79results about How to "Good drug sustained release performance" patented technology

The invention discloses a preparation method of a fibroin and graphene oxide composite bracket material. The preparation method comprises the steps of: performing dissolution, filtration, dialysis and centrifugation on degumming fibrous fibroin in sequence, and then condensing to obtain a silk fibroin aqueous solution; dispersing graphene oxide aqueous solution ultrasonically; filtering in a vacuum manner to remove impurities; mixing the graphene oxide aqueous solution with the silk fibroin solution; mixing uniformly; oscillating at the presence of ultrasonic waves for mutual crosslinking; then centrifuging to obtain a mixed solution; then preparing by adopting a freeze-drying method so as to obtain the porous fibroin and graphene oxide composite bracket material. The high-concentration fibroin and the graphene oxide blended aqueous solution has good mixing property, the obtained composite bracket material is excellent in air permeability and drug-carrying ability, is good in hygroscopic property and waste liquid removal effect, and has wide application foreground.

The invention relates to a biodegradable unsaturated polyphosphate ester containing phosphate ester and fumarate ester bonds and discloses a preparation method of the polyphosphate ester and a method for the application of the polyphosphate ester as a medical sustained release preparation for injecting into a treated part and as a hard tissue repair and filling material. The mixture composed of the polyphosphate ester, a cross-linking vinyl monomer, a free radical thermal initiator or photo initiator being capable of initiating or assist in initiating covalent cross-linking reaction and biologically active drugs has excellent medical sustained release effect and no toxic side effects. As a material for repairing the defects of osseous tissue, the biodegradable unsaturated polyphosphate ester can stimulate the formation of new bones; and the material can also be degraded gradually and finally be substituted by a new bone completely. The biodegradable unsaturated polyphosphate ester has outstanding biocompatibility and no obvious inflammation reactions and teratogenesis.

The invention provides a composite material as well as a preparation method and an application thereof. The preparation method of the composite material comprises the following steps: carrying out self-assembly reaction on a polymer with charges and micron or nano-scale doped material particles with surface charges in a solvent to generate a colloid, and removing the solvent from the colloid to obtain the composite material. The invention further provides a medicine carrying system which takes the composite material as a carrier. The composite material prepared from micron or nano-scale doped material particles which can be dispersed uniformly by coating the solvent with the colloid has a micron or nano-scale uniform and repetitive structure. Because the micron or nano-scale doped material particles for preparing the composite material are doped uniformly, and the polymer highly coats the micron or nano-scale doped material particles, the composite material has strong mechanical performance. The medicine carrying system with a micron or nano-scale structure can ensure that the medicines carried by the composite material are distributed uniformly. Because the polymer highly coats the micron or nano-scale doped material particles, the medicine carrying system has a better medicine slow-release effect than the traditional medicine carrying systems and can release the medicines more uniformly in a three-dimensional space than the traditional medicine carrying systems.

The invention relates to the technical field of fabric manufacturing, and discloses a method for preparing a mite-preventing fabric. The method comprises the steps that firstly, CaCO3 is adopted as a wall material, mite-preventing medicine is adopted as a core material, and mite-preventing microcapsules covered with CaCO3 are prepared; then mite-preventing finishing liquid is prepared, and contains the mite-preventing microcapsules and a waterborne polyurethane adhesive; finally, a fabric is soaked in the mite-preventing finishing liquid, and the mite-preventing fabric is obtained after drying. The mite-preventing microcapsules prepared from CaCO3 as the wall material are free of toxins and high in strength, the situation that the mite-preventing microcapsules are broken in the finishing process, and consequently the medicine is released and leaked is not prone to happen, and the good medicine slow release effect is achieved. When the mite-preventing finishing liquid is prepared, the waterborne polyurethane adhesive is added, the bonding force of the mite-preventing microcapsules and the fabric is improved, and therefore the mite-preventing durability of the fabric is remarkably improved. The selected mite-preventing medicine has the good mite resisting effect, and is low in toxicity to the human body and small in skin irritation. The method can be widely applied to various fabrics prepared from natural fibers or synthetic fibers.

The invention provides a preparation method and application of a Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere. The preparation method comprises the following steps: preparing Fe2O3 nanoparticles by using a solvothermal method; under the condition that no surfactant is added and TEOS is used as a silicon source, preparing a Fe3O4@SiO2 composite microsphere with controllable morphology under mild conditions by using a combination of a template method and a hydrothermal method; corroding the Fe3O4@SiO2 composite microsphere with hydrochloric acid with a certain concentration so as to obtain a Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere; and carrying out reduction so as to prepare the Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere with superparamagnetism. The prepared Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere has a specific surface area of 173 m<2>/g and drug loading capacity of 139 mg/g; and with doxorubicin hydrochloride as a drug model, the Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere has a drug release rate of as high as 68.4% within 72 h in a PBS buffer solution with a pH value of 7.4, so the composite microsphere presents good slow drug release performance.

The invention relates to a nanofiber membrane carrying an anti-tumor photosensitizer and a preparation method thereof. The nanofiber membrane carrying the anti-tumor photosensitizer is characterized by comprising the anti-tumor photosensitizer and a biodegradable high polymer material. The preparation method is characterized by comprising the following specific steps of: adding the anti-tumor photosensitizer and the biodegradable high polymer material into an organic solvent to obtain spinning solution; and performing electrostatic spinning on the spinning solution to prepare the nanofiber membrane carrying the anti-tumor photosensitizer. The membrane has the advantage of anti-tumor function. The preparation method has the advantages of simple operation, low cost, excellent medicament controlled-release performance and wide application prospect.

The invention discloses a preparation method of chitosan quaternary ammonium salt hyaluronic acid nanogel coated with basic fibroblast growth factors. The preparation method of chitosan quaternary ammonium salt hyaluronic acid nanogel coated with basic fibroblast growth factors is characterized by taking chitosan quaternary ammonium salt and sodium hyaluronate as raw materials and synthesizing a target product through a two-step process of ionic cross-linking and polymer condensation. The preparation method comprises the following steps: firstly mixing a chitosan quaternary ammonium salt solution with a basic fibroblast growth factor solution, and then dropwise adding a sodium tripolyphosphate solution into the mixed solution to prepare an ionic cross-linked mixed solution; and finally dropping sodium hyaluronate into the ionic cross-linked mixed solution for carrying out polymer condensation to prepare chitosan quaternary ammonium salt hyaluronic acid nanogel coated with basic fibroblast growth factors. The average particle diameter of the nanogel is 150-230nm; the Zeta potential is -28.6 to -36.7mV. The nanogel can be used for treating dental ulcer and has good research, development and utilization prospects.

The invention discloses a preparation method and application of drug sustained-release carrier hydrogel, and belongs to the technical field of medical polymers. The preparation method comprises the following steps: firstly, synthesizing beta-cyclodextrin with a bisacrylamide group with a hydrophobic cavity structure by taking beta-cyclodextrin and acryloyl chloride as raw materials, then preparing methylacryloylated gelatin from gelatin and methacrylic anhydride, and then performing free radical copolymerization under 365nm ultraviolet light by taking Irgacure2959 as an initiator, thereby obtaining the hydrogel. The drug loading capacity of the drug carrier hydrogel can reach 40.86 mg/g, and the drug carrier hydrogel can be continuously released for more than 96 hours in different environments (normal in-vivo physiological environment, lesion site environment and simulated gastric juice environment). A drug sustained-release carrier hydrogel system prepared by the invention is safe and non-toxic, has solubilization on hydrophobic drugs, improves the medication efficiency, and broadens the application range of the hydrogel in the field of medicines.

The invention discloses a curcumin nano crystal self-stabilizing Pickering emulsion and a preparation method thereof. Raw materials for preparing the curcumin nano self-stabilizing Pickering emulsion comprise the following components by percentage: 0.1-5% of curcumin, 5-10% of an oil phase, and the balance water, wherein the total amount of all the components is 100%. The preparation method comprises the steps: adding distilled water to the curcumin raw material medicine, carrying out shear dispersion by using a homogenizer to obtain a primary curcumin nano crystal suspension, and then preparing a curcumin nano crystal suspension by a high pressure homogenizer; and adding the oil phase to the curcumin nano crystal suspension, homogenating to obtain a curcumin nano crystal self-stabilizing Pickering primary emulsion, and then adding the primary emulsion into the high pressure homogenizer, to prepare the curcumin nano crystal self-stabilizing Pickering primary emulsion. The curcumin nano crystal as a stabilizer replaces traditional surfactants, the safety of the emulsion is improved, the stability is good, and slow release of curcumin can be kept for a long time while the emulsion drug loading capacity is increased.

The invention relates to an anti-cancer drug-loading nanofiber film and a preparation method thereof. The nanofiber film is composed of a loading drug and a substrate, wherein a photosensitizer and a chemotherapeutic drug in a molar ratio of 1:(1-2) are used as the loading drug of the nanofiber film; a biodegradable high molecular material is used as the substrate of the nanofiber film; and the total drug mass is 4% of the substrate mass. The preparation method comprises the steps of: (1) adding the chemotherapeutic drug to glacial acetic acid, heating to dissolve the drug to obtain a chemotherapeutic drug solution; adding the photosensitizer and the biodegradable high molecular material into an organic solvent, uniformly stirring, and then adding the chemotherapeutic drug solution to prepare a high polymer solution; and (2) carrying out electrostatic spinning on the high polymer solution, and volatilizing the organic solvent and the glacial acetic acid to obtain the anti-cancer drug-loading nanofiber film. The anti-cancer drug-loading nanofiber film can be used as a wound dressing at an operation wound for preventing infection, stopping bleeding and promoting healing of the operation wound; and the preparation method has the advantages of simplicity in operation, low cost, good drug slow-release performance and broad application prospect.

The invention discloses a preparation method of high-yield core-shell drug-loading PAN nanofiber; a simple solution system is utilized to prepare gel fiber by electrostatic spinning through nanospider electrostatic spinning machine, and the gel fiber is vacuum-dried to obtain the core-shell drug-loading PAN nanofiber having a diameter range of 100-800 nm. The spinning system prepared herein is stable, the preparation process is simple, there is no need to add an emulsifying agent, the cost is low, and energy consumption is low; the fiber prepared by using the method has high yield, and 0.5-1 g of the fiber may be prepared per min. The core-shell PAN nanofiber has effective slow release of drug and has potential application prospect in the field of slow release of drug.

The invention relates to a bone grafting material of gradient porous beta-TCP with bioactivity and an anti-infection effect. The bone grafting material consists of anti-infection medicaments, BMP-2 and beta-TCP. The invention also provides a method for preparing the bone grafting material of the gradient porous beta-TCP with the bioactivity and the anti-infection effect. The method comprises the following steps of: constructing the gradient porous beta-TCP; and compounding the gradient porous beta-TCP with the anti-infection medicaments and the BMP-2. The invention also provides the application of the bone grafting material. The grafting material has the advantages that: different structures are manufactured in the same ceramic by a manufacturing process of constructing a gradient porous bioceramic with the bioactivity and the anti-infection effect; the BMP-2 and antibiotics are compounded in the same material separately; and the physical and chemical properties of the material are ensured to be free from influence and the co-existence of two active substances are ensured, so that a good osteogenic active protein and a medicament sustained-release effect are achieved.

The invention relates to a preparation method of a modified PLGA-PEG nano-fiber blanket. The preparation method of the modified PLGA-PEG nano-fiber blanket comprises the steps of dissolving PLGA in solvent, adding EDC to the solvent, adding mPEG-NH2 to the solvent after reaction of 3-5 hours, crystallizing, purifying and drying after reaction of 3-5 days, obtaining the PLGA-PEG, then adding the PLGA-PEG to the solvent, stirring, obtaining a spinning solution, adding AMX to the spinning solution, stirring, spinning in an electrostatic mode, drying in a vacuum mode, and then obtaining the modified PLGA-PEG nano-fiber blanket. The preparation method is simple in process, and products are easy to obtain. The PLGA and mPEG-NH2 used in the preparation method are low in cost and have good biocompatibility. The prepared PLGA-PEG nano-fiber blanket has good blood compatibility and biocompatibility, slows down the phenomenon of burst release at the same time, is an excellent drug carrier, and has wide application prospect.

The invention provides a fluorescent material which contains a mesoporous material and a modified silicon nanocrystal. The modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on a silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3, wherein R1 is an alkenyl group, and R2 is a substituted or unsubstituted alkyl group. The invention also provides a preparation method of the fluorescent material, which comprises the following step: in the presence of an organic solvent, mixing and contacting the modified silicon nanocrystal and the mesoporous material, wherein the modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on the silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3, wherein R1 is an alkenyl group, and R2 is a substituted or unsubstituted alkyl group. The invention also provides application of the fluorescent material as a drug conduction carrier. The fluorescent material has fluorescent characteristic, and has the advantages of high capacity for resisting photofading and better drug slow-release property.

The invention provides memantine hydrochloride sustained release micro-pill tablets and a preparation method thereof. The memantine hydrochloride sustained release micro-pill tablets are prepared by directly pressing self-protected multi-layer micro-pills, and a filling agent, a disintegrating agent and other auxiliary tablet materials do not need to be added. The self-protected multi-layer micro-pill is composed of a pill core, a medicine layer, a sustained release layer, a protective layer and a compressible composite auxiliary material layer, can tolerate extrusion of a certain tabletting pressure, and contributes to keeping the integrity of a micro-pill sustained release coating and good sustained release properties of the medicine. The self-protected multi-layer micro-pill also has high compressibility, disintegration and lubricating property and can be directly pressed into tablets, and the prepared memantine hydrochloride sustained release micro-pill tablets have good drug content uniformity.

The invention discloses a polymer which is folate-polyoxyethylene-polypropylene oxide-polyoxyethylene-polycaprolactone (FA-F127-PCL) containing a folate-targeted group and an amphiphilic block taking polyoxyethylene-propylene oxide-ethylene oxide as a hydrophilic segment and polycaprolactone as a hydrophobic segment and having a novel chemical structure and a preparation method of the compound. The compound is good in slow-release effect.

The invention discloses composite-structure bacterial cellulose/polyacrylonitrile medicine-carrying fiber prepared with an anti-inflammatory agent as the model medicine according to the characteristics of compactness and hydrophobicity of polyacrylonitrile. The composite medicine-carrying fiber is prepared from bacterial cellulose, polyacrylonitrile, anti-inflammatory agent and a medicine skin penetration enhancer through three steps. Compared with bacterial cellulose fiber, the bacterial cellulose/polyacrylonitrile composite medicine-carrying fiber has greatly improved mechanical performance, dry-strength larger than or equal to 3.0 cN/dtex, wet-strength larger than or equal to 2.0 cN/dtex, dry extensibility of 15% and wet extensibility of 25%, and overcomes the defect that bacterial cellulose is poor in wet-strength; the fiber has a skin-core structure prepared through polyacrylonitrile coating soaking treatment, and coarse surface appearance becomes smooth; the fiber has better medicine slow-release property, and the slow-release time can be controlled to be 1-10 days according to a composite process; the composite medicine-carrying fiber can be woven into a suture with anti-inflammatory and analgesic functions and can also be woven into fabric and used as external dressing with anti-inflammatory, anti-rheumatism, analgesic, anti-febrile and anti-coagulation functions.

The invention discloses a preparation method of a layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer, wherein the preparation method comprises the following steps: 1) preparing an aqueous solution/suspension by using layered silicate nanoclay, and allowing to stand for standby application; and 2) dissolving a traditional Chinese medicine active monomer into a solvent in a reaction vessel, and then adding a functional monomer, a crosslinking agent and an initiator; in an inert gas atmosphere, adding the aqueous solution/suspension obtained in the step 1) by a dropping way; stirring to be uniform at room temperature, heating up to 60-70 DEG C, and carrying out a constant-temperature reaction until the reaction is finished; carrying out suction filtration, collecting a solid, and repeatedly washing the solid with an eluent until the traditional Chinese medicine active monomer as template molecules is eluted; and then drying to constant weight, and thus obtaining the layered silicate nanoclay/traditional Chinese medicine active monomer molecularly imprinted polymer. The preparation method is simple; and the obtained product can effectively improve the shortcomings of template molecules of a traditional method, effectively improves the drug loading capacity, and can be used as a novel drug carrier.

The invention provides a fluorescent material which contains an ordered mesoporous material and a modified silicon nanocrystal. The modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on a silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3. The invention also provides a preparation method of the fluorescent material, which comprises the following step: in the presence of an organic solvent, mixing and contacting the modified silicon nanocrystal and the ordered mesoporous material, wherein the modified silicon nanocrystal is prepared by performing silicon hydrogenation reaction on the silicon nanocrystal and silane compounds of which the general formula is R1Si(OR2)3. The invention also provides application of the fluorescent material as a drug conduction carrier. The fluorescent material has fluorescent characteristic, and has the advantages of high capacity for resisting photofading and better drug slow-release property.

The invention relates to a preparation method of an ibuprofen transdermal sustained-release preparation. According to the method, a biodegradable high-molecular material of polylactic acid is used asa shell layer material, a high-molecular material of polyvinylpyrrolidone is used as a core layer material, ibuprofen which is a medicament with strong crystallinity is loaded on the core layer of fiber by using a coaxial electrostatic spinning means, and the prepared ibuprofen transdermal sustained-release preparation has a core-shell structure. The invention utilizes the double-layer shielding function established by the special core-shell structure of the coaxial electrostatic spinning fiber to realize the inhibition of ibuprofen crystallization, and the coaxial electrostatic spinning fiberhas larger specific surface area, thereby improving the transdermal penetration effect and the drug treatment effect of the ibuprofen. The ibuprofen transdermal sustained-release preparation preparedby the method can flexibly adjust and control the drug loading ratio by adjusting the quality of the added drug, does not contain a penetration enhancer, can be directly applied to skin, has good usecomfort and drug sustained-release performance, and is beneficial to drug transdermal penetration and treatment.

The invention discloses a modified-montmorillonite-stabilized curcumin-carrying pickering emulsion and a preparing method thereof. The modified-montmorillonite-stabilized curcumin-carrying pickering emulsion is prepared from, by weight, 0.05% to 0.5% of curcumin bulk drugs, 0.1% to 5% of a stabilizer, 5% to 10% of oil phase matter and the balance water, wherein the total mass of the ingredients is 100%, and the stabilizer is curcumin-carrying modified montmorillonite. According to the modified-montmorillonite-stabilized curcumin-carrying pickering emulsion prepared with the preparing method, the emulsion is stabilized through the modified montmorillonite instead of a surfactant, and the toxic and side effects of the surfactant on the human body are avoided. As the drugs are loaded into the stabilizer montmorillonite, the drug loading capacity of the emulsion is increased.

The invention belongs to the technical field of regenerative medicine, and particularly relates to a sodium alginate/collagen composite bone scaffold as well as a preparation method and application thereof, and the preparation method comprises the following steps: providing hydroxyapatite hollow microspheres loaded with antibacterial drugs; carrying out a pre-crosslinking reaction on water, hydroxyapatite nanoparticles, a collagen crosslinking agent, collagen, D-glucolactone, sodium alginate and the hydroxyapatite hollow microspheres loaded with the antibacterial drugs, so as to obtain a pre-crosslinked mixture; printing the pre-crosslinked mixture to obtain a primary bone scaffold; subjecting the primary bone scaffold and bivalent copper ions to a re-crosslinking reaction so as to prepare the sodium alginate/collagen composite bone scaffold. The sodium alginate/collagen composite bone scaffold obtained by using the preparation method disclosed by the invention has good mechanical properties and a relatively stable structure, and has an antibacterial effect.

The invention provides a drug sustained-release material and a preparation method of the drug sustained-release material. The preparation method of the drug sustained-release material is as follows: (1) mixing and stirring low molecular weight chitosan, polyanionic cellulose, silk fibroin peptide, polycaprolactone, bovine serum albumin, glycollic acid, aloe polysaccharide and deionized water to obtain a component A; (2) mixing and stirring garlic oil, N,N'-bioleoyl ethidene diamine diethyl sodium sulfonate and polyethylene glycol to obtain a component B; (3) mixing the component A with the component B, and conducting ultrasonic shearing; (4) adding sodium tripolyphosphate and glutaraldehyde, heating and stirring; (5) standing and separating to obtain an aqueous phase, regulating the pH value to 8, centrifuging at the low speed to remove larger particles; (6) regulating the pH value of a suspension to neutral, centrifuging, abandoning a solvent, and drying. The drug sustained-release material is higher in water absorption, good in hydrophily and high in encapsulation efficiency, has an excellent drug sustained-release effect at the same time, and is most suitable for a drug taking 1dose per 24h.

The invention discloses a chitosan non-woven fabric and a preparation method and application thereof. The preparation method is characterized in that polymethylacrylic acid serves as a co-spinning high polymer material, polymethylacrylic acid and chitosan are subjected to electrostatic co-spinning to prepare chitosan superfine fibers, then the chitosan superfine fibers are subjected to high-temperature crosslinking, and the chitosan non-woven fabric is prepared. The chitosan non-woven fabric prepared through the electrostatic spinning technology has the advantages that the fibers are fine, and high porosity and a high specific surface area are achieved; polymethylacrylic acid serves as a co-spinning reagent and a cross-linking reagent at the same time, the spinnability of chitosan is improved, N,N-dimethyl formamide or dimethyl sulfoxide is used as a co-solvent, and the morphology of nano-fibers in the non-woven fabric is improved; the cross-linked chitosan non-woven fabric shows good structural stability, solvent-resistant performance, acid-alkali-resistant performance and drug slow release performance; the drug slow release performance can be adjusted by adjusting cross-linking time and temperature, and therefore the application range of the chitosan non-woven fabric is widened.

The present invention belongs to the technical field of the nano material, especially relating to a hollow silica submicron ball with a kernel and the preparation method and the use. In an alcohol system, a silicon ester and a silane coupling agent hydrolyze together under an ammonia catalysis, which produces the hybrid silica submicron ball. The hydrofluoric acid liquor processes a sol of the hybrid silica submicron ball, which produces the hollow silica submicron ball with the kernel. The particle size of the round submicron ball is between 100nm and 1000nm and the thickness of a shell is between 20nm and 200 nm. A movable round silica kernel with the particle size between 50nm and 600nm is in a hollow cavity. The submicron ball has a mesopore structure, of which the average pore diameter is between 3nm and 10nm and the specific surface area is between 140m2/g and 500 m<2>/g. the present invention can serve as a release carrier for a therapeutic medicine and can be used to build a photonic crystal, serving as a micro reactor, a energy storage material and a catalyst carrier of the chemical reaction. The present invention has the simple method and process and short production period.