Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof
A nanofiber membrane, photosensitizer technology, applied in antitumor drugs, fibrochemical characteristics, pharmaceutical formulations, etc., can solve the problems of large side effects of chemotherapy, damage to normal tissues, and restrict the actual curative effect of the therapy, and the specific surface area is conducive to, The effect of restoring normal function and preventing tumor recurrence
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Embodiment 1
[0023] Weigh 0.66g poly-L-lactic acid PLLA (molecular weight 8W-30W) and 0.0133g purpurin-18 with a balance, dissolve them in 7ml chloroform, and seal the bottle mouth to prevent solvent volatilization. Stir on a magnetic stirrer until completely dissolved. After the uniformly mixed solution was left to stand for 5 hours, the bottle was opened, and 3ml of acetone was added, and stirred evenly to obtain the spinning stock solution. Electrospinning was performed on the obtained solution, the applied voltage was 15KV, the receiving distance was 12cm, the spinning speed was 0.7ml / h, and the diameter of the spinneret was 0.8mm. The diameter of the obtained nanofiber is between 350nm and 1000nm. Such as figure 2 Shown is a 2000 times magnified scanning electron micrograph of the nanofibrous membrane loaded with an anti-tumor photosensitizer.
Embodiment 2
[0025] Take by balance 2.5g PLGA (molecular weight is 8W-30W) and 0.0133g hypoporphyrin, dissolve it in the mixed solvent of 7ml tetrahydrofuran and 3mlN-N dimethylformamide, and seal the bottle mouth, prevent solvent volatilization . Stir on a magnetic stirrer until completely dissolved. The uniformly mixed solution was left to stand for 5 hours to obtain the spinning dope. The obtained solution was electrospun with an applied voltage of 20KV, a receiving distance of 12cm, a spinning speed of 0.8ml / h, and a spinneret diameter of 0.8mm. The diameter of the obtained nanofiber is between 500nm and 1500nm.
Embodiment 3
[0027] Take by weighing 0.727g PCL (molecular weight is 8W-30W) and 0.0121g temoporphin with balance, it is dissolved in the mixed solvent of 7ml dichloromethane and 3mlN-N dimethylformamide, and seals bottle mouth, Prevent solvent from evaporating. Stir on a magnetic stirrer until completely dissolved. After the uniformly mixed solution was left to stand for 5 hours, the bottle was opened, and 3ml of acetone was added, and stirred evenly to obtain the spinning stock solution. Electrospinning was performed on the obtained solution, the applied voltage was 15KV, the receiving distance was 12cm, the spinning speed was 0.7ml / h, and the diameter of the spinneret was 0.8mm. The diameter of the obtained nanofiber is between 350nm and 1000nm.
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