Preparation of functional area of sea purse blood vessel growth inhibition factor 1 and use of the functional area of sea purse blood vessel growth inhibition factor 1 in medicaments for preventing and curing tumors

Abstract

The invention relates to the preparation of a functional area of a sea purse blood vessel growth inhibition factor 1 and the use of the functional area of the sea purse blood vessel growth inhibition factor 1 in medicaments for preventing and curing tumors. In the invention, a gene engineering technique is used to realize the cloning, expression and recombination of the sea purse blood vessel growth inhibition factor 1; the recombinant functional fragment of the sea purse blood vessel growth inhibition factor 1 has the bioactivities for resisting the growth of blood vessels, tumor growth, tumor transplantation, acute toxicity tests and stability tests; and the functional area of the sea purse blood vessel growth inhibition factor 1 can be mixed with or dissolved in pharmaceutically acceptable carriers to prepare the medicaments for curing various tumors. The functional area of the sea purse blood vessel growth inhibition factor 1 has high action specificity, has the characteristics of easy expression, low degradation rate and the like of gene engineering medicaments and has the effects of inhibiting blood vessel growth, tumor growth and tumor transplantation; the provided gene engineering technique can realize the industrial production of the functional area of the sea purse blood vessel growth inhibition factor 1; and the functional area of the sea purse blood vessel growth inhibition factor 1 prepared by the gene engineering technique can be used in the preparation of medicaments for inhibiting blood vessel growth and preventing and curing tumors.

Description

technical field [0001] The invention belongs to the preparation of a ray angiogenesis inhibitory factor 1 functional region and its application in anti-tumor drugs. Background technique [0002] Angiogenesis is the process of generating new blood vessels from pre-existing blood vessels, such as capillaries and postcapillary venules. Mechanisms that control normal tissue angiogenesis cannot control tumor angiogenesis, which is regulated by tumor angiogenesis factors and tumor angiogenesis inhibitors. [0003] 95% of cancers eventually form a mass called a solid tumor. In the early stage of solid malignant tumor cells, in the absence of blood vessel growth, they can obtain nutrients through the diffusion of surrounding tissues, and the tumor volume generally does not exceed 2-3mm 3 . When the volume increases to 2 ~ 3mm 3 At this time, the tumor can no longer rely solely on diffusion to obtain oxygen and nutrients. If there is no new capillary formation, the tumor tissue w...

AI Technical Summary

Problems solved by technology

[0012] The existing clinically used anti-tumor angiogenesis agents are expensive, have limited effects, and have a single mechanism of action, mostly through down-regulation of VEGF to achieve their effects

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