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Preparation method of bionic bracket material in bone tissue engineering

A technology of bone tissue engineering and scaffold materials, which is applied in the field of biomaterials and tissue engineering for the regeneration and repair of bone tissue defects. The effect of promoting new bone growth

Inactive Publication Date: 2010-09-15
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the wood is directly impregnated with ceramic or glass precursor sol and then heat-treated, the strength of the obtained scaffold is not ideal.
Some researchers formed CaC by reactively infiltrating metallic calcium vapor into porous charcoal (pine and rattan). 2 , and then oxidized by air to CaO, CO 2 carbonization to CaCO 3 , and finally hydrothermally react with potassium dihydrogen phosphate to form hydroxyapatite (Tampieri A, et al. J Mater Chem, 2009, 19, 4973-4980), but the preparation process involves multiple high-temperature gas phase reactions, and the reaction conditions are difficult to control

Method used

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  • Preparation method of bionic bracket material in bone tissue engineering
  • Preparation method of bionic bracket material in bone tissue engineering
  • Preparation method of bionic bracket material in bone tissue engineering

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preparation example Construction

[0031] refer to figure 1 As shown, the preparation method includes the following steps: (1) mechanically processing a certain shape of wood, rattan or straw plant tissue templates, such as paulownia, pine, wisteria, sugar cane, etc., in a vacuum or inert gas environment with 1 Heat up to 400-650°C at a heating rate of ~15°C / min, and carbonize for 2-5 hours; (2) Using calcium nitrate, sodium nitrate, ethyl orthosilicate, butyl titanate, triethyl phosphate, etc. as raw materials, Prepare the mixture according to the chemical composition of the target product, dissolve it in a mixed solvent of ethanol and water at a concentration of 0.5-2mol / L, and synthesize hydroxyapatite sol and 45S5 glass sol with a solid content of 10-40wt% in an environment of pH 2-11 , calcium silicate sol, calcium titanate sol, etc.; (3) the porous carbon obtained in (1) is placed in an impregnation tank, first vacuumed and kept for 0.5 to 3 hours, after adding the inorganic sol obtained in (2), the Use ...

Embodiment 1

[0036] (1) Plant template selection and forming: choose the woody rattan wisteria as the initial template, its tubular hole diameter is 20-240 μm, the porosity is 86%, and it is made into a cylindrical block material through mechanical addition;

[0037] (2) Carbonization: Place the bulk material in (1) in a vacuum resistance furnace, heat it to 550°C at a heating rate of 5°C / min, and keep it carbonized for 3 hours to obtain a porous material that retains the external geometry and internal pore structure of the template. carbon;

[0038] (3) Sol preparation and vacuum / pressure impregnation: according to the Ca / P molar ratio of 1.67, measure the corresponding amount of calcium nitrate and triethyl phosphate, under the catalysis of hydrochloric acid, in a mixed solvent of ethanol and water, prepare at room temperature The hydroxyapatite precursor sol with a solid content of 20wt%; after aging at room temperature for 12 hours, the porous carbon is impregnated by a vacuum / pressure...

Embodiment 2

[0041] (1) plant template selection and shaping: same as (1) in embodiment 1;

[0042] (2) Carbonization: Place the bulk material in (1) in a vacuum resistance furnace, heat it to 500°C at a heating rate of 2°C / min, and keep it carbonized for 5 hours to obtain a porous material that retains the external geometry and internal pore structure of the template. carbon;

[0043] (3) Sol preparation and vacuum / pressure impregnation: according to the composition of SiO 2 ,P 2 o 5 , CaO and Na 2 The mass percent of O is respectively 45wt%, 6wt%, 24.5wt% and 24.5wt%, measures corresponding amount of tetraethyl orthosilicate, triethyl phosphate, calcium nitrate and sodium nitrate respectively, under citric acid catalysis, In a mixed solvent of ethanol and water, 45S5 bioactive glass precursor sol with a solid content of 30wt% was prepared at room temperature; after aging at room temperature for 24 hours, the porous carbon was impregnated by vacuum / pressure impregnation process, as fo...

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Abstract

The invention discloses a preparation method of a novel bionic supporting material in bone tissue engineering, belonging to the field of the bone tissue engineering. The preparation method comprises the following steps of: using a natural plant tissue as a template and preparing a bioceramic or bioactive glass porous bracket material with a bionic structure through processes of carbonization, vacuum / pressure impregnation of an inorganic sol, template removal by oxidation in the air, high temperature sintering and the like. The porous bracket material prepared by the invention has favorable physicochemical and biological properties, particularly has a plant tissue porous structure obviously characterized by tubular holes, wherein the structure is extremely similar to a cancellous bone and has a porosity of 70-95% and aperture range of 10-28 mu m. The unique porous structure of the porous bracket material can quicken the substance exchange speed outside and inside the bracket, is in favor of controlling the degradation speed of the bracket material and promoting the growth of new bones. The preparation method of the bionic bracket material of the bone tissue engineering has wide application potential in the generation and repair fields of hard tissues of the orthopaedics, the dentistry, the maxillofacial surgery and the like.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to the technical field of tissue engineering for bone tissue defect regeneration and repair; in particular, it relates to a preparation method of a bionic scaffold material for bone tissue engineering. Background technique [0002] Bone defects caused by trauma or disease are very common in clinical practice, which not only seriously affects the quality of life of patients, but also brings them a heavy economic burden. However, due to the limited ability of bone to repair itself, its repair has always been a difficult problem in clinical surgery, and there is no effective treatment so far. At present, autologous / allogeneic bone transplantation, periosteum transplantation, bone cell transplantation, microfracture and other repair methods are mostly used clinically. However, they have shortcomings such as limited donor sources, small repair area, immune rejection, loss of transp...

Claims

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Application Information

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IPC IPC(8): A61L27/42
Inventor 钱军民张伟康亚红
Owner XI AN JIAOTONG UNIV
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