10 results about "Bony Tissues" patented technology

According to the in-situ printing track planning method provided by the invention, an integrated point cloud data processing flow is designed after 3D scanning, so that manual intervention is reduced; the LSCM algorithm and the ARAP algorithm are respectively utilized to carry out plane parameterization and dimension reduction on the three-dimensional triangular mesh so as to reduce the implementation difficulty and improve the path planning efficiency, and the two methods are mutually verified so as to ensure the parameterization effect; solving a grid correspondence problem by utilizing vertex topology uniqueness, and designing a dynamic reasoning mechanism, namely, when fingerprints are not completely unique, gradually deducing to global correspondence through limited vertex corresponding information in a triangle to adapt to uncertainty of defective grid information; a defective skull layering path is integrally generated through input bone tissue parameters and curved surface defect grids, and the structural characteristics of an original skull are simulated. The whole process of the method from point cloud preprocessing to path generation is automatic, intervention is reduced, response is quick, adaptation individuation is improved, and skull tissue function recovery is promoted through bionic design.

An apparatus for extraction of osseous tissue is disclosed. The apparatus includes a fixed portion and a clamp oriented along a generally central area of the fixed portion. The apparatus includes a first bone cutting device and a second bone cutting device coupled to the fixed portion and oriented around the clamp. The first bone cutting device and the second bone cutting device are coupled to the fixed portion using respective joints that accommodate orientations of the first bone cutting device and the second bone cutting device relative to the fixed portion along different horizontal and vertical axes. The clamp is configured to engage a first bone portion during a surgical procedure. The first bone cutting device and the second bone cutting device are configured to remove a second bone portion.

This invention belongs to the field of hard tissue pathology slide preparation technology and discloses an embedding device for easy fixation of hard tissue. It includes an embedding layer with a curling deformation function, and several fixing units are provided on one side of the embedding layer. When the embedding layer is curled into a ring, the fixing units surround the hard tissue and compress and fix it. This invention uses the curling deformation of the embedding layer to drive the fixing units to distribute around the hard tissue, compressing and fixing it. The embedding layer is placed in an embedding bottle to maintain its curled shape. This fixation method is simple and convenient, and can fix biological bone tissue in the desired position and direction. The embedding layer and fixing units are made of polypropylene, which has stable chemical properties, is not prone to chemical reaction with the embedding liquid, and has relatively soft physical properties, making it less likely to cause defects in the embedded block. It also does not affect subsequent cutting, deplasticizing, or other processes.

The invention relates to a method for enhancing the osteogenic differentiation of mesenchymal stromal cells (MSCs) by culturing same in an osteogenic medium with an added EphB3-receptor blocking reagent. The blocking reagent may be selected from polyclonal antibodies, monoclonal antibodies, fusion proteins or a combination thereof. The invention also relates to the cells of the osteogenic lineage obtained using the described method and to the EphB3-receptor blocking reagents, for use in the treatment of bone diseases causing bony tissue deficiency and / or bone fractures. The invention also relates to pharmaceutical compositions containing the cells of the osteogenic lineage obtained using the method and / or the EphB3-receptor blocking reagents.

The present invention relates to a vertebral system comprising a vertebral implant (2) and a plurality of inserts, said implant being designed to be implanted in a vertebral segment composed of at least two vertebrae and including a body (20) the walls whereof delimit a cavity (23) leading to the outside of the body (20) through at least one opening in at least one of said walls, at least one passage (21) passing through the implant (2) from the periphery to an upper or lower surface to receive a bone-anchoring device (1) capable of anchoring the implant (2) in at least one of said vertebrae, the system being characterized in that it includes at least two inserts selected from among the following inserts:at least one graft insert (3, 3A, 3B, 4, 5A, 5B, 6A, 6B, 6C, 6D, 202, 250) capable of being colonized by bone tissue and / or receiving at least one bone tissue graft and / or at least one substitute;and / orat least one bone-anchoring insert (210) comprising said passage (21) capable of receiving said bone-anchoring device (1).

A device for cutting bone tissue and, more particularly, a sonotrode suitable for use with an ultrasonic surgical instrument. The sonotrode has a head and a distal end piece, the distal end piece being equipped as a rectangular blade for cutting bones using mechanical vibration. The sonotrode has at least one structural element and the structural element is selected from the group including: a support structure, a lateral depression on each side, an increased width of the blade together with a slit at the distal end of the blade, or at least one lateral rib.

The present application relates to a double-nanoparticle co-stable 3D printing Pickering emulsion ink, a preparation method and an application, wherein trace functional element hydroxyapatite (X-HA) and gelatin nanoparticles (GNPs) are used as stabilizers, a mixed solution composed of distilled water, gelatin molecules and a crosslinking agent is used as a continuous phase, n-hexane is used as a dispersed phase, a Pickering emulsion ink is obtained after homogenization emulsification, a porous scaffold material is obtained through a direct ink writing technology of 3D printing, the porous scaffold material is soaked in salt solutions with different concentrations to improve mechanical properties, the dispersed phase is removed, and a hierarchical interconnected porous scaffold is obtained through freeze-drying.The 3D printing Pickering emulsion ink constructed by the present application has excellent rheological properties, can stably flow through a printer nozzle and allow an extruded filament to be immediately deposited.The printed product is stable, has a variety of channel structures, has good biocompatibility, and can be applied to the field of promoting bone repair in bone tissue engineering.

The invention relates to a method and a system for laser ablation of biological hard tissue based on ultrasonic-induced pulsed water jet. The system mainly comprises an ultrasonic system, a water supply system, an air supply system, a laser transmission system, an optical fiber fixing system and a waste liquid recovery system. Ultrasonic waves are adopted to induce pulse water jet to be coaxial with the hollow optical fiber, gas with a certain pressure intensity is introduced into the hollow optical fiber, and a laser beam is reflected into the hollow optical fiber through a reflector to be coupled and then acts on biological hard tissue. Water transmitted by the water supply system passes through the water cavity and flows to a laser ablation area along the outer wall of the optical fiber, the ultrasonic system generates vibration through a transducer to drive water flow to form pulsating water jet to impact the surface of the ablation area, and the water jet is helpful to enter a narrow kerf under the pulsating effect and is helpful to discharge ablation debris. Therefore, large-depth and high-quality drilling and slotting of biological hard tissues can be realized. Meanwhile, the air supply system controls the thickness of a water layer in a laser acting area on the surface of the bone tissue by introducing gas with certain pressure through the center of the hollow optical fiber, so that the water layer is prevented from greatly absorbing the laser, and high ablation efficiency is ensured. According to the invention, large depth, high ablation efficiency and high cooling efficiency can be simultaneously realized in laser ablation of biological hard tissues.

1. Name of the design product: Medical shaving handle. 2. Use of the design product: It is used in surgical operations in cooperation with shaving tools or grinding drill tools to achieve shaving or drilling of bone tissue and / or soft tissue. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Perspective view of Design 1. 5. Design 1 is designated as the basic design. 6. Other situations that need to be explained: In Design 1, part A is made of transparent or translucent material.

Investigations of fine tissue structures, such as those in non-neural, non-bony tissues or organs, are best carried out in intact tissues. Compositions and methods for rendering tissues transparent for subsequent three-dimensional analysis are described herein. The inventive compositions as tissue clearing compositions consist of four core components: (1) homogenizing agents such as N-methylglucamine, urea, thiourea, guanidine, guanidine chloride, lithium perchlorate, ethylenediamine and its derivatives; (2) water-soluble regulators such as iohexol, sodium thiosulfate, polyethylene glycol and its derivatives; (3) lipid-soluble regulators such as 2,2'-thiodiethanol, propylene glycol and its derivatives; and (4) borate compounds such as boric acid, tetraboric acid, disodium tetraborate and its derivatives. The disclosed tissue clearing compositions are particularly suitable for non-neural, non-bony tissues or organs. These tissues or organs can be fresh, archived or recovered from paraffin-embedded tissues.