4results about How to "Reduce degradation rate" patented technology

This invention discloses a method for producing granules that reduces the loss of active ingredients, relating to the field of granule preparation technology. This method addresses the problem of active ingredient loss in traditional granule production due to high temperatures, oxidation, mechanical friction, and solvent residue. It employs a four-stage process—low-temperature pretreatment, inert gas-protected granulation, gradient drying, and nano-coating and end-capping—combined with the application of a specialized composite binder, significantly improving the retention rate of active ingredients. Experimental data shows that granules produced using this method have a higher retention rate of active ingredients than those produced by traditional methods, while also exhibiting high granule formation rate and dissolution rates that meet relevant standards. The process of this invention is highly stable and widely adaptable, and can be widely applied to granule production in the pharmaceutical, pesticide, food, and feed industries.

The present application belongs to the technical field of lithium battery, especially to a method for testing electronic conductivity of solid electrolyte. The steps of the present application are as follows: S1, preparing solid electrolyte sheet: taking solid battery material and placing it in a mold, then pressurizing and pressure maintaining the mold, obtaining the solid electrolyte sheet and measuring its thickness and bottom diameter; S2, conductivity test: pretreating the solid electrolyte sheet, then using a constant potential instrument to measure the direct current polarization of the solid electrolyte sheet under step voltage of 0.1 V, 0.2 V, 0.3 V, 0.4 V and 0.5 V, respectively, to obtain current data under constant voltage polarization; S3, data processing: drawing the direct current polarization curve and the equilibrium current response curve under step voltage by using the obtained current data, and calculating the electronic conductivity of the solid electrolyte sheet. The method of the present application is simple in testing, short in testing time and reliable in data.

This application relates to the field of new energy vehicle charging control technology, and in particular to a vehicle-charging station coordinated charging control method, device, equipment, storage medium, and computer program product. The method acquires power battery status information collected from the vehicle side and sends this information to the charging side. The power battery status information includes parameters related to battery thermal state, charging state, and health state. Based on the power battery status information, the method determines the temperature evolution information of the power battery within a preset prediction range. Based on the power battery status information and temperature evolution information, the method determines the health degradation information of the power battery within the preset prediction range. Based on the temperature evolution information and health degradation information, the method generates corresponding coordinated risk characterization results. Based on the coordinated risk characterization results, the method determines corresponding charging adjustment commands and controls the charging side to adjust the charging of the power battery according to the charging adjustment commands.

This invention relates to the field of biomedical technology, and particularly to a responsive RNA delivery system for glioma, its preparation method, and its applications. By fusing the blood-brain barrier-penetrating peptide ANG-2 to mediate cross-blood-brain barrier delivery, and simultaneously combining it with Siglec-15-mediated immune targeting recognition, a dual-targeting mechanism is constructed. This guides the delivery system to accurately identify glioma lesions, significantly increasing the enrichment of the delivery system in the lesion area, laying the foundation for the efficacy of nucleic acid drugs, effectively improving the targeting and effectiveness of treatment, and avoiding damage to normal brain tissue. The dual stimulation release mechanism of acid response and reactive oxygen species response can accurately respond to endogenous stimuli within glioma lesions and cells. Through the synergistic combination of the GO-C14 carrier and charge-reversed polylysine, the loading efficiency of YTHDF2 siRNA is effectively improved, while simultaneously enhancing the cyclic stability of nucleic acid drugs in vivo.