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Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof

A nanofiber membrane and photosensitizer technology, applied in antitumor drugs, fibrous chemical characteristics, pharmaceutical formulations, etc., can solve the problems of large side effects, low concentration, and restrict the actual efficacy of chemotherapy, and achieve a specific surface area that is beneficial to biological Good compatibility and the effect of preventing tumor recurrence

Inactive Publication Date: 2012-05-23
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large side effects of chemotherapy, it is difficult for patients to tolerate long-term treatment, which limits the curative effect; while radiotherapy has the problem that some tumors cannot be locally controlled after increasing the radiation dose. Oxygen cells, in order to enhance the therapeutic effect, it is often necessary to increase the radiation dose, but if the radiation dose exceeds a certain limit, normal tissues will be damaged
Surgical resection is the most commonly used method, but there are often residual tumor cells after surgery, resulting in recurrence, which seriously restricts the actual curative effect of this therapy
[0003] After using traditional drug administration methods (oral, injection, intravenous infusion, etc.), there are still problems that the drug is released periodically in the human body, and the concentration will fluctuate, which is likely to cause toxic and side effects, and the utilization rate is low.

Method used

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  • Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof
  • Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof
  • Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 0.66g poly-L-lactic acid PLLA (molecular weight 8W-30W) and 0.0133g purpurin-18 with a balance, dissolve them in 7ml chloroform, and seal the bottle mouth to prevent solvent volatilization. Stir on a magnetic stirrer until completely dissolved. After the uniformly mixed solution was left to stand for 5 hours, the bottle was opened, and 3ml of acetone was added, and stirred evenly to obtain the spinning stock solution. Electrospinning was performed on the obtained solution, the applied voltage was 15KV, the receiving distance was 12cm, the spinning speed was 0.7ml / h, and the diameter of the spinneret was 0.8mm. The diameter of the obtained nanofiber is between 350nm and 1000nm. like figure 2 Shown is a 2000 times magnified scanning electron micrograph of the nanofibrous membrane loaded with an anti-tumor photosensitizer.

Embodiment 2

[0025] Take by balance 2.5g PLGA (molecular weight is 8W-30W) and 0.0133g hypoporphyrin, dissolve it in the mixed solvent of 7ml tetrahydrofuran and 3mlN-N dimethylformamide, and seal the bottle mouth, prevent solvent volatilization . Stir on a magnetic stirrer until completely dissolved. The uniformly mixed solution was left to stand for 5 hours to obtain the spinning dope. The obtained solution was electrospun with an applied voltage of 20KV, a receiving distance of 12cm, a spinning speed of 0.8ml / h, and a spinneret diameter of 0.8mm. The diameter of the obtained nanofiber is between 500nm and 1500nm.

Embodiment 3

[0027] Take by weighing 0.727g PCL (molecular weight is 8W-30W) and 0.0121g temoporphin with balance, it is dissolved in the mixed solvent of 7ml dichloromethane and 3mlN-N dimethylformamide, and seals bottle mouth, Prevent solvent from evaporating. Stir on a magnetic stirrer until completely dissolved. After the uniformly mixed solution was left to stand for 5 hours, the bottle was opened, and 3ml of acetone was added, and stirred evenly to obtain the spinning stock solution. Electrospinning was performed on the obtained solution, the applied voltage was 15KV, the receiving distance was 12cm, the spinning speed was 0.7ml / h, and the diameter of the spinneret was 0.8mm. The diameter of the obtained nanofiber is between 350nm and 1000nm.

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Abstract

The invention relates to a nanofiber membrane carrying an anti-tumor photosensitizer and a preparation method thereof. The nanofiber membrane carrying the anti-tumor photosensitizer is characterized by comprising the anti-tumor photosensitizer and a biodegradable high polymer material. The preparation method is characterized by comprising the following specific steps of: adding the anti-tumor photosensitizer and the biodegradable high polymer material into an organic solvent to obtain spinning solution; and performing electrostatic spinning on the spinning solution to prepare the nanofiber membrane carrying the anti-tumor photosensitizer. The membrane has the advantage of anti-tumor function. The preparation method has the advantages of simple operation, low cost, excellent medicament controlled-release performance and wide application prospect.

Description

technical field [0001] The invention relates to a nanofiber membrane loaded with an anti-tumor photosensitizer and a preparation method thereof. Background technique [0002] Tumor is a common and frequently-occurring disease that seriously threatens human life. At present, the commonly used methods for clinical treatment of tumors include chemotherapy, radiotherapy and surgical resection. Due to the large side effects of chemotherapy, it is difficult for patients to tolerate long-term treatment, which limits the curative effect; while radiotherapy has the problem that some tumors cannot be locally controlled after increasing the radiation dose, the main reason is that many tumors have insufficient radiation sensitivity. Oxygen cells, in order to enhance the therapeutic effect, it is often necessary to increase the radiation dose, but if the radiation dose exceeds a certain limit, normal tissues will be damaged. Surgical resection is the most commonly used method, but ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/34A61K41/00A61P35/00D01F1/02
Inventor 陈志龙李毓陵董莎严懿嘉陈芬杨晓霞达雅静
Owner DONGHUA UNIV
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