is greater than 2000mg / kg.

The application discloses a PET tracer targeting carbonic anhydrase IX (CA IX) and a preparation method and application thereof. 68 The tracer is prepared from a DOTA-bis-sulfonamide precursor compound and GaCl3 reaction. The tracer has high hydrophilicity, excellent stability in vitro and in vivo, low uptake of non-target organs and is mainly excreted through the kidney. Micro-PET / CT imaging shows that the tumor uptake is linearly correlated with the CA IX protein expression level measured by immunohistochemistry. Acute toxicity experiments show that the tracer has good biological safety. The application further provides a radiopharmaceutical composition containing the tracer and application of the tracer in preparation of a PET imaging agent for diagnosing CA IX positive tumors. The tracer has the advantages of high labeling efficiency, low background interference, accurate quantification and potential integration of diagnosis and treatment, and is suitable for precise molecular imaging of CA IX high expression tumors such as clear cell renal cell carcinoma and colorectal cancer.

The invention discloses establishment and application of gobiocypris rarus eye cells, and the gobiocypris rarus eye cells Gbr-eye are constructed by utilizing the eyes of the gobiocypris rarus, and are gobiocypris rarus eye cell lines capable of realizing continuous passage. The culture method of the gobiocypris rarus eye cell line comprises the steps of primary culture, subculture, cryopreservation and recovery. A chemical and environmental water acute toxicity assessment method is established based on the gobiocypris rarus eye cell line, and the method specifically comprises the steps of inoculation of gobiocypris rarus eye cells, exposure of 3, 4-dichloroaniline and environmental water and toxic effect detection of 3, 4-dichloroaniline on the gobiocypris rarus eye cells. According to the establishment method and application of the gobiocypris rarus eye cells, the application of the gobiocypris rarus in toxicity detection of chemicals and environmental water bodies is expanded, and reference is provided for acute toxicity test based on fish cells.

The present application relates to the technical field of biological medicine, in particular to a kind of tricyclic sophoridine compound and its preparation method and application, pharmaceutical composition.The tricyclic sophoridine compound provided in the present application has good potential in preventing and / or treating diseases with lipid metabolic disorder syndrome such as fatty liver disease, diabetes, obesity, etc., and the tricyclic sophoridine compound has low toxicity and high safety.As shown in the test results of examples, the tricyclic sophoridine compound provided in the present application can significantly reduce the body weight of MASLD model mice induced by high-fat feed, improve liver function, glucose-lipid metabolic disorder, insulin resistance index and liver steatosis and other pathological abnormalities, and no toxic side effects are observed for 6 weeks of 100mg / kg dose gavage, and acute toxicity test also shows that it has very high safety.

This invention provides a composite adjuvant, its preparation method, and its application in vaccine preparation, belonging to the field of vaccine adjuvant technology. The composite adjuvant of this invention has low viscosity, only 12 mPa·s at 20°C, ensuring smooth injection; it exhibits high biocompatibility, with no deaths or organ abnormalities in acute toxicity experiments in mice, and no local or systemic adverse reactions or stress responses in chickens after injection; it also demonstrates excellent immunogenicity, achieving a 90% seroconversion rate for Mycoplasma cambogia and an 80% seroconversion rate for Mycoplasma synoviae 28 days after immunization with an inactivated Mycoplasma synoviae vaccine.

The application discloses a liposome vaccine adjuvant and a preparation method thereof, and belongs to the technical field of vaccine adjuvants. The adjuvant comprises hydrogenated soybean phospholipid, cholesterol, saponin adjuvant QS-21, membrane functional lipid and a stabilizer. The preparation method comprises the following steps: dissolving lipid components in an organic solvent to form a film, hydrating the film with a buffer solution containing the stabilizer, forming blank liposomes through high-pressure homogenization, incubating the blank liposomes with a QS-21 solution after purification to load drugs, and finally purifying and sterilizing to obtain the liposome vaccine adjuvant. Through the synergistic cooperation of the above components and the process, the technical problems of low encapsulation efficiency, poor storage stability and high hemolyticity existing in the traditional liposome encapsulation of QS-21 are successfully solved. Moreover, the prepared liposome vaccine adjuvant passes strict acute toxicity and local irritation tests, has good biological safety, and has important clinical application value.

The invention provides application of ciliates in heavy metal toxicity detection and a heavy metal toxicity detection method, and relates to the technical field of heavy metal toxicity evaluation. Specifically, the invention provides application of the Nalklukella marrimilis as a detection organism in heavy metal toxicity detection. The research finds that compared with other marine organisms, the nanokallukella marrimilis has the advantages that the acute toxicity response time of the nanokallukella marrimilis to heavy metals is shorter, and the threshold value is more sensitive. Therefore, the nanokallukella margaritae can be used for detecting the toxicity of the heavy metals, a reference is provided for evaluating the toxicity effect of deep-sea organisms on the heavy metals, and a scientific basis is also provided for evaluating the marine pollution risk. The method is of great significance to environmental protection.

The invention discloses a compound biological enzyme preparation for dispelling effects of alcohol and preventing drunkenness and application thereof, and relates to the technical field of biology. The composite biological enzyme preparation comprises the following raw materials: 3-15 of papain, bromelain, alkaline protease, acid protease, pepsin, trypsin, alpha-amylase, lactase, lipase, cellulase, pectinase, glucoamylase, nuclease, nattokinase and serrapeptase. The composite biological enzyme preparation provided by the invention can obviously prolong the drunkenness latency period and greatly shorten the awakening time; the safety performance is excellent, the acute toxicity test shows that the compound meets the actual non-toxic level standard, and the oral administration safety is high. The alcohol effect dispelling and drunkenness preventing product developed by the invention has the core competitiveness of high efficiency, safety and strong adaptability, and has a wide application prospect.

The invention discloses a feed additive and application thereof, ovomucin is prepared from egg white, and the ovomucin is used as a core component to prepare a functional feed for preventing and treating rodent diarrhea and improving weaning survival rate. Experiments prove that ovomucin nutritional composition intervention can significantly improve mouse diarrhea and death caused by weaning stress, improve inflammatory damage caused by bacterial toxins to intestinal mucosa tissues, promote secretion of intestinal immune factors sIgA, and improve oxidative stress imbalance caused by bacterial toxins; the ovomucin nutritional composition has no obvious acute toxicity, and has the potential of being used as a functional feed additive and a good application prospect.

The invention belongs to the technical field of medicines, and discloses an application of a rhododendron molle toxin VI derivative in analgesia. Specifically, the invention discloses a derivative shown as a formula I or a pharmacodynamically acceptable salt thereof, a pharmaceutical composition containing the derivative or the pharmacodynamically acceptable salt thereof, an application of the compound in preparation of a medicine for preventing or treating pain and an acute toxicity research of the compound.